Cited by 209Protein Hydrolysis and Bioactive PeptidesSeaweed-derived Bioactive CompoundsMast cells and histamine

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Purification of novel anti-inflammatory peptides from enzymatic hydrolysate of the edible microalgal Spirulina maxima

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Vo, Thanh-Sang, Ryu, BoMi, Kim, Se-Kwon·2013·Journal of Functional Foods

DOI 10.1016/j.jff.2013.05.001

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Abstract

Abstract Natural bioactive peptides have been known as ingredients in nutraceuticals and pharmaceuticals. In this study, the potential anti-inflammatory peptides were purified from enzymatic hydrolysate of the edible microalgae Spirulina maxima using gastrointestinal endopeptidases (trypsin, α-chymotrypsin, and pepsin). Purification of the hydrolysate resulted in two peptides with amino acid sequences of LDAVNR (P1, 686 Da) and MMLDF (P2, 655 Da). It was found that peptides P1 and P2 exhibited significant inhibition on the release and production of histamine from antigen-stimulated RBL-2H3 mast cells. Moreover, the suppressive effect of P1 and P2 on production as well as expression of interleukin-8 in histamine-stimulated EA.hy926 endothelial cells was determined. Notably, the production of intracellular reactive oxygen species from mast cells and endothelial cells was decreased in the presence of P1 or P2. Collectively, the peptides P1 and P2 from S. maxima could be used as functional ingredients with potent anti-inflammatory benefits.

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Authors: Vo, T.-S., Ryu, B., & Kim, S.-K.
Affiliations: Pukyong National University (KR)
The University of Queensland (AU)
Corresponding author: Kim, Se-Kwon
ORCID: Vo, Thanh-Sang
Ryu, BoMi
Kim, Se-Kwon
Venue: Journal of Functional Foods
Publisher: Elsevier BV
Published: 2013-07
Volume: 5
Issue: 3
Pages: 1336-1346
ISSN: 1756-4646 (ISSN-L)
DOI: 10.1016/j.jff.2013.05.001
OpenAlex: W2083421143
Semantic Scholar: 08ed729b45ce31cef2ca7b019a57bb5d305e4885
Cited by: 209
References: 43
Citations by year: 2026: 16 · 2025: 29 · 2024: 25 · 2023: 22 · 2022: 27 · 2021: 21 · 2020: 13 · 2019: 14 · 2018: 13 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 7 · 2013: 2
FWCI: 3.28
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Functional Foods (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords: anti-inflammatory peptides, Spirulina maxima, enzymatic hydrolysate, peptide purification, histamine release, mast cells, RBL-2H3 cells, interleukin-8, endothelial cells, reactive oxygen species, microalgae, nutraceuticals

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Purification of novel anti-inflammatory peptides from enzymatic hydrolysate of the edible microalgal Spirulina maxima

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