Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease
Open accessAbstract
INTRODUCTION: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. METHODS: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. RESULTS: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P = .0046). DISCUSSION: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PART is unlikely to explain the findings in the TSC cohort.
“For these reasons, PART is unlikely to explain our findings in the TSC cohort.”
From Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation (2022) · cites this paper as [2]
The Discussion (> PART and AD; page not available) describes PART’s pathology and cognitive profile relative to Alzheimer’s disease, but does not assess a TSC cohort. The Methods (> Clinical cohorts and cognitive assessment; page not available) identifies the study cohorts as BLSA and Johns Hopkins participants. Searches for TSC and for the proposed explanation found no passage addressing whether PART explains the citing authors’ findings. (LLM, conf=0.78)
Experimental — accuracy not yet measuredAn isolated amnestic syndrome of the hippocampal type with only tau biomarker positivity can occur in primary age-related tauopathy or in atypical presentations of mixed 3 repeat or 4 repeat tau frontotemporal lobar degeneration.
“However, an isolated amnestic syndrome of the hippocampal type with only tau biomarker positivity can occur in primary age-related tauopathy37,38 or in atypical presentations of mixed 3 repeat or 4 repeat tau frontotemporal lobar degeneration100,102 (appendix p 2).”
From Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group (2021) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941 · see citing works
Ageing populations: the challenges ahead
Christensen, K., Doblhammer, G., Rau, R., & Vaupel, J. W. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61460-4 · Cited by 3,764 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
Hixson, J., & Vernier, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43176-1 · Cited by 2,933 · see citing works
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357 · see citing works
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Primary age-related tauopathy (PART): a common pathology associated with human aging
Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · see citing works
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works
Incidence of dementia over three decades in the Framingham heart study
Satizabal, C. L., Beiser, A. S., Chouraki, V., Chêne, G., Dufouil, C., & Seshadri, S. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1504327 · Cited by 1,051 · see citing works
A harmonized classification system for FTLD-TDP pathology
Mackenzie, I. R., Neumann, M., Baborie, A., Sampathu, D. M., du Plessis, D., Jaros, E., Perry, R. H., Trojanowski, J. Q., Mann, D. M. A., & Lee, V. M. ‐. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0845-8 · Cited by 1,013 · see citing works
Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
Baker, M., Litvan, I., Houlden, H., Adamson, J., Dickson, D., Perez-Tur, J., Hardy, J., Lynch, T., Bigio, E., & Hutton, M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.711 · Cited by 781 · see citing works
Tang, M.-X. (1998) · JAMA · doi:10.1001/jama.279.10.751 · Cited by 771 · see citing works
The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681 · see citing works
Jack, C. R., Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., et al. (2012) · Annals of Neurology · doi:10.1002/ana.22628 · Cited by 602 · see citing works
TDP-43 is a key player in the clinical features associated with Alzheimer’s disease
Josephs, K. A., Whitwell, J. L., Weigand, S. D., Murray, M. E., Tosakulwong, N., Liesinger, A. M., Petrucelli, L., Senjem, M. L., Knopman, D. S., Boeve, B. F., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1269-z · Cited by 481 · see citing works
Updated TDP-43 in Alzheimer’s disease staging scheme
Josephs, K. A., Murray, M. E., Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Petrucelli, L., Liesinger, A. M., Petersen, R. C., Parisi, J. E., & Dickson, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1537-1 · Cited by 366 · see citing works
Hippocampal sclerosis in advanced age: clinical and pathological features
Nelson, P. T., Schmitt, F. A., Lin, Y., Abner, E. L., Jicha, G. A., Patel, E., Thomason, P. C., Neltner, J. H., Smith, C. D., Santacruz, K. S., et al. (2011) · Brain · doi:10.1093/brain/awr053 · Cited by 279 · see citing works
Lifespan brain activity, β-amyloid, and Alzheimer's disease
Jagust, W. J., & Mormino, E. C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.09.004 · Cited by 221 · see citing works
Lipoproteins in the Central Nervous System
LaDu, M. J., Reardon, C. A., Eldik, L. J. V., Fagan, A. M., Bu, G., HOLTZMAN, D., & Getz, G. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06365.x · Cited by 206 · see citing works
Altered Proteins in the Aging Brain
Elobeid, A., Libard, S., Leino, M., Popova, S. N., & Alafuzoff, I. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw002 · Cited by 202 · see citing works
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
Nelson, P. T., Smith, C. D., Abner, E. L., Wilfred, B. R., Wang, W., Neltner, J. H., Baker, M., Fardo, D. W., Kryscio, R. J., Scheff, S. W., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1154-1 · Cited by 196 · see citing works
PART, a distinct tauopathy, different from classical sporadic Alzheimer disease.
