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Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)
De Nardis, Camilla, Lössl, Philip, van den Biggelaar, Maartje, Madoori, Pramod K., Leloup, Nadia, Mertens, Koen, Heck, Albert J.R., Gros, Piet·2017·Journal of Biological Chemistry
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LRPAP1 antagonizes all known natural ligands of the LDL receptor family with nanomolar affinity.
“LRPAP1 antagonizes all known natural ligands of the LDL receptor family with nanomolar affinity (9–14).”
From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [14]
Reported dissociation constants (KD) of LRPAP1 for LRP1, LRP-2, ApoER2, VLDL receptor, and LDL receptor are 1-14 nM, 8 nM, 5 nM, 0.7 nM, and 250 nM, respectively.
“The dissociation constant (KD) of LRPAP1 for these receptors, reported in the literature, are as follows: LRP1 [1-14 nM (9, 14)], LRP-2 [KD: 8 nM (11)], ApoER2 [KD: 5 nM (12)], VLDL receptor [KD: 0.7 nM (10)] and LDL receptor [KD: 250 nM (13)].”
From LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation (2023) · cites this paper as [14]
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Snijder, J., van de Waterbeemd, M., Damoc, E., Denisov, E., Grinfeld, D., Bennett, A., Agbandje-McKenna, M., Makarov, A., & Heck, A. J. R. (2014) · Journal of the American Chemical Society · doi:10.1021/ja502616y · Cited by 168
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Cited by
Sorted by citations
LRP1 is a master regulator of tau uptake and spread
Rauch, J. N., Luna, G., Guzman, E., Audouard, M., Challis, C., Sibih, Y. E., Leshuk, C., Hernandez, I., Wegmann, S., Hyman, B. T., et al. (2020) · Nature · doi:10.1038/s41586-020-2156-5 · Cited by 541
Reid, K. M., & Brown, G. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1286474 · Cited by 13
Metadata
- Authors
- De Nardis, C., Lössl, P., van den Biggelaar, M., Madoori, P. K., Leloup, N., Mertens, K., Heck, A. J. R., & Gros, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 292
- Issue
- 3
- Pages
- 912-924
- ISSN
- 0021-9258
- Cited by
- 24
- References
- 2
- Language
- en
- Licence
- Funders
- Seventh Framework Programme (317371, 283570)
- The Netherlands Organization for Scientific Research (184.032.201)
- Landsteiner Foundation for Blood Transfusion Research (1517)
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