Clearance deficiency and systemic lupus erythematosus (SLE)
Abstract
Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease. Impaired clearance functions for dying cells may explain accumulation of nuclear autoantigens in various tissues of SLE patients. Our data show that in a subgroup of patients with SLE, apoptotic cells accumulated in the germinal centres of the lymph nodes. Apoptotic material was attached to the surfaces of follicular dendritic cells. Furthermore, we found an accumulation of apoptotic cells in the skin of patients with cutaneous lupus after UV exposure. Granulocytes and monocytes in whole blood of SLE patients showed a reduced uptake of albumin- and polyglobin-coated beads. Furthermore, we analysed sera from SLE patients in migration assays and observed that the attraction signals for macrophages were reduced by sera of approximately 25% of the SLE patients. Analyses of high-affinity DNA binding IgG autoantibodies of SLE patients revealed that those antibodies had gained their DNA reactivity in a germinal centre reaction. We suggest a stepwise maturation from a non-anti-DNA reactive B cell to an anti-dsDNA autoreactive B cell. We conclude that impaired clearance in early phases of apoptosis leads to a secondary necrotic status of the cells. Danger signals are released; modified autoantigens are accessible, favouring an autoimmune reaction.
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DAMPs released from dying cells induce immune responses to cellular antigens whether the cell is a tumor cell, autologous tissue or infected with a pathogen.
“DAMPs are released from dying cells and induce immune responses to cellular antigens whether the cell is a tumor cell, autologous tissue or infected with a pathogen.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [4]
Cites
The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519 · see citing works
Hochberg, M. C. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400928 · Cited by 11,409 · see citing works
Immunobiology: the immune system in health and disease
(1995) · Choice Reviews Online · doi:10.5860/choice.32-3876 · Cited by 4,110 · see citing works
Danger signals: SOS to the immune system
Gallucci, S., & Matzinger, P. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00191-6 · Cited by 1,204 · see citing works
Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967 · see citing works
Self-citationPathogenesis of systemic lupus erythematosus
Mok, C. C., & Lau, C. S. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.56.7.481 · Cited by 947 · see citing works
Complement-dependent Clearance of Apoptotic Cells by Human Macrophages
Mevorach, D., Mascarenhas, J., Gershov, D., & Elkon, K. (1998) · Journal of Experimental Medicine · doi:10.1084/jem.188.12.2313 · Cited by 776 · see citing works
Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724 · see citing works
Gershov, D., Kim, S., Brot, N., & Elkon, K. B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1353 · Cited by 695 · see citing works
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., Yoshikawa, H., & Nagata, S. (2006) · Nature · doi:10.1038/nature05245 · Cited by 467 · see citing works
C1q and Systemic Lupus Erythematosus
Walport, M. J., Davies, K. A., & Botto, M. (1998) · Immunobiology · doi:10.1016/s0171-2985(98)80032-6 · Cited by 395 · see citing works
Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function.
