The initial resuscitation of septic shock
Abstract
Septic shock is the most severe form of sepsis, characterized by (a) persistent hypotension despite fluid resuscitation and (b) the presence of tissue hypoperfusion. Delays in the diagnosis and initiation of treatment of septic shock is associated with increasing risk for mortality. Early and effective fluid resuscitation and vasopressor administration play a crucial role in maintaining tissue perfusion in septic shock patients. A low diastolic arterial pressure (DAP) correlates with severity of arteriolar vasodilation, compromises left ventricle oxygen supply and can be used for identifying septic shock patients that would potentially benefit from earlier vasopressor therapy. Controversy currently exists as to the balance of fluids and vasopressors to maintain target mean arterial pressure. The aim of this article is to review the rationale for fluid resuscitation and vasopressor therapy and the importance of both mean and diastolic blood pressure during the initial resuscitation of the septic shock. We relate our personal prescription of balancing fluids and vasopressors in the resuscitation of septic shock.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neither SIRS nor qSOFA are ideal sepsis screening tools.
“Neither SIRS nor qSOFA are ideal screening tools for sepsis and the bedside clinician needs to understand the limitations of each.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [43]
qSOFA is more specific but less sensitive than two of four SIRS criteria for early identification of infection-induced organ dysfunction.
“Studies have shown that qSOFA is more specific but less sensitive than having two of four SIRS criteria for early identification of infection induced organ dysfunction [40–43].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [43]
Cites
1 retracted
The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill
Finfer, S., Norton, R., Bellomo, R., Boyce, N., French, J., & Myburgh, J. (2004) · Vox Sanguinis · doi:10.1111/j.1741-6892.2004.00468.x · Cited by 48 · see citing works
RetractedThe third international consensus definitions for sepsis and septic shock (Sepsis-3).
Singer, M., Deutschman, C. S., Seymour, C. W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G. R., Chiche, J.-D., Coopersmith, C. M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0287 · Cited by 28,250 · see citing works
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,192 · see citing works
Self-citationEarly goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743 · see citing works
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Self-citationDellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,282 · see citing works
Self-citationSurviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Self-citationKumar, A., Roberts, D., Wood, K. E., Light, B., Parrillo, J. E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217961.75225.e9 · Cited by 6,109 · see citing works
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Levy, M. M., Fink, M. P., Marshall, J. C., Abraham, E. H., Angus, D. C., Cook, D., Cohen, J., Opal, S. M., Vincent, J., & Ramsay, G. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000050454.01978.3b · Cited by 5,976 · see citing works
Seymour, C. W., Liu, V. X., Iwashyna, T. J., Brunkhorst, F. M., Rea, T. D., Scherag, A., Rubenfeld, G., Kahn, J. M., Shankar-Hari, M., Singer, M., et al. (2016) · JAMA · doi:10.1001/jama.2016.0288 · Cited by 3,939 · see citing works
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J., Gea‐Banacloche, J., Keh, D., Marshall, J. C., Parker, M. M., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2210-z · Cited by 3,298 · see citing works
Self-citationSurviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J., Gea‐Banacloche, J., Keh, D., Marshall, J. C., Parker, M. M., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000117317.18092.e4 · Cited by 3,012 · see citing works
Self-citationA Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit
The SAFE Study Investigators (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040232 · Cited by 2,827 · see citing works
A randomized trial of protocol-based care for early septic shock.
The ProCESS Investigators (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401602 · Cited by 2,414 · see citing works
Time to treatment and mortality during mandated emergency care for sepsis.
Seymour, C. W., Gesten, F., Prescott, H. C., Friedrich, M. E., Iwashyna, T. J., Phillips, G. S., Lemeshow, S., Osborn, T., Terry, K. M., & Levy, M. M. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1703058 · Cited by 2,225 · see citing works
Goal-Directed Resuscitation for Patients with Early Septic Shock
The ARISE Investigators and the ANZICS Clinical Trials Group (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1404380 · Cited by 2,023 · see citing works
Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
Russell, J. A., Walley, K. R., Singer, J., Gordon, A. C., Hébert, P. C., Cooper, D. J., Holmes, C. L., Mehta, S., Granton, J. T., Storms, M. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa067373 · Cited by 1,924 · see citing works
Dellinger, R. P. (2004) · Critical Care Medicine · Cited by 1,848 · see citing works
Self-citationTrial of early, goal-directed resuscitation for septic shock.
Mouncey, P. R., Osborn, T. M., Power, G. S., Harrison, D. A., Sadique, M. Z., Grieve, R. D., Jahan, R., Harvey, S. E., Bell, D., Bion, J. F., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500896 · Cited by 1,604 · see citing works
Mortality after Fluid Bolus in African Children with Severe Infection
Maitland, K., Kiguli, S., Opoka, R. O., Engoru, C., Olupot‐Olupot, P., Akech, S., Nyeko, R., Mtove, G. A., Reyburn, H., Lang, T. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1101549 · Cited by 1,595 · see citing works
Elevation of Systemic Oxygen Delivery in the Treatment of Critically Ill Patients
Hayes, M., Timmins, A. C., Yau, E. H. S., Palazzo, M. G. A., Hinds, C., & Watson, D. I. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406163302404 · Cited by 1,530 · see citing works
Boyd, J. H., Forbes, J., Nakada, T.-A., Walley, K. R., & Russell, J. A. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181feeb15 · Cited by 1,517 · see citing works
Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour
Ferrer, R., Martín‐Loeches, I., Phillips, G. S., Osborn, T. M., Townsend, S. R., Dellinger, R. P., Artigas, A., Schorr, C., & Levy, M. M. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000330 · Cited by 1,489 · see citing works
Self-citationThe surviving sepsis campaign bundle: 2018 update
Levy, M. M., Evans, L. E., & Rhodes, A. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5085-0 · Cited by 1,445 · see citing works
Balanced crystalloids versus saline in critically ill adults.
