Efficacy of Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Older Adults: Systematic Review, Meta-Analysis, and Meta-Regression
Abstract
Objective Generalized anxiety disorder (GAD) is a common disorder in older adults producing functional impairment, and psychotherapy is the preferred treatment option. Meta-analytic methods sought to determine the efficacy of outpatient cognitive behavioral therapy (CBT) with respect to the hallmark feature of GAD-uncontrolled and excessive worry. In order to optimize clinical applicability, variables associated with GAD treatment outcomes were also examined.Methods Systematic search of relevant databases and iterative searches of references from articles retrieved. All studies were required to have been a randomized control trial (RCT), to have used the Penn State Worry Questionnaire (PSWQ) or its abbreviated version (PSWQ-A) as an outcome measure, and to have conducted CBT with outpatient older adults. Fourteen RCTs (N = 985) were suitable and random-effects meta-analyses and univariate meta-regressions were conducted.Results At the end of treatment, and at 6-month follow-up, significant treatment effects favoring CBT were found in comparison to a waitlist or treatment-as-usual. When CBT was compared with active controls, a small nonsignificant treatment advantage was found for CBT at the end of treatment, with equivalence of outcomes at follow-up. Treatment effect size of CBT for GAD was significantly associated with attrition rates and depression outcomes.Conclusions CBT is more helpful than having no treatment for GAD in later life. Nevertheless, whether CBT shows long-term durability, or is superior to other commonly available treatments (such as supportive psychotherapy), remains to be tested. The relationship between treatment effects for GAD and depression following CBT warrants further research.
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CBT also works well when delivered remotely, and to a lesser extent in the elderly.
“CBT also works well when delivered remotely [107], and to a lesser extent in the elderly [108,109].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [108]
The Discussion reports that CBT is efficacious for older adults with generalized anxiety disorder compared with a waitlist or treatment as usual. It says the treatment effects add to evidence *suggesting* CBT may be less effective for older adults than younger adults; the citing sentence presents that relative difference more definitively. This source is cited for the elderly clause, not the remote-delivery clause. (LLM, conf=0.85)
Experimental — accuracy not yet measuredCBT may be less effective when applied to older adults as compared with younger populations.
“Furthermore, several studies have suggested that CBT may be less effective when applied to older adults as compared with younger populations, potentially because of age-related cognitive decline [20, 21], comorbidities such as generalised anxiety disorder [22–24], or general low perceived need or reluctance to seek for mental health treatment due to poor expectancies or stigma [25, 26].”
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“…has been speculated that older adults may benefit less from treatment due to factors such as cognitive decline and differences in the clinical expression of GAD symptoms (Covin et al ., 2008; Mohlman, 2008; Wolitzky-Taylor et al ., 2010; Hall et al ., 2016), especially when offered in group format.”
Anxiety and Fear-Related Disorders: Generalized Anxiety Disorder
Rosellini, A. J., & Brown, T. A. (2024) · Tasman’s Psychiatry · doi:10.1007/978-3-030-51366-5_74 · Cited by 1 · see citing works
- Authors
- Hall, J., Kellett, S., Berrios, R., Bains, M. K., & Scott, S.
- Affiliations
- University of Sheffield (GB)
- Sheffield Health and Social Care NHS Foundation Trust (GB)
- Corresponding author
- Hall, Jo
- ORCID
- Kellett, Stephen
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 24
- Issue
- 11
- Pages
- 1063-1073
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2429546986
- Cited by
- 157
- References
- 74
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 17 · 2023: 23 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 11 · 2018: 9 · 2017: 9 · 2016: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
- Keywords
- generalized anxiety disorder, cognitive behavioral therapy, older adults, outpatient psychotherapy, Penn State Worry Questionnaire, worry, treatment discontinuation, depression, treatment durability, psychotherapy efficacy
- MeSH terms
- Aged, Anxiety Disorders, Humans, Regression Analysis, Cognitive Behavioral Therapy, Treatment Outcome
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