Lifespan brain activity, β-amyloid, and Alzheimer's disease

Jagust, William J.; Mormino, Elizabeth C.

doi:10.1016/j.tics.2011.09.004

Cited by 221Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Lifespan brain activity, β-amyloid, and Alzheimer's disease

Open access

Jagust, William J., Mormino, Elizabeth C.·2011·Trends in Cognitive Sciences

DOI 10.1016/j.tics.2011.09.004PMC PMC3206968

Open this paper in CoChat — free account

Abstract

Alzheimer's disease (AD) is the most common cause of progressive cognitive decline and dementia in adults. While the amyloid cascade hypothesis of AD posits an initiating role for the β-amyloid (Aβ) protein, there is limited understanding of why Aβ is deposited. A growing body of evidence based on in vitro, animal studies and human imaging work suggests that synaptic activity increases Aβ, which is deposited preferentially in multimodal brain regions that show continuous levels of heightened activation and plasticity across the lifespan. Imaging studies of people with genetic predispositions to AD are consistent with these findings, suggesting a mechanism whereby neural efficiency or cognitive reserve may diminish Aβ deposition. The aggregated findings unify observations from cellular and molecular studies with human cognitive neuroscience to reveal potential mechanisms of AD development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tics.2011.09.004

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

APP and Aβ homeostasis are exquisitely regulated processes, and bioenergetic metabolism regulates these processes.
“Overall, we feel we can confidently state APP and Aβ homeostasis are exquisitely regulated processes, and bioenergetic metabolism regulates these processes.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [184]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Correspondence of the brain's functional architecture during activation and rest
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905267106 · Cited by 5,150 · see citing works
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951 · see citing works
Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862 · see citing works
The adaptive brain: aging and neurocognitive scaffolding
Park, D. C., & Reuter-Lorenz, P. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093656 · Cited by 2,790 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
An active and socially integrated lifestyle in late life might protect against dementia
Fratiglioni, L., Paillard-Borg, S., & Winblad, B. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00767-7 · Cited by 2,135 · see citing works
Aging Gracefully: Compensatory Brain Activity in High-Performing Older Adults
Cabeza, R., Anderson, N. D., Locantore, J. K., & McIntosh, A. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1280 · Cited by 1,964 · see citing works
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works
APP Processing and Synaptic Function
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works
Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., & Mackay, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811879106 · Cited by 1,613 · see citing works
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works
Principles of Behavioral and Cognitive Neurology
(2000) · doi:10.1093/oso/9780195134759.001.0001 · Cited by 1,448 · see citing works
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366 · see citing works
Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
Wilson, R. S. (2002) · JAMA · doi:10.1001/jama.287.6.742 · Cited by 1,312 · see citing works
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease
Lacor, P. N., Buniel, M. C., Furlow, P. W., Sanz Clemente, A., Velasco, P. T., Wood, M., Viola, K. L., & Klein, W. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-06.2007 · Cited by 1,188 · see citing works
Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027 · see citing works
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977 · see citing works
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Lopresti, B. J., Ziolko, S., Bi, W., Paljug, W. R., et al. (2008) · Brain · doi:10.1093/brain/awn016 · Cited by 933 · see citing works
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
Lazarov, O., Robinson, J., Tang, Y.-P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M.-Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K., & Sisodia, S. S. (2005) · Cell · doi:10.1016/j.cell.2005.01.015 · Cited by 885 · see citing works
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · cited 1× · see citing works
“Although there is evidence that suggests an impact of APOE4 on AD via Aβ and non-Aβ pathways [26], it is difficult to separate these effects in human studies when Aβ measurements are unavailable.”
Background
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults
Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841 · see citing works
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., & Mintun, M. A. (2010) · Annals of Neurology · doi:10.1002/ana.21843 · Cited by 830 · see citing works
Regional aerobic glycolysis in the human brain
Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., Mintun, M. A., & Raichle, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010459107 · Cited by 738 · see citing works
Linguistic Ability in Early Life and Cognitive Function and Alzheimer's Disease in Late Life: Findings From the Nun Study
Snowdon, D. A. (1996) · JAMA · doi:10.1001/jama.1996.03530310034029 · Cited by 696 · see citing works
Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden
Hedden, T., Van Dijk, K. R. A., Becker, J. A., Mehta, A., Sperling, R. A., Johnson, K. A., & Buckner, R. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3189-09.2009 · Cited by 598 · see citing works
Medial temporal lobe function and structure in mild cognitive impairment
Dickerson, B. C., Salat, D. H., Bates, J. F., Atiya, M., Killiany, R., Greve, D. N., Dale, A. M., Stern, C. E., Blacker, D., Albert, M., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20163 · Cited by 561 · see citing works
Alzheimer's disease
Mucke, L. (2009) · Nature · doi:10.1038/461895a · Cited by 456 · see citing works
Neuroplasticity Failure in Alzheimer's Disease
Mesulam, M.-M. (1999) · Neuron · doi:10.1016/s0896-6273(00)81109-5 · Cited by 449 · see citing works
APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF Aβ42
Sheline, Y. I., Morris, J. C., Snyder, A. Z., Price, J. L., Yan, Z., D’Angelo, G., Liu, C., Dixit, S., Benzinger, T. L. S., Fagan, A. M., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3987-10.2010 · Cited by 430 · see citing works
Quantitative synaptic alterations in the human neocortex during normal aging
Masliah, E., Mallory, M. E., Hansen, L. A., DeTeresa, R. M., & Terry, R. D. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.192 · Cited by 408 · see citing works
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition
Vlassenko, A. G., Vaishnavi, S. N., Couture, L., Sacco, D., Shannon, B. J., Mach, R. H., Morris, J. C., Raichle, M. E., & Mintun, M. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010461107 · Cited by 404 · see citing works
Reimagining Alzheimer's Disease—An Age-Based Hypothesis
Herrup, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-10.2010 · Cited by 386 · see citing works
Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift
Golde, T. E., Schneider, L. S., & Koo, E. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.002 · Cited by 382 · see citing works
Widespread Changes in Synaptic Markers as a Function of Sleep and Wakefulness in Drosophila
Gilestro, G. F., Tononi, G., & Cirelli, C. (2009) · Science · doi:10.1126/science.1166673 · Cited by 360 · see citing works
Exercise and Alzheimer’s disease biomarkers in cognitively normal older adults