Semler, M. W., Self, W. H., Wanderer, J. P., Ehrenfeld, J. M., Wang, L., Byrne, D. W., Stollings, J. L., Kumar, A. B., Hughes, C. G., Hernandez, A., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1711584 · Cited by 1,433 · see citing works
Albumin Replacement in Patients with Severe Sepsis or Septic Shock
Caironi, P., Tognoni, G., Masson, S., Fumagalli, R., Pesenti, A. M., Romero, M., Fanizza, C., Caspani, L., Faenza, S., Grasselli, G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1305727 · Cited by 1,314 · see citing works
High versus low blood-pressure target in patients with septic shock.
Asfar, P., Meziani, F., Hamel, J.-F., Grelon, F., Megarbane, B., Anguel, N., Mira, J.-P., Dequin, P.-F., Gergaud, S., Weiss, N., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312173 · Cited by 1,239 · see citing works
Balanced Crystalloids versus Saline in Noncritically Ill Adults
Self, W. H., Semler, M. W., Wanderer, J. P., Wang, L., Byrne, D. W., Collins, S. P., Slovis, C. M., Lindsell, C. J., Ehrenfeld, J. M., Siew, E. D., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1711586 · Cited by 1,156 · see citing works
Brok, J. S., Thorlund, K., Gluud, C. N., & Wetterslev, J. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.10.007 · Cited by 1,116 · see citing works
Adjunctive glucocorticoid therapy in patients with septic shock.
Venkatesh, B., Finfer, S., Cohen, J., Rajbhandari, D., Arabi, Y., Bellomo, R., Billot, L., Correa, M., Glass, P., Harward, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705835 · Cited by 1,037 · see citing works
Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock
Landry, D. W., Levin, H. R., Gallant, E. M., Ashton, R. C., Seo, S., D'Alessandro, D., Oz, M. C., & Oliver, J. A. (1997) · Circulation · doi:10.1161/01.cir.95.5.1122 · Cited by 990 · see citing works
Hernández, G., Ospina-Tascón, G. A., Damiani, L. P., Estenssoro, E., Dubin, A., Hurtado, J., Friedman, G., Castro, R., Alegría, L., Teboul, J.-L., et al. (2019) · JAMA · doi:10.1001/jama.2019.0071 · Cited by 946 · see citing works
Hydrocortisone plus fludrocortisone for adults with septic shock.
Annane, D., Renault, A., Brun-Buisson, C., Megarbane, B., Quenot, J.-P., Siami, S., Cariou, A., Forceville, X., Schwebel, C., Martin, C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705716 · Cited by 939 · see citing works
López, A., Lorente, J. A., Steingrub, J. S., Bakker, J., McLuckie, A., Willatts, S. M., Brockway, M., Anzueto, A., Holzapfel, L., Breen, D. P., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105581.01815.c6 · Cited by 917 · see citing works
Angiotensin II for the Treatment of Vasodilatory Shock
Khanna, A., English, S. W., Wang, X. S., Ham, K., Tumlin, J., Szerlip, H., Busse, L. W., Altaweel, L., Albertson, T. E., Mackey, C., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1704154 · Cited by 916 · see citing works
Paoli, C. J., Reynolds, M. A., Sinha, M., Gitlin, M. D., & Crouser, E. D. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003342 · Cited by 748 · see citing works
The glycocalyx: a novel diagnostic and therapeutic target in sepsis
Uchimido, R., Schmidt, E. P., & Shapiro, N. I. (2019) · Critical Care · doi:10.1186/s13054-018-2292-6 · Cited by 736 · see citing works
Malbrain, M. L. N. G., Marik, P. E., Witters, I., Cordemans, C., Kirkpatrick, A. W., Roberts, D. J., & Regenmortel, N. V. (2014) · Anestezjologia, Intensywna Terapia · doi:10.5603/ait.2014.0060 · Cited by 707 · see citing works
The Surviving Sepsis Campaign Bundle: 2018 Update
Levy, M. M., Evans, L. E., & Rhodes, A. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003119 · Cited by 679 · see citing works
Malbrain, M. L. N. G., Van Regenmortel, N., Saugel, B., De Tavernier, B., Van Gaal, P.-J., Joannes-Boyau, O., Teboul, J.-L., Rice, T. W., Mythen, M., & Monnet, X. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0402-x · Cited by 632 · see citing works
Annane, D., Vignon, P., Renault, A., Bollaert, P., Charpentier, C., Martin, C., Troché, G., Ricard, J.-D., Nitenberg, G., Papazian, L., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61344-0 · Cited by 557 · see citing works
Sepsis-associated hyperlactatemia
García-Alvarez, M., Marik, P. E., & Bellomo, R. (2014) · Critical Care · doi:10.1186/s13054-014-0503-3 · Cited by 517 · see citing works
Desautels, T., Calvert, J., Hoffman, J., Jay, M., Kerem, Y., Shieh, L., Shimabukuro, D., Chettipally, U., Feldman, M. D., Barton, C., et al. (2016) · JMIR Medical Informatics · doi:10.2196/medinform.5909 · Cited by 509 · see citing works
Lactate Measurements in Sepsis-Induced Tissue Hypoperfusion
Casserly, B. P., Phillips, G. S., Schorr, C., Dellinger, R. P., Townsend, S. R., Osborn, T. M., Reinhart, K., Selvakumar, N., & Levy, M. M. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000742 · Cited by 466 · see citing works
Self-citationAnnane, D., Pastores, S., Rochwerg, B., Arlt, W., Balk, R., Beishuizen, A., Briegel, J., Carcillo, J., Christ-Crain, M., Cooper, M., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-017-4919-5 · Cited by 434 · see citing works
Circulating vasopressin levels in septic shock
Sharshar, T., Blanchard, A., Paillard, M., Raphaël, J., Gajdos, P., & Annane, D. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000063046.82359.4a · Cited by 412 · see citing works
Castelli, G. P., Pognani, C., Meisner, M., Stuani, A., Bellomi, D., & Sgarbi, L. (2004) · Critical Care · doi:10.1186/cc2877 · Cited by 411 · see citing works
