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Molecular chaperone RAP interacts with LRP1 in a dynamic bivalent mode and enhances folding of ligand-binding regions of other LDLR family receptors
Marakasova, Ekaterina, Olivares, Philip, Karnaukhova, Elena, Chun, Haarin, Hernandez, Nancy E., Kurasawa, James H., Hassink, Gabriela U., Shestopal, Svetlana A., Strickland, Dudley K., Sarafanov, Andrey G.·2021·Journal of Biological Chemistry
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LRPAP1 antagonizes all known natural ligands of the LDL receptor family with nanomolar affinity.
“LRPAP1 antagonizes all known natural ligands of the LDL receptor family with nanomolar affinity (9–14).”
From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [9]
Reported dissociation constants (KD) of LRPAP1 for LRP1, LRP-2, ApoER2, VLDL receptor, and LDL receptor are 1-14 nM, 8 nM, 5 nM, 0.7 nM, and 250 nM, respectively.
“The dissociation constant (KD) of LRPAP1 for these receptors, reported in the literature, are as follows: LRP1 [1-14 nM (9, 14)], LRP-2 [KD: 8 nM (11)], ApoER2 [KD: 5 nM (12)], VLDL receptor [KD: 0.7 nM (10)] and LDL receptor [KD: 250 nM (13)].”
From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [9]
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More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration
Lane-Donovan, C., Philips, G. T., & Herz, J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.005 · Cited by 158
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Sorted by citations
Reid, K. M., & Brown, G. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1286474 · Cited by 13
Metadata
- Authors
- Marakasova, E., Olivares, P., Karnaukhova, E., Chun, H., Hernandez, N. E., Kurasawa, J. H., Hassink, G. U., Shestopal, S. A., Strickland, D. K., & Sarafanov, A. G.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 297
- Issue
- 1
- Pages
- 100842
- ISSN
- 0021-9258
- PMC
- PMC8239462
- Cited by
- 20
- References
- 2
- Language
- en
- Licence
- Funders
- NIH
- US FDA
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