The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review
Open accessAbstract
Abstract Some plant polysaccharides cannot be digested by humans, arriving intact to the colon, where they are fermented by a distinct group of anaerobic beneficial bacterial species ( Lactobacillus, Bifidobacterium, Roseburia, Faecalibacterium, Anaerostipes, Coprococcus , etc.). As a result of this fermentation, in the case of some of these compounds, diverse short-chain fatty acids (SCFA) are produced in situ in the colon lumen, mainly acetate, propionate, and butyrate. Acetate and propionate possess principally energetic effects for eukaryotic cells. Butyrate is the preferred energy source for normal colonocytes, contributing to their normal homeostasis, and it is a strong antitumour compound for tumour colonocytes, downregulating cell multiplication pathways and promoting pro-apoptotic routes. These polysaccharides that increase beneficial colon bacteria populations in the colon are called prebiotics. This review will describe their different dietary sources and structures, as well as the metabolic pathways leading to SCFA and the antitumour and anti-inflammatory effect of these SCFA.
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Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,679
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · The Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,667
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,816
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179
Prebiotic effects: metabolic and health benefits
Roberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., Wolvers, D., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,085
Elleuch, M., Bedigian, D., Roiseux, O., Besbes, S., Blecker, C., & Attia, H. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2010.06.077 · Cited by 1,713
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Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines
Feng, W., Ao, H., & Peng, C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01354 · Cited by 367
Antiproliferative and palliative activity of flavonoids in colorectal cancer
Fernández, J., Silván, B., Entrialgo-Cadierno, R., Villar, C. J., Capasso, R., Uranga, J. A., Lombó, F., & Abalo, