Role of antioxidants in the skin: Anti-aging effects

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The Neutrophil NADPH Oxidase

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Intradermal Treatment with a Hyaluronic Acid Complex Supplemented with Amino Acids and Antioxidant Vitamins Improves Cutaneous Hydration and Viscoelasticity in Healthy Subjects

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The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity

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A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from Pterocarpus Marsupium

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Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats

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Air pollution, UV irradiation and skin carcinogenesis: what we know, where we stand and what is likely to happen in the future?

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Topical or oral treatment of peach flower extract attenuates UV-induced epidermal thickening, matrix metalloproteinase-13 expression and pro-inflammatory cytokine production in hairless mice skin

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Chemistry, oxidative stability and bioactivity of oil extracted from Rosa rugosa (Thunb.) seeds by supercritical carbon dioxide

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Exosomes from hypoxia‐pretreated adipose‐derived stem cells attenuate ultraviolet light‐induced skin injury via delivery of circ‐Ash1l

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Improvement of polyphenol properties upon glucosylation in a UV‐induced skin cell ageing model

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Nanoethosomal formulation of gammaoryzanol for skin-aging protection and wrinkle improvement: a histopathological study

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Uncovering key mechanisms and intervention therapies in aging skin

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Baicalein inhibits matrix metalloproteinase 1 expression via activation of TRPV 1‐Ca‐ ERK pathway in ultraviolet B–irradiated human dermal fibroblasts

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Rhus coriaria L. Fruit Extract Prevents UV-A-Induced Genotoxicity and Oxidative Injury in Human Microvascular Endothelial Cells

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Antioxidant Bioactivity of Extracts from Beach Cast Leaves of Posidonia oceanica (L.) Delile

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Oleuropein Multicompartment Nanovesicles Enriched with Collagen as A Natural Strategy for The Treatment of Skin Wounds Connected with Oxidative Stress

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Anti-Melanogenic and Antioxidant Effects of Cell-Free Supernatant from Lactobacillus gasseri BNR17

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ErZhiFormula prevents UV-induced skin photoaging by Nrf2/HO-1/NQO1 signaling: An in vitro and in vivo studies

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Extraction, analysis of antioxidant activities and structural characteristics of flavonoids in fruits of Diospyros lotus L.

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Poria cocos (Fuling) targets TGFβ /Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts

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Research progress on the potential delaying skin aging effect and mechanism of tea for oral and external use

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Nutrition and youthful skin

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Cosmeceutical Potentials of Grammatophyllum speciosum Extracts: Anti-Inflammations and Anti-Collagenase Activities with Phytochemical Profile Analysis Using an Untargeted Metabolomics Approach

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Astaxanthin Protects Ultraviolet B-Induced Oxidative Stress and Apoptosis in Human Keratinocytes via Intrinsic Apoptotic Pathway

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Protective effects of the phenolic compounds from mung bean hull against H2O2-induced skin aging through alleviating oxidative injury and autophagy in HaCaT cells and HSF cells

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Low Plant Density Improves Fruit Quality without Affecting Yield of Cucumber in Different Cultivation Periods in Greenhouse

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Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer

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Skin Anti-Aging Potential of Ipomoea pes-caprae Ethanolic Extracts on Promoting Cell Proliferation and Collagen Production in Human Fibroblasts (CCD-986sk Cells)

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Geniposidic Acid from Eucommia ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT/NRF2 Signaling

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Hyaluronic acid/polyphenol sunscreens with broad-spectrum UV protection properties from tannic acid and quercetin

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Anti-aging Potential of Extracts Prepared from Fruits and Medicinal Herbs Cultivated in the Gyeongnam Area of Korea

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Effects of Antioxidant, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase of The Extract and Fraction From Turbinaria decurrens Bory.

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Ultraviolet B irradiation induced Nrf2 degradation occurs via activation of TRPV1 channels in human dermal fibroblasts

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Anti-inflammatory, antioxidant effects, and antimicrobial effect of Bacillus subtilis P223

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Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes

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Antioxidant and antitumor activity of trolox, trolox succinate, and α-tocopheryl succinate conjugates with nitroxides

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Skin Rejuvenation through HIF-1α Modulation

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Effects of low-dose ALA-PDT on fibroblast photoaging induced by UVA irradiation and the underlying mechanisms

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New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities

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Photoprotective and Antiaging Effects of a Standardized Red Orange (Citrus sinensis (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study

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Wild Mushrooms in Nepal: Some Potential Candidates as Antioxidant and ACE‐Inhibition Sources

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Redox proteomics and drug development

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Protective Effect of Super-Critical Carbon Dioxide Fluid Extract from Flowers and Buds of Chrysanthemum indicum Linnén Against Ultraviolet-Induced Photo-Aging in Mice

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Antioxidant, cell-protective, and anti-melanogenic activities of leaf extracts from wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) cultivars

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Micromeria myrtifolia: The influence of the extracting solvents on phenolic composition and biological activity

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Quality Control of Vitamins A and E and Coenzyme Q10 in Commercial Anti-Ageing Cosmetic Products

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Metabolite Profiling and Anti-Aging Activity of Rice Koji Fermented with Aspergillus oryzae and Aspergillus cristatus: A Comparative Study

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Fast Identification of Radical Scavengers from Securigera varia by Combining 13C-NMR-Based Dereplication to Bioactivity-Guided Fractionation

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Time-resolved singlet oxygen luminescence detection under photodynamic therapy relevant conditions: comparison of ex vivo application of two photosensitizer formulations

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A review of sebum in mammals in relation to skin diseases, skin function, and the skin microbiome

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Proteomic Analysis of the Human Skin Proteome after In Vivo Treatment with Sodium Dodecyl Sulphate

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Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway

Petkovic, M., Leal, E. C., Alves, I., Bose, C., Palade, P., Singh, P., Awasthi, S., Børsheim, E., Dalgaard, L. T., Singh, S. P., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108817 · Cited by 28

Anti-tyrosinase flavone derivatives and their anti-melanogenic activities: Importance of the β-phenyl-α,β-unsaturated carbonyl scaffold

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High pressure phase equilibrium of the crude green coffee oil – CO2 – ethanol system and the oil bioactive compounds

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Systemic Glutathione as a Skin-Whitening Agent in Adult

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Gly-Pro protects normal human dermal fibroblasts from UVA-induced damages via MAPK-NF-κB signaling pathway

Liu, S., Mohri, S., Manabe, Y., Ejima, A., Sato, K., & Sugawara, T. (2022) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2022.112601 · Cited by 24

Inhibition of UV-induced ROS and collagen damage by Phyllanthus emblica extract in normal human dermal fibroblasts.

Majeed, S., Bhat, B., Anand, S., Sivakumar, A. S., Paliwal, P., & Geetha, K. (2011) · PubMed · Cited by 24

Cosmeceutical effect of ethyl acetate fraction of Kombucha tea by intradermal administration in the skin of aged mice

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A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

Son, D. H., Yang, D. J., Sun, J. S., Kim, S. K., Kang, N., Kang, J. Y., Choi, Y., Lee, J. H., Moh, S.-H., Shin, D. M., et al. (2018) · Marine Drugs · doi:10.3390/md16080262 · Cited by 24

The non‐homogenous distribution and aggregation of carotenoids in the stratum corneum correlates with the organization of intercellular lipids in vivo

Choe, C., Ri, J., Schleusener, J., Lademann, J. M., & Darvin, M. E. (2019) · Experimental Dermatology · doi:10.1111/exd.14018 · Cited by 24

Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging

Poomanee, W., Khunkitti, W., Chaiyana, W., Intasai, N., Lin, W., Lue, S.-C., & Leelapornpisid, P. (2021) · Toxicological Research · doi:10.1007/s43188-020-00079-6 · Cited by 24

Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage

Kang, M., Park, S., Son, S.-R., Noh, Y., Jang, D. S., & Lee, S. (2024) · Molecules · doi:10.3390/molecules29225479 · Cited by 23

Vitamin D and the aging skin: insights into oxidative stress, inflammation, and barrier function

Gao, H., Xie, T., Zhang, Y., Zhao, S., Su, L., Chen, Z., & Wang, G. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00536-6 · Cited by 28

Cosmeceutical potentials of Curcuma mangga Val. extract in human BJ fibroblasts against MMP1, MMP3, and MMP13

Pujimulyani, D., Suryani, C. L., Setyowati, A., Handayani, R. A. S., Arumwardana, S., Widowati, W., & Maruf, A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04921 · Cited by 24

Influence of Benincasa hispida Peel Extracts on Antioxidant and Anti-Aging Activities, including Molecular Docking Simulation

Phumat, P., Chaichit, S., Potprommanee, S., Preedalikit, W., Sainakham, M., Poomanee, W., Chaiyana, W., & Kiattisin, K. (2023) · Foods · doi:10.3390/foods12193555 · Cited by 23

What do we know about sulforaphane protection against photoaging?

