The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery
Abstract
Injectable hydrogels with multifunctional properties, including tissue adhesiveness and pH-sensitivity are highly desired for localized drug delivery in disease treatment, and their design is still challenging. We developed a series of multifunctional injectable mucoadhesive and pH-responsive hydrogels based on chitosan-grafted-dihydrocaffeic acid (CS-DA) and oxidized pullulan (OP) via a Schiff base reaction. These hydrogels exhibited good injectability, suitable gelation time, in vitro pH-dependent equilibrated swelling ratios, morphologies, and rheological characteristics. The desirable in vitro pH-sensitive drug release behavior of these hydrogels was demonstrated by a drug release test with anti-cancer drug doxorubicin (DOX) loaded hydrogels at different pH values. The hydrogels showed good DOX release, effectively killing colon tumor cells (HCT116 cells) and good antibacterial properties against E. coli and S. aureus in vitro when the antibacterial model drug amoxicillin was encapsulated in the hydrogels. A lap-shear test was also carried out with these hydrogels. The hydrogels exhibited good mucosal adhesion, indicating their potential use in mucosa-localized drug delivery systems. All these results suggest that these injectable pH-responsive adhesive hydrogels are ideal candidates for development of colon cancer drug delivery carriers or mucoadhesive drug delivery systems.
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Cites
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Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
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Self-citation
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Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Self-citationDeng, Z., Hu, T., Lei, Q., He, J., Ma, P. X., & Guo, B. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b20178 · Cited by 486
Self-citationReview of polysaccharide particle-based functional drug delivery
Barclay, T. G., Day, C. M., Petrovsky, N., & Garg, S. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.05.067 · Cited by 396
Li, M., Chen, J., Shi, M., Zhang, H., Ma, P. X., & Guo, B. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.121999 · Cited by 322
Self-citationChitosan based bioadhesives for biomedical applications: A review
Hamedi, H., Moradi, S., Hudson, S. M., Tonelli, A. E., & King, M. W. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119100 · Cited by 281
Metadata
- Authors
- Liang, Y., Zhao, X., Ma, P. X., Guo, B., Du, Y., & Han, X.
- Venue
- Journal of Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 536
- Pages
- 224-234
- ISSN
- 0021-9797 (ISSN-L)
- OpenAlex
- W2897999456
- Cited by
- 433
- References
- 6
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liang, Y., Zhao, X., Ma, P. X., Guo, B., Du, Y., & Han, X. (2019). pH-responsive injectable hydrogels with mucosal adhesiveness based on chitosan-grafted-dihydrocaffeic acid and oxidized pullulan for localized drug delivery. Journal of Colloid and Interface Science. https://doi.org/10.1016/j.jcis.2018.10.056
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