Cited by 646Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDendrimers and Hyperbranched Polymers

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Preparation and application of pH-responsive drug delivery systems

Ding, Haitao, Tan, Ping, Fu, Shiqin, Tian, Xiaohe, Zhang, Hu, Ma, Xuelei, Gu, Zhongwei, Luo, Kui·2022·Journal of Controlled Release

DOI 10.1016/j.jconrel.2022.05.056

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Abstract

Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive DDSs have gained popularity since the pH in the diseased tissues such as cancer, bacterial infection and inflammation differs from a physiological pH of 7.4 and this difference could be harnessed for DDSs to release encapsulated drugs specifically to these diseased tissues. A variety of synthetic approaches have been developed to prepare pH-sensitive DDSs, including introduction of a variety of pH-sensitive chemical bonds or protonated/deprotonated chemical groups. A myriad of nano DDSs have been explored to be pH-responsive, including liposomes, micelles, hydrogels, dendritic macromolecules and organic-inorganic hybrid nanoparticles, and micron level microspheres. The prodrugs from drug-loaded pH-sensitive nano DDSs have been applied in research on anticancer therapy and diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases. We have systematically summarized synthesis strategies of pH-stimulating DDSs, illustrated commonly used and recently developed nanocarriers for these DDSs and covered their potential in different biomedical applications, which may spark new ideas for the development and application of pH-sensitive nano DDSs.

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3 retracted

RETRACTED: Carboxymethyl chitosan-based nanogels via acid-labile ortho ester linkages mediated enhanced drug delivery
Li, S., Hu, L., Li, D., Wang, X., Zhang, P., Wang, J., Yan, G., & Tang, R. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.072 · Cited by 47
Retracted
RETRACTED ARTICLE: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin
Chunyun, W., Qi, P., Lu, Y., Liu, L., Zhang, Y., Sheng, Q., Wang, T., Zhang, M., Wang, R., & Song, S. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1726526 · Cited by 47
Retracted
RETRACTED: pH-sensitive and pluronic-modified pullulan nanogels for greatly improved antitumor in vivo
Zheng, Y., Lv, X., Xu, Y., Cheng, X., Wang, X., & Tang, R. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.220 · Cited by 36
Retracted
New developments in liposomal drug delivery
Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,557
pH-Sensitive nano-systems for drug delivery in cancer therapy
Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121
Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing
Liang, Y., Li, Z., Huang, Y. P., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,089
Tumour acidosis: from the passenger to the driver's seat
Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 1,028
Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review
Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004
Ph sensitive hydrogels in drug delivery: brief history, properties, swelling, and release mechanism, material selection and applications
Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844

Show all 340 references

Research works printed but not linked: 9

Han, 2020, pH-Sensitive tumor-targeted hyperbranched system based on glycogen nanoparticles for liver cancer therapy[J], Appl. Mater. Today, 18
HerasMozos, 2022, Chitosan films as pH-responsive sustained release systems of naturally occurring antifungal volatile compounds[J], Carbohydr. Polym., 283
Maldonado, 1865, Advances and novel perspectives on colloids, hydrogels, and aerogels based on coordination bonds with biological interest ligands[J], Nanomaterials, 2021, 11
Rayamajhi, 2020, pH-responsive cationic liposome for endosomal escape mediated drug delivery[J], Colloid Surf. B-Biointerfaces, 188, 10.1016/j.colsurfb.2020.110804 · DOI
dos Reis, 2020, Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes[J], Biomed. Pharmacother., 134
Gandhi, 2017, Formulation and evaluation of sol-gel drug delivery system for intracanal ph sensitive controlled delivery of chlorhexidine[J], J. Clin. Diagn. Res., 11
Nong, 2021, The structural appeal of metal–organic frameworks in antimicrobial applications[J], Coord. Chem. Rev., 442
Sun, 2022, TfR-T12 short peptide and pH sensitive cell transmembrane peptide modified nano-composite micelles for glioma treatment via remodeling tumor microenvironment[J], Nanomedicine, 41
Xu, 2022, pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (beta-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis[J], Nanomedicine, 39

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Authors: Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K.
Affiliations: Sichuan University (CN)
Amgen (United States) (US)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Ma, Xuelei
Luo, Kui
ORCID: Tan, Ping
Tian, Xiaohe
Zhang, Hu
Ma, Xuelei
Gu, Zhongwei
Luo, Kui
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2022-08
Volume: 348
Pages: 206-238
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2022.05.056
OpenAlex: W4281865876
Cited by: 645
References: 340
Citations by year: 2026: 182 · 2025: 261 · 2024: 114 · 2023: 76 · 2022: 12
FWCI: 7.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (51873120, 52073193, 81621003, 82002692)
Sichuan University
Sichuan University West China Hospital (ZYJC21013)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: targeted drug delivery, prodrugs, liposomes, micelles, hydrogels, dendritic macromolecules, organic-inorganic hybrid nanoparticles, microspheres, cancer therapy, cancer diagnosis, inflammation, neurological disorders
MeSH terms: Drug Carriers, Humans, Hydrogen-Ion Concentration, Inflammation, Micelles, Neoplasms, Drug Delivery Systems, Nanoparticles, Tumor Microenvironment

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Preparation and application of pH-responsive drug delivery systems

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