Jellinger, K. A., Alafuzoff, I., Attems, J., Beach, T. G., Cairns, N. J., Crary, J. F., Dickson, D. W., Hof, P. R., Hyman, B. T., Jack, C. R., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1407-2 · Cited by 171 · see citing works
Josephs, K. A., Murray, M. E., Tosakulwong, N., Whitwell, J. L., Knopman, D. S., Machulda, M. M., Weigand, S. D., Boeve, B. F., Kantarci, K., Petrucelli, L., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1681-2 · Cited by 166 · see citing works
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
Senile Dementia with Tangles (Tangle Predominant Form of Senile Dementia)
Jellinger, K. A., & Bancher, C. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00160.x · Cited by 148 · see citing works
Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging
Troncoso, J. C., Martin, L. J., Dal Forno, G., & Kawas, C. H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00028-0 · Cited by 138 · see citing works
Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)
O'Brien, R. J., Resnick, S. M., Zonderman, A. B., Ferrucci, L., Crain, B. J., Pletnikova, O., Rudow, G., Iacono, D., Riudavets, M. A., Driscoll, I., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1179 · Cited by 137 · see citing works
Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly
Driscoll, I., Resnick, S. M., Troncoso, J. C., An, Y., O'Brien, R., & Zonderman, A. B. (2006) · Annals of Neurology · doi:10.1002/ana.21031 · Cited by 132 · see citing works
Self-citationNelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Santacruz, K., Smith, C. D., Patel, E., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181aacbe9 · Cited by 115 · see citing works
Brain pathologies in extreme old age
Neltner, J. H., Abner, E. L., Jicha, G. A., Schmitt, F. A., Patel, E., Poon, L. W., Marla, G., Green, R. C., Davey, A., Johnson, M. A., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.009 · Cited by 106 · see citing works
Overlapping but distinct TDP‐43 and tau pathologic patterns in aged hippocampi
Smith, V. D., Bachstetter, A. D., Ighodaro, E. T., Roberts, K. N., Abner, E. L., Fardo, D. W., & Nelson, P. T. (2017) · Brain Pathology · doi:10.1111/bpa.12505 · Cited by 104 · see citing works
Arnold, S. J., Dugger, B. N., & Beach, T. G. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1110-0 · Cited by 100 · see citing works
Individual estimates of age at detectable amyloid onset for risk factor assessment
Bilgel, M., An, Y., Zhou, Y., Wong, D. F., Prince, J. L., Ferrucci, L., & Resnick, S. M. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.08.166 · Cited by 91 · see citing works
Jack, C. R. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1362-3 · Cited by 88 · see citing works
The MAPT H1 haplotype is associated with tangle-predominant dementia
Santa‐María, I., Haggiagi, A. M., Liu, X., Wasserscheid, J., Nelson, P. T., Dewar, K., Clark, L. N., & Crary, J. F. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1017-1 · Cited by 83 · see citing works
Tau imaging in the study of ageing, Alzheimer's disease, and other neurodegenerative conditions
Villemagne, V. L., & Okamura, N. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.09.002 · Cited by 66 · see citing works
Cognitive decline associated with pathological burden in primary age‐related tauopathy
Jefferson‐George, K., Wolk, D. A., Lee, E. B., & McMillan, C. T. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.01.028 · Cited by 63 · see citing works
Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy
Besser, L. M., Crary, J. F., Mock, C., & Kukull, W. A. (2017) · Neurology · doi:10.1212/wnl.0000000000004521 · Cited by 58 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group
Dubois, B., Villain, N., Frisoni, G. B., Rabinovici, G. D., Sabbagh, M., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00066-1 · Cited by 1,051 · see citing works
“On the other hand, an isolated amnestic syndrome of the hippocampal type with only tau biomarker positivity can be encountered in primary age-related tauopathy (PART) 77,78 or in atypical presentations of mixed 3R/4R frontotemporal lobar degeneration (FTLD) tau 75,79 (Supplementary Figure 1).”
