Suicidality and depression disparities between sexual minority and heterosexual youth: A meta-analytic review
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Purpose To examine disparities between sexual minority youth (SMY) and heterosexual youth in rates of suicidality and depression symptoms.Methods Separate meta-analyses were conducted to examine suicidality and depression disparities. Studies were included if the average age of the participants was <18 years, and if suicidality or depression symptoms were compared across SMY and heterosexual youth.Results SMY reported significantly higher rates of suicidality (odds ratio [OR] = 2.92) and depression symptoms (standardized mean difference, d = .33) as compared with the heterosexual youth. Disparities increased with the increase in the severity of suicidality (ideation [OR = 1.96], intent/plans [OR = 2.20], suicide attempts [OR = 3.18], suicide attempts requiring medical attention [OR = 4.17]). Effects did not vary across gender, recruitment source, and sexual orientation definition.Conclusions Disparities in suicidality and depression may be influenced by negative experiences including discrimination and victimization. Clinicians should assess sexual orientation, analyze psychosocial histories to identify associated risk factors, and promote prevention and intervention opportunities for SMY and their families.
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The pooled OR for the association between sexual orientation and youth suicidality (behavior and suicidal ideation) is 2.92.
“Marshal et al. (2011) studied the association between sexual orientation and youth suicidality (behavior and suicidal ideation) through 19 studies with 122,955 participants, revealing a pooled OR of 2.92.”
From Risk and Protective Factors of Self-harm and Suicidality in Adolescents: An Umbrella Review with Meta-Analysis (2024) · cites this paper as Marshal et al. (2011)
The Results > Suicidality section reports 19 studies and an overall weighted OR of 2.92 (95% CI 2.11–4.03). The Method > Coding of Studies section includes suicidal ideation and suicidal behavior in its definition of suicidality. Our copy does not substantiate the citing sentence’s total of 122,955 participants (searched: “122,955,” “122955,” and sample sizes). (LLM, conf=0.87)
Experimental — accuracy not yet measuredDepression disproportionately affects young people who identify as LGBTQ.
“Depression is a debilitating and burdensome mental health disorder that disproportionately affects young people who identify as lesbian, gay, bisexual, transgender, or queer (LGBTQ) [1,2,3,4].”
From Findings from a feasibility study of an adapted cognitive behavioral therapy group intervention to reduce depression among lgbtq (Lesbian, gay, bisexual, transgender, or queer) young people (2019) · cites this paper as [2]
The Discussion (Clinical Implications for Adolescent Mental Health Services; page unavailable) reports that sexual minority youth have a substantially heightened risk of depression. The Introduction defines that group by same-sex attraction or behavior or gay/lesbian identity, and the Results consider bisexuality status. The paper does not establish the disparity for transgender or queer youth as such, so the broader LGBTQ wording exceeds its evidence. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThere is a significant association between bisexual youth and suicidal behaviors and ideations (OR 4.92).
“The review also investigated specifically bisexual youth, including four studies with 42,413 participants, and found a significant association between bisexual youth and suicidal behaviors and ideations (OR: 4.92) (Tables 1, 2).”
From Risk and Protective Factors of Self-harm and Suicidality in Adolescents: An Umbrella Review with Meta-Analysis (2024) · cites this paper as Marshal et al. (2011)
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Homelessness and Emergency Medicine: A Review of the Literature
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Persecution Experiences and Mental Health of LGBT Asylum Seekers
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Reviewing evidence of LGBTQ+ discrimination and exclusion in sport
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Suicide Risk and Sexual Orientation: A Critical Review
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Sexual Orientation and Non-Suicidal Self-Injury: A Meta-Analytic Review
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Disparities for LGBTQ and Gender Nonconforming Adolescents
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Coping With Sexual Orientation–Related Minority Stress
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“These include higher rates of mental health difficulties, such as depression and suicidality [2-4]; physical and sexual health problems, such as the incidence of HIV [5]; cigarette and”
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Peer Victimization and Dating Violence Among LGBTQ Youth
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The Language of LGBTQ+ Minority Stress Experiences on Social Media
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Depression and Suicidality in Gay Men: Implications for Health Care Providers
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Mental Health, Drug, and Violence Interventions for Sexual/Gender Minorities: A Systematic Review
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“Marshal et al. (2011) studied the association between sexual orientation and youth suicidality (behavior and suicidal ideation) through 19 studies with 122,955 participants, revealing a pooled OR of 2.92.”
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Mental Health in the Young Athlete
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- Authors
- Marshal, M. P., Dietz, L. J., Friedman, M. S., Stall, R., Smith, H. A., McGinley, J., Thoma, B. C., Murray, P. J., D'Augelli, A. R., & Brent, D. A.
- Affiliations
- University of Pittsburgh (US)
- University of North Carolina at Chapel Hill (US)
- University of Utah (US)
- West Virginia University (US)
- Corresponding author
- Marshal, Michael P.
- ORCID
- Venue
- Journal of Adolescent Health
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 49
- Issue
- 2
- Pages
- 115-123
- ISSN
- 1054-139X (ISSN-L)
- PMC
- PMC3649127
- OpenAlex
- W2097960714
- Cited by
- 1,215
- References
- 60
- Citations by year
- 2026: 46 · 2025: 75 · 2024: 90 · 2023: 108 · 2022: 113 · 2021: 139 · 2020: 147 · 2019: 92 · 2018: 81 · 2017: 80 · 2016: 81 · 2015: 52 · 2014: 49 · 2013: 38 · 2012: 14
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Adolescent Health (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institute on Drug Abuse (R01DA026312, R01DA030385)
- Topics
- Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- suicidality, depression, sexual minority youth, heterosexual youth, disparity, suicidal ideation, suicide attempts, sexual orientation, discrimination, victimization, adolescent mental health
- MeSH terms
- Adolescent, Bisexuality, Depression, Female, Homosexuality, Humans, Male, Suicide, Suicide, Attempted, Odds Ratio, Sexuality, Heterosexuality
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