Chondroitin sulphate proteoglycan-based perineuronal net establishment is largely activity-independent in chick visual system
Abstract
Extracellular matrix components consisting of large aggregating chondroitin sulphate proteoglycans accumulate around neuronal perikarya to establish perineuronal nets. These perineuronal nets surround subpopulations of neurons in many vertebrates including man. In chickens, perineuronal nets show very fast matrix maturation after hatching which is probably due to the rapid establishment of neuronal morphology and immediate functional and behavioural performance of the animals. In mammals, maturation of extracellular matrix including perineuronal nets largely depends upon specific afferent activation. The present study shows that extracellular matrix maturation in mesencephalic, diencephalic and telencephalic visual centers of chicks tectofugal system is not principally determined by light activation. Perineuronal nets show an equally developed phenotypic character on monocularly light deprived animals in all investigated brain regions. Results suggest that establishment of extracellular matrix and perineuronal nets are largely activity-independent in the investigated precocial bird.
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CSPG-enriched PNNs form in an activity-dependent manner during late postnatal development, completing neuronal maturation.
“CSPG-enriched PNNs form in an activity-dependent manner during late postnatal development, completing neuronal maturation.32, 33, 34”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [33]
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- Authors
- Gáti, G., Morawski, M., Lendvai, D., Matthews, R. T., Jäger, C., Zachar, G., Arendt, T., & Alpár, A.
- Affiliations
- Semmelweis University (HU)
- Leipzig University (DE)
- SUNY Upstate Medical University (US)
- Venue
- Journal of Chemical Neuroanatomy
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 40
- Issue
- 3
- Pages
- 243-247
- ISSN
- 0891-0618 (ISSN-L)
- OpenAlex
- W2056249898
- Cited by
- 18
- References
- 47
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chemical Neuroanatomy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- perineuronal nets, chondroitin sulfate proteoglycans, extracellular matrix maturation, light deprivation, monocular deprivation, precocial birds, midbrain, diencephalon, telencephalon, neuronal perikarya
- MeSH terms
- Animals, Chickens, Extracellular Matrix, Female, Male, Chondroitin Sulfate Proteoglycans, Visual Cortex
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