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Cited by 156Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

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Morawski, M., Brückner, G., Jäger, C., Seeger, G., Arendt, T.·2010·Neuroscience
DOI 10.1016/j.neuroscience.2010.05.022
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Abstract

The biological basis for the selective vulnerability of neurons in Alzheimer's disease (AD) is elusive. Aggrecan-based perineuronal nets (PNs) of the extracellular matrix have been considered to contribute to neuroprotection in the cerebral cortex. In the present study, we investigated the organization of the aggrecan-based extracellular matrix in subcortical regions known to be preferentially affected by tau pathology in AD. Immunocytochemistry of aggrecan core protein was combined with detection of neurofibrillary degeneration. The results show that many regions affected by tau pathology in AD, such as the basal nucleus of Meynert, the dorsal thalamus, hypothalamic nuclei, raphe nuclei, and the locus coeruleus were devoid of a characteristic aggrecan-based extracellular matrix. Regions composed of nuclei with clearly different intensity of tau pathology, such as the amygdala, the thalamus and the oculomotor complex, showed largely complementary distribution patterns of neurofibrillary tangles and PNs. Quantification in the rostral interstitial nucleus of the longitudinal fascicle potentially affected by tau pathology in AD revealed that tau pathology was not accompanied by loss of aggrecan-based PNs. Neuro-fibrillary tangles in net-associated neurons extremely rarely occurred in the pontine reticular formation. We conclude that the low vulnerability of neurons ensheathed by PNs previously described for cortical areas in AD represents a more general phenomenon that also applies to subcortical regions. The aggrecan-based extracellular matrix of PNs may thus, be involved in neuroprotection.

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  • Perineuronal nets protect neurons against tau and amyloid-beta pathology.

    “PNNs are reported to protect neurons against tau [37, 38] and Aβ pathology [39]”

    From Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain (2020) · cites this paper as [38]

  • Neurons that exhibit buildup of tau protein and neurofibrillary tangles are more likely to lack PNNs.

    “Neurons that exhibit buildup of tau protein and neurofibrillary tangles are more likely to lack PNNs (Brückner et al., 1999; Morawski et al., 2010).”

    From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Morawski et al., 2010

  • PNN and PNN-component changes have been tied to several brain disorders, including stroke, epilepsy, multiple sclerosis, prion disease, and Alzheimer's disease.

    “a number of studies have shown alterations in PNNs and their constituents to be linked to various brain diseases, such as Alzheimer’s disease (Morawski et al., 2010, 2012; Kobayashi et al., 1989; Baig et al., 2005), epilepsy (McRae and Porter, 2012), multiple sclerosis (Gray et al., 2008), prion disease (Guentchev et al., 1999, Franklin et al., 2008) and stroke”

    From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Morawski et al., 2010

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Authors
Morawski, M., Brückner, G., Jäger, C., Seeger, G., & Arendt, T.
Affiliations
Leipzig University (DE)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2010-09
Volume
169
Issue
3
Pages
1347-1363
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2010.05.022
OpenAlex
W2035362565
Cited by
156
References
96
Citations by year
2026: 10 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 18 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 13 · 2013: 5 · 2012: 6
FWCI
4.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders
  • German Research Foundation
  • EU-Project “Neuropro” (223077)
  • Universität Leipzig
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
tau pathology, neurofibrillary tangles, Alzheimer's disease, subcortical structures, neuroprotection, extracellular matrix, nucleus basalis of Meynert, dorsal thalamus, hypothalamic nuclei, raphe nuclei, locus coeruleus, pontine reticular formation, amygdala
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Extracellular Matrix, Female, Humans, Male, Middle Aged, Neurons, Organ Specificity, Neurofibrillary Tangles, tau Proteins, Aggrecans

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