Raghunathan, K., Shaw, A., Nathanson, B. H., Stürmer, T., Brookhart, A. M., Stefan, M. S., Setoguchi, S., Beadles, C. A., & Lindenauer, P. K. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000305 · Cited by 404 · see citing works
Glycocalyx and sepsis-induced alterations in vascular permeability
Chelazzi, C., Villa, G., Mancinelli, P., Gaudio, A. R. D., & Adembri, C. (2015) · Critical Care · doi:10.1186/s13054-015-0741-z · Cited by 398 · see citing works
Molecular biology of inflammation and sepsis: A primer*
Cinel, İ., & Opal, S. M. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819267fb · Cited by 386 · see citing works
Self-citationDopamine versus norepinephrine in the treatment of septic shock
Backer, D. D., Aldecoa, C., Njimi, H., & Vincent, J. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31823778ee · Cited by 384 · see citing works
Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol*
Shapiro, N. I., Howell, M. D., Talmor, D. S., Lahey, D., Ngo, L. H., Buras, J. A., Wolfe, R. E., Weiss, J. W., & Lisbon, A. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000206104.18647.a8 · Cited by 348 · see citing works
Delaney, A. P., Dan, A., McCaffrey, J., & Finfer, S. R. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181ffe217 · Cited by 344 · see citing works
Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER). A Randomized Trial
Permpikul, C., Tongyoo, S., Viarasilpa, T., Trainarongsakul, T., Chakorn, T., & Udompanturak, S. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1034oc · Cited by 323 · see citing works
Fluid Resuscitation in Sepsis: A Systematic Review and Network Meta-analysis
Rochwerg, B., Alhazzani, W., Sindi, A., Heels-Ansdell, D., Thabane, L., Fox-Robichaud, A., Mbuagbaw, L., Szczeklik, W., Alshamsi, F., Altayyar, S., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m14-0178 · Cited by 309 · see citing works
Translating Research to Clinical Practice
Trzeciak, S. W., Dellinger, R. P., Abate, N. L., Cowan, R. M., Stauss, M. P., Kilgannon, J. H., Zanotti, S. L., & Parrillo, J. E. (2006) · CHEST Journal · doi:10.1378/chest.129.2.225 · Cited by 307 · see citing works
Self-citationVasopressors for the treatment of septic shock: Systematic review and meta-analysis.
Avni, T., Lador, A., Lev, S., Leibovici, L., Paul, M., & Grossman, A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0129305 · Cited by 293 · see citing works
The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta-analysis
Hoeboer, S. H., van der Geest, P. J., Nieboer, D., & Groeneveld, A. B. J. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2014.12.026 · Cited by 282 · see citing works
Tan, M., Lü, Y., Jiang, H., & Zhang, L. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27870 · Cited by 278 · see citing works
Usman, O. A., Usman, A. A., & Ward, M. A. (2018) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2018.10.058 · Cited by 276 · see citing works
Prediction of sepsis patients using machine learning approach: a meta-analysis
Islam, M. M., Nasrin, T., Walther, B. A., Wu, C.-C., Yang, H.-C., & Li, Y.-C. (2019) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2018.12.027 · Cited by 259 · see citing works
A rational approach to fluid therapy in sepsis
Marik, P. E., & Bellomo, R. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev349 · Cited by 257 · see citing works
Zampieri, F. G., Damiani, L. P., Bakker, J., Ospina-Tascón, G. A., Castro, R., Cavalcanti, A. B., & Glenn Hernández, P. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201905-0968oc · Cited by 253 · see citing works
Intravenous fluid therapy in critically ill adults
Finfer, S. R., Myburgh, J., & Bellomo, R. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0044-0 · Cited by 251 · see citing works
Askim, Å., Moser, F., Gustad, L. T., Stene, H., Gundersen, M., Åsvold, B. O., Dale, J., Bjørnsen, L. P., Damås, J. K., & Solligård, E. (2017) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-017-0399-4 · Cited by 247 · see citing works
Jones, A. E., Focht, A., Horton, J. M., & Kline, J. A. (2007) · CHEST Journal · doi:10.1378/chest.07-0234 · Cited by 236 · see citing works
Vasopressor therapy in critically ill patients with shock
Russell, J. A. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05801-z · Cited by 236 · see citing works
Clinical guidelines on central venous catheterisation
Frykholm, P., Pikwer, A., Hammarskjöld, F., Larsson, A., Lindgren, S., LINDWALL, R., Taxbro, K., ÖBERG, F., Acosta, S., & Åkeson, J. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12295 · Cited by 218 · see citing works
Effects of norepinephrine on mean systemic pressure and venous return in human septic shock*
Persichini, R., Silva, S., Teboul, J., Jozwiak, M., Chemla, D., Richard, C., & Monnet, X. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e318260c6c3 · Cited by 218 · see citing works
Safety of peripheral intravenous administration of vasoactive medication
Cardenas‐Garcia, J., Schaub, K. F., Belchikov, Y. G., Narasimhan, M., Koenig, S. J., & Mayo, P. H. (2015) · Journal of Hospital Medicine · doi:10.1002/jhm.2394 · Cited by 217 · see citing works
Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation
Hippensteel, J. A., Uchimido, R., Tyler, P. D., Burke, R. C., Han, X., Zhang, F., McMurtry, S. A., Colbert, J. F., Lindsell, C. J., Angus, D. C., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2534-2 · Cited by 217 · see citing works
Hamzaoui, O., Georger, J.-F., Monnet, X., Ksouri, H., Maizel, J., Richard, C., & Teboul, J. (2010) · Critical Care · doi:10.1186/cc9207 · Cited by 206 · see citing works
