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Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract

Zhang, Shuhao, Zhu, Chaoran, Huang, Wanting, Liu, Hua, Yang, Mingzhu, Zeng, Xuejiao, Zhang, Zhenzhong, Liu, Junjie, Shi, Jinjin, Hu, Yurong, Shi, Xiufang, Wang, Zhi-Hao·2023·Journal of Controlled Release
DOI 10.1016/j.jconrel.2023.07.005
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Abstract

Oral administration is a convenient administration route for gastrointestinal disease therapy with good patient compliance. But the nonspecific distribution of the oral drugs may cause serious side effects. In recent years, oral drug delivery systems (ODDS) have been applied to deliver the drugs to the gastrointestinal disease sites with decreased side effects. However, the delivery efficiency of ODDS is tremendously limited by physiological barriers in the gastrointestinal sites, such as the long and complex gastrointestinal tract, mucus layer, and epithelial barrier. Micro/nanomotors (MNMs) are micro/nanoscale devices that transfer various energy sources into autonomous motion. The outstanding motion characteristics of MNMs inspired the development of targeted drug delivery, especially the oral drug delivery. However, a comprehensive review of oral MNMs for the gastrointestinal diseases therapy is still lacking. Herein, the physiological barriers of ODDS were comprehensively reviewed. Afterward, the applications of MNMs in ODDS for overcoming the physiological barriers in the past 5 years were highlighted. Finally, future perspectives and challenges of MNMs in ODDS are discussed as well. This review will provide inspiration and direction of MNMs for the therapy of gastrointestinal diseases, pushing forward the clinical application of MNMs in oral drug delivery.

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Metadata

Authors
Zhang, S., Zhu, C., Huang, W., Liu, H., Yang, M., Zeng, X., Zhang, Z., Liu, J., Shi, J., Hu, Y., Shi, X., & Wang, Z.-H.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2023-08
Volume
360
Pages
514-527
ISSN
0168-3659
DOI
10.1016/j.jconrel.2023.07.005
Cited by
59
References
3
Language
en
Licence

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