Patterns of growth and decline in lung function in persistent childhood asthma
Open accessAbstract
BACKGROUND: Tracking longitudinal measurements of growth and decline in lung function in patients with persistent childhood asthma may reveal links between asthma and subsequent chronic airflow obstruction. METHODS: We classified children with asthma according to four characteristic patterns of lung-function growth and decline on the basis of graphs showing forced expiratory volume in 1 second (FEV1), representing spirometric measurements performed from childhood into adulthood. Risk factors associated with abnormal patterns were also examined. To define normal values, we used FEV1 values from participants in the National Health and Nutrition Examination Survey who did not have asthma. RESULTS: Of the 684 study participants, 170 (25%) had a normal pattern of lung-function growth without early decline, and 514 (75%) had abnormal patterns: 176 (26%) had reduced growth and an early decline, 160 (23%) had reduced growth only, and 178 (26%) had normal growth and an early decline. Lower baseline values for FEV1, smaller bronchodilator response, airway hyperresponsiveness at baseline, and male sex were associated with reduced growth (P<0.001 for all comparisons). At the last spirometric measurement (mean [±SD] age, 26.0±1.8 years), 73 participants (11%) met Global Initiative for Chronic Obstructive Lung Disease spirometric criteria for lung-function impairment that was consistent with chronic obstructive pulmonary disease (COPD); these participants were more likely to have a reduced pattern of growth than a normal pattern (18% vs. 3%, P<0.001). CONCLUSIONS: Childhood impairment of lung function and male sex were the most significant predictors of abnormal longitudinal patterns of lung-function growth and decline. Children with persistent asthma and reduced growth of lung function are at increased risk for fixed airflow obstruction and possibly COPD in early adulthood. (Funded by the Parker B. Francis Foundation and others; ClinicalTrials.gov number, NCT00000575.).
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
More recent findings suggest that childhood asthma is related to longitudinal lung function trajectories that are "below normal" within both the general population and asthmatics.
“More recent findings suggest that childhood asthma is related to longitudinal lung function trajectories that are “below normal” within both the general population (162) and asthmatics (163).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [163]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Measurement of Observer Agreement for Categorical Data
Landis, J. R., & Koch, G. G. (1977) · Biometrics · doi:10.2307/2529310 · Cited by 81,148 · see citing works
Statistical Methods for Rates and Proportions
Fleiss, J. L., Levin, B., & Paik, M. C. (2003) · Wiley Series in Probability and Statistics · doi:10.1002/0471445428 · Cited by 18,646 · see citing works
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983 · see citing works
Hosmer, D. W., Lemeshow, S., & Sturdivant, R. X. (2013) · Wiley Series in Probability and Statistics · doi:10.1002/9781118548387 · Cited by 13,861 · see citing works
Spirometric Reference Values from a Sample of the General U.S. Population
Hankinson, J., Odencrantz, J. R., & Fedan, K. B. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.1.9712108 · Cited by 4,220 · see citing works
Hosmer, D. W., Lemeshow, S. A., & May, S. J. (2008) · Wiley series in probability and statistics · doi:10.1002/9780470258019 · Cited by 3,818 · see citing works
Applied Survival Analysis: Regression Modeling of Time-to-Event Data
Hosmer, D. W., Lemeshow, S. A., & May, S. J. (2008) · Cited by 3,030 · see citing works
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022363 · Cited by 1,460 · see citing works
Long-Term Effects of Budesonide or Nedocromil in Children with Asthma
The Childhood Asthma Management Program Research Group (2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431501 · Cited by 1,373 · see citing works
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease
Lange, P., Celli, B., Agustí, A., Boje Jensen, G., Divo, M., Faner, R., Guerra, S., Marott, J. L., Martinez, F. D., Martinez-Camblor, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411532 · Cited by 1,284 · see citing works
A 15-year follow-up study of ventilatory function in adults with asthma
Lange, P., Parner, J., Vestbo, J., Schnohr, P., & Jensen, G. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810223391703 · Cited by 1,250 · see citing works
LOWESS: A Program for Smoothing Scatterplots by Robust Locally Weighted Regression
Cleveland, W. S. (1981) · The American Statistician · doi:10.2307/2683591 · Cited by 1,182 · see citing works
Stern, D. A., Morgan, W. J., Wright, A. L., Guerra, S., & Martinez, F. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61379-8 · Cited by 615 · see citing works
The overlap syndrome of asthma and COPD: what are its features and how important is it?
Gibson, P. G., & Simpson, J. L. (2009) · Thorax · doi:10.1136/thx.2008.108027 · Cited by 607 · see citing works
Swanney, M. P., Ruppel, G. L., Enright, P., Pedersen, O. F., Crapo, R. O., Miller, M. R., Jensen, R. L., Falaschetti, E., Schouten, J. P., Hankinson, J., et al. (2008) · Thorax · doi:10.1136/thx.2008.098483 · Cited by 536 · see citing works
Early life origins of chronic obstructive pulmonary disease
Svanes, C., Sunyer, J., Plana, E., Dharmage, S., Heinrich, J., Jarvis, D., de Marco, R., Norback, D., Raherison, C., Villani, S., et al. (2010) · Thorax · doi:10.1136/thx.2008.112136 · Cited by 466 · see citing works
Decline in Lung Function in the Busselton Health Study
James, A. L., Palmer, L. J., Kicic, E., Maxwell, P. S., Lagan, S. E., Ryan, G. F., & Musk, A. W. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-230oc · Cited by 397 · see citing works
Early lung development: lifelong effect on respiratory health and disease
Stocks, J., Hislop, A., & Sonnappa, S. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70118-8 · Cited by 390 · see citing works
Enslein, K., Fletcher, C. M., Peto, R., Tinker, C. M., & Speizer, F. E. (1978) · Technometrics · doi:10.2307/1268722 · Cited by 362 · see citing works
The Childhood Asthma Management Program (CAMP)
Childhood Asthma Management Program Research Group (1999) · Controlled Clinical Trials · doi:10.1016/s0197-2456(98)00044-0 · Cited by 352 · see citing works
The association between childhood asthma and adult chronic obstructive pulmonary disease
Tai, A., Tran, H., Roberts, M. F., Clarke, N., Wilson, J. W., & ROBERTSON, C. F. (2014) · Thorax · doi:10.1136/thoraxjnl-2013-204815 · Cited by 305 · see citing works
Vonk, J. M. (2003) · Thorax · doi:10.1136/thorax.58.4.322 · Cited by 241 · see citing works
Self-citationHospers, J. J., Postma, D. S., Rijcken, B., Weiss, S. T., & Schouten, J. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02815-4 · Cited by 219 · see citing works
Self-citationThe effects of cigarette smoke on airway inflammation in asthma and COPD: Therapeutic implications
Tamimi, A., Serdarevic, D., & Hanania, N. A. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.11.003 · Cited by 180 · see citing works
GROL, M. H., Gerritsen, J., Vonk, J. M., Schouten, J. P., Koëter, G. H., Rijcken, B., & Postma, D. S. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9812100 · Cited by 180 · see citing works
Self-citationLower limit of normal or FEV1/FVC <0.70 in diagnosing COPD: An evidence-based review
Hoesein, F. A. A. M., Zanen, P., & Lammers, J. J. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.01.008 · Cited by 168 · see citing works
Mild to moderate asthma affects lung growth in children and adolescents
Strunk, R. C., Weiss, S. T., Yates, K. P., Tonascia, J., Zeiger, R. S., & Szefler, S. J. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.07.053 · Cited by 158 · see citing works
Self-citationOutcome of asthma: longitudinal changes in lung function
Ulrik, C. S. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.13d35.x · Cited by 152 · see citing works
Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in Adolescents
Hollams, E. M., de Klerk, N. H., Holt, P. G., & Sly, P. D. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201302-0323oc · Cited by 122 · see citing works
EPIDEMIOLOGY OF CHRONIC MUCUS HYPERSECRETION AND OBSTRUCTIVE AIRWAYS DISEASE
Speizer, F. E., & Tager, I. B. (1979) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036206 · Cited by 116 · see citing works
Bronchodilation and bronchoconstriction: Predictors of future lung function in childhood asthma
Tantisira, K. G., Fuhlbrigge, A. L., Tonascia, J. M., Natta, M. V., Zeiger, R. S., Strunk, R. C., Szefler, S. J., & Weiss, S. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.050 · Cited by 94 · see citing works
Self-citation1. Epidemiology and Natural History
Klein, J. O., Tos, M., Casselbrant, M. L., et al. (1994) · Annals of Otology Rhinology & Laryngology · doi:10.1177/00034894941030s804 · Cited by 91 · see citing works
Risk factors for adult‐onset asthma: A 14‐year longitudinal study
Jamrozik, E., Knuiman, M. W., JAMES, A., Divitini, M., & Musk, A. (2009) · Respirology · doi:10.1111/j.1440-1843.2009.01562.x · Cited by 66 · see citing works
The course of persistent airflow limitation in subjects with and without asthma
Guerra, S., Sherrill, D. L., Kurzius‐Spencer, M., Venker, C., Halonen, M. J., Quan, S. F., & Martínez, F. D. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.04.011 · Cited by 66 · see citing works
Asthma, airflow limitation and mortality risk in the general population
Huang, S., Vasquez, M. M., Halonen, M. J., Martínez, F. D., & Guerra, S. (2014) · European Respiratory Journal · doi:10.1183/09031936.00108514 · Cited by 60 · see citing works
Determinants of Maximally Attained Level of Pulmonary Function
Wang, X., Mensinga, T. T., Schouten, J. P., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2201011 · Cited by 59 · see citing works
