Cited by 646Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDendrimers and Hyperbranched Polymers

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Preparation and application of pH-responsive drug delivery systems

Ding, Haitao, Tan, Ping, Fu, Shiqin, Tian, Xiaohe, Zhang, Hu, Ma, Xuelei, Gu, Zhongwei, Luo, Kui·2022·Journal of Controlled Release

DOI 10.1016/j.jconrel.2022.05.056

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Abstract

Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive DDSs have gained popularity since the pH in the diseased tissues such as cancer, bacterial infection and inflammation differs from a physiological pH of 7.4 and this difference could be harnessed for DDSs to release encapsulated drugs specifically to these diseased tissues. A variety of synthetic approaches have been developed to prepare pH-sensitive DDSs, including introduction of a variety of pH-sensitive chemical bonds or protonated/deprotonated chemical groups. A myriad of nano DDSs have been explored to be pH-responsive, including liposomes, micelles, hydrogels, dendritic macromolecules and organic-inorganic hybrid nanoparticles, and micron level microspheres. The prodrugs from drug-loaded pH-sensitive nano DDSs have been applied in research on anticancer therapy and diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases. We have systematically summarized synthesis strategies of pH-stimulating DDSs, illustrated commonly used and recently developed nanocarriers for these DDSs and covered their potential in different biomedical applications, which may spark new ideas for the development and application of pH-sensitive nano DDSs.

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Authors: Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K.
Affiliations: Sichuan University (CN)
Amgen (United States) (US)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Ma, Xuelei
Luo, Kui
ORCID: Tan, Ping
Tian, Xiaohe
Zhang, Hu
Ma, Xuelei
Gu, Zhongwei
Luo, Kui
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2022-08
Volume: 348
Pages: 206-238
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2022.05.056
OpenAlex: W4281865876
Cited by: 645
References: 340
Citations by year: 2026: 182 · 2025: 261 · 2024: 114 · 2023: 76 · 2022: 12
FWCI: 7.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (51873120, 52073193, 81621003, 82002692)
Sichuan University
Sichuan University West China Hospital (ZYJC21013)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: targeted drug delivery, prodrugs, liposomes, micelles, hydrogels, dendritic macromolecules, organic-inorganic hybrid nanoparticles, microspheres, cancer therapy, cancer diagnosis, inflammation, neurological disorders
MeSH terms: Drug Carriers, Humans, Hydrogen-Ion Concentration, Inflammation, Micelles, Neoplasms, Drug Delivery Systems, Nanoparticles, Tumor Microenvironment

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Preparation and application of pH-responsive drug delivery systems

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