Liang, K. Y., Mintun, M. A., Fagan, A. M., Goate, A. M., Bugg, J. M., Holtzman, D. M., Morris, J. C., & Head, D. (2010) · Annals of Neurology · doi:10.1002/ana.22096 · Cited by 340 · see citing works
Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging
Mormino, E. C., Smiljic, A., Hayenga, A. O., Onami, S. H., Greicius, M. D., Rabinovici, G. D., Janabi, M., Baker, S. L., Yen, I. V., Madison, C. M., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr025 · Cited by 332 · see citing works
Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
Kok, E., Haikonen, S., Luoto, T., Huhtala, H., Goebeler, S., Haapasalo, H., & Karhunen, P. J. (2009) · Annals of Neurology · doi:10.1002/ana.21696 · Cited by 299 · see citing works
Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline
O’Brien, J. L., O’Keefe, K., LaViolette, P. S., DeLuca, A. N., Blacker, D., Dickerson, B. C., & Sperling, R. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e3966e · Cited by 297 · see citing works
Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain
Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M. L., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. (2008) · Science · doi:10.1126/science.1161591 · Cited by 295 · see citing works
Longitudinal evidence for diminished frontal cortex function in aging
Nyberg, L., Salami, A., Andersson, M., Eriksson, J., Kalpouzos, G., Kauppi, K., Lind, J., Pudas, S., Persson, J., & Nilsson, L.-G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012651108 · Cited by 290 · see citing works
Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study
Shaw, P., Lerch, J. P., Pruessner, J. C., Taylor, K. N., Rose, A. B., GREENSTEIN, D. K., CLASEN, L. S., Evans, A. C., Rapoport, J. L., & Giedd, J. N. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70106-0 · Cited by 287 · see citing works
Better Memory and Neural Efficiency in Young Apolipoprotein E 4 Carriers
Mondadori, C. R. A., de Quervain, D. J. ‐., Buchmann, A., Mustovic, H., Wollmer, M. A., Schmidt, C. F., Boesiger, P., Hock, C., Nitsch, R. M., Papassotiropoulos, A., et al. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl103 · Cited by 265 · see citing works
Socioeconomic status predicts hemispheric specialisation of the left inferior frontal gyrus in young children
Raizada, R. D. S., Richards, T. L., Meltzoff, A., & Kuhl, P. K. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.021 · Cited by 246 · see citing works
Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices
Nitsch, R. M., Farber, S. A., Growdon, J. H., & Wurtman, R. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5191 · Cited by 244 · see citing works
Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriers
Dennis, N. A., Browndyke, J. N., Stokes, J., Need, A., Burke, J. R., Welsh‐Bohmer, K. A., & Cabeza, R. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2009.07.003 · Cited by 201 · see citing works
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup
Sperling, R. A., Aisen, P. S. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J. A., Montine, T. J., et al. (2011) · Cited by 197 · see citing works
Differential effects of the APOE genotype on brain function across the lifespan
Filippini, N., Ebmeier, K. P., MacIntosh, B. J., Trachtenberg, A. J., Frisoni, G. B., Wilcock, G. K., Beckmann, C. F., Smith, S. M., Matthews, P. M., & Mackay, C. E. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.009 · Cited by 195 · see citing works
Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease
Hyman, B. T. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.70 · Cited by 192 · see citing works
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients
Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., & Wisniewski, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.007 · Cited by 189 · see citing works
Functional imaging studies of episodic memory in Alzheimer's disease: a quantitative meta-analysis
Schwindt, G., & Black, S. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.024 · Cited by 171 · see citing works
Larger temporal volume in elderly with high versus low beta-amyloid deposition
Chételat, G., Villemagne, V. L., Pike, K. E., Baron, J.-C., Bourgeat, P., Jones, G., Faux, N. G., Ellis, K. A., Salvado, O., Szoeke, C., et al. (2010) · Brain · doi:10.1093/brain/awq187 · Cited by 159 · see citing works
Not quite PIB-positive, not quite PIB-negative: Slight PIB elevations in elderly normal control subjects are biologically relevant
Mormino, E. C., Brandel, M. G., Madison, C. M., Rabinovici, G. D., Marks, S., Baker, S. L., & Jagust, W. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.098 · Cited by 158 · see citing works
Self-citation
Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene
Valla, J., Yaari, R., Wolf, A. B., Kusne, Y., Beach, T. G., Roher, A. E., Corneveaux, J. J., Huentelman, M. J., Caselli, R. J., & Reiman, E. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100129 · Cited by 150 · see citing works
A Deposition in Aging Is Associated with Increases in Brain Activation during Successful Memory Encoding
Mormino, E. C., Brandel, M. G., Madison, C. M., Marks, S. M., Baker, S. L., & Jagust, W. J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr255 · Cited by 146 · see citing works
ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory
Levi, O., Jongen‐Rêlo, A. L., Feldon, J., Roses, A. D., & Michaelson, D. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00045-7 · Cited by 145 · see citing works
Effect of Apolipoprotein E Allele ε4 on the Initial Phase of Amyloid β-Protein Accumulation in the Human Brain
Morishima-Kawashima, M., Oshima, N., Ogata, H., Yamaguchi, H., Yoshimura, M., Sugihara, S., & Ihara, Y. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64847-x · Cited by 119 · see citing works
Enhanced brain activity may precede the diagnosis of Alzheimer's disease by 30 years
Mondadori, C. R. A., Buchmann, A., Mustovic, H., Schmidt, C. F., Boesiger, P., Nitsch, R. M., Höck, C., Streffer, J. R., & Henke, K. (2006) · Brain · doi:10.1093/brain/awl266 · Cited by 118 · see citing works
Altered deactivation in individuals with genetic risk for Alzheimer's disease
Persson, J., Lind, J., Larsson, A., Ingvar, M., Sleegers, K., Van Broeckhoven, C., Adolfsson, R., Nilsson, L.-G., & Nyberg, L. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.01.026 · Cited by 102 · cited 1× · see citing works
“Specifically, mice expressing APOE4 show reduced synaptic plasticity and spine density [21,22] and older cognitively normal human carriers show reduced glucose metabolism [23] as well as impaired DMN deactivation during episodic memory (EM) encoding [24].”
Background
The effects of APOE-ε4 on the BOLD response
Trachtenberg, A. J., Filippini, N., & Mackay, C. E. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.009 · Cited by 96 · see citing works
Targets for the Prevention of Dementia
Middleton, L. E., & Yaffe, K. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091657 · Cited by 94 · see citing works
Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
Richter‐Schmidinger, T., Alexopoulos, P., Horn, M., Maus, S., Reichel, M., Rhein, C., Lewczuk, P., Sidiropoulos, C., Kneib, T., Perneczky, R., et al. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0539-8 · Cited by 93 · see citing works
Age and amyloid-related alterations in default network habituation to stimulus repetition
Vannini, P., Hedden, T., Becker, J. A., Sullivan, C., Putcha, D., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.01.003 · Cited by 82 · see citing works
Hippocampal Volume Differences Between Healthy Young Apolipoprotein E ε2 and ε4 Carriers
Alexopoulos, P., Richter‐Schmidinger, T., Horn, M., Maus, S., Reichel, M., Sidiropoulos, C., Rhein, C., Lewczuk, P., Doerfler, A., & Kornhuber, J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110356 · Cited by 69 · see citing works

