Deaths in the United States among persons with Alzheimer's disease (2010–2050)
Open accessAbstract
Background: Alzheimer's disease (AD) profoundly affects the end‐of‐life experience. Yet, counts of deaths attributable to AD understate this burden of AD in the population. Therefore, we estimated the annual number of deaths in the United States among older adults with AD from 2010 to 2050. Methods: We calculated probabilities of AD incidence and mortality from a longitudinal population‐based study of 10,802 participants. From this population, 1913 previously disease‐free individuals, selected via stratified random sampling, underwent 2577 detailed clinical evaluations. Over the course of follow‐up, 990 participants died. We computed age‐, sex‐, race‐, and education‐specific AD incidences and education‐adjusted AD mortality proportions specific to age, sex, and race group. We then combined these probabilities with US‐wide census, education, and mortality data. Results: In 2010, approximately 600,000 deaths occurred among individuals aged 65 years or older with AD, comprising 32% of all older adult deaths. By 2050, this number is projected to be 1.6 million, 43% of all older adult deaths. Conclusion: Individuals with AD comprise a substantial number of older adult deaths in the United States, a number expected to rise considerably in coming decades.
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Based on CHAP data, in 2020 an estimated 700,000 people age 65 and older in the United States had Alzheimer's dementia at death.
“Based on data from the Chicago Health and Aging Project (CHAP) study, in 2020 an estimated 700,000 people age 65 and older in the United States had Alzheimer's dementia at death.”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [383]
The Methods say the estimates used CHAP data, and the Results concern US adults aged 65 and older who died with Alzheimer’s disease. The Results give 700,000 for 2011, not 2020; the passages in our copy do not establish the claimed 2020 figure. (LLM, conf=0.82)
Experimental — accuracy not yet measuredBased on data from the Chicago Health and Aging Project study, in 2020 an estimated 700,000 people age 65 and older in the United States had Alzheimer's dementia at death.
“Based on data from the Chicago Health and Aging Project (CHAP) study, in 2020 an estimated 700,000 people age 65 and older in the United States had Alzheimer's dementia at death.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [413]
The Methods section says the estimates used CHAP data, and the Results concern US adults aged 65 and older who died with Alzheimer’s disease. But the Results assign the 700,000 estimate to 2011, not 2020; our copy does not give that figure for 2020. (LLM, conf=0.86)
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Self-citation
- Authors
- Weuve, J., Hebert, L. E., Scherr, P. A., & Evans, D. A.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- Weuve, Jennifer
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-03
- Volume
- 10
- Issue
- 2
- Pages
- e40-6
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC3976898
- OpenAlex
- W2056452325
- Cited by
- 173
- References
- 38
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 12 · 2023: 8 · 2022: 21 · 2021: 10 · 2020: 16 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 20 · 2015: 13 · 2014: 7
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AG011101)
- National Institute on Aging (AG011101)
- Alzheimer's Association (NIRG‐12‐242395)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Demography › Insurance, Mortality, Demography, Risk Management
- Keywords
- Alzheimer's disease, mortality
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Forecasting, Humans, Longitudinal Studies, Male, Population Surveillance, Probability, United States, Incidence
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