Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology
Open accessAbstract
Cirrhosis-associated duodenal dysbiosis is not yet clearly defined. In this research, duodenal mucosal microbiota was analyzed in 30 cirrhotic patients and 28 healthy controls using 16S rRNA gene pyrosequencing methods. The principal coordinate analysis revealed that cirrhotic patients were colonized by remarkable different duodenal mucosal microbiota in comparison with controls. At the genus level, Veillonella, Megasphaera, Dialister, Atopobium, and Prevotella were found overrepresented in cirrhotic duodenum. And the duodenal microbiota of healthy controls was enriched with Neisseria, Haemophilus, and SR1 genera incertae sedis. On the other hand, based on predicted metagenomes analyzed, gene pathways related to nutrient absorption (e.g. sugar and amino acid metabolism) were highly abundant in cirrhosis duodenal microbiota, and functional modules involved in bacterial proliferation and colonization (e.g. bacterial motility proteins and secretion system) were overrepresented in controls. When considering the etiology of cirrhosis, two operational taxonomic units (OTUs), OTU-23 (Neisseria) and OTU-36 (Gemella), were found discriminative between hepatitis-B-virus related cirrhosis and primary biliary cirrhosis. The results suggest that the structure of duodenal mucosa microbiota in cirrhotic patients is dramatically different from healthy controls. The duodenum dysbiosis might be related to alterations of oral microbiota and changes in duodenal micro-environment.
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Recent studies show differences in duodenal and salivary microbiota between healthy controls and patients with cirrhosis, suggesting upper gastrointestinal changes may link to distal microbiota and contribute to chronic liver disease pathophysiology and hepatocellular carcinoma.
“Recent studies have demonstrated differences in the duodenal and salivary microbiota between healthy controls and patients with cirrhosis86,88, suggesting that there are also qualitative and quantitative changes in the upper gastrointestinal tract that might be linked to changes in the more distal microbiota and contribute to the pathophysiology of CLD as well as the development of HCC.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [86]
A recent small-scale study described differences in the gut microbiota between different types of underlying liver disease.
“However, a recent small-scale study described differences in the gut microbiota between different types of underlying liver disease86.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [86]
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- Authors
- Chen, Y., Ji, F., Guo, J., Shi, D., Fang, D., & Li, L.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Chen, Yanfei
- Li, Lanjuan
- Venue
- Scientific Reports
- Published
- 2016-09-30
- Volume
- 6
- Issue
- 1
- Pages
- 34055-34055
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5043180
- OpenAlex
- W2524544908
- Cited by
- 205
- References
- 45
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 25 · 2023: 21 · 2022: 30 · 2021: 26 · 2020: 27 · 2019: 24 · 2018: 19 · 2017: 16 · 2016: 1
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (10002004, 2012AA020204, 81400633)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- liver cirrhosis, duodenal microbiota, dysbiosis, small intestinal microbiota, hepatitis B cirrhosis, primary biliary cirrhosis, cirrhosis etiology, Veillonella, Megasphaera, Dialister, Atopobium, Prevotella, Neisseria, Gemella, oral microbiota
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