Cited by 800Skin Protection and AgingAntioxidant Activity and Oxidative Stressmelanin and skin pigmentation

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Role of antioxidants in the skin: Anti-aging effects

Masaki, Hitoshi·2010·Journal of Dermatological Science

DOI 10.1016/j.jdermsci.2010.03.003

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Abstract

Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS generation and ROS elimination in the body are summarized. The effects of ROS generated in the skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of representative antioxidants on the skin are summarized with a focus on skin aging.

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Authors: Masaki, H.
Affiliations: Cosmos Technical Center Co., Ltd. (Japan) (JP)
Corresponding author: Masaki, Hitoshi
ORCID: Masaki, Hitoshi
Venue: Journal of Dermatological Science
Publisher: Elsevier BV
Published: 2010-05
Volume: 58
Issue: 2
Pages: 85-90
ISSN: 0923-1811 (ISSN-L)
DOI: 10.1016/j.jdermsci.2010.03.003
OpenAlex: W2078923345
Cited by: 788
References: 83
Citations by year: 2026: 48 · 2025: 71 · 2024: 77 · 2023: 61 · 2022: 87 · 2021: 73 · 2020: 56 · 2019: 58 · 2018: 53 · 2017: 36 · 2016: 37 · 2015: 36 · 2014: 37 · 2013: 17 · 2012: 18
FWCI: 3.25
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Dermatological Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: antioxidants, skin aging, oxidative stress, reactive oxygen species, photoaging, ultraviolet radiation, wrinkles, hyperpigmentation, reactive oxygen species scavenging
MeSH terms: Aging, Antioxidants, Ascorbic Acid, Carotenoids, Flavonoids, Humans, Inflammation, Models, Biological, Phenols, Sebaceous Glands, Skin, Ultraviolet Rays, Vitamin E, Skin Aging, Reactive Oxygen Species, Oxidative Stress, Polyphenols

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Role of antioxidants in the skin: Anti-aging effects

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