Flagged first, then by citations

Sorted by citations

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
Jack, C. R., Andrews, J. S., Beach, T. G., Buracchio, T., Dunn, B., Graf, A., Hansson, O., Ho, C., Jagust, W., McDade, E., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13859 · Cited by 2,803 · see citing works
Sleep and Alzheimer disease pathology--a bidirectional relationship
Ju, Y.-E. S., Lucey, B. P., & Holtzman, D. M. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.269 · Cited by 996 · see citing works
How Does it STAC Up? Revisiting the Scaffolding Theory of Aging and Cognition
Reuter‐Lorenz, P. A., & Park, D. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9270-9 · Cited by 955 · see citing works
Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve
Barulli, D., & Stern, Y. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.012 · Cited by 924 · see citing works
What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus
Fjell, A. M., McEvoy, L., Holland, D., Dale, A. M., & Walhovd, K. B. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.02.004 · Cited by 799 · see citing works
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works
The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works
Sleep Quality and Preclinical Alzheimer Disease
Ju, Y.-E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C., & Holtzman, D. M. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2334 · Cited by 744 · see citing works
Resting-state functional connectivity in normal brain aging
Ferreira, L. K., & Busatto, G. F. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.017 · Cited by 586 · see citing works
Cascading network failure across the Alzheimer’s disease spectrum
Jones, D. T., Knopman, D. S., Gunter, J. L., Graff‐Radford, J., Vemuri, P., Boeve, B. F., Petersen, R. C., Weiner, M. W., & Jack, C. R. (2015) · Brain · doi:10.1093/brain/awv338 · Cited by 532 · see citing works
The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain
Mather, M., & Harley, C. W. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.01.001 · Cited by 485 · see citing works
Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men: A Randomized Clinical Trial
Ooms, S., Overeem, S., Besse, K., Rikkert, M. O., Verbeek, M., & Claassen, J. A. H. R. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1173 · Cited by 438 · see citing works
Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
Tijms, B. M., Wink, A. M., de Haan, W., van der Flier, W. M., Stam, C. J., Scheltens, P., & Barkhof, F. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.020 · Cited by 416 · see citing works
Resistance vs resilience to Alzheimer disease
Arenaza‐Urquijo, E. M., & Vemuri, P. (2018) · Neurology · doi:10.1212/wnl.0000000000005303 · Cited by 372 · see citing works
Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s disease
Kunz, L., Schröder, T. N., Lee, H. L., Montag, C., Lachmann, B., Sariyska, R., Reuter, M., Stirnberg, R., Stöcker, T., Messing-Floeter, P. C., et al. (2015) · Science · doi:10.1126/science.aac8128 · Cited by 345 · see citing works
Association of Lifetime Cognitive Engagement and Low β-Amyloid Deposition
Marks, S. M. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.2748 · Cited by 342 · see citing works
Life-span cognitive activity, neuropathologic burden, and cognitive aging
Wilson, R. S., Boyle, P. A., Yu, L., Barnes, L. L., Schneider, J. A., & Bennett, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31829c5e8a · Cited by 296 · see citing works
Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression
Huijbers, W., Mormino, E. C., Schultz, A. P., Wigman, S. E., Ward, A. M., Larvie, M., Amariglio, R. E., Marshall, G. A., Rentz, D. M., Johnson, K. A., et al. (2015) · Brain · doi:10.1093/brain/awv007 · Cited by 247 · see citing works
The serendipitous discovery of the brain's default network
Buckner, R. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.035 · Cited by 304 · see citing works
Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment
Mattsson, N., Tosun, D., Insel, P. S., Simonson, A., Jack, C. R., Beckett, L. A., Donohue, M., Jagust, W., Schuff, N. W., & Weiner, M. W. (2014) · Brain · doi:10.1093/brain/awu043 · Cited by 211 · see citing works
Early detection of Alzheimer's disease using PiB and FDG PET
Cohen, A. D., & Klunk, W. E. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.001 · Cited by 202 · see citing works
Neural compensation in older people with brain amyloid-β deposition
Elman, J. A., Oh, H., Madison, C. M., Baker, S. L., Vogel, J. W., Marks, S. M., Crowley, S., O’Neil, J. P., & Jagust, W. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3806 · Cited by 184 · see citing works
The sleep–wake Cycle and Alzheimer’s Disease: What do We know?
Lim, M. M., Gerstner, J. R., & Holtzman, D. M. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.33 · Cited by 168 · see citing works
Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging
Jagust, W. J., Landau, S. M., & Initiative, F. T. A. D. N. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3266-12.2012 · Cited by 162 · see citing works
Cognitive reserve and lifestyle: moving towards preclinical Alzheimer’s disease
Arenaza-Urquijo, E., Wirth, M., & Chételat, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00134 · Cited by 153 · see citing works
Intrinsic Connectivity Identifies the Hippocampus as a Main Crossroad between Alzheimer’s and Semantic Dementia-Targeted Networks
Joie, R. L., Landeau, B., Perrotin, A., Bejanin, A., Egret, S., Pèlerin, A., Mézenge, F., Belliard, S., Sayette, V. D. L., Eustache, F., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.026 · Cited by 156 · see citing works
Spatial patterns of atrophy, hypometabolism, and amyloid deposition in Alzheimer's disease correspond to dissociable functional brain networks: Network-Specificity of AD Pathology
Grothe, M. J., Teipel, S. J., & Initiative, F. T. A. D. N. (2016) · Human Brain Mapping · doi:10.1002/hbm.23018 · Cited by 150 · see citing works
Ushering in the study and treatment of preclinical Alzheimer disease
Langbaum, J. B. S., Fleisher, A., Chen, K., Ayutyanont, N., Lopera, F. J., Quiroz, Y. T., Caselli, R. J., Tariot, P. N., & Reiman, E. M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.107 · Cited by 145 · see citing works
Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease
Myers, N., Pasquini, L., Göttler, J., Grimmer, T., Koch, K., Ortner, M., Neitzel, J., Mühlau, M., Förster, S., Kurz, A., et al. (2014) · Brain · doi:10.1093/brain/awu103 · Cited by 132 · see citing works
Cortical hypermetabolism in MCI subjects: a compensatory mechanism?
Ashraf, A., Fan, Z., Brooks, D. J., & Edison, P. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2919-z · Cited by 136 · see citing works
Gene-Environment Interactions: Lifetime Cognitive Activity, APOE Genotype, and Beta-Amyloid Burden
Wirth, M., Villeneuve, S., Joie, R. L., Marks, S. M., & Jagust, W. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4612-13.2014 · Cited by 131 · see citing works
Brain imaging in the study of Alzheimer's disease
Reiman, E. M., & Jagust, W. J. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.075 · Cited by 134 · see citing works
Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults
Wirth, M., Haase, C. M., Villeneuve, S., Vogel, J. W., & Jagust, W. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.015 · Cited by 127 · see citing works
Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults
Farrell, M. E., Chen, X., Rundle, M. M., Chan, M. Y., Wig, G. S., & Park, D. C. (2018) · Neurology · doi:10.1212/wnl.0000000000006469 · Cited by 126 · see citing works
Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability
Elman, J. A., Madison, C. M., Baker, S. L., Vogel, J. W., Marks, S. M., Crowley, S., O’Neil, J. P., & Jagust, W. J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu259 · Cited by 119 · see citing works
Unmasking selective path integration deficits in Alzheimer’s disease risk carriers
Bierbrauer, A., Kunz, L., Gomes, C. A., Luhmann, M., Deuker, L., Getzmann, S., Wascher, E., Gajewski, P. D., Hengstler, J. G., Fernandez-Alvarez, M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba1394 · Cited by 115 · see citing works
Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline
Leal, S. L., Landau, S. M., Bell, R. K., & Jagust, W. J. (2017) · eLife · doi:10.7554/elife.22978 · Cited by 117 · see citing works
Self-citation
Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer’s Disease
Mormino, E. C., & Papp, K. V. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179928 · Cited by 117 · see citing works
Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease
Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M. S., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.215 · Cited by 111 · see citing works
Obstructive sleep apnoea and Alzheimer’s disease: In search of shared pathomechanisms
Polšek, D., Gildeh, N., Cash, D., Winsky‐Sommerer, R., Williams, S., Turkheimer, F., Leschziner, G. D., Morrell, M. J., & Rosenzweig, I. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.12.004 · Cited by 112 · see citing works
Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets
Fišar, Z. (2022) · Biomolecules · doi:10.3390/biom12111676 · Cited by 110 · see citing works
Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain
Ossenkoppele, R., Iaccarino, L., Schonhaut, D. R., Brown, J. A., Joie, R. L., O’Neil, J. P., Janabi, M., Baker, S. L., Kramer, J. H., Gorno‐Tempini, M., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101848 · Cited by 103 · see citing works
Transcranial Magnetic Stimulation in Alzheimer’s Disease: Are We Ready?
Weiler, M., Stieger, K. C., Long, J. M., & Rapp, P. R. (2019) · eNeuro · doi:10.1523/eneuro.0235-19.2019 · Cited by 105 · see citing works
