Negative Affectivity, Aging, and Depression: Results From the Neurobiology of Late-Life Depression (NBOLD) Study
Open accessAbstract
Objective Neuroticism is a common yet understudied condition in older adults. We hypothesized that presence of high negativity affectivity (NA), a key feature of neuroticism, would be associated with different prefrontal cortex (PFC) activity and connectivity patterns in depressed and never-depressed older adults.Methods This is a baseline cross-sectional analysis of a cohort study of 52 depressed and 36 never-depressed older adults. Assessments included NA scores from the Type D Scale-14 and Montgomery-Åsberg Depression Rating Scale scores. All subjects had a 3T brain functional magnetic resonance imaging resting scan, neuronal activity determined by amplitude of low-frequency fluctuations (ALFFs) were obtained, and resting state functional connectivity (FC) analyses were performed. Analyses of covariance were conducted on ALFFs and FC to examine significant differences between groups.Results In the ALFF analyses there were clearly different patterns between depressed and comparison groups in the correlation of ALFFs and NA. The correlation differences between the two groups were significant in the dorsomedial PFC, insula, amygdala, and posterior cingulate cortex (PCC). FC analyses revealed different between-group connectivity patterns. Significantly higher ventromedial PFC-amygdala FC with NA correlation was found in the depressed group than that in the never-depressed group.Conclusion This study confirms differential activity of the dorsal and ventral regions of the medial PFC in individuals with high neuroticism. Our findings suggest increased rostral medial PFC activity may be a marker of resilience to depression in the elderly and decreased anterior ventromedial PFC, PCC, and amygdala activity may be a result of successful emotion regulation in never-depressed higher NA individuals.
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In older adults, executive functioning and neuroticism are separate factors that both raise risk for and maintain mood problems and cognitive decline.
“Converging neuropsychological and neuroimaging evidence indicates the cognitive process of executive functioning and the personality trait of neuroticism each individually and independently predispose and perpetuate mood disturbance and cognitive decline in older adults9–12.”
From State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome (2018) · cites this paper as [12]
In late-life depression, neuroticism correlates with stronger resting connectivity between medial prefrontal cortex and amygdala.
“Increased resting state functional connectivity in the mPFC and amygdala is also correlated with neuroticism in LLD12.”
From State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome (2018) · cites this paper as [12]
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Self-citationSintomas depressivos e pré-frontais em idosos institucionalizados e não institucionalizados
Ferreira, O. D. L., Reinaldo, D. P., Ferreira, M. D. L., & Alchieri, J. C. (2021) · Research Society and Development · doi:10.33448/rsd-v10i10.18705 · Cited by 2 · see citing works
Local brain abnormalities in emotional disorders: Evidence from resting state fMRI studies
Jia, X., Li, M.-T., Wang, C., Antwi, C. O., Darko, A. P., Zhang, B., & Ren, J. (2024) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1694 · Cited by 1 · see citing works
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- Authors
- Steffens, D. C., Wang, L., Manning, K. J., & Pearlson, G. D.
- Affiliations
- University of Connecticut (US)
- Hartford Hospital (US)
- Corresponding author
- Steffens, David C.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 25
- Issue
- 10
- Pages
- 1135-1149
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC5600659
- OpenAlex
- W2604973720
- Cited by
- 40
- References
- 58
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 6 · 2018: 6
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 MH096725)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- negative affectivity, neuroticism, geriatric depression, older adults, prefrontal cortex, amplitude of low-frequency fluctuation, resting-state functional connectivity, dorsomedial prefrontal cortex, ventromedial prefrontal cortex, amygdala, posterior cingulate cortex, insula, emotion regulation, aging
- MeSH terms
- Neuroticism, Affect, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Major Depressive Disorder, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prefrontal Cortex, Connectome
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