Rovere, P. Q., Vallinoto, C., Bondanza, A., Crosti, M., Rescigno, M., Ricciardi‐Castagnoli, P., Rugarli, C., & Manfredi, A. A. (1998) · PubMed · Cited by 352 · see citing works
Ren, Y., Tang, J., Mok, M. Y., Chan, A. W. K., Wu, A., & Lau, C. S. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11237 · Cited by 350 · see citing works
Paleolog, E. M., Young, S., Stark, A. C., McCloskey, R. V., Feldmann, M., & Maini, R. N. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199807)41:7 · Cited by 318 · see citing works
Cutting Edge: Bystander Apoptosis Triggers Dendritic Cell Maturation and Antigen-Presenting Function
Rovere, P. Q., Vallinoto, C., Bondanza, A., Crosti, M., Rescigno, M., Ricciardi‐Castagnoli, P., Rugarli, C., & Manfredi, A. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4467 · Cited by 309 · see citing works
Russell, A. I. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh021 · Cited by 294 · see citing works
Furukawa, F., Kashihara‐Sawami, M., Lyons, M. B., & Norris, D. A. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12873930 · Cited by 242 · see citing works
Analysis of immunoglobulin variable region genes from human IgG anti‐DNA hybridomas
Winkler, T. H., Fehr, H. K., & Kalden, J. R. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220709 · Cited by 239 · see citing works
Self-citationThe Epigenetic Face of Systemic Lupus Erythematosus
Ballestar, E., Esteller, M., & Richardson, B. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7143 · Cited by 225 · see citing works
Kuhn, A., i, M. H., Kleber, S., Beckmann-Welle, M., Fehsel, K., Martín-Villalba, A., Lehmann, P. M., Ruzicka, T., Krammer, P. H., & Kolb-Bachofen, V. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21658 · Cited by 221 · see citing works
Self-citationImpaired clearance of dying cells in systemic lupus erythematosus
Gaipl, U. S., Voll, R. E., Sheriff, A., Franz, S., Kalden, J. R., & i, M. H. (2004) · Autoimmunity Reviews · doi:10.1016/j.autrev.2004.10.007 · Cited by 212 · see citing works
Self-citationThe evolution of human anti-double-stranded DNA autoantibodies
Wellmann, U., Letz, M., i, M. H., Angermüller, S., Kalden, J. R., & Winkler, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500132102 · Cited by 210 · see citing works
Self-citationCastan, L., & O'Neill, H. C. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104664 · Cited by 198 · see citing works
Clearance of Apoptotic Cells in Human SLE
Gaipl, U. S., Kuhn, A., Sheriff, A., Munoz, L. E., Franz, S., Voll, R. E., Kalden, J. R., & i, M. H. (2005) · KARGER eBooks · doi:10.1159/000090781 · Cited by 170 · see citing works
Self-citationQuartier, P., Potter, P. K., Ehrenstein, M. R., Walport, M. J., & Botto, M. (2004) · European Journal of Immunology · doi:10.1002/eji.200425497 · Cited by 166 · see citing works
Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus
Chitrabamrung, S., Rubin, R. L., & Tan, E. M. (1981) · Rheumatology International · doi:10.1007/bf00541153 · Cited by 160 · see citing works
Gaipl, U. S., Kuenkele, S., Voll, R. E., Beyer, T. D., Kolowos, W., Heyder, P., Kalden, J. R., & i, M. H. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400826 · Cited by 159 · see citing works
Self-citationRegulation of Macrophage Phagocytosis of Apoptotic Cells by cAMP
Rossi, A. G., McCutcheon, J. C., Roy, N., Chilvers, E. R., Haslett, C., & Dransfield, I. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3562 · Cited by 150 · see citing works
Endogenous retroviruses: potential etiologic agents in autoimmunity
Krieg, A. Μ., Gourley, M. F., & Perl, A. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.8.1592206 · Cited by 145 · see citing works
The molecular determinants of sunburn cell formation
Murphy, G., Young, A. R., Wulf, H. C., Kulms, D., & Schwarz, T. (2001) · Experimental Dermatology · doi:10.1034/j.1600-0625.2001.010003155.x · Cited by 122 · see citing works
Clinical Manifestations of Cutaneous Lupus Erythematosus
Kuhn, A., Sticherling, M., & Bonsmann, G. (2007) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2007.06554.x · Cited by 113 · see citing works
Self-citationCooperation between C1q and DNase I in the clearance of necrotic cell–derived chromatin
