A correspondence analysis revealed frailty deficits aggregate and are multidimensional
Open accessAbstract
Objective To examine the relationships among seven frailty domains: nutrition, physical activity, mobility, strength, energy, cognition, and mood, using data from three studies.Study design and setting Data from three studies were separately analyzed using multiple correspondence analysis (MCA). The graphical output of MCA was used to assess (1) if the presence of deficits in the frailty domains separate from the absence of deficits on the graph, (2) the dimensionality of the domains, (3) the clustering of domains within each dimension, and (4) their relationship with age, sex, and disability. Results were compared across the studies.Results In two studies, presence of deficits for all domains separated from absence of deficits. In the third study, there was separation in all domains except cognition. Three main dimensions were retained in each study; however, assigned dimensionality of domains differed. The clustering of mobility with energy and/or strength was consistent across studies. Deficits were associated with older age, female sex, and disability.Conclusion Our results suggest that frailty is a multidimensional concept for which the relationships among domains differ according to the population characteristics. These domains, with the possible exception of cognition, appear to aggregate together and share a common underlying construct.
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- Authors
- Sourial, N., Wolfson, C., Bergman, H., Zhu, B., Karunananthan, S., Quail, J., Fletcher, J., Weiss, D., Bandeen-Roche, K., & Béland, F.
- Affiliations
- Jewish General Hospital (CA)
- McGill University Health Centre (CA)
- Corresponding author
- Wolfson, Christina
- ORCID
- Venue
- Journal of Clinical Epidemiology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 63
- Issue
- 6
- Pages
- 647-654
- ISSN
- 0895-4356 (ISSN-L)
- PMC
- PMC3718711
- OpenAlex
- W2134792789
- Cited by
- 85
- References
- 26
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 11 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 7
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (82945, 82945_1, 68739)
- National Institute on Aging (P50AG-021334-01, P30AG021334)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- frailty, multidimensional frailty, nutrition, physical activity, mobility (physical function), muscle strength, energy, cognition, mood, aging, sex differences, disability
- MeSH terms
- Affect, Aged, Aged, 80 and over, Cognition, Disability Evaluation, Female, Health Status, Humans, Male, Motor Activity, Geriatric Assessment, Nutrition Assessment, Cluster Analysis, Frail Elderly, Muscle Strength
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