BackgroundResultAmyloid-β-independent regulators of tau pathology in Alzheimer disease
van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0240-3 · Cited by 580 · see citing works
Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
Rawat, P., Sehar, U., Bisht, J., Selman, A., Culberson, J., & Reddy, P. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112841 · Cited by 509 · see citing works
Jeremic, D., Jiménez-Díaz, L., & Navarro-López, J. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101496 · Cited by 306 · see citing works
Minoshima, S., Cross, D. J., Thientunyakit, T., Foster, N. L., & Drzezga, A. E. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.263194 · Cited by 179 · see citing works
Limbic-predominant age-related TDP-43 encephalopathy, ADNC pathology, and cognitive decline in aging
Kapasi, A., Yu, L., Boyle, P. A., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2020) · Neurology · doi:10.1212/wnl.0000000000010454 · Cited by 96 · see citing works
Is tau in the absence of amyloid on the Alzheimer’s continuum?: A study of discordant PET positivity
Weigand, A. J., Bangen, K. J., Thomas, K. R., Delano‐Wood, L., Gilbert, P. E., Brickman, A. M., Bondi, M. W., & Initiative, A. D. N. (2019) · Brain Communications · doi:10.1093/braincomms/fcz046 · Cited by 86 · see citing works
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
Iida, M. A., Farrell, K. W., Walker, J. M., Richardson, T. E., Marx, G. A., Bryce, C., Purohit, D. P., Ayalon, G., Beach, T. G., Bigio, E. H., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01233-3 · Cited by 78 · see citing works
Liu, X., Zhao, Y., Zhu, H., Wu, M., Zheng, Y., Yang, M., Cheng, Z., Ding, C., & Liu, W. (2021) · Food & Function · doi:10.1039/d1fo01349a · Cited by 77 · see citing works
Sha, J., Zhou, Y., Yang, J.-Y., Leng, J., Li, J., Hu, J., Liu, W., Jiang, S., Wang, Y., Chen, C., et al. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b04614 · Cited by 74 · see citing works
Ramanan, V. K., Castillo, A. M., Knopman, D. S., Graff‐Radford, J., Lowe, V. J., Petersen, R. C., Jack, C. R., Mielke, M. M., & Vemuri, P. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.13909 · Cited by 71 · see citing works
Cognitive trajectory in mild cognitive impairment due to primary age-related tauopathy
Teylan, M., Mock, C., Gauthreaux, K. M., Chen, Y., Chan, K. C. G., Hassenstab, J. J., Besser, L. M., Kukull, W. A., & Crary, J. F. (2019) · Brain · doi:10.1093/brain/awz403 · Cited by 67 · see citing works
The complex pathway between amyloid β and cognition: implications for therapy
Jagust, W. J., Teunissen, C. E., & DeCarli, C. S. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00128-x · Cited by 63 · see citing works
Rubinski, A., Franzmeier, N., Neitzel, J., Ewers, M., & (ADNI), T. A. D. N. I. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00702-6 · Cited by 63 · see citing works
Ferrer, I., Andrés‐Benito, P., Ausín, K., Pamplona, R., del Rı́o, J. A., Fernández‐Irigoyen, J., & Santamaría, E. (2021) · Brain Pathology · doi:10.1111/bpa.12996 · Cited by 60 · see citing works
A data-driven study of Alzheimer's disease related amyloid and tau pathology progression
Aksman, L., Oxtoby, N. P., Scelsi, M. A., Wijeratne, P. A., Young, A. L., Alves, I. L., Collij, L. E., Vogel, J. W., Barkhof, F., Alexander, D. C., et al. (2023) · Brain · doi:10.1093/brain/awad232 · Cited by 63 · see citing works
Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults
Chen, X., Cassady, K. E., Adams, J. N., Harrison, T. M., Baker, S. L., & Jagust, W. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2111-20.2020 · Cited by 58 · see citing works
Hypothesis review: Alzheimer's overture guidelines
Ferrer, I. (2022) · Brain Pathology · doi:10.1111/bpa.13122 · Cited by 54 · see citing works
Chang, K.-P., Ling, J. P., Redding-Ochoa, J., An, Y., Li, L., Dean, S. A., Blanchard, T. G., Pylyukh, T., Barrett, A., Irwin, K. E., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02653-2 · Cited by 38 · see citing works
Abnormal tau in amyloid PET negative individuals
Yoon, B., Guo, T., Provost, K., Korman, D., Ward, T. J., Landau, S. M., & Jagust, W. J. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.09.019 · Cited by 48 · see citing works
Costoya‐Sánchez, A., Moscoso, A., Silva‐Rodríguez, J., Pontecorvo, M. J., Devous, M. D., Aguiar, P., Schöll, M., Grothe, M. J., Initiative, A. D. N., Weiner, M. W., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.2560 · Cited by 48 · see citing works
Naude, J., Wang, M., Leon, R., Smith, E. E., & Ismail, Z. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.006 · Cited by 49 · see citing works
Hickman, R. A., Flowers, X. E., & Wısnıewskı, T. (2020) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01063-1 · Cited by 48 · see citing works
Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation
Hsu, W., Huang, N., Shiao, Y., Lu, C., Chao, Y., Huang, Y.-J., Yeh, C. C., & Lin, Y. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153576 · Cited by 46 · see citing works
Neuroimaging of Alzheimer’s disease: focus on amyloid and tau PET
Matsuda, H., Yoko, S., & Sato, N. (2019) · Japanese Journal of Radiology · doi:10.1007/s11604-019-00867-7 · Cited by 40 · see citing works
Jacklin, K. M., Pitawanakwat, K., Blind, M. J., O’Connell, M. E., Walker, J. D., Lemieux, A. M., & Warry, W. (2020) · Innovation in Aging · doi:10.1093/geroni/igaa038 · Cited by 40 · see citing works
Maldonado‐Díaz, C., Hiya, S., Yokoda, R. T., Farrell, K. W., Marx, G. A., Kauffman, J., Daoud, E. V., Gonzales, M. M., Parker, A. S., Canbeldek, L., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02716-y · Cited by 36 · see citing works
Genome-wide association study and functional validation implicates JADE1 in tauopathy
Farrell, K. W., Kim, S., Han, N., Iida, M. A., Gonzalez, E. M., Otero‐García, M., Walker, J. M., Richardson, T. E., Renton, A. E., Andrews, S. J., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02379-z · Cited by 36 · see citing works
Walker, J. M., Goette, W. F., Farrell, K. W., Iida, M. A., Karlovich, E., The PART Working Group, White, C. L., Crary, J. F., & Richardson, T. E. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12966 · Cited by 34 · see citing works
Zhao, Z., Zhang, L., Wen, Q., Luo, W., Zheng, W., Liu, T., Zhang, Y., Zhu, K., & Wu, D. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118584 · Cited by 29 · see citing works
Primary age‐related tauopathy in a Finnish population‐based study of the oldest old (Vantaa 85+)
Savola, S. E., Kaivola, K., Raunio, A., Kero, M., Mäkelä, M., Pärn, K., Palta, P., Tanskanen, M., Tuimala, J., Polvikoski, T. M., et al. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12788 · Cited by 28 · see citing works
Influence of APOE genotype in primary age-related tauopathy
Robinson, A., Davidson, Y. S., Roncaroli, F., Minshull, J., Tinkler, P., Horan, M. A., Payton, A., Pendleton, N., & Mann, D. M. A. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01095-1 · Cited by 27 · see citing works
FDG‐PET markers of heterogeneity and different risk of progression in amnestic MCI
Caminiti, S. P., Francesco, S. D., Tondo, G., Galli, A., Redolfi, A., Perani, D., Initiative, T. A. D. N., & the Interceptor Project (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13385 · Cited by 27 · see citing works