Hallberg, J., Anderson, M. P., Wickman, M. C., & Svartengren, M. (2010) · Pediatric Pulmonology · doi:10.1002/ppul.21190 · Cited by 24 · see citing works
Airway hyperresponsiveness and development of lung function in adolescence and adulthood
Harmsen, L., Ulrik, C. S., Porsbjerg, C. M., et al. (2014) · Respiratory Medicine · doi:10.1016/j.rmed.2014.01.009 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200 · see citing works
After asthma: redefining airways diseases
Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073 · see citing works
Bui, D. S., Lodge, C. J., Burgess, J. A., Lowe, A. J., Perret, J., Bui, M. Q., Bowatte, G., Gurrin, L., Johns, D. P., Thompson, B. R., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30100-0 · Cited by 602 · see citing works
Ramratnam, S. K., Bacharier, L. B., & Guilbert, T. W. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.04.031 · Cited by 119 · see citing works
Association of perfluoroalkyl substances exposure with impaired lung function in children
Qin, X.-D., Qian, Z. (., Dharmage, S. C., Perret, J., Geiger, S. D., Rigdon, S. E., Howard, S., Zeng, X.-W., Hu, L.-W., Yang, B.-Y., et al. (2017) · Environmental Research · doi:10.1016/j.envres.2017.01.025 · Cited by 90 · see citing works
Disaggregating asthma: big investigation versus big data
Belgrave, D., Henderson, J., Simpson, A., Buchan, I., Bishop, C., & Custovic, A. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.003 · Cited by 67 · see citing works
Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma
McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., et al. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201602-0250oc · Cited by 25 · see citing works
Self-citationTsuneyoshi, S., Kawayama, T., Sasaki, J., Kinoshita, T., Yano, C., Tokunaga, Y., Matsuoka, M., Imaoka, H., Matsunaga, K., Furukawa, K., et al. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s366453 · Cited by 8 · see citing works
- Authors
- McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., Cho, M. H., Croteau-Chonka, D. C., Castaldi, P. J., Jain, G., Sanyal, A., Zhan, Y., Lajoie, B. R., Dekker, J., Stamatoyannopoulos, J., Covar, R. A., Zeiger, R. S., Adkinson, N. F., Williams, P. V., Kelly, H. W., Grasemann, H., Vonk, J. M., Koppelman, G. H., Postma, D. S., Raby, B. A., Houston, I., Lu, Q., Fuhlbrigge, A. L., Tantisira, K. G., Silverman, E. K., Tonascia, J., Weiss, S. T., & Strunk, R. C.
- Affiliations
- Johns Hopkins University (US)
- National Jewish Health (US)
- University of Colorado Denver (US)
- Brigham and Women's Hospital (US)
- University of Massachusetts Chan Medical School (US)
- Howard Hughes Medical Institute (US)
- University of Washington (US)
- University Medical Center Groningen (NL)
- Harvard University (US)
- Washington University in St. Louis (US)
- ORCID
- McGeachie, Michael J.
- Yates, Katherine P.
- Zhou, Xiaobo
- Guo, Feng
- Wise, Robert A.
- Szefler, Stanley J.
- Kho, Alvin T.
- Cho, Michael H.
- Castaldi, Peter J.
- Jain, Gaurav
- Sanyal, Amartya
- Zhan, Ye
- Lajoie, Bryan R.
- Dekker, Job
- Stamatoyannopoulos, John
- Covar, Ronina A.
- Zeiger, Robert S.
- Williams, Paul V.
- Grasemann, Hartmut
- Vonk, Judith M.
- Koppelman, Gerard H.
- Postma, Dirkje S.
- Raby, Benjamin A.
- Lu, Quan
- Fuhlbrigge, Anne L.
- Tantisira, Kelan G.
- Silverman, Edwin K.
- Tonascia, James
- Weiss, Scott T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-05-12
- Volume
- 374
- Issue
- 19
- Pages
- 1842-1852
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC5032024
- OpenAlex
- W2357940608
- Cited by
- 608
- References
- 39
- Citations by year
- 2026: 32 · 2025: 47 · 2024: 65 · 2023: 53 · 2022: 59 · 2021: 71 · 2020: 75 · 2019: 64 · 2018: 58 · 2017: 64 · 2016: 20
- FWCI
- 55.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- UNM’s Digital Repository (University of New Mexico) (submittedVersion)
- eScholarship@UMassChan (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (K08HL102265, K25HL091124, R33HL120794, U01HL065899, R01HL113264, U01HL091075, R01HL089856, R01HL075478, P01HL105339, U01HL089856, R01HL124233, U01HL075408, R21HL120794, K08HL097029, P01HL083069, R01HL127200, U01HL105569, T32HL007427)
- National Human Genome Research Institute (HG007010, HG003143, U54HG007010, R01HG003143)
- National Institute of Nursing Research (R01NR013391)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- lung function decline, lung function growth, FEV1, chronic airflow obstruction, chronic obstructive pulmonary disease, airway hyperresponsiveness, bronchodilator response, male sex, risk factors
- MeSH terms
- Administration, Inhalation, Adolescent, Anti-Inflammatory Agents, Asthma, Bronchodilator Agents, Child, Child, Preschool, Female, Forced Expiratory Volume, Humans, Longitudinal Studies, Lung, Male, Risk Factors, Sex Factors, Spirometry, Nedocromil, Budesonide, Kaplan-Meier Estimate, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