β-Amyloid PET and neuropathology in dementia with Lewy bodies
Kantarci, K., Lowe, V. J., Chen, Q., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Jack, C. R., Graff‐Radford, J., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008818 · Cited by 104 · see citing works
Covarying alterations in Aβ deposition, glucose metabolism, and gray matter volume in cognitively normal elderly
Oh, H., Habeck, C. G., Madison, C. M., & Jagust, W. J. (2012) · Human Brain Mapping · doi:10.1002/hbm.22173 · Cited by 101 · see citing works
Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation
Arenaza‐Urquijo, E. M., Bejanin, A., Gonneaud, J., Wirth, M., Joie, R. L., Mutlu, J., Gaubert, M., Landeau, B., Sayette, V. D. L., Eustache, F., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.016 · Cited by 94 · see citing works
Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer’s Disease-Like Pathologies in AβPPswe/PS1ΔE9 Mice
Qiu, H., Zhong, R., Liu, H., Zhang, F., Li, S., & Le, W. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150774 · Cited by 94 · see citing works
Bilingualism and Cognitive Reserve: A Critical Overview and a Plea for Methodological Innovations
Calvo, N., García, A. M., Manoiloff, L. M. V., & Ibáñez, A. M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00249 · Cited by 93 · see citing works
Asymmetries of amyloid-β burden and neuronal dysfunction are positively correlated in Alzheimer’s disease
Frings, L., Hellwig, S., Spehl, T. S., Bormann, T., Buchert, R., Vach, W., Minkova, L., Heimbach, B., Klöppel, S., & Meyer, P. T. (2015) · Brain · doi:10.1093/brain/awv229 · Cited by 90 · see citing works
Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity
Pereira, J. B., Ossenkoppele, R., Palmqvist, S., Strandberg, T. O., Smith, R. A., Westman, E., & Hansson, O. (2019) · eLife · doi:10.7554/elife.50830 · Cited by 91 · see citing works
Daytime Sleepiness and Sleep Inadequacy as Risk Factors for Dementia
Tsapanou, A., Gu, Y., Manly, J. J., Schupf, N., Tang, M., Zimmerman, M. E., Scarmeas, N., & Stern, Y. (2015) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000431311 · Cited by 90 · see citing works
Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults
Huijbers, W., Mormino, E. C., Wigman, S. E., Ward, A. M., Vannini, P., McLaren, D. G., Becker, J. A., Schultz, A. P., Hedden, T., Johnson, K. A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3579-13.2014 · Cited by 89 · see citing works
Effect of Cognitive Reserve Markers on Alzheimer Pathologic Progression
Lo, R. Y., & Jagust, W. J. (2013) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182900b2b · Cited by 88 · see citing works
Cognitive and neural signatures of the APOE E4 allele in mid-aged adults
Evans, S., Dowell, N. G., Tabet, N., Tofts, P. S., King, S. L., & Rusted, J. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.145 · Cited by 86 · see citing works
Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease
Soldan, A., Pettigrew, C. A., Li, S., Wang, M., Moghekar, A., Selnes, O. A., Albert, M., & O’Brien, R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.017 · Cited by 84 · see citing works
Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer’s disease-risk genes
Ma, Z., Jiang, W., & Zhang, E. E. (2016) · Scientific Reports · doi:10.1038/srep36035 · Cited by 78 · see citing works
Functional connectivity with the retrosplenial cortex predicts cognitive aging in rats
Ash, J. A., Lu, H., Taxier, L. R., Long, J. M., Yang, Y., Stein, E. A., & Rapp, P. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525309113 · Cited by 79 · see citing works
Insula and Inferior Frontal Gyrus’ Activities Protect Memory Performance Against Alzheimer’s Disease Pathology in Old Age
Lin, F. V., Ren, P., Lo, R. Y., Chapman, B. P., Jacobs, A., Baran, T. M., Porsteinsson, A. P., Foxe, J. J., & Initiative, A. D. N. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160715 · Cited by 76 · see citing works
Sleep quality and cognitive decline in a community of older adults in Daqing City, China
Niu, J., Han, H., Wang, Y., Wang, L., Gao, X., & Liao, S. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.07.033 · Cited by 75 · see citing works
Influence of Cognitive Reserve on Cognitive Trajectories
Li, X., Song, R., Qi, X., Xu, H., Yang, W., Kivipelto, M., Bennett, D. A., & Xu, W. (2021) · Neurology · doi:10.1212/wnl.0000000000012728 · Cited by 73 · see citing works
Cerebrospinal Fluid Amyloid-β Levels are Increased in Patients with Insomnia
Chen, D., Wang, J., Zhang, L., Wang, Y., & Gao, C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170032 · Cited by 74 · see citing works
Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study
Millar, P. R., Gordon, B. A., Luckett, P. H., Benzinger, T. L. S., Cruchaga, C., Fagan, A. M., Hassenstab, J. J., Perrin, R. J., Schindler, S. E., Allegri, R., et al. (2023) · eLife · doi:10.7554/elife.81869 · Cited by 72 · see citing works