Distinct Brain Regions in Physiological and Pathological Brain Aging
Lee, J. S., Park, Y. H., Park, S., Yoon, U., Choe, Y. S., Cheon, B. K., Hahn, A., Cho, S. H., Kim, S. J., Kim, J. P., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00147 · Cited by 27 · see citing works
The Effects of Amyloid and Tau on Functional Network Connectivity in Older Populations
Wales, R. M., & Leung, H.-C. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0902 · Cited by 26 · see citing works
Chronic Traumatic Encephalopathy and Neuropathological Comorbidities
Stein, T. D., & Crary, J. F. (2020) · Seminars in Neurology · doi:10.1055/s-0040-1713628 · Cited by 27 · see citing works
TDP ‐43 Pathology Exacerbates Cognitive Decline in Primary Age‐Related Tauopathy
Smirnov, D. S., Salmon, D. P., Galasko, D. R., Edland, S. D., Pizzo, D. P., Goodwill, V., & Hiniker, A. O. (2022) · Annals of Neurology · doi:10.1002/ana.26438 · Cited by 26 · see citing works
Chen, X., Toueg, T. N., Harrison, T. M., Baker, S. L., & Jagust, W. J. (2023) · Annals of Neurology · doi:10.1002/ana.26813 · Cited by 26 · see citing works
Almeida, F., Santos, A. C., Jesus, T., Coelho, A., Quintas-Neves, M., Gauthreaux, K. M., Mock, C., Kukull, W. A., Crary, J. F., & Oliveira, T. G. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14191 · Cited by 25 · see citing works
Tau pathology mediates age effects on medial temporal lobe structure
Wisse, L. E. M., Xie, L., Das, S. R., de Florès, R., Hansson, O., Habes, M., Doshi, J. J., Davatzikos, C. A., Yushkevich, P. A., & Wolk, D. A. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.09.017 · Cited by 23 · see citing works
Rosa, G., Giannotti, C., Martella, L. A., Massa, F., Serafini, G., Pardini, M., Nobili, F. M., & Monacelli, F. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191075 · Cited by 21 · see citing works
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 21 · see citing works
Impact of APOE genotype on prion-type propagation of tauopathy
Williams, T., Ruiz, A. J., Ruiz, A. M., Vo, Q., Tsering, W., Xu, G. M., McFarland, K. N., Giasson, B. I., Sullivan, P. M., Borchelt, D., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01359-y · Cited by 21 · see citing works
Richardson, T. E., Walker, J. M., Farrell, K. W., Oliveira, T. G., White, C. L., & Crary, J. F. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02943-x · Cited by 21 · see citing works
Quintas-Neves, M., Teylan, M., Morais‐Ribeiro, R., Almeida, F., Mock, C., Kukull, W. A., Crary, J. F., & Oliveira, T. G. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.04.013 · Cited by 18 · see citing works
Stein-O’Brien, G., Palaganas, R. G., Meyer, E. M., Redding‐Ochoa, J., Pletniková, O., Guo, H., Bell, W. R., Troncoso, J. C., Huganir, R. L., & Morris, M. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115422 · Cited by 18 · see citing works
Walker, J. M., Gonzales, M. M., Goette, W. F., Farrell, K. W., White, C. L., Crary, J. F., & Richardson, T. E. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230022 · Cited by 18 · see citing works
Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies
Almeida, F., Marx, G. A., Rohde, S. K., Gonzales, M. M., Maldonado‐Díaz, C., Hiya, S., Clare, K. M., Samanamud, J. L., Slocum, C., Kauffman, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70575 · Cited by 14 · see citing works
Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice
Liaoa, A., Lyu, X., Ma, J., Hou, Y., Hui, M., Liu, N., Zhao, Y., Cui, Y., & Huang, J. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.10.012 · Cited by 16 · see citing works