Pruinelli, L., Westra, B. L., Yadav, P., Hoff, A., Steinbach, M. S., Kumar, V., Delaney, C. W., & Simon, G. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000002949 · Cited by 194 · see citing works
Current use of vasopressors in septic shock
Scheeren, T., Bakker, J., Backer, D. D., Annane, D., Asfar, P., Boerma, E. C., Cecconi, M., Dubín, A., Dünser, M. W., Duranteau, J., et al. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0498-7 · Cited by 193 · see citing works
Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature
Léone, M., Asfar, P., Radermacher, P., Vincent, J., & Martin, C. (2015) · Critical Care · doi:10.1186/s13054-015-0794-z · Cited by 189 · see citing works
Yunos, N. M., Bellomo, R., Glassford, N. J., Sutcliffe, H., Lam, Q. T., & Bailey, M. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3593-0 · Cited by 181 · see citing works
Gu, W.-J., Zhang, Z., & Bakker, J. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3955-2 · Cited by 175 · see citing works
Kondo, Y., Umemura, Y., Hayashida, K., Hara, Y., Aihara, M., & Yamakawa, K. (2019) · Journal of Intensive Care · doi:10.1186/s40560-019-0374-4 · Cited by 166 · see citing works
Nagendran, M., Russell, J. A., Walley, K. R., Brett, S. J., Perkins, G. D., Hajjar, L., Mason, A. J., Ashby, D., & Gordon, A. C. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05620-2 · Cited by 161 · see citing works
Safety of peripheral administration of vasopressor medications: A systematic review
Tian, D. H., Smyth, C., Keijzers, G., Macdonald, S. P., Peake, S., Udy, A., & Delaney, A. (2020) · Emergency Medicine Australasia · doi:10.1111/1742-6723.13406 · Cited by 160 · see citing works
Moeller, C., Fleischmann, C., Thomas-Rueddel, D., Vlasakov, V., Rochwerg, B., Theurer, P., Gattinoni, L., Reinhart, K., & Hartog, C. S. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.04.011 · Cited by 159 · see citing works
The Role of Venous Return in Critical Illness and Shock—Part I
Funk, D. J., Jacobsohn, E., & Kumar, A. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182772ab6 · Cited by 149 · see citing works
Safety of the Peripheral Administration of Vasopressor Agents
Lewis, T. C., Merchan, C., Altshuler, D., & Papadopoulos, J. (2017) · Journal of Intensive Care Medicine · doi:10.1177/0885066616686035 · Cited by 146 · see citing works
Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx
Milford, E. M., & Reade, M. C. (2019) · Critical Care · doi:10.1186/s13054-019-2369-x · Cited by 145 · see citing works
Xu, J., Chen, Q., Xie, J., Pan, C. S., Liu, S., Huang, L., Yang, C., Liu, L., Huang, Y., Guo, F., et al. (2014) · Critical Care · doi:10.1186/s13054-014-0702-y · Cited by 144 · see citing works
Fluid management in sepsis: The potential beneficial effects of albumin
Vincent, J., Backer, D. D., & Wiedermann, C. J. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.04.019 · Cited by 144 · see citing works
Self, W. H., Semler, M. W., Bellomo, R., Brown, S. M., deBoisblanc, B. P., Exline, M. C., Ginde, A. A., Grissom, C. K., Janz, D. R., Jones, A. E., et al. (2018) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2018.03.039 · Cited by 144 · see citing works
A global perspective on vasoactive agents in shock
Annane, D., Ouanes-Besbes, L., Backer, D. D., Du, B., Gordon, A. C., Glenn Hernández, P., Olsen, K. M., Osborn, T. M., Peake, S., Russell, J. A., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5242-5 · Cited by 144 · see citing works
Ventriculoarterial decoupling in human septic shock
Guarracino, F., Ferro, B., Morelli, A., Bertini, P., Baldassarri, R., & Pinsky, M. R. (2014) · Critical Care · doi:10.1186/cc13842 · Cited by 141 · see citing works
Macdonald, S. P. J., Keijzers, G., Taylor, D. M., Kinnear, F., Arendts, G., Fatovich, D. M., Bellomo, R., McCutcheon, D., Fraser, J. F., Ascencio-Lane, J.-C., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5433-0 · Cited by 129 · see citing works
Cecconi, M., Hernandez, G., Dunser, M., Antonelli, M., Baker, T., Bakker, J., Duranteau, J., Einav, S., Groeneveld, A. B. J., Harris, T., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-018-5415-2 · Cited by 128 · see citing works
Symmetrical Peripheral Gangrene and Disseminated Intravascular Coagulation
Molos, M. A. (1985) · Archives of Dermatology · doi:10.1001/archderm.1985.01660080111027 · Cited by 127 · see citing works
Rhodes, A., Lamb, F. J., Malagon, I., Newman, P. J., Grounds, R. M., & Bennett, E. D. (1999) · Critical Care Medicine · doi:10.1097/00003246-199911000-00007 · Cited by 117 · see citing works
Ischemic Limb Gangrene with Pulses
Warkentin, T. E. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1316259 · Cited by 112 · see citing works
Norepinephrine exerts an inotropic effect during the early phase of human septic shock
Hamzaoui, O., Jozwiak, M., Geffriaud, T., Sztrymf, B., Prat, D., Jacobs, F., Monnet, X., Trouiller, P., Richard, C., & Teboul, J. (2017) · British Journal of Anaesthesia · doi:10.1016/j.bja.2017.11.065 · Cited by 110 · see citing works
Pan, J., Peng, M., Liao, C., Hu, X., Wang, A., & Li, X. (2019) · Medicine · doi:10.1097/md.0000000000014453 · Cited by 107 · see citing works
Medlej, K., Kazzi, A. A. N., Chehadeh, A. A.-H., Eldine, M. S., Chami, A., Bachir, R. H., Zebian, D., & Dagher, G. A. (2017) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2017.09.007 · Cited by 105 · see citing works
Role of the Venous Return in Critical Illness and Shock
Funk, D. J., Jacobsohn, E., & Kumar, A. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827bfc25 · Cited by 103 · see citing works
Vascular effects of the stereoisomers of dobutamine.
