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Cited by 20Nanoparticle-Based Drug DeliveryCellular Mechanics and InteractionsExtracellular vesicles in disease

The DOI matches its Crossref record; 275 of the 279 references it cites were found in a registry or an index.

Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance

Ding, Xinyue, Liang, Yiyu, Zhou, Siyuan, Wu, Yao, Sałata, Patricia, Mikolajczk-Martinez, Agata, Khosrawipour, Veria, Zhang, Zhiwen·2025·Journal of Controlled Release
DOI 10.1016/j.jconrel.2025.113786
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Abstract

Each stage of tumor development is intrinsically linked to the tumor microenvironment (TME), wherein the extracellular matrix (ECM) serves as a vital and abundant component in tumor tissues. The ECM is a non-cellular, three-dimensional macromolecular network scaffold that provides structural support to cells, stores bioactive molecules, and mediates signaling pathways through specific binding to cell surface receptors. Moreover, the ECM in tumor tissues plays a crucial role in impeding drug diffusion and resisting apoptosis induced by conventional anti-cancer therapies that primarily target cancer cells. Therefore, directing attentions towards the tumor ECM can facilitate the identification of novel targets and the development of new therapies. This review aims to summarize the composition, structure, remodeling, and function of tumor ECM, its association with drug resistance, and current targeting strategies, with a specific emphasis on nanoparticles (NPs).

Overview

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Crossref · 10.1016/j.jconrel.2025.113786

Cites

275 of 275 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 7

  1. Fukazawa, 2015, Laminin β3 expression as a prognostic factor and a predictive marker of chemoresistance in colorectal cancer, Jpn. J. Clin. Oncol., 45, 533
  2. Li, 2022, Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of laminin α5/FAK signaling, Commun. Biol., 5, 1
  3. Toth, 2019, Hypoxia-induced PIM kinase and laminin-activated integrin α6 mediate resistance to PI3K inhibitors in bone-metastatic CRPC, Am. J. Clin. Exp. Urol., 7, 297
  4. Colak, 2017, Targeting TGF-β signaling in Cancer, trends, Cancer, 3, 56
  5. Peng, 2022, Local release of TGF-β inhibitor modulates tumor-associated neutrophils and enhances pancreatic Cancer response to combined irreversible electroporation and immunotherapy, Adv Sci (Weinh), 9
  6. Nguyen, 2019, YAP/TAZ signaling and resistance to Cancer therapy, trends, Cancer, 5, 283
  7. Ogawa, 2021, Three distinct stroma types in human pancreatic Cancer identified by image analysis of fibroblast subpopulations and collagen, clinical, Cancer Res., 27, 107

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Metadata

Authors
Ding, X., Liang, Y., Zhou, S., Wu, Y., Sałata, P., Mikolajczk-Martinez, A., Khosrawipour, V., & Zhang, Z.
Affiliations
  • Fudan University (CN)
  • Wrocław University of Environmental and Life Sciences (PL)
Corresponding author
  • Khosrawipour, Veria
  • Zhang, Zhiwen
ORCID
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2025-07
Volume
383
Pages
113786
ISSN
0168-3659 (ISSN-L)
DOI
10.1016/j.jconrel.2025.113786
OpenAlex
W4409885575
Cited by
20
References
279
Citations by year
2026: 15 · 2025: 5
FWCI
1.17
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Science and Technology of the People's Republic of China
  • National Key Research and Development Program of China (2023YFE0104300)
  • National Natural Science Foundation of China (32271461)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
tumor extracellular matrix, nanoparticles, drug resistance, tumor microenvironment, extracellular matrix remodeling, apoptosis resistance, cancer therapy
MeSH terms
Animals, Antineoplastic Agents, Extracellular Matrix, Humans, Neoplasms, Drug Delivery Systems, Drug Resistance, Neoplasm, Nanoparticles, Tumor Microenvironment

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