Liu, A. J., Lusk, J. B., Ervin, J., Burke, J., O’Brien, R., & Wang, S.-H. J. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01330-x · Cited by 15 · see citing works
Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
Shi, Y., Tu, T., Jiang, J., Zhang, Q., Ai, J.-Q., Pan, A., Manavis, J., Tu, E., & Yan, X. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.596894 · Cited by 15 · see citing works
Lehmann, S., Schraen‐Maschke, S., Buée, L., Vidal, J., Delaby, C., Hirtz, C., Blanc, F., Paquet, C., Allinquant, B., Bombois, S., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00755-3 · Cited by 15 · see citing works
Browne, D. F., Smirnov, D. S., Coughlin, D. G., Peng, I., Standke, H. G., Kim, Y., Pizzo, D. P., Unapanta, A., Andreasson, T., Hiniker, A. O., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56469-7 · Cited by 15 · see citing works
Does early cognitive decline require the presence of both tau and amyloid-β?
Schöll, M., & Maaß, A. (2019) · Brain · doi:10.1093/brain/awz399 · Cited by 15 · see citing works
Ferrer, I., Andrés‐Benito, P., Sala‐Jarque, J., Gil, V., & del Rı́o, J. A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00101 · Cited by 14 · see citing works
ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease
Lennol, M. P., Bordier, C., Kamelher, L., Ulrich, J. D., Holtzman, D. M., & Gratuze, M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20250965 · Cited by 14 · see citing works
The unique neuropathological vulnerability of the human brain to aging
Ferrer, I. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101916 · Cited by 14 · see citing works
Yu, X. F., Duan, C., Gong, P., Zhao, Q., Wang, X. H., Geng, F., Zeng, J., Luo, T., Xu, Y., & Zhao, J. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117152 · Cited by 13 · see citing works
Genetics and Neuropathology of Neurodegenerative Dementias
Scholz, S. W., & Cobos, I. (2024) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001505 · Cited by 13 · see citing works
Lagarde, J., Olivieri, P., Tonietto, M., Gervais, P., Comtat, C., Caillé, F., Bottlaender, M., & Sarazin, M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01628-9 · Cited by 13 · see citing works
Zhao, Z.-Y., Zhang, L., Luo, W.-R., Cao, Z.-Z., Zhu, Q.-F., Kong, X.-Q., Zhu, K.-Q., Zhang, J., & Wu, D. (2022) · Human Brain Mapping · doi:10.1002/hbm.26062 · Cited by 12 · see citing works
Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy
Morris, M., Coste, G. I., Redding‐Ochoa, J., Guo, H., Graves, A. R., Troncoso, J. C., & Huganir, R. L. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad064 · Cited by 12 · see citing works
Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer’s Disease
Tredici, K. D., Schön, M., Feldengut, S., Ghebremedhin, E., Kaufman, S. K., Wiesner, D., Roselli, F., Mayer, B., Amunts, K., & Braak, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240483 · Cited by 11 · see citing works
Shepherd, T. M., & Nayak, G. K. (2019) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0000000000000225 · Cited by 11 · see citing works
Brain aging and Alzheimer’s disease, a perspective from non-human primates
Ferrer, I. (2024) · Aging · doi:10.18632/aging.206143 · Cited by 10 · see citing works
Zhao, Z., Cao, Z., Zhu, Q., Xu, H., Li, S., Zhu, L., Xu, G., Zhu, K., Zhang, J., & Wu, D. (2025) · Human Brain Mapping · doi:10.1002/hbm.70222 · Cited by 10 · see citing works
Primary age‐related tauopathy (PART) and Alzheimer's disease (AD)
Jellinger, K. A. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.01.005 · Cited by 10 · see citing works
The Adult Neurogenesis Theory of Alzheimer’s Disease
Abbate, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221279 · Cited by 8 · see citing works