Gaipl, U. S., Beyer, T. D., Heyder, P., Kuenkele, S., Böttcher, A., Voll, R. E., Kalden, J. R., & Herrmann, M. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20034 · Cited by 110 · see citing works
Self-citationShoshan, Y., Shapira, I., Toubi, E., Frolkis, I., Yaron, M., & Mevorach, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5963 · Cited by 98 · see citing works
Jersmann, H. P. A., Dransfield, I., & Hart, S. P. (2003) · Clinical Science · doi:10.1042/cs20030126 · Cited by 95 · see citing works
Serologic studies of monozygotic twins with systemic lupus erythematosus
Reichlin, M., Harley, J. B., & Lockshin, M. D. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350416 · Cited by 92 · see citing works
Inefficient Clearance of Dying Cells and Autoreactivity
Gaipl, U. S., Sheriff, A., Franz, S., Munoz, L. E., Voll, R. E., Kalden, J. R., & i, M. H. (2006) · Springer eBooks · doi:10.1007/3-540-29714-6_8 · Cited by 90 · see citing works
Self-citationSantos, S. P., Morrás, P. G., Otero, R. M., Merino, M. J. G.-B., & Herreros, C. S. (2005) · Springer eBooks · doi:10.1007/b137847 · Cited by 90 · see citing works
Cairns, A. P., Crockard, A. D., McConnell, J. R., Courtney, P. A., & Bell, A. L. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.10.950 · Cited by 77 · see citing works
IgG human monoclonal anti-DNA autoantibodies from patients with systemic lupus erythematosus
Winkler, T. H., JAHN, S., & Kalden, J. R. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05735.x · Cited by 75 · see citing works
Self-citationAltered structure of autoantigens during apoptosis
Hall, J. C., Casciola-Rosen, L. A., & Rosen, A. (2004) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.04.012 · Cited by 75 · see citing works
Tinigible Body Macrophages in Regulation of Germinal Center Reactions
Smith, J. P., Burton, G. F., Tew, J. G., & Szakal, A. K. (1997) · Journal of Immunology Research · doi:10.1155/1998/38923 · Cited by 66 · see citing works
Links between complement deficiency and apoptosis.
Botto, M. (2001) · Arthritis Research · doi:10.1186/ar301 · Cited by 66 · see citing works
The infectious etiology of the antiphospholipid syndrome: links between infection and autoimmunity
Harel, M., Aron-Maor, A., Sherer, Y., Blank, M., & Shoenfeld, Y. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.10.004 · Cited by 55 · see citing works
Gorgani, N. N., Smith, B. A., Kono, D. H., & Theofilopoulos, A. N. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4745 · Cited by 50 · see citing works
Antinuclear antibodies (ANA): Immunologic and clinical significance
Fernández-Madrid, F., & Mattioli, M. (1976) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(76)90018-4 · Cited by 49 · see citing works
Reefman, E., de Jong, M. C., Kuiper, H., Jonkman, M. F., Limburg, P. C., Kallenberg, C. G. M., & Bijl, M. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2051 · Cited by 49 · see citing works
Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine.
Hoffman, R. D., Kligerman, M., Sundt, T. M., Anderson, N. D., & Shin, H. S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.10.3285 · Cited by 44 · see citing works
Removal of dying cells and systemic lupus erythematosus
Grossmayer, G. E., Munoz, L. E., Gaipl, U. S., Franz, S., Sheriff, A., Voll, R. E., Kalden, J. R., & i, M. H. (2005) · Modern Rheumatology · doi:10.1007/s10165-005-0430-x · Cited by 34 · see citing works
Self-citationReefman, E., Kuiper, H., Jonkman, M. F., Limburg, P. C., Kallenberg, C. G. M., & Bijl, M. (2005) · Lara D. Veeken · doi:10.1093/rheumatology/kei249 · Cited by 34 · see citing works
Kuenkele, S., Beyer, T. D., Voll, R. E., Kalden, J. R., & i, M. H. (2003) · Current Rheumatology Reports · doi:10.1007/s11926-003-0061-1 · Cited by 30 · see citing works
Self-citationPathophysiology of cutaneous lupus erythematosus -- novel aspects
Kuhn, A. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel284 · Cited by 24 · see citing works
Self-citationDiagnosis of Systemic Lupus Erythematosus
Nisengard, R. J. (1975) · Archives of Dermatology · doi:10.1001/archderm.1975.01630220062003 · Cited by 13 · see citing works
The role of Fc gamma receptors in mononuclear phagocyte system function.