Distinct influence of specific versus global connectivity on the different Alzheimer’s disease biomarkers
Mutlu, J., Landeau, B., Gaubert, M., Sayette, V. D. L., Desgranges, B., & Chételat, G. (2017) · Brain · doi:10.1093/brain/awx279 · Cited by 70 · see citing works
Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease.
Verfaillie, S., Binette, A. P., Vachon-Presseau, É., Tabrizi, S., Savard, M., Bellec, L. P., Ossenkoppele, R., Scheltens, P., van der Flier, W. M., Breitner, J., et al. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.11.012 · Cited by 68 · see citing works
Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease
Mattsson, N., Schott, J. M., Hardy, J., Turner, M. R., & Zetterberg, H. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311321 · Cited by 71 · see citing works
The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly
Wirth, M., Oh, H., Mormino, E. C., Markley, C., Landau, S. M., & Jagust, W. J. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.10.012 · Cited by 67 · see citing works
Cognitive debt and Alzheimer’s disease
Marchant, N. L., & Howard, R. J. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141515 · Cited by 68 · see citing works
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Morrone, C. D., Raghuraman, R., Hussaini, S. A., & Yu, W. H. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00617-4 · Cited by 64 · see citing works
Default Mode Network Lateralization and Memory in Healthy Aging and Alzheimer’s Disease
Banks, S. J., Zhuang, X., Bayram, E., Bird, C. M., Cordes, D., Caldwell, J., Cummings, J. L., & Initiative, A. D. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180541 · Cited by 58 · see citing works
Connectivity of EEG synchronization networks increases for Parkinson’s disease patients with freezing of gait
Asher, E. E., Plotnik, M., Günther, M., Moshel, S., Levy, O., Havlin, S., Kantelhardt, J. W., & Bartsch, R. P. (2021) · Communications Biology · doi:10.1038/s42003-021-02544-w · Cited by 60 · see citing works
Role of Sleep Disturbance in the Trajectory of Alzheimer’s Disease
Kang, D. W., Lee, C. U., & Lim, H. K. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.2.89 · Cited by 60 · see citing works
Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease
Millar, P. R., Luckett, P. H., Gordon, B. A., Benzinger, T. L. S., Schindler, S. E., Fagan, A. M., Cruchaga, C., Bateman, R. J., Allegri, R., Jucker, M., et al. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119228 · Cited by 59 · see citing works
Cerebral hyperactivation across the Alzheimer’s disease pathological cascade
Corriveau‐Lecavalier, N., Adams, J. N., Fischer, L., Molloy, E. N., & Maaß, A. (2024) · Brain Communications · doi:10.1093/braincomms/fcae376 · Cited by 56 · see citing works
Cognitive decline and brain pathology in aging – need for a dimensional, lifespan and systems vulnerability view
Walhovd, K. B., Fjell, A. M., & Espeseth, T. (2014) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12120 · Cited by 55 · see citing works
Amyloid-β and Cognition in Aging and Alzheimer's Disease: Molecular and Neurophysiological Mechanisms
Hampel, H. J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129003 · Cited by 56 · see citing works
Gray matter network disruptions and amyloid beta in cognitively normal adults
Tijms, B. M., Kate, M. T., Wink, A. M., Visser, P. J., Ecay, M., Clerigue, M., Estanga, A., Garcia Sebastian, M., Izagirre, A., Villanua, J., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.015 · Cited by 59 · see citing works
Developmental neuroplasticity and the origin of neurodegenerative diseases
Schaefers, A. T. U., & Teuchert, G. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.797104 · Cited by 54 · see citing works
Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology
Grothe, M. J., Sepulcre, J., Gonzalez-Escamilla, G., Jelistratova, I., Schöll, M., Hansson, O., Teipel, S. J., & Initiative, A. D. N. (2018) · Brain · doi:10.1093/brain/awy189 · Cited by 142 · see citing works
Rethinking on the concept of biomarkers in preclinical Alzheimer’s disease
Berti, V., Polito, C., Lombardi, G., Ferrari, C., Sorbi, S., & Pupi, A. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2477-1 · Cited by 51 · see citing works
Ginseng gintonin, aging societies, and geriatric brain diseases
Choi, S.-H., Lee, R., Nam, S. M., Kim, D.-G., Cho, I., Kim, H., Cho, Y., Rhim, H., & Nah, S.-Y. (2020) · Integrative Medicine Research · doi:10.1016/j.imr.2020.100450 · Cited by 51 · see citing works
Is sleep disruption a risk factor for Alzheimer's disease?
Macedo, A. C., Balouch, S., & Tabet, N. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161287 · Cited by 49 · see citing works
Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Mihaescu, A. S., Valli, M., Uribe, C., Díez‐Cirarda, M., Masellis, M., Graff‐Guerrero, A., & Strafella, A. P. (2022) · Molecular Brain · doi:10.1186/s13041-022-00964-1 · Cited by 49 · see citing works
Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels
Arenaza‐Urquijo, E. M., Molinuevo, J. L., Sala‐Llonch, R., Solé‐Padullés, C., Balasa, M., Bosch, B., Olives, J., Antonell, A., Lladó, A., Sánchez‐Valle, R., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121906 · Cited by 49 · see citing works
Risk for Alzheimer’s disease: A review of long-term episodic memory encoding and retrieval fMRI studies
McDonough, I. M., Festini, S. B., & Wood, M. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101133 · Cited by 49 · see citing works
The relevance of beta-amyloid on markers of Alzheimer’s disease in clinically normal individuals and factors that influence these associations
Mormino, E. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9267-4 · Cited by 44 · see citing works
Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice
Ong, Q.-R., Chan, E. S., Lim, M.-L., Cole, G. M., & Wong, B.-S. (2014) · Scientific Reports · doi:10.1038/srep03754 · Cited by 44 · see citing works
Is Verbal Episodic Memory in Elderly with Amyloid Deposits Preserved Through Altered Neuronal Function?
Ossenkoppele, R., Madison, C. M., Oh, H., Wirth, M., van Berckel, B. N. M., & Jagust, W. J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht076 · Cited by 45 · see citing works
Degree‐based statistic and center persistency for brain connectivity analysis
Yoo, K., Lee, P., Chung, M. K., Sohn, W. S., Chung, S. J., Na, D. L., Ju, D., & Jeong, Y. (2016) · Human Brain Mapping · doi:10.1002/hbm.23352 · Cited by 42 · see citing works
Sleep-Based Interventions in Alzheimer’s Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory
Cordone, S., Scarpelli, S., Alfonsi, V., Gennaro, L. D., & Gorgoni, M. (2021) · Pharmaceuticals · doi:10.3390/ph14040383 · Cited by 49 · see citing works
Impact of lifestyle dimensions on brain pathology and cognition
Schreiber, S., Vogel, J. W., Schwimmer, H., Marks, S. M., Schreiber, F., & Jagust, W. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.01.012 · Cited by 44 · see citing works
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer’s disease
Quevenco, F. C., Preti, M. G., Bergen, J. M. G. V., Hua, J., Wyss, M., Li, X., Schreiner, S. J., Steininger, S. C., Meyer, R., Meier, I. B., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0249-7 · Cited by 43 · see citing works
Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer’s Disease
Weiler, M., Casseb, R. F., de Campos, B. M., Teixeira, C. V. L., Carletti‐Cassani, A. F. M. K., Vicentini, J. E., Magalhães, T. N. C., de Almeira, D. Q., Talib, L. L., Forlenza, O. V., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00255 · Cited by 41 · see citing works
Reference tissue normalization in longitudinal 18F-florbetapir positron emission tomography of late mild cognitive impairment
Shokouhi, S., Mckay, J. W., Baker, S. L., Kang, H., Brill, A. B., Gwirtsman, H. E., Riddle, W. R., Claassen, D. O., Rogers, B. P., & Initiative, A. D. N. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0172-3 · Cited by 42 · see citing works
The functional oculomotor network and saccadic cognitive control in healthy elders
Pa, J., Dutt, S., Mirsky, J. B., Heuer, H. W., Keselman, P., Kong, E. L., Trujillo, A. J., Gazzaley, A. H., Kramer, J. H., Seeley, W. W., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.03.051 · Cited by 41 · see citing works
Advances in functional magnetic resonance imaging data analysis methods using Empirical Mode Decomposition to investigate temporal changes in early Parkinson's disease
Cordes, D., Zhuang, X., Kaleem, M. F., Sreenivasan, K. R., Yang, Z., Mishra, V. R., Banks, S. J., Bluett, B., & Cummings, J. L. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.04.009 · Cited by 40 · see citing works
Physical activity and beta-amyloid pathology in Alzheimer's disease: A sound mind in a sound body
Ebrahimi, K., Majdi, A., Baghaiee, B., Hosseini, S. H., & Sadigh-Eteghad, S. (2017) · EXCLI Journal : Experimental and Clinical Sciences · doi:10.17179/excli2017-475 · Cited by 43 · see citing works
Sex-Based Memory Advantages and Cognitive Aging: A Challenge to the Cognitive Reserve Construct?
Caselli, R., Dueck, A., Locke, D. E. C., Baxter, L., Woodruff, B., & Geda, Y. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000016 · Cited by 37 · see citing works
Metabolic brain networks in aging and preclinical Alzheimer's disease
Arnemann, K. L., Stöber, F., Narayan, S., Rabinovici, G. D., & Jagust, W. J. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.12.037 · Cited by 38 · see citing works
Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation
Hodgetts, C. J., Shine, J. P., Williams, H., Postans, M., Sims, R., Williams, J. H., Lawrence, A. D., & Graham, K. S. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.026 · Cited by 38 · see citing works