Ruffolo, R. R., Jr., & Yaden, E. L. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33428-2 · Cited by 93 · see citing works
Small volume resuscitation with 20% albumin in intensive care: physiological effects
Mårtensson, J., Bihari, S., Bannard‐Smith, J., Glassford, N. J., Lloyd‐Donald, P., Cioccari, L., Luethi, N., Tanaka, A., Crisman, M., de Castro, N. R., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5253-2 · Cited by 85 · see citing works
The hemodynamic effects of norepinephrine: far more than an increase in blood pressure!
Foulon, P., & Backer, D. D. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.09.27 · Cited by 80 · see citing works
A users’ guide to the 2016 Surviving Sepsis Guidelines
Dellinger, R. P., Schorr, C., & Levy, M. M. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4681-8 · Cited by 69 · see citing works
Self-citationDiastolic Arterial Blood Pressure: A Reliable Early Predictor of Survival in Human Septic Shock
Benchekroune, S., Karpati, P. C. J., Berton, C., Nathan, C., Matéo, J., Chaara, M., Riché, F. C., Laisné, M.-J. C., Payen, D. M., & Mebazaa, A. (2008) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e31811f3a45 · Cited by 66 · see citing works
Angiotensin II in Refractory Septic Shock
Antonucci, E., Gleeson, P. J., Annoni, F., Agosta, S., Orlando, S., Taccone, F. S., Velissaris, D., & Scolletta, S. (2016) · Shock · doi:10.1097/shk.0000000000000807 · Cited by 64 · see citing works
The Importance of Vascular Capacitance in Cardiovascular Control
HAINSWORTH, R. (1990) · Physiology · doi:10.1152/physiologyonline.1990.5.6.250 · Cited by 63 · see citing works
Systemic and microcirculatory effects of dobutamine in patients with septic shock
Enrico, C., Edul, V. S. K., Vázquez, A., Pein, M. C., de la Hoz, R. A. P., İnce, C., & Dubín, A. (2012) · Journal of Critical Care · doi:10.1016/j.jcrc.2012.08.002 · Cited by 61 · see citing works
Norepinephrine in septic shock: when and how much?
Hamzaoui, O., Scheeren, T., & Teboul, J. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000418 · Cited by 59 · see citing works
Importance of diastolic arterial pressure in septic shock: PRO
Hamzaoui, O., & Teboul, J. (2018) · Journal of Critical Care · doi:10.1016/j.jcrc.2018.10.032 · Cited by 57 · see citing works
Vasopressors and Inotropes in Sepsis
Stratton, L., Berlin, D., & Arbo, J. E. (2016) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2016.09.005 · Cited by 56 · see citing works
Dubin, A., Lattanzio, B., & Gatti, L. (2017) · Revista Brasileira de Terapia Intensiva · doi:10.5935/0103-507x.20170068 · Cited by 56 · see citing works
Macdonald, S. P. J., Taylor, D. M., Keijzers, G., Arendts, G., Fatovich, D. M., Kinnear, F. B., Brown, S. G. A., Bellomo, R., Burrows, S., Fraser, J. F., et al. (2017) · Trials · doi:10.1186/s13063-017-2137-7 · Cited by 50 · see citing works
The role of procalcitonin in the diagnosis of bacterial infection after major abdominal surgery
Spoto, S., Valeriani, E., Caputo, D. D., Cella, E., Fogolari, M., Pesce, E., Mulè, M. T., Cartillone, M. M., Costantino, S., Dicuonzo, G., et al. (2018) · Medicine · doi:10.1097/md.0000000000009496 · Cited by 50 · see citing works
Angiotensin converting enzyme defects in shock: implications for future therapy
Chawla, L. S., Chen, S., Bellomo, R., & Tidmarsh, G. F. (2018) · Critical Care · doi:10.1186/s13054-018-2202-y · Cited by 48 · see citing works
A Users’ Guide to the 2016 Surviving Sepsis Guidelines
Dellinger, R. P., Schorr, C., & Levy, M. M. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002257 · Cited by 47 · see citing works
Self-citationHeterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shock
Jellema, W. T., Groeneveld, A. B. J., Wesseling, K. H., THIJS, L. G., Westerhof, N., & LIESHOUT, J. J. V. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000233871.52553.cd · Cited by 44 · see citing works
Cheng, L., Yan, J., Han, S., Chen, Q., Chen, M., Jiang, H., & Lü, J. (2019) · Critical Care · doi:10.1186/s13054-019-2427-4 · Cited by 43 · see citing works
Norepinephrine improves cardiac function during septic shock, but why?
Backer, D. D., & Pinsky, M. R. (2017) · British Journal of Anaesthesia · doi:10.1016/j.bja.2017.11.069 · Cited by 41 · see citing works
Norepinephrine in septic shock
Hernández, G., Teboul, J., & Bakker, J. (2019) · Intensive Care Medicine · doi:10.1007/s00134-018-5499-8 · Cited by 41 · see citing works
Sequential C-reactive protein measurements in patients with serious infections: does it help?
