The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment
Open accessAbstract
Introduction: It is unclear whether white matter hyperintensities (WMHs), magnetic resonance imaging markers of small‐vessel cerebrovascular disease, promote neurodegeneration and associated clinical decline in Alzheimer's disease (AD), or simply co‐occur with recognized pathogenic processes. Methods: In 169 patients with mild cognitive impairment, followed for 3 years, we examined the association of (1) baseline regional WMH and cerebral spinal fluid–derived t‐tau (total tau) with entorhinal cortex atrophy rates, as a marker of AD‐related neurodegeneration, and conversion to AD; and (2) baseline regional WMH with change in t‐tau level. Results: In participants with low baseline t‐tau, higher regional WMH volumes were associated with faster entorhinal cortex atrophy. Higher parietal WMH volume predicted conversion to AD in those with high t‐tau. Higher parietal and occipital WMH volumes predicted increasing t‐tau. Discussion: WMHs affect AD clinical and pathologic processes both directly and interacting with tau.
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White matter lesions attributable to aberrant myelin breakdown have been widely reported in the brains of individuals with mild cognitive impairment.
“white matter lesions attributable to aberrant myelin breakdown have been widely reported in the brains of individuals with mild cognitive impairment (MCI) [127].”
From Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau (2021) · cites this paper as [127]
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- Authors
- Tosto, G., Zimmerman, M. E., Hamilton, J. L., Carmichael, O. T., Brickman, A. M., & Initiative, A. D. N.
- Affiliations
- Columbia University Irving Medical Center (US)
- Albert Einstein College of Medicine (US)
- Pennington Biomedical Research Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Corresponding author
- Brickman, Adam M.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2015-06-13
- Volume
- 11
- Issue
- 12
- Pages
- 1510-1519
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC4677059
- OpenAlex
- W575146699
- Cited by
- 112
- References
- 55
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 8 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 13 · 2019: 9 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 2
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense (W81XWH‐12‐1‐0013, W81XWH‐12‐2‐0012)
- Alzheimer's Disease Neuroimaging Initiative
- National Institutes of Health (U01 AG024904)
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Foundation for the National Institutes of Health
- Northern California Institute for Research and Education
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- white matter hyperintensities, mild cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Peptide Fragments, Amyloid beta-Peptides, tau Proteins, Disease Progression, Entorhinal Cortex, Cognitive Dysfunction, White Matter
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