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Enzyme-digested Colla Corii Asini (E’jiao) accelerates wound healing and prevents ultraviolet A-induced collagen synthesis decline and wrinkle formation in three-dimensional skin equivalents

Xiao, L., Liao, F., Fan, Y., & Miwa, N. (2020) · Human Cell · doi:10.1007/s13577-020-00405-y · Cited by 23

Evaluation of selected skin parameters following the application of 5% vitamin C concentrate

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Innovative Cosmeceuticals: Sirtuin Activators and Anti-Glycation Compounds

Farris, P. K. (2011) · Seminars in Cutaneous Medicine and Surgery · doi:10.1016/j.sder.2011.05.004 · Cited by 22

In silico Analysis of Phytochemical Compound Found in Snake Fruit (Salacca zalacca) Peel as Anti-aging Agent

Girsang, E., Ginting, C. N., Lister, I. N. E., Widowati, W., Wibowo, S. H. B., Perdana, F. S., & Rizal, R. (2019) · The Thai Journal of Pharmaceutical Sciences · doi:10.56808/3027-7922.2427 · Cited by 22

Formulation and penetration study of liposome gel xanthone of extract mangosteen pericarp (Garcinia mangostana L.)

Widyanati, P., Jufri, M., & Elya, B. (2014) · International Journal of Pharmaceutical Sciences Review and Research · Cited by 21

Melanogenesis regulatory activity of the ethyl acetate fraction from Arctium lappa L. leaf on α-MSH–induced B16/F10 melanoma cells

Lee, C. J., Park, S. K., Kang, J. Y., Kim, J. M., Yoo, S. K., Han, H. J., Kim, D., & Heo, H. J. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111581 · Cited by 21

THE COSMETIC EFFECTS OF VARIOUS NATURAL BIOFUNCTIONAL INGREDIENTS AGAINST SKIN AGING: A REVIEW

Naser, W. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021v13i1.39806 · Cited by 22

Tandem mass spectrometry of aqueous extract from Ficus dubia sap and its cell-based assessments for use as a skin antioxidant

Chansriniyom, C., Nooin, R., Nuengchamnong, N., Wongwanakul, R., Petpiroon, N., Srinuanchai, W., Chantarasuwan, B., Pitchakarn, P., Temviriyanukul, P., & Nuchuchua, O. (2021) · Scientific Reports · doi:10.1038/s41598-021-96261-3 · Cited by 21

Insights into Health Risks of Face Paint Application to Opera Performers: The Release of Heavy Metals and Stage-Light-Induced Production of Reactive Oxygen Species

Wang, B., Tian, L., Tian, L., Wang, X., He, Y., & Ji, R. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c03595 · Cited by 21

Comparison of Biological Activities and Protective Effects on PAH-Induced Oxidative Damage of Different Coffee Cherry Pulp Extracts

Preedalikit, W., Chittasupho, C., Leelapornpisid, P., Potprommanee, S., & Kiattisin, K. (2023) · Foods · doi:10.3390/foods12234292 · Cited by 23

Preparation of alpha‐bisabolol and phenylethyl resorcinol/TiO2 hybrid composites for potential applications in cosmetics

Leong, H. J., Jang, I., Hyun, K. ‐., Jung, S.-K., Hong, G. ‐., Jeong, H. ‐., & Oh, S. (2016) · International Journal of Cosmetic Science · doi:10.1111/ics.12339 · Cited by 21

Protective effect of Schizandrin B against damage of UVB irradiated skin cells depend on inhibition of inflammatory pathways

Gao, C., Chen, H., Niu, C., Hu, J., & Cao, B. (2016) · Bioengineered · doi:10.1080/21655979.2016.1227572 · Cited by 21

Health Benefits of Bioactive Seaweed Substances

Qin, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813312-5.00009-1 · Cited by 21

Cell proliferation and migration mechanism of caffeoylserotonin and serotonin via serotonin 2B receptor in human keratinocyte HaCaT cells

Kim, H., Cho, H. J., Ishihara, A., Kim, B.-K., & Kim, O. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.4.209 · Cited by 21

Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study

Poomanee, W., Yaowiwat, N., Pattarachaidaecharuch, T., & Leelapornpisid, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-32738-7 · Cited by 20

Rebalancing redox homeostasis: A pivotal regulator of the cGAS-STING pathway in autoimmune diseases

Zhao, Y., Xu, T., Wu, Z., Li, N., & Liang, Q. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103823 · Cited by 21