Lobo, S. M. (2012) · Critical Care · doi:10.1186/cc11347 · Cited by 35 · see citing works
Castro, R., Regueira, T., Aguirre, M. L. C., Llanos, O. P., Bruhn, A. R., Bugedo, G. J., Dougnac, A., Castillo, L., Andresen, M., & Glenn Hernández, P. (2008) · PubMed · Cited by 35 · see citing works
Prognostic value of serial lactate levels in septic patients with and without shock
Innocenti, F., Meo, F., Giacomelli, I., Tozzi, C., Ralli, M. L., Donnini, C., Tassinari, I., Caldi, F., Zanobetti, M., & Pini, R. (2019) · Internal and Emergency Medicine · doi:10.1007/s11739-019-02196-z · Cited by 32 · see citing works
Warkentin, T. E., & Pai, M. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13219 · Cited by 30 · see citing works
Stressed vs. unstressed volume and its relevance to critical care practitioners
Spiegel, R. J. (2016) · Clinical and Experimental Emergency Medicine · doi:10.15441/ceem.16.128 · Cited by 29 · see citing works
Vasopressor use in septic shock: an update
Léone, M., & Martin, C. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3282f46d20 · Cited by 28 · see citing works
Baumann, B. M., Greenwood, J. C., Lewis, K., Nuckton, T. J., Darger, B., Shofer, F. S., Troeger, D., Jung, S. Y., Kilgannon, J. H., & Rodriguez, R. M. (2019) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2019.07.003 · Cited by 28 · see citing works
Annane, D., Pastores, S. M., Rochwerg, B. N., Arlt, W., BALK, R. A., Beishuizen, A., Briegel, J., Carcillo, J. A., Christ‐Crain, M., Cooper, M. S., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5071-6 · Cited by 25 · see citing works
Kievlan, D., Zhang, L. A., Chang, C. H., Angus, D. C., & Seymour, C. W. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003360 · Cited by 25 · see citing works
Hydroxyethyl starch in severe sepsis: end of starch era?
Estrada, C. A., & Murugan, R. (2013) · Critical Care · doi:10.1186/cc12531 · Cited by 24 · see citing works
Time to re-think the use of dobutamine in sepsis
Sato, R., & Nasu, M. (2017) · Journal of Intensive Care · doi:10.1186/s40560-017-0264-6 · Cited by 23 · see citing works
The Physiology of Volume Resuscitation
Marik, P. E. (2014) · Current anesthesiology reports · doi:10.1007/s40140-014-0080-7 · Cited by 22 · see citing works
Singer, M., & Shankar‐Hari, M. (2018) · Annals of Internal Medicine · doi:10.7326/m17-3415 · Cited by 22 · see citing works
Caironi, P. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.03.048 · Cited by 18 · see citing works
Diagnostic reliability of the procalcitonin serum marker in septic frail patient
Romano, A. D., Buglio, A. L., Bellanti, F., Villani, R., Serviddio, G., & Vendemiale, G. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1020-z · Cited by 18 · see citing works
Vincent, J. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5401-8 · Cited by 18 · see citing works
Septic shock resuscitation in the first hour
Simpson, N., Lamontagne, F., & Shankar‐Hari, M. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000460 · Cited by 16 · see citing works
Zhang, Z., Brusasco, C., Anile, A., Corradi, F., Mariyaselvam, M. Z. A., Young, P., Almog, Y., Du, B., Yu, X., Zhu, H., et al. (2018) · Journal of Emergency and Critical Care Medicine · doi:10.21037/jeccm.2018.05.05 · Cited by 16 · see citing works
Vasoactive Agents for Adult Septic Shock: An Update and Review
Dalimonte, M. A., DeGrado, J. R., & Anger, K. E. (2019) · Journal of Pharmacy Practice · doi:10.1177/0897190019844124 · Cited by 15 · see citing works
Warkentin, T. E. (2018) · Clinical Pulmonary Medicine · doi:10.1097/cpm.0000000000000253 · Cited by 9 · see citing works
Ding, X., Yang, D., Ke, C., Gong, L., Zhan, H., Yan, R., Chen, Y., Li, H., & Wang, J. (2017) · Medicine · doi:10.1097/md.0000000000008152 · Cited by 5 · see citing works
Hemodynamic states during the course of norepinephrine weaning
Kipnis, É., Tytgat, H., Bruneau, N., Leroy, B., Lebuffe, G., Tavernier, B., & Vallet, B. (2010) · Critical Care · doi:10.1186/cc8327 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082 · see citing works
Self-citationSurviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935 · see citing works
Self-citationThe pathophysiology of sepsis — 2021 update: Part 2, organ dysfunction and assessment
Jacobi, J. (2021) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxab393 · Cited by 85 · see citing works
Jacobi, J. (2021) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxab380 · Cited by 74 · see citing works
Sartelli, M., Tascini, C., Coccolini, F., Dellai, F., Ansaloni, L., Antonelli, M. M., Bartoletti, M., Bassetti, M., Boncagni, F., Carlini, M., et al. (2024) · World Journal of Emergency Surgery · doi:10.1186/s13017-024-00551-w · Cited by 62 · see citing works
Xiao, W., Liu, W., Zhang, J., Liu, Y., Hua, T., & Yang, M. (2022) · European journal of medical research · doi:10.1186/s40001-022-00930-6 · Cited by 32 · see citing works
Expert consensus on blood pressure management in critically ill patients
Yu, Y., Gong, Y., Hu, B., Ouyang, B., Pan, A., Liu, J., Liu, F., Shang, X., Yang, X., Tu, G.-W., et al. (2023) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2023.06.001 · Cited by 30 · see citing works
Sepsis Management, Controversies, and Advancement in Nanotechnology: A Systematic Review
Choudhary, R. (2022) · Cureus · doi:10.7759/cureus.22112 · Cited by 20 · see citing works
Neuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis
Atıcı, A. E., Tamer, S. A., Levent, H. N., Eyüboğlu, İ. P., Ercan, F., Akkіprіk, M., & Yeğen, B. Ç. (2021) · Inflammation · doi:10.1007/s10753-021-01545-5 · Cited by 18 · see citing works
Gül, F., Gönen, Z. B., Jones, O. Y., Taşlı, P. N., Zararsız, G., Ünal, E., Özdarendeli, A., Şahi̇n, F., Eken, A., Yılmaz, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.963309 · Cited by 16 · see citing works
Self-citationComprehensive Management of Blood Pressure in Patients with Septic AKI
Deng, J., Li, L., Feng, Y., & Yang, J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12031018 · Cited by 16 · see citing works
Nanotechnology Applications in Sepsis: Essential Knowledge for Clinicians
Vasconcelos, I., & Santos, T. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061682 · Cited by 19 · see citing works
Saito, A., Osawa, I., Shibata, J., Sonoo, T., Nakamura, K., & Goto, T. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282148 · Cited by 12 · see citing works
Ramasco, F., Aguilar, G., Aldecoa, C., Bakker, J., Carmona, P., Dominguez, D., Galiana, M., Glenn Hernández, P., Kattan, E., Olea, C., et al. (2024) · Revista Española de Anestesiología y Reanimación · doi:10.1016/j.redar.2023.07.006 · Cited by 12 · see citing works
Hu, T., Qiao, Z., & Mei, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.737654 · Cited by 10 · see citing works
Should we initiate vasopressors earlier in patients with septic shock: A mini systemic review
Zhou, H.-X., Yang, C.-F., Wang, H.-Y., Teng, Y., & He, H. (2023) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v12.i4.204 · Cited by 9 · see citing works
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2023) · European journal of medical research · doi:10.1186/s40001-023-01315-z · Cited by 9 · see citing works
Wang, Y., Chen, Y., Zheng, Y., Huang, Y.-C., Chen, W., Ji, R., Xu, L., Yang, Z., Sheng, H., Qu, H., et al. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9818 · Cited by 9 · see citing works
Ramasco, F., Aguilar, G., Aldecoa, C., Bakker, J., Carmona, P., Dominguez, D., Galiana, M., Glenn Hernández, P., Kattan, E., Olea, C., et al. (2024) · Revista Española de Anestesiología y Reanimación (English Edition) · doi:10.1016/j.redare.2024.01.003 · Cited by 7 · see citing works
Wiedermann, C. J., Zaboli, A., & Turcato, G. (2025) · Heart & Lung · doi:10.1016/j.hrtlng.2025.01.010 · Cited by 6 · see citing works
Case study: An older COVID ‐19 patient in a Turkish intensive care unit with prolonged stay
Kebapçı, A., Kütük, K., & Eker, E. (2021) · Nursing in Critical Care · doi:10.1111/nicc.12602 · Cited by 5 · see citing works
Li, W., & Deng, J. (2024) · Military Medicine · doi:10.1093/milmed/usae369 · Cited by 4 · see citing works
Li, D. (2025) · American Journal of Translational Research · doi:10.62347/pgbb6148 · Cited by 5 · see citing works
Zheng, X., Zhao, Y., Wang, D., Pan, S., Yushuaima, Huang, Z., Ye, M., & Zhang, S. (2023) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.14193 · Cited by 4 · see citing works
Heart/breathing rate ratio (HBR) as a predictor of mortality in critically ill patients
Zhang, T., Du, Y. J., Hou, Y. Z., Du, Q., Dou, H. R., & Gao, X. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31187 · Cited by 4 · see citing works
Kanbakan, A. (2024) · doi:10.5152/2314 · Cited by 3 · see citing works
Liu, X., Chi, Y.-F., Wu, Y., & Chai, J. (2024) · Burns · doi:10.1016/j.burns.2024.04.012 · Cited by 4 · see citing works
Kim, Y., Kim, J. W., Lee, K. R., Hong, D. Y., Park, S. O., Lee, Y. H., & Kim, S. Y. (2023) · Emergency Medicine International · doi:10.1155/2023/8852135 · Cited by 2 · see citing works
Alfhili, M. A., Alazmi, S. A., & Alsughayyir, J. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s537039 · Cited by 2 · see citing works
Murata, J., Buckley, M. S., Lehn, J. M., Agarwal, S., Stevenson, B., Martinez, B. K., & MacLaren, R. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900221078270 · Cited by 2 · see citing works
Morgaan, H. A., Sallam, M. Y., El-Deeb, N. M., El‐Gowelli, H. M., El‐Gowilly, S. M., & El‐Mas, M. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-87586-4 · Cited by 2 · see citing works
Bedside measurement of microcirculation in critically ill patients: A scoping review protocol
Sarmadi, S., Sanaie, N., Monjazebi, F., & Zare‐Kaseb, A. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341435 · Cited by 1 · see citing works
Yadgarov, M. Y., Бондоевич, Б. Л., Polyakov, P. A., Kadantseva, K., Yakovlev, A. A., & Likhvantsev, V. V. (2026) · Annals of critical care · doi:10.21320/1818-474x-2026-2-122-139 · Cited by 1 · see citing works
Babayiğit, M., Yıldız, G., Türksal, E., Babayiğit, M. A., Firat, P., Selvi, A., & KILINÇARSLAN, A. (2021) · Medical Journal of Western Black Sea · doi:10.29058/mjwbs.895193 · Cited by 1 · see citing works
The influence of solution choice on fluid resuscitation in patients with septic shock
Zuo, T., & Solyarik, S. (2021) · ScienceRise Medical Science · doi:10.15587/2519-4798.2021.224654
ABORDAGEM LINEAR DO PACIENTE SÉPTICO: REVISÃO DE LITERATURA
Toni, L. P., Viana, J. F. M., Filho, C. R. G. D. S., Carvalho, L. F. D. Q., Mendes, V. P. D. S., LIMA, R. K. S. D., de Queiroz, J. V. J., Montenegro, B. V., Damasceno, A. B., Cavalcanti, B. B., et al. (2022) · Editora Pasteur eBooks · doi:10.29327/554269.3-29
Özkavak, S., Eray, O., & Korkut, M. (2022) · International Emergency Nursing · doi:10.1016/j.ienj.2022.101213
Septic Shock Resuscitation: Continuous Fluids or Early Vasopressors?