Sporadic Creutzfeldt-Jakob Disease and Other Proteinopathies in Comorbidity
Parobková, E., van der Zee, J., Dillen, L., Broeckhoven, C. V., Rusina, R., & Matěj, R. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.596108 · Cited by 8 · see citing works
Hayashi, T., Shimonaka, S., Elahi, M., Matsumoto, S., Ishiguro, K., Takanashi, M., Hattori, N., & Motoi, Y. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201002 · Cited by 8 · see citing works
Chang, H., Huang, C., Huang, S., Hsu, S., Lin, K., Ho, T., Wu, H., & Chang, C. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13680 · Cited by 7 · see citing works
Yoshida, K., Hata, Y., Ichimata, S., Tanaka, R., & Nishida, N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14037 · Cited by 6 · see citing works
Significance of a positive tau PET scan with a negative amyloid PET scan
Robinson, C. G., Lee, J., Min, H.-K. P., Przybelski, S. A., Josephs, K. A., Jones, D. T., Graff‐Radford, J., Boeve, B. F., Knopman, D. S., Jack, C. R., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13608 · Cited by 6 · see citing works
Agrawal, S., Yu, L., Barnes, L. L., Bennett, D. A., Boyle, P. A., & Schneider, J. A. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02916-0 · Cited by 6 · see citing works
Robinson, A., Davidson, Y. S., Roncaroli, F., Minshull, J., Tinkler, P., Horan, M. A., Payton, A., Pendleton, N., & Mann, D. M. A. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12726 · Cited by 6 · see citing works
Primary age-related tauopathy in a Chinese cohort
Wang, X., Zhang, L., Lü, H., Wu, J., Liang, H., Liu, C., Tao, Q., Wu, Z., & Zhu, K. (2020) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900262 · Cited by 5 · see citing works
Cho, S. H., Kim, S., Choi, S., Kim, B. C., & Initiative, A. D. N. (2024) · Chonnam Medical Journal · doi:10.4068/cmj.2024.60.1.51 · Cited by 5 · see citing works
CCCDTD5: research diagnostic criteria for Alzheimer's Disease
Gauthier, S. G., Chertkow, H. M., Theriault, J., Chayer, C., Ménard, M., Lacombe, G., Rosa‐Neto, P., & Ismail, Z. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12036 · Cited by 5 · see citing works
Az Alzheimer-kór heterogenitása
Balázs, N., & Kovács, T. (2021) · Orvosi Hetilap · doi:10.1556/650.2021.32130 · Cited by 5 · see citing works
Suri, K., Ramesh, M., Bhandari, M., Gupta, V., Kumar, V., Govindaraju, T., & Murugan, N. A. (2024) · ChemBioChem · doi:10.1002/cbic.202400224 · Cited by 5 · see citing works
Lavrova, A., Pham, N. T. T., Vernon, C. J., Graff‐Radford, J., Boeve, B. F., Knopman, D. S., Kantarci, K., Jack, C. R., Nguyen, A. T., Ross, R. R., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70568 · Cited by 4 · see citing works
Tau Pathology Without Aβ—A Limited PART of Clinical Progression
Landau, S. M., & Mormino, E. C. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.1081 · Cited by 4 · see citing works
LATE, Hippocampal Sclerosis, and Primary Age-related Tauopathy
Ramanan, V. K., & Graff‐Radford, J. (2024) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001499 · Cited by 3 · see citing works
Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline
Thom, M., & Koepp, M. (2021) · Progress in inflammation research · doi:10.1007/978-3-030-67403-8_7 · Cited by 3 · see citing works
Alzheimer mimicry: LATE and PART
Bogdanović, N., Smailović, U., & Jelić, V. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02916-0 · Cited by 3 · see citing works
A demenciaellátás innovatív irányai
Dallos, R. G. (2022) · Máltai Tanulmányok · doi:10.56699/mt.2022.4.7 · Cited by 2 · see citing works
