Nature and implications of sex differences in AD pathology

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works

Alzheimer’s Disease

Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works

2018 Alzheimer's disease facts and figures

Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912 · see citing works

Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences

Mielke, M., Vemuri, P., & Rocca, W. (2014) · Clinical Epidemiology · doi:10.2147/clep.s37929 · Cited by 1,021 · see citing works

Sex modifies the <i>APOE</i> ‐related risk of developing Alzheimer disease

Altmann, A., Tian, L., Henderson, V. W., Greicius, M. D., & Alzheimer's Disease Neuroimaging Initiative Investigators (2014) · Annals of Neurology · doi:10.1002/ana.24135 · Cited by 891 · see citing works

Sex Differences in the Clinical Manifestations of Alzheimer Disease Pathology

Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A., & Bennett, D. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.685 · Cited by 643 · see citing works

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

Hohman, T. J., Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., Gifford, K. A., Bush, W. S., Chibnik, L. B., Mukherjee, S., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0821 · Cited by 340 · see citing works

Sex differences in Alzheimer’s disease and common neuropathologies of aging

Oveisgharan, S., Arvanitakis, Z., Yu, L., Farfel, J., Schneider, J. A., & Bennett, D. A. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1920-1 · Cited by 330 · see citing works

Sex, amyloid, and <i>APOE</i> ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts

Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., Lim, Y. Y., Papp, K. V., Jacobs, H. I. L., Burnham, S., Hanseeuw, B. J., et al. (2018) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2018.04.010 · Cited by 276 · see citing works

Gender Modulates the APOE  4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels

Damoiseaux, J. S., Seeley, W. W., Zhou, J., Shirer, W. R., Coppola, G., Karydas, A., Rosen, H. J., Miller, B. L., Kramer, J. H., Greicius, M. D., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0305-12.2012 · Cited by 267 · see citing works

Assessment of demographic, genetic, and imaging variables associated with brain resilience and cognitive resilience to pathological tau in patients with Alzheimer disease

Ossenkoppele, R., Lyoo, C. H., Jester-Broms, J., Sudre, C. H., Cho, H., Ryu, Y. H., Choi, J. Y., Smith, R., Strandberg, O., Palmqvist, S., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.5154 · Cited by 161 · see citing works

The foundation and architecture of precision medicine in neurology and psychiatry

Hampel, H. J., Gao, P., Cummings, J. L., Toschi, N., Thompson, P. M., Hu, Y., Cho, M., & Vergallo, A. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2022.12.004 · Cited by 151 · see citing works

Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE ε4 genotype

Mofrad, R. B., Tijms, B. M., Scheltens, P., Barkhof, F., van der Flier, W. M., Sikkes, S. A. M., & Teunissen, C. E. (2020) · Neurology · doi:10.1212/wnl.0000000000010629 · Cited by 80 · see citing works

Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation

Shi, W., Sheng, X., Dorr, K. M., Hutton, J. E., Emerson, J. I., Davies, H. A., Andrade, T. D., Wasson, L. K., Greco, T. M., Hashimoto, Y., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.09.022 · Cited by 75 · see citing works

Impact of intestinal disorders on central and peripheral nervous system diseases

El-Hakim, Y., Bake, S., Mani, K. K., & Sohrabji, F. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105627 · Cited by 54 · see citing works

Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer’s disease: relevance for precision medicine in neurodegenerative diseases

Lista, S., Vergallo, A., Teipel, S. J., Lemercier, P., Giorgi, F. S., Gabelle, A., Garaci, F., Mercuri, N. B., Babiloni, C., Gaire, B. P., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101819 · Cited by 46 · see citing works

Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies

Beek, M. H. C. T. V., Mofrad, R. B., van Steenoven, I., Vanderstichele, H., Scheltens, P., Teunissen, C. E., Lemstra, A. W., & van der Flier, W. M. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00610-9 · Cited by 38 · see citing works

Loss of CTRP4 alters adiposity and food intake behaviors in obese mice

Sarver, D. C., Stewart, A. N., Rodriguez, S., Little, H. C., Aja, S. M., & Wong, G. W. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00448.2020 · Cited by 38 · see citing works

Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD

Vergallo, A., Houot, M., Cavedo, E., Lemercier, P., Vanmechelen, E., De Vos, A., Habert, M., Potier, M., Dubois, B., Lista, S., et al. (2019) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2019.07.001 · Cited by 32 · see citing works

Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease

Chen, J., Chen, J.-S., Li, S., Zhang, F., Deng, J., Zeng, L., & Tan, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0308 · Cited by 30 · see citing works

Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice

Mowry, F. E., Espejo‐Porras, F., Jin, S., Quadri, Z., Wu, L., Bertolio, M., Jarvis, R., Reynolds, C. R., Alananzeh, R., Bieberich, E., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106213 · Cited by 27 · see citing works

CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice

Tan, S. Y., Lei, X., Little, H. C., Rodriguez, S., Sarver, D. C., Cao, X., & Wong, G. W. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00533.2019 · Cited by 22 · see citing works

Mild Cognitive Impairment and Neurofeedback: A Randomized Controlled Trial

Lavy, Y., Dwolatzky, T., Kaplan, Z., Guez, J., & Todder, D. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.657646 · Cited by 22 · see citing works

Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60–102 Years

Legdeur, N., Tijms, B. M., Konijnenberg, E., den Braber, A., ten Kate, M., Sudre, C. H., Tomassen, J., Badissi, M., Yaqub, M. M., Barkhof, F., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz180 · Cited by 16 · see citing works

Determinants of informal care time, distress, depression, and quality of life in care partners along the trajectory of Alzheimer's disease

Mank, A., van Maurik, I. S., Rijnhart, J. J. M., Rhodius‐Meester, H. F. M., Visser, L. N. C., Lemstra, A. W., Sikkes, S. A. M., Teunissen, C. E., van de Giessen, E., Berkhof, J. H., et al. (2023) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12418 · Cited by 15 · see citing works

Cerebral Hemodynamics and Carotid Atherosclerosis in Patients With Subcortical Ischemic Vascular Dementia

Liu, X.-J., Che, P., Xing, M., Tian, X.-B., Gao, C., Li, X., & Zhang, N. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.741881 · Cited by 14 · see citing works

Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex

Wen, H., He, Y., Tang, Y., Zhu, L., Tao, Q., Jin, B., Luo, T., Peng, Y., Wei, Y., Lei, J., et al. (2024) · Brain Pathology · doi:10.1111/bpa.13318 · Cited by 12 · see citing works

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

Barrera, J., Song, L., Safi, A., Yun, Y., Garrett, M. E., Gamache, J., Premasinghe, I., Sprague, D., Chipman, D., Li, J., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00481-0 · Cited by 12 · see citing works

Cardiac Sex Differences are Established Prior to Gonad FormationPreprint

Shi, W., Sheng, X., Dorr, K. M., Hutton, J. E., Davies, H. A., Andrade, T. D., Greco, T. M., Hashimoto, Y., Federspiel, J. D., Robbe, Z. L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.29.319194 · Cited by 3 · see citing works

Distinct neuronal vulnerability and metabolic dysfunctions are characteristic features of fast-progressing Alzheimer's patients with Lewy bodies

Rahman, M., Sharma, P., Chattopadhyay, T., & Saroja, S. R. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108396 · Cited by 2 · see citing works

Epigenetic Pathways from Dietary Fat to Psychopathology

Ragsdale, G. (2024) · Epigenetics and human health · doi:10.1007/978-3-031-54215-2_12 · Cited by 1 · see citing works

Multimodal MRI combined with RNA sequencing reveals pathological signatures in the 9-month-old 3×Tg-AD mouse brain

Li, Y., Tang, Z., Yao, M., Ran, Y., & Qiu, Z. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00006

Outcomes relevant to patients and care partners along the trajectory of Alzheimer’s disease

Mank, A. (2024) · doi:10.5463/thesis.337

Additional file 1 of Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies

van de Beek, M., Babapour Mofrad, R., van Steenoven, I., Vanderstichele, H., Scheltens, P., Teunissen, C. E., Lemstra, A. W., & van der Flier, W. M. (2020) · Figshare · doi:10.6084/m9.figshare.12150774

Additional file 2 of Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains

Barrera, J., Song, L., Gamache, J., Garrett, M. E., Safi, A., Yun, Y., Premasinghe, I., Sprague, D., Chipman, D., Li, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16435926

Sex differences in Alzheimer’s disease: Understanding the molecular impact

Toro, C. A., Zhang, L., Cao, J., & Cai, D. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.031 · Cited by 97 · see citing works

Sex Differences in Alzheimer’s Disease Pathogenesis

Jung, E. S., & Mook‐Jung, I. (2024) · Springer eBooks · doi:10.1007/978-981-97-0130-8_24 · Cited by 1 · see citing works

Sex Differences in the Clinical Manifestations of Alzheimer Disease Pathology

Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A., & Bennett, D. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.685 · Cited by 643 · see citing works

Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

Carter, C. L., Resnick, E. M., Mallampalli, M., & Kalbarczyk, A. (2012) · Journal of Women's Health · doi:10.1089/jwh.2012.3789 · Cited by 231 · see citing works

Sex difference in Alzheimer's disease: An updated, balanced and emerging perspective on differing vulnerabilities

Dubal, D. B. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00018-7 · Cited by 88 · see citing works