Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study
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Introduction: The trends in prevalence and incidence of Alzheimer's disease (AD) dementia remain uncertain. Methods: A sample of 2794 participants with a clinical diagnosis for AD dementia were included. Results: The 2010 census standardized prevalence of AD dementia was 14.5% (95% CI = 13.7–15.3), and annual incidence was 2.3% (1.7–2.9). Both prevalence and incidence showed substantial variation over time, but no secular trends. The prevalence of AD dementia did not change significantly from 14.6% (95% CI = 13.0, 16.2) in 1994–1997 to 14.7% (95% CI = 13.2, 16.2) in 2010–2012 (P = .84). The annual incidence of AD dementia was 2.8% (95% CI = 2.2, 3.2) in 1998–2000 and 2.2% (95% CI = 1.6, 2.8) in 2004–2006 (P = .20) and remained steady in 2010–2012. The prevalence and incidence among African Americans were approximately twice than those among European Americans. Conclusions: The prevalence and incidence of AD dementia showed substantial variation between 1994 and 2012, but no secular trend.
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In 2011, the average annual incidence of Alzheimer's dementia was 0.4% at ages 65-74, 3.2% at ages 75-84, and 7.6% at ages 85 and older.
“in 2011 the average annual incidence in people age 65 to 74 was 0.4% (meaning four of every 1,000 people age 65 to 74 developed Alzheimer's dementia in 2011); in people age 75 to 84, the annual incidence was 3.2% (32 of every 1,000 people); and in people age 85 and older, the incidence was 7.6% (76 of every 1,000 people).259”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [259]
The Results section, “Average Prevalence and Annual Incidence of AD dementia” (page unavailable), says annual incidence rose sharply with age. But the passages in our copy do not give the claimed 0.4%, 3.2%, and 7.6% age-specific rates for 2011; the time-specific Results instead report an overall annual rate for 2010–2012. (LLM, conf=0.82)
Experimental — accuracy not yet measuredApproximately 910,000 people age 65 or older developed Alzheimer's dementia in the United States in 2011, and this number would be expected to be higher in 2023 if CHAP estimates were available for that year.
“approximately 910,000 people age 65 or older developed Alzheimer's dementia in the United States in 2011, a number that would be expected to be even higher in 2023 if CHAP estimates were available for that year.259”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [259]
The Results (‘Number of People in the US with Prevalence and Incidence of AD dementia’; page not provided) estimate 910,051 new US cases in 2011, based on CHAP projections for adults over 65. The Discussion identifies population aging as a driver of future estimates, but the paper does not estimate or state that the annual number of new cases would exceed the 2011 figure in 2023. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMost other prevalence studies indicate that Black older adults are about twice as likely to have Alzheimer's or other dementias as White older adults.
“Most other prevalence studies also indicate that Black older adults are about twice as likely to have Alzheimer's or other dementias as White older adults.”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [259]
The Results (page unavailable in our copy) report that Alzheimer’s disease dementia prevalence was nearly twice as high among African Americans as European Americans (27.0% versus 13.3%) in this study. The Introduction says prior research found higher prevalence among African Americans, but the paper does not establish that most other studies found a twofold difference or address other dementias. (LLM, conf=0.87)
Experimental — accuracy not yet measuredApproximately 910,000 people age 65 or older developed Alzheimer's dementia in the U.S. in 2011, a number that would be expected to be even higher in 2024 if CHAP estimates were available for that year.
“According to estimates using data from the CHAP study and the U.S. Census Bureau, approximately 910,000 people age 65 or older developed Alzheimer's dementia in the U.S. in 2011, a number that would be expected to be even higher in 2024 if CHAP estimates were available for that year.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [284]
The Results section ('Number of People in the US with Prevalence and Incidence of AD dementia'; page unavailable) estimates 910,051 new U.S. cases in 2011, using CHAP estimates projected to the U.S. population aged over 65. The Discussion says population aging will increase future estimates, but the paper gives no 2024 incidence estimate or explicit prediction that new cases in 2024 would exceed the 2011 count. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe rate at which new cases of Alzheimer's develop increases dramatically with age: in 2011 the average annual incidence in people age 65 to 74 was 0.4%; in people age 75 to 84, annual incidence was 3.2%; and in people age 85 and older, incidence was 7.6%.
“The rate at which new cases of Alzheimer's develop increases dramatically with age: according to estimates from CHAP, in 2011 the average annual incidence in people age 65 to 74 was 0.4% (meaning four of every 1,000 people age 65 to 74 developed Alzheimer's dementia in 2011); in people age 75 to 84, the annual incidence was 3.2% (32 of every 1,000 people); and in people age 85 and older, the incid”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [284]
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Experimental — accuracy not yet measured
Most other prevalence studies indicate that Black older adults are about twice as likely to have Alzheimer's or other dementias as White older adults.
“In line with these observations, most other prevalence studies indicate that Black older adults are about twice as likely to have Alzheimer's or other dementias as White older adults.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [284]
The Results (page not provided) report that Alzheimer’s disease dementia prevalence was nearly twice as high among African Americans as among European Americans (27.0% versus 13.3%). The Introduction says earlier research found higher prevalence among African Americans, but the paper does not establish that most other studies found a twofold difference or address other dementias. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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- Authors
- Rajan, K. B., Weuve, J., Barnes, L. L., Wilson, R. S., & Evans, D. A.
- Affiliations
- University of California, Davis (US)
- Boston University (US)
- Rush University Medical Center (US)
- Rush University (US)
- Corresponding author
- Rajan, Kumar B.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2018-09-06
- Volume
- 15
- Issue
- 1
- Pages
- 1-7
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6531287
- OpenAlex
- W2891083286
- Cited by
- 245
- References
- 21
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 47 · 2023: 38 · 2022: 36 · 2021: 37 · 2020: 29 · 2019: 17 · 2018: 1
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (RF1-AG057532, R01-AG051635, R01-AG11101)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- Alzheimer's disease, dementia
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Black or African American, Female, Humans, Male, Prospective Studies, Risk Factors, United States, Incidence, Prevalence, White People
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