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Cited by 353

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

A Moderate Serving of High-Quality Protein Maximally Stimulates Skeletal Muscle Protein Synthesis in Young and Elderly Subjects

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Symons, T. Brock, Sheffield-Moore, Melinda, Wolfe, Robert R., Paddon-Jones, Douglas·2009·Journal of the American Dietetic Association
DOI 10.1016/j.jada.2009.06.369
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Abstract

Ingestion of sufficient dietary protein is a fundamental prerequisite for muscle protein synthesis and maintenance of muscle mass and function. The elderly are often at increased risk for protein-energy malnutrition, sarcopenia and a diminished quality of life. This study sought to compare changes in muscle protein synthesis and anabolic efficiency in response to a single moderate (113 g; 220 kcal; 30 g protein) or large serving (340 g; 660 kcal; 90 g protein) of 90% lean beef. Venous blood and vastus lateralis muscle biopsy samples were obtained during a primed, constant infusion (0.08 μmol/kg/min) of L-[ring-13C6] phenylalanine in healthy young (n=17; 34±3yrs) and elderly (n=17; 68±2yrs) individuals. Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive period and for 5 h following meal ingestion. Data were analysed using a two-way repeated measures ANOVA with Tukey's pair-wise comparisons. A 113 g serving of lean beef increased muscle protein synthesis by approximately 50% in both young and older volunteers. Despite a 3-fold increase in protein and energy content, there was no further increase in protein synthesis following ingestion of 340 g of lean beef in either age group. Ingestion of more than 30 g of protein in a single meal does not further enhance the stimulation of muscle protein synthesis in young and elderly.

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Metadata

Authors
Symons, T. B., Sheffield-Moore, M., Wolfe, R. R., & Paddon-Jones, D.
Venue
Journal of the American Dietetic Association
Publisher
Elsevier BV
Published
2009-09
Volume
109
Issue
9
Pages
1582-1586
ISSN
0002-8223 (ISSN-L)
DOI
10.1016/j.jada.2009.06.369
OpenAlex
W2065285042
Cited by
353
References
11
FWCI
6.62
Type
journal article
Language
en
Open access
green

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