Cited by 121Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments

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Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer’s disease

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Nowrangi, Milap A., Lyketsos, Constantine G., Leoutsakos, Jeannie‐Marie S., Oishi, Kenichi, Albert, Marilyn, Mori, Susumu, Mielke, Michelle M.·2013·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2012.05.2186PMC PMC3639296

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Abstract

BACKGROUND: Diffusion tensor imaging (DTI) is a promising method for identifying significant cross-sectional differences of white-matter tracts in normal controls (NC) and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD). There have not been many studies establishing its longitudinal utility. METHODS: Seventy-five participants (25 NC, 25 amnestic MCI, and 25 AD) had 3-Tesla MRI scans and clinical evaluations at baseline and 3, 6, and 12 months. Fractional anisotropy (FA) and mean diffusivity (MD) were analyzed at each time-point and longitudinally in eight a priori-selected areas taken from four regions of interest (ROIs). RESULTS: Cross-sectionally, MD values were higher, and FA values lower in the fornix and splenium of the AD group compared with either MCI or NC (P < .01). Within-group change was more evident in MD than in FA over 12 months: MD increased in the inferior, anterior cingulum, and fornix in both the MCI and AD groups (P < .01). CONCLUSIONS: There were stable, cross-sectional, region-specific differences between the NC and AD groups in both FA and MD at each time-point over 12 months. Longitudinally, MD was a better indicator of change than FA. Significant increases of fornix MD in the MCI group suggest this is an early indicator of progression.

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Diffusion tensor imaging (DTI) in the detection of white matter lesions in patients with mild cognitive impairment (MCI) Sali DimitraD. A. VerganelakisE. GotsisP. ToulasJ. Papatriantafillou • C. KarageorgiouT. ThomaidesE. Z. KapsalakiG. Hadjigeorgiou •
Papadimitriou, A. G. (2013)

Authors: Nowrangi, M. A., Lyketsos, C. G., Leoutsakos, J. S., Oishi, K., Albert, M., Mori, S., & Mielke, M. M.
Affiliations: Johns Hopkins University (US)
Mayo Clinic (US)
Corresponding author: Nowrangi, Milap A.
ORCID: Lyketsos, Constantine G.
Leoutsakos, Jeannie‐Marie S.
Oishi, Kenichi
Albert, Marilyn
Mori, Susumu
Mielke, Michelle M.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2012-12-14
Volume: 9
Issue: 5
Pages: 519-528
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2012.05.2186
PMC: PMC3639296
OpenAlex: W2030309279
Cited by: 120
References: 64
Citations by year: 2026: 6 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 3 · 2021: 7 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 6 · 2016: 7 · 2015: 16 · 2014: 7 · 2013: 5
FWCI: 6.36
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: GlaxoSmithKline
National Institute on Aging (P50-AG005146, P50-AG021334, R21 AG033774)
National Institutes of Health (R21AG033774, P50AG005146)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: mild cognitive impairment, Alzheimer's disease
MeSH terms: Aged, Alzheimer Disease, Brain, Female, Humans, Image Interpretation, Computer-Assisted, Longitudinal Studies, Male, Nerve Fibers, Myelinated, Anisotropy, Diffusion Magnetic Resonance Imaging, Cognitive Dysfunction

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Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer’s disease

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