Kimberly, R. P., Je, S., Edberg, J., & Gibofsky, A. (1989) · PubMed · Cited by 12 · see citing works
Occurrence of deficient monocyte yeast cell phagocytosis in presence of rheumatic sera.
Svensson, B. (1980) · PubMed · Cited by 11 · see citing works
Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus
Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5 · see citing works
Self-citationNisengard, R. J. (1975) · Archives of Dermatology · doi:10.1001/archderm.111.10.1298 · Cited by 2 · see citing works
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Self-citationYe, X., Zhou, S., & Zhang, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02334 · Cited by 292 · see citing works
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Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282 · see citing works
Definition of human autoimmunity — autoantibodies versus autoimmune disease
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Berda‐Haddad, Y., Robert, S., Salers, P., Zekraoui, L., Farnarier, C., Dinarello, C. A., Dignat‐George, F., & Kaplanski, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116848108 · Cited by 232 · see citing works
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Self-citationDying cell clearance and its impact on the outcome of tumor radiotherapy
Lauber, K., Ernst, A., Orth, M., i, M. H., & Belka, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00116 · Cited by 186 · see citing works
Self-citationRodriguez‐Manzanet, R., Sanjuán, M. A. F., Wu, H. Y., Quintana, F. J., Xiao, S., Anderson, A. C., Weiner, H. L., Green, D. R., & Kuchroo, V. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910359107 · Cited by 182 · see citing works
Katsiari, C. G., Liossis, S. C., & Sfikakis, P. P. (2009) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2008.11.002 · Cited by 182 · see citing works
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Rich, R. L., & Myszka, D. G. (2008) · Journal of Molecular Recognition · doi:10.1002/jmr.928 · Cited by 177 · see citing works
Burstyn-Cohen, T., Lew, E. D., Través, P. G., Burrola, P. G., Hash, J. C., & Lemke, G. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.015 · Cited by 163 · see citing works
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Munoz, L. E., Janko, C., Schulze, C., Schorn, C., Sarter, K., Schett, G. A., & i, M. H. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2010.08.015 · Cited by 156 · see citing works
Self-citationAlessandri, C., Barbati, C., Vacirca, D., Piscopo, P., Confaloni, A., Sanchez, M., Maselli, A., Colasanti, T., Conti, F., Truglia, S., et al. (2012) · The FASEB Journal · doi:10.1096/fj.12-206060 · Cited by 156 · see citing works
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Inflammatory etiopathogenesis of systemic lupus erythematosus: an update
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Lleò, A., Invernizzi, P., Selmi, C. F., Coppel, R. L., Alpini, G. D., Podda, M., Mackay, I. R., & Gershwin, M. E. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.06.003 · Cited by 98 · see citing works
The immune functions of phosphatidylserine in membranes of dying cells and microvesicles
Frey, B., & Gaipl, U. S. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0228-6 · Cited by 97 · see citing works
Self-citationThe role of dendritic cells in the pathogenesis of systemic lupus erythematosus
Fransen, J. H., van der Vlag, J., Ruben, J. M., Adema, G. J., Berden, J. H. M., & Hilbrands, L. B. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2966 · Cited by 97 · see citing works
Rahman, Z. S. M., Shao, W.-H., Khan, T. N., Zhen, Y., & Cohen, P. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001187 · Cited by 92 · see citing works
Kumar, S., Calianese, D. C., & Birge, R. B. (2017) · Immunological Reviews · doi:10.1111/imr.12587 · Cited by 92 · see citing works
Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells
Griffith, T. S., & Ferguson, T. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.011 · Cited by 92 · see citing works
Epigenetic regulation and the pathogenesis of systemic lupus erythematosus
Pan, Y., & Sawalha, A. H. (2008) · Translational research · doi:10.1016/j.trsl.2008.10.007 · Cited by 91 · see citing works
Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells
Figueiredo, C., Wittmann, M., Wang, D., Dressel, R., Seltsam, A. W., Blasczyk, R., & Eiz‐Vesper, B. (2008) · Blood · doi:10.1182/blood-2008-06-162727 · Cited by 89 · see citing works
Evidence for a pathogenetic role of interleukin‐18 in cutaneous lupus erythematosus
Wang, D., Drenker, M., Eiz‐Vesper, B., Werfel, T., & Wittmann, M. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23868 · Cited by 88 · see citing works
Fundamental role of C1q in autoimmunity and inflammation
Son, M., Diamond, B., & Santiago‐Schwarz, F. (2015) · Immunologic Research · doi:10.1007/s12026-015-8705-6 · Cited by 86 · see citing works
ADAM17 at the interface between inflammation and autoimmunity
Lisi, S., D’Amore, M., & Sisto, M. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.08.008 · Cited by 86 · see citing works
Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
Mackern‐Oberti, J. P., Llanos, C., Vega, F., Salazar‐Onfray, F., Riedel, C. A., Bueno, S. M., & Kalergis, A. M. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.10.010 · Cited by 83 · see citing works
Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease
Александровна, П. И., Михайловна, К. И., Fedotkina, T. V., Ryabkova, V. A., Владимировна, Ч. М., Churilov, L. P., & Черешнев, В. А. (2021) · Antibodies · doi:10.3390/antib10010009 · Cited by 83 · see citing works
Chemerin Peptides Promote Phagocytosis in a ChemR23- and Syk-Dependent Manner
Cash, J. L., Christian, A., & Greaves, D. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903378 · Cited by 81 · see citing works
Developments in the scientific understanding of lupus
Ardoin, S. P., & Pisetsky, D. S. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2488 · Cited by 80 · see citing works
Sjöwall, C., Zapf, J., von Löhneysen, S., Magorivska, I., Biermann, M. H. C., Janko, C., Winkler, S., Bilyy, R. O., Schett, G. A., i, M. H., et al. (2014) · Lupus · doi:10.1177/0961203314558861 · Cited by 77 · see citing works
Self-citationWang, Y., Liang, J. F., Qin, H., Ge, Y., Du, J., Lin, J., Zhu, X., Wang, J., & Xu, J. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1158-z · Cited by 77 · see citing works
Rodríguez-Fernández, S., Pujol‐Autonell, I., Briansó, F., Perna‐Barrull, D., Cano‐Sarabia, M., García‐Jimeno, S., Villalba, A., Sánchez‐Pla, Á., Aguilera, E., Vázquez, F., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00253 · Cited by 77 · see citing works
Histidine-Rich Glycoprotein Modulation of Immune/Autoimmune, Vascular, and Coagulation Systems
Blank, M., & Shoenfeld, Y. (2008) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-007-8058-6 · Cited by 76 · see citing works
The Pathogenesis of Lupus Nephritis
Grande, J. P. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000205 · Cited by 75 · see citing works
Sunlight Triggers Cutaneous Lupus through a CSF-1-Dependent Mechanism in MRL-Fas lpr Mice
Weinmann‐Menke, J., Hsu, M., Byrne, K. T., Lucas, J. A., Rabacal, W., Croker, B. P., Zong, X.-H., Stanley, E. R., & Kelley, V. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7367 · Cited by 74 · see citing works
Lauber, K., Keppeler, H., Munoz, L. E., Koppe, U., Schröder, K., Yamaguchi, H., Krönke, G., Uderhardt, S., Wesselborg, S., Belka, C., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.82 · Cited by 73 · see citing works
Self-citationHigh Ro52 Expression in Spontaneous and UV-Induced Cutaneous Inflammation
Oke, V., Vassilaki, I., Espinosa, A., Strandberg, L., Kuchroo, V. K., Nyberg, F., & Wahren‐Herlenius, M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.453 · Cited by 73 · see citing works