Chang, H., Huang, K., Huang, C.-G., Huang, C., Huang, S., Lin, K., & Chang, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115607 · Cited by 2 · see citing works
Matsubara, T., Ishii, K., Saito, Y., Tokumaru, A. M., Arakawa, A., Kurihara, M., Kurihara, M., Sengoku, R., Kanemaru, K., Iwata, A., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01815-x · Cited by 2 · see citing works
Andersen, L. S. N., Simonsen, A. H., Vogel, A., McWilliam, O. H., Hasselbalch, S. G., & Frederiksen, K. S. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251339679 · Cited by 2 · see citing works
Johnson, A. S., Ziaggi, G., Smith, A. C., Houlihan, H. M., Heuer, L. B., Guzmán, D. S., Okafor, A., Huey, E. D., Talmasov, D., Provenzano, F. A., et al. (2024) · medRxiv · doi:10.1101/2024.01.12.24301221 · Cited by 2 · see citing works
Liu, H., Liu, X., Tian, F., Chen, Y., Li, J., Wang, X. B., Qiu, W., Wang, X., Ma, C., & Ge, W. (2025) · Advanced Science · doi:10.1002/advs.202506044 · Cited by 1 · see citing works
Takayama, T., Hirose, T., Goto, M., Daida, H., Nakajima, M., Nakanishi, A., Murakami, K., & Motoi, Y. (2026) · Psychogeriatrics · doi:10.1111/psyg.70158 · Cited by 1 · see citing works
A “Stress Test” of the 2018 NIA AA Research Criteria for Alzheimer’s Disease
Hildebrandt, H., Kastrup, A., & Eling, P. (2020) · Zeitschrift für Neuropsychologie · doi:10.1024/1016-264x/a000281 · Cited by 1 · see citing works
Impact of the New Conceptual Framework of Alzheimer’s Disease in Imaging Studies
Dubois, B., Villain, N., Jacova, C., & Uspenskaya, O. (2020) · Springer eBooks · doi:10.1007/978-3-030-53168-3_13 · Cited by 1 · see citing works
Role of Alkoxyglycerol to Pause Tau-Induced Alzheimer’s Disease
Sharma, A., Prakash, S., Salih, S. M., Vinesh, P. M., Kumari, P., Lakshmi, S., & Elumalai, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-6703-9_9 · Cited by 1 · see citing works
The aging brain and brain banking
Jeżewski, R. C., Halliday, G. M., & Shepherd, C. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00010-x
Human genetics: Establishment of cause-and-effect relationships
Saido, T. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28979-8.00013-9
Cognitive Trajectory in Alzheimer Disease and Clinical Mimics
Barragan, C., Beyene, K. M., Decourt, B., & Sabbagh, M. N. (2025) · Neurology Open Access · doi:10.1212/wn9.0000000000000034
A Review of Supervised Learning Techniques for Dementia Detection from Cognitive Data
Alshehhi, T., Yang, Y., Chen, F., & Ayesh, A. (2025) · Journal of Information & Knowledge Management · doi:10.1142/s0219649225500601
- Authors
- Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M. S., Rabins, P. V., Resnick, S. M., & Troncoso, J. C.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- Department of Pathology Division of Neuropathology Johns Hopkins University School of Medicine Baltimore MD USA
- Department of Neurology Duke University School of Medicine Durham NC USA
- Corresponding author
- Troncoso, Juan C.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2018-11-19
- Volume
- 15
- Issue
- 1
- Pages
- 8-16
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6542566
- OpenAlex
- W2900909585
- Cited by
- 111
- References
- 47
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 10
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Hall Family Foundation
- BrightFocus Foundation
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- primary age-related tauopathy, Alzheimer's disease
- MeSH terms
- Neuropathology, Aged, 80 and over, Aging, Alzheimer Disease, Autopsy, Brain, Genotype, Humans, Longitudinal Studies, Memory, Neuropsychological Tests, Baltimore, Tauopathies, Apolipoprotein E4, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