Choudhuri, A. H. (2023) · Journal of Acute Care · doi:10.5005/jp-journals-10089-0050
A Personalized Approach to Monitoring and Therapy of Critical Conditions
Кirov, М. Y., Владимирович, К. В., Fot, E. V., & Smetkin, A. A. (2023) · Herald of the Russian Academy of Sciences · doi:10.1134/s101933162302003x
Editorial: Cardiovascular involvement during sepsis: therapeutic and prognostic consequences
Innocenti, F., & Palmieri, V. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1314834
A personalized approach to monitoring and therapy of critical conditions
Кirov, М. Y., Владимирович, К. В., Fot, E. V., & Smetkin, A. A. (2023) · Вестник Российской академии наук · doi:10.31857/s0869587323030040
Sıvı ve Elektrolit Bozuklukları
DEMIRTAKAN, T. (2024) · doi:10.5152/2311
Akdeniz, Y. S. (2024) · doi:10.5152/2313
Erişkin İleri Kardiyak Yaşam Desteği
BIBEROĞLU, S. (2024) · doi:10.5152/2303
Aman, G. (2024) · doi:10.5152/2307
ÖZKAN, S. (2024) · doi:10.5152/2305
Batıkan, E. (2024) · doi:10.5152/2315
Non-İnvaziv ve İnvaziv Mekanik Ventilasyon
İPEKCI, A. (2024) · doi:10.5152/2302
Pediatrik İleri Kardiyak Yaşam Desteği
ÖZKAN, S. (2024) · doi:10.5152/2304
Akdeniz, Y. S., & Çirkin, Y. (2024) · doi:10.5152/2310
Orhan, Ç. (2024) · doi:10.5152/2306
Kırmızı Alan: Acilde Kritik Vakalar I
Ikızcelı, İ., Özkan, S., İpekci, A., Kanbakan, A., Orhan, Ç., Batıkan, E., Çakmak, F., Aman, G., Yılmaz, N., Biberoğlu, S., et al. (2024) · doi:10.5152/2300
İPEKCI, A. (2024) · doi:10.5152/2312
Akdeniz, Y. S. (2024) · doi:10.5152/2316
Initial management of ballistic trauma: feedback through observational study of 32 CasesPreprint
Khallikane, S., Mehdi, D., Elabdi, M., & Seddiki, R. (2024) · Research Square · doi:10.21203/rs.3.rs-5396117/v1
Phulpoto, A. H., Kumar, M., Aziz, A., Memon, A. Q., Channa, M. A., & Parvez, S. A. (2024) · Pakistan Journal of Health Sciences · doi:10.54393/pjhs.v5i12.2348
Elghareeb, S. H., Mohamed, H., Elaleem, A. A. A., & Mahmoud, M. S. (2025) · Anaesthesia Pain & Intensive Care · doi:10.35975/apic.v29i4.2813
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616124
Xiao, W., Liu, W., Zhang, J., Liu, Y., Hua, T., & Yang, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552824
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616130
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616148
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616136
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616142
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616133
Xiao, W., Liu, W., Zhang, J., Liu, Y., Hua, T., & Yang, M. (2024) · Figshare · doi:10.6084/m9.figshare.26552821
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616139
Gao, Z., Li, C., Chen, H., Chen, D., Ma, S., Xie, J., Wu, C., Liu, L., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26616145
Functional status of the pulmonary detoxification in patients with polytrauma complicated by sepsis
Boboaliev, A. M., KURBANOV, S. K., Rakhimov, N. O., Rasulov, R. N., Ehsonov, A. A., Yoftov, S. R., & Nurkhonov, D. N. (2026) · Health care of Tajikistan · doi:10.52888/0514-2515-2026-369-2-21-31
Management of abdominal sepsis: Principles, pitfalls, and perspectives
Sartelli, M. (2026) · Intensive Care Science · doi:10.1016/j.iics.2026.08.004
- Authors
- Cinel, I., Kasapoglu, U. S., Gul, F., & Dellinger, R. P.
- Affiliations
- Cooper University Hospital (US)
- Corresponding author
- Dellinger, R. Phillip
- Venue
- Journal of Critical Care
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 57
- Pages
- 108-117
- ISSN
- 0883-9441 (ISSN-L)
- OpenAlex
- W3006115571
- Cited by
- 69
- References
- 140
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 31 · 2023: 12 · 2022: 6 · 2021: 11
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Critical Care (publishedVersion)
- PubMed (publishedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Abdominal Surgery and Complications
- Keywords
- septic shock, fluid resuscitation, vasopressor therapy, diastolic arterial pressure, mean arterial pressure, hypotension, tissue hypoperfusion, early treatment initiation, sepsis mortality
- MeSH terms
- Blood Pressure, Catheterization, Central Venous, Fluid Therapy, Humans, Hypotension, Perfusion, Resuscitation, Shock, Septic, Steroids, Vasoconstrictor Agents, Ventricular Function, Left, Treatment Outcome, Sepsis, Arterial Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review