Atehortúa, L., Rojas, M., Vásquez, G. M., & Castaño, D. (2017) · Mediators of Inflammation · doi:10.1155/2017/9680729 · Cited by 71 · see citing works
Lee, W., Sung, M.-S., Lee, E., Yoo, H.-G., Cheon, Y., Chae, H., & Yoo, W. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.6a0214-097r · Cited by 70 · see citing works
HMGB1 in Systemic Lupus Erythematosus
Liu, T., Son, M., & Diamond, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01057 · Cited by 69 · see citing works
Ma, Q., Liang, M., Limjunyawong, N., Dan, Y., Xing, J., Li, J., Xu, J., & Dou, C. (2020) · Theranostics · doi:10.7150/thno.45170 · Cited by 70 · see citing works
Moonlighting osteoclasts as undertakers of apoptotic cells
Steffen, U., Keppeler, H., Ipseiz, N., Derer, A., Poller, K., Aigner, M., Schett, G. A., i, M. H., & Lauber, K. (2012) · Autoimmunity · doi:10.3109/08916934.2012.719950 · Cited by 68 · see citing works
Self-citationRecarte-Pelz, P., Tàssies, D., Espinosa, G., Hurtado, B., Sala, N., Cervera, R., Reverter, J. C., & de Frutos, P. G. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4199 · Cited by 68 · see citing works
Interaction between glutathione and apoptosis in systemic lupus erythematosus
Shah, D., Sah, S., & Nath, S. K. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.12.007 · Cited by 67 · see citing works
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Grootveld, A. K., Kyaw, W., Panova, V., Lau, A. W. Y., Ashwin, E., Seuzaret, G., Dhenni, R., Bhattacharyya, N. D., Khoo, W. H., Biro, M., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.004 · Cited by 66 · see citing works
Xia, C., Campbell, K. A., & Clare-Salzler, M. J. (2009) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e32832ce943 · Cited by 66 · see citing works
Microvesicles in Autoimmune Diseases
Liu, M., Williams, K. J., & Werth, V. P. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.06.005 · Cited by 65 · see citing works
Wittmann, M., Macdonald, A., & Renne, J. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.03.003 · Cited by 62 · see citing works
Seredkina, N., Zykova, S. N., & Rekvig, O. P. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080943 · Cited by 61 · see citing works
Tsai, P., Ka, S., Chang, J., Lai, J., Dai, M., Jheng, H.-L., Kuo, M.-T., Chen, P., & Chen, A. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33328 · Cited by 61 · see citing works
Infection and apoptosis as a combined inflammatory trigger
Torchinsky, M. B., Garaude, J., & Blander, J. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.003 · Cited by 59 · see citing works
Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin
Borg, R. J., Samson, A. L., Au, A. E., Scholzen, A., Fuchsberger, M., Kong, Y., Freeman, R., Mifsud, N. A., Plebanski, M., & Medcalf, R. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131216 · Cited by 58 · see citing works
Requirements for innate immune pathways in environmentally induced autoimmunity
Pollard, K. M., & Kono, D. H. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-100 · Cited by 57 · see citing works
Gerl, V., Lischka, A., Panne, D., Großmann, P., Berthold, R., Hoyer, B. F., Biesen, R., Bruns, A., Alexander, T., Jacobi, A. M., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.111021 · Cited by 55 · see citing works
Bacteria-induced phagocyte secondary necrosis as a pathogenicity mechanism
Silva, M. T. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0410205 · Cited by 55 · see citing works
The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation
Pereira‐Lopes, S., Celhar, T., Sans-Fons, G., Serra, M., Fairhurst, A., Lloberas, J., & Celada, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301603 · Cited by 54 · see citing works
Yoo, E. J., Oh, K., Piao, H., Kang, H. J., Jeong, G. W., Park, H., Lee, C. J., Ryu, H., Yang, S. H., Kim, M.-G., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.03.030 · Cited by 51 · see citing works
Influence of Atg5 Mutation in SLE Depends on Functional IL-10 Genotype