Antioxidant and anti-aging potential of a peptide formulation (Gal 2 –Pep) conjugated with gallic acid

Lee, H., Kim, K., Oh, C., Park, C., Aliya, S., Kim, H.-S., Bajpai, V. K., & Huh, Y. S. (2021) · RSC Advances · doi:10.1039/d1ra03421a · Cited by 20

UV Protection in the Cornea: Failure and Rescue

Volatier, T. L. A., Schumacher, B., Cursiefen, C., & Notara, M. (2022) · Biology · doi:10.3390/biology11020278 · Cited by 21

Stalked sea squirt (Styela clava) tunic waste as a valuable bioresource: Cosmetic and antioxidant activities

Lee, S.-M., Lee, Y.-R., Cho, K.-S., Cho, Y.-N., Lee, H. A., Hwang, D., Jung, Y., & Son, H. (2015) · Process Biochemistry · doi:10.1016/j.procbio.2015.07.018 · Cited by 20

Novel In Vitro Antioxidant and Photoprotection Capacity of Plants from High Altitude Ecosystems of Colombia

Mejía‐Giraldo, J. C., Henao‐Zuluaga, K., Gallardo, C., Atehortúa, L., & Puertas-Mejía, M. A. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12543 · Cited by 22

Roughness based perceptual analysis towards digital skin imaging system with haptic feedback

Kim, K. (2015) · Skin Research and Technology · doi:10.1111/srt.12270 · Cited by 20

Changes to Cuticle Surface Ultrastructure and Some Biological Functions in the Nematode Caenorhabditis Elegans Exposed to Excessive Copper

Song, S., Guo, Y., Zhang, X., Zhang, X., Zhang, J., & Ma, E. (2014) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-013-9991-4 · Cited by 20

Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes

Liu, C., Guo, H., Dain, J. A., Wan, Y., Gao, X., Chen, H., Seeram, N. P., & Ma, H. (2020) · Food & Function · doi:10.1039/d0fo00359j · Cited by 20

The association of the sebum excretion rate with melasma, erythematotelangiectatic rosacea, and rhytides

Foolad, N., Shi, V. Y., Prakash, N., Kamangar, F., & Sivamani, R. K. (2015) · Dermatology Online Journal · doi:10.5070/d3216027810 · Cited by 20

Fish collagen-containing drink is subcutaneously absorbed and attenuates the UVA-induced tissue-integrity destruction and DNA damages in 3D-human skin tissue model

Kato, S., Matsui, H., Saitoh, Y., & Miwa, N. (2010) · Journal of Functional Foods · doi:10.1016/j.jff.2010.11.005 · Cited by 20

Pholiota nameko Polysaccharides Protect against Ultraviolet A-Induced Photoaging by Regulating Matrix Metalloproteinases in Human Dermal Fibroblasts

Lin, H., Cheng, K., Lin, J., Hsieh, L.-P., Chou, C.-H., Wang, Y., Lai, P., Chu, P.-C., & Hsieh, C. (2022) · Antioxidants · doi:10.3390/antiox11040739 · Cited by 19

Potential of Hibiscus sabdariffa L. and Hibiscus Acid to Reverse Skin Aging

Wang, D., Nagata, M., Matsumoto, M., Amen, Y. M., Wang, D., & Shimizu, K. (2022) · Molecules · doi:10.3390/molecules27186076 · Cited by 19

Cosmetic and Skincare Benefits of Cultivated Mycelia from the Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes)

Cheng, W., Wei, X.-Q., Siu, K., Song, A.-X., & Wu, J. (2018) · International journal of medicinal mushrooms · doi:10.1615/intjmedmushrooms.2018026883 · Cited by 19

Comparison of Metabolome and Functional Properties of Three Korean Cucumber Cultivars

Jo, H. E., Son, S. Y., & Lee, C. H. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.882120 · Cited by 19

Antioxidants and Skin Aging

Masaki, H. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_100

Antioxidants and Skin Aging 167

Masaki, H. (2014)

Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review

Hussen, N. H., Abdulla, S. K., Ali, N. M., Ahmed, V. A., Hasan, A. H., & Qadir, E. E. (2025) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2025.100063 · Cited by 122

Skin photoaging,reactive oxygen species and antioxidant

Hao, F. (2005) · Chinese Journal of Aesthetic Medicine

Oxidative Stress, Skin Aging and Antioxidant Therapy

Stojiljković, D., Pavlovic, D. D., & Arsić, I. (2013) · AFMN Biomedicine · doi:10.2478/afmnai-2014-0026 · Cited by 35