Prevalence of Health Conditions and Predictors of Mortality in Oldest Old Mexican Americans and Non-Hispanic Whites
Open accessAbstract
Background The oldest old represent a unique group of older adults. This group is rapidly growing worldwide and yet there are gaps in the knowledge related to their health condition. Ethnic differences in disease prevalence and mortality must be understood to better care for the oldest old.Objective To compare prevalence of common health conditions and predictors of mortality in oldest old Mexican Americans and non-Hispanic whites.Methods This study included 568 community-dwelling Mexican Americans (MA) aged 85 years and older from the Hispanic Established Population for the Epidemiological Study of the Elderly 2004-2005 and 933 non-Hispanic whites (NHW) of the same age from the Health and Retirement Study 2004. Measures included sociodemographic variables, self-reported medical conditions, activities of daily living (ADLs), and instrumental activities of daily living. Logistic regression analysis was used to examine 2-year mortality in both populations.Results Heart attack was significantly more prevalent in oldest old NHW compared with MA, regardless of gender. Conversely, diabetes was significantly more prevalent among MA men and women compared with their NHW counterparts. Compared with NHW men, MA men had significantly higher prevalence of cognitive impairment and hypertension. Additionally, prevalence of hip fracture was significantly higher for MA women compared with NHW women. Significant differences in ADL disability were observed only between both groups of women, whereas significant differences in instrumental activities of daily living disability were observed only between men. MA men and women had higher prevalence of obesity compared with NHW. Predictors of 2-year mortality for both ethnic groups included older age, male gender, and ADL disability. Cognitive impairment was a mortality predictor only for NHW. Similarly, lung disease was a predictor only for MA.Conclusion Health-related conditions that affect the oldest old vary by gender and ethnicity and entail careful evaluation and monitoring in the clinical setting. Better care requires inclusion of such differences as part of the comprehensive evaluation of the oldest old adults.
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Some studies indicate Hispanic older adults are about one and one-half times as likely to have Alzheimer's or other dementias as White older adults, though others show similar prevalences.
“Some other studies indicate Hispanic older adults are about one and one-half times as likely to have Alzheimer's or other dementias as White older adults, [299][300][301] though others have shown similar prevalences among Hispanic older adults and White older adults.149”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [301]
The Results report higher cognitive-impairment prevalence among Mexican American men aged 85 and older than among non-Hispanic White men (16.3% versus 5.8%), but no significant difference among women. This does not establish the claimed one-and-one-half-times likelihood of Alzheimer's or other dementias among Hispanic older adults generally. The Discussion also notes that the two groups were asked different cognitive-impairment questions. (LLM, conf=0.86)
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“5 times more likely to experience dementia compared with non-Hispanic whites [40], the reasons are not well understood.”
BackgroundNeuropsychiatric Symptoms Among Hispanics: Results of the Maracaibo Aging Study
Gil, M., Alliey‐Rodriguez, N., López-Alvarenga, J. C., Diego, V. P., Gaona, C. A., Mata, L., Pirela, R. V., Chavez, C. A., de Erausquin, G. A., Melgarejo, J. D., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201144 · Cited by 5 · see citing works
“Hispanics are disproportionately affected by AD, with almost a two-fold elevated risk of developing AD [6, 7] and earlier onset of the disease than non-Hispanic whites [8].”
BackgroundFeuz, M. A., Odierna, D. H., Katen, M. T., Volow, A. M., McMahan, R. D., Ritchie, C. S., McSpadden, S., Dearman, K., & Sudore, R. L. (2019) · Journal of Palliative Medicine · doi:10.1089/jpm.2018.0429 · Cited by 5 · see citing works
Impact of white matter hyperintensity volume on cognition among US Mexican American adults
Graves, L. V., Diaz, M. M., Dayan, E., & For the Health and Aging Brain Study: Health Disparities (HABS-HD) Team (2024) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617724000316 · Cited by 4 · see citing works
“Moreover, relative to older non-Hispanic White (NHW) adults, older Latino adults are about 1.5 times as likely to develop ADRD (Alzheimer ’ s Association, 2020; Haan et al., 2003; Samper-Ternent et al., 2012).”
InfluentialLawson, K. M., Sutin, A. R., Atherton, O. E., & Robins, R. W. (2023) · Psychology and Aging · doi:10.1037/pag0000755 · Cited by 4 · see citing works
Stress and Coping: Conceptual Models for Understanding Dementia Among Latinos
Montoro‐Rodríguez, J., & Gallagher-Thompson, D. E. (2020) · Springer eBooks · doi:10.1007/978-1-0716-0132-7_13 · Cited by 4 · see citing works
Boza-Calvo, C., Faustin, A., Zhang, Y., Briggs, A., Bernard, M. A., Bubu, O. M., Rao, J. A., Gurin, L. J., Tall, S. O., Osorio, R. S., et al. (2024) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887241263097 · Cited by 3 · see citing works
Pérez‐Arce, F., Burke, J., Rabinovich, L., Zhang, Q., Monfared, A. A. T., & Mattke, S. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100036 · Cited by 3 · see citing works
Demographics and the Epidemiological Risk Factors for Dementia in Hispanic/Latino Populations
Fernández, L., & Johnson, N. J. (2020) · Springer eBooks · doi:10.1007/978-1-0716-0132-7_1 · Cited by 3 · see citing works
Wilson, D. M., & Low, G. (2016) · Journal of Gerontological Nursing · doi:10.3928/00989134-20160727-01 · Cited by 3 · see citing works
Diabetes Complications and Pain Among Mexican Americans Aged 80 and Older
Onwudebe, C. K., Snih, S. A., Raji, M. A., & Milani, S. A. (2023) · Innovation in Aging · doi:10.1093/geroni/igad099 · Cited by 2 · see citing works
“(7).”
Recent studies of the genetics of complex diseases associated with impaired cognitive functions
Бочарова, А. В., & Степанов, В. А. (2022) · Сибирский журнал клинической и экспериментальной медицины · doi:10.29001/2073-8552-2021-36-4-37-44 · Cited by 2 · see citing works
“Работы по другим этническим группам не многочисленны, но по их данным, например, риск развития БА у негроидов в 2 раза выше, чем у европеоидов [8], а у американцев латиноамериканского происхождения риск развития БА и других деменций в 1,5 раза выше, чем у европеоидного населения США [9].”
Health Status, Perceptions and Needs of Hispanics in Rural Shelbyville, Kentucky
Ramos, I. N., Appana, S. N., Brock, G. N., Kalbfleisch, T., He, Q., & Ramos, K. S. (2013) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-013-9907-4 · Cited by 2 · see citing works
“This finding is consistent with national statistics showing that Hispanics are frequently impacted by these chronic diseases [6–8].”
ResultXia, R., Jian, X., Rodrigue, A., Bressler, J., Boerwinkle, E., Cui, B.-Q., Daviglus, M., Decarli, C., Gallo, L., Glahn, D., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.14082 · Cited by 1 · see citing works
Toxic agents and health disparities in the socially marginalized
García, J. J., Serpas, D. G., Williams, M. J., Zelaya, D. G., Rosales, R., & Torres, Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00720-x · Cited by 2 · see citing works
Neuropsychiatric Symptoms and Mortality in Cognitively Normal Older Mexican Americans
Cantu, P. A., Snih, S. A., Markides, K., & Raji, M. A. (2025) · Hispanic Journal of Behavioral Sciences · doi:10.1177/07399863241310476 · Cited by 1 · see citing works
“However, cognitive impairment was only a predictor for mortality for non-Hispanic white oldest-old adults (Samper-Ternent et al., 2012).”
Self-citationSolis, G. R., Olvera, H. A., & Castillo, R. (2015) · Ehquidad Revista Internacional de Políticas de Bienestar y Trabajo Social · doi:10.15257/ehquidad.2015.0001 · Cited by 1 · see citing works
PRESENT POSITION Professor (with tenure) Don W. and Frances Powell Professor in Aging Research
Kuo, Y. (2013)
Self-citationWeiss, J., & Shean, J. (2021) · American Public Health Association eBooks · doi:10.2105/9780875533162ch01
Lawson, K. M., Sutin, A. R., Atherton, O. E., & Robins, R. W. (2023) · doi:10.31234/osf.io/w9kgu
How and why your race impacts your risk of dementia?
ZEIDAN, H. M., & ZEIDAN, I. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21632-9.00005-4
Fong, J. C., Chavez, F. I., Silos, K., Arroyo‐Miranda, M. L., Castro, G. C., Kunik, M. E., Shulman, J. M., & Medina, L. D. (2025) · medRxiv · doi:10.1101/2025.08.19.25334002
Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohortPreprint
Vazquez, J., Bernal, R., Aguirre, L. A., Melgarejo, J. D., Maestre, G. E., Seshadri, S. S., Hazuda, H. P., Wang, C., & Satizábal, C. L. (2025) · medRxiv · doi:10.1101/2025.10.23.25338553
Hernandez, V., Nasser, L., & Snih, S. A. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.12.016
Dueñas, K. R., Flores, M. A., Ingram, M., Yuan, N. P., Ruiz, J. M., Torres, E., & Carvajal, S. C. (2025) · Journal of Prevention & Intervention in the Community · doi:10.1080/10852352.2025.2604176
Weaver, R. D., & Lei, M. (2026) · Alzheimer s & Dementia Behavior & Socioeconomics of Aging · doi:10.1002/bsa3.70069
Fong, J. C., Chavez, F. I., Silos, K., Arroyo‐Miranda, M. L., Castro, G. C., Kunik, M. E., Shulman, J. M., & Medina, L. D. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70241
Alzheimer's disease and related dementias (ADRD) after COVID‐19 infection: trends and disparities
Gupta, S., Simon, K. I., & Perry, B. L. (2026) · Alzheimer s & Dementia Behavior & Socioeconomics of Aging · doi:10.1002/bsa3.70084
Peltzer, K., Pengpid, S., & Skaal, L. (2026) · Archives of Medicine and Health Sciences · doi:10.4103/amhs.amhs_312_25
- Authors
- Samper-Ternent, R., Kuo, Y. F., Ray, L. A., Ottenbacher, K. J., Markides, K. S., & Al Snih, S.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 13
- Issue
- 3
- Pages
- 254-259
- ISSN
- 1525-8610 (ISSN-L)
- PMC
- PMC3128678
- OpenAlex
- W1977267943
- Cited by
- 79
- References
- 44
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 11 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Medical Directors Association (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG017638, R03AG029959, R01AG010939, P30AG024832)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD052023)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- oldest old, Mexican Americans, non-Hispanic whites, ethnic differences, mortality risk factors, activities of daily living, instrumental activities of daily living, cognitive impairment, myocardial infarction, diabetes mellitus, hypertension, hip fracture, obesity, lung disease, gender differences, community-dwelling older adults
- MeSH terms
- Aged, 80 and over, Cross-Sectional Studies, Female, Health Status Indicators, Humans, Male, Mortality, Southwestern United States, Mexican Americans, White People, Health Status Disparities
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