López, P., Alonso‐Perez, E., Rodríguez‐Carrio, J., & Suárez, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078756 · Cited by 51 · see citing works
Cellular Regulation of the Inflammatory Response
Janssen, W. J., & Henson, P. M. (2011) · Toxicologic Pathology · doi:10.1177/0192623311428477 · Cited by 50 · see citing works
Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption
Bates, M. A., Brandenberger, C., Langohr, I. M., Kumagai, K., Lock, A. L., Harkema, J. R., Holian, A., & Pestka, J. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160622 · Cited by 51 · see citing works
Majai, G. E., Kiss, E. V., Tarr, T., Zahuczky, G., Hartman, Z. C., Szegedi, G. Y., & Fésüs, L. (2013) · Lupus · doi:10.1177/0961203313511557 · Cited by 50 · see citing works
Systemic Lupus Erythematosus and DNA Degradation and Elimination Defects
Arneth, B. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01697 · Cited by 49 · see citing works
Munoz, L. E., Peter, C., i, M. H., Wesselborg, S., & Lauber, K. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.11.016 · Cited by 49 · see citing works
Self-citationPeripheral B cell abnormalities and disease activity in systemic lupus erythematosus
Hostmann, A., Jacobi, A., Mei, H. E., Hiepe, F., & Dörner, T. (2008) · Lupus · doi:10.1177/0961203308095138 · Cited by 48 · see citing works
Marée, A. F. M., Komba, M., Finegood, D. T., & Leah Edelstein-keshet, A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00514.2007 · Cited by 48 · see citing works
Khan, T. N., Wong, E. B., Soni, C., & Rahman, Z. S. M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200824 · Cited by 48 · see citing works
He, X., Ding, Y., Xiang, W., & Dang, X. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000453135 · Cited by 48 · see citing works
Dörner, T., & Lipsky, P. E. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000000 · Cited by 48 · see citing works
Apoptotic molecular mechanisms implicated in autoimmune diseases.
Cacciapaglia, F., Spadaccio, C., Chello, M., Gigante, A., Coccia, R., Afeltra, A., & Amoroso, A. (2009) · PubMed · Cited by 46 · see citing works
Bone marrow transplantation, refractory autoimmunity and the contributions of Susumu Ikehara
Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.12.006 · Cited by 46 · see citing works
Monsiváis-Urenda, A. E., Niño-Moreno, P., Abud‐Mendoza, C., Baranda, L., Layseca‐Espinosa, E., López‐Botet, M., & González‐Amaro, R. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.05.003 · Cited by 44 · see citing works
Chen, J., Zhao, Y., & Liu, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00656 · Cited by 43 · see citing works
- Authors
- Gaipl, U. S., Munoz, L. E., Grossmayer, G., Lauber, K., Franz, S., Sarter, K., Voll, R. E., Winkler, T., Kuhn, A., Kalden, J., Kern, P., & Herrmann, M.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Tübingen (DE)
- Heinrich Heine University Düsseldorf (DE)
- ORCID
- Venue
- Journal of Autoimmunity
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 28
- Issue
- 2-3
- Pages
- 114-121
- ISSN
- 0896-8411 (ISSN-L)
- OpenAlex
- W2021273693
- Cited by
- 277
- References
- 56
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 12 · 2018: 11 · 2017: 18 · 2016: 14 · 2015: 18 · 2014: 25 · 2013: 21 · 2012: 19
- FWCI
- 18.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Autoimmunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- systemic lupus erythematosus, efferocytosis, germinal center, follicular dendritic cells, cutaneous lupus erythematosus, UV-induced apoptosis, macrophage migration, anti-dsDNA antibodies, B cell maturation, damage-associated molecular patterns, nuclear autoantigens, secondary necrosis
- MeSH terms
- B-Lymphocytes, Humans, Immunohistochemistry, Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Systemic, Macrophages, Monocytes, Phagocytosis, Apoptosis, Models, Immunological, Germinal Center, In Situ Nick-End Labeling
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