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Cited by 58Bone health and osteoporosis researchLGBTQ Health, Identity, and PolicyHIV-related health complications and treatments

Prevalence of Low Bone Mass in Relation to Estrogen Treatment and Body Composition in Male-to-Female Transsexual Persons

T'Sjoen, Guy, Weyers, Steven, Taes, Youri, Lapauw, Bruno, Toye, Kaatje, Goemaere, S., Kaufman, Jean-Marc·2009·Journal of Clinical Densitometry
DOI 10.1016/j.jocd.2008.11.002
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Abstract

Bone health is a parameter of interest in the daily follow-up of male-to-female (M --> F) transsexual persons both before and after sex reassignment surgery (SRS) due to an intensely changing hormonal milieu. We have studied body composition, areal, geometric, and volumetric bone parameters, using DXA and peripheral quantitative computed tomography at different sites in 50 M --> F transsexual persons, at least 3 yr after the start of the hormonal treatment and 1 yr after SRS. In this cross-sectional study, hormone levels and markers of bone metabolism were assessed using immunoassays. Prevalence of low bone mass as defined by a Z-score < or = -2.0 according to DXA criteria was 26% at lumbar spine and 2% at the total hip. We found no major differences in hormonal parameters between participants with a Z-score < or = or > -2.0. Markers of bone turnover were comparable between subjects with or without low bone mass, indicating a stable bone turnover at the time of investigation. No significant differences in bone size or density were observed between patients on transdermal vs. oral estrogens. Low bone mass is not uncommon in M --> F transsexual persons. Smaller bone size, and a strikingly lower muscle mass compared with men appear to underlie these findings.

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  • In a study of 50 non-athlete transwomen who had undergone gender-affirming surgery (GAS) coupled with HRT, a reduction in muscle mass and bone mineral density was reported together with an increase in fat mass following HRT initially and 1 year after GAS.

    “In a study of 50 non-athlete transwomen who had undergone gender-affirming surgery (GAS) coupled with HRT, a reduction in muscle mass and bone mineral density was reported together with an increase in fat mass following HRT initially and 1 year after GAS [48].”

    From Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement (2021) · cites this paper as [48]

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Authors
T'Sjoen, G., Weyers, S., Taes, Y., Lapauw, B., Toye, K., Goemaere, S., & Kaufman, J.-M.
Affiliations
Ghent University Hospital (BE)
Corresponding author
T'Sjoen, Guy
ORCID
Venue
Journal of Clinical Densitometry
Publisher
Elsevier BV
Published
2009-07
Volume
12
Issue
3
Pages
306-313
ISSN
1094-6950 (ISSN-L)
DOI
10.1016/j.jocd.2008.11.002
OpenAlex
W2089210484
Cited by
58
References
28
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 3 · 2012: 2
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Clinical Densitometry (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Keywords
osteopenia, male-to-female transsexuals, estrogen therapy, body composition, gender-affirming surgery, bone mineral density, bone turnover markers, muscle mass, transdermal estrogen, lumbar spine, hip, bone size
MeSH terms
Administration, Cutaneous, Administration, Oral, Adult, Androgen Antagonists, Body Composition, Cross-Sectional Studies, Estrogens, Feminization, Humans, Male, Middle Aged, Orchiectomy, Osteoporosis, Transsexualism, Prevalence, Case-Control Studies, Bone Remodeling

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