Authors: Jagust, W. J., & Mormino, E. C.
Affiliations: Lawrence Berkeley National Laboratory (US)
University of California, Berkeley (US)
Corresponding author: Jagust, William J.
ORCID: Jagust, William J.
Mormino, Elizabeth C.
Venue: Trends in Cognitive Sciences
Publisher: Elsevier BV
Published: 2011-11
Volume: 15
Issue: 11
Pages: 520-526
ISSN: 1364-6613 (ISSN-L)
DOI: 10.1016/j.tics.2011.09.004
PMC: PMC3206968
OpenAlex: W1996496731
Cited by: 221
References: 74
Citations by year: 2026: 8 · 2025: 9 · 2024: 16 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 19 · 2018: 11 · 2017: 14 · 2016: 14 · 2015: 17 · 2014: 29 · 2013: 19 · 2012: 8
FWCI: 1.99
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cognitive Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (F31AG032814, AG034570, AG032814, R01AG034570)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, amyloid-beta, amyloid hypothesis, synaptic activity, neural efficiency, cognitive reserve, amyloid deposition, cognitive decline, dementia
MeSH terms: Alzheimer Disease, Animals, Brain, Brain Mapping, Cognition Disorders, Humans, Models, Biological, Neurons, Amyloid beta-Peptides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lifespan brain activity, β-amyloid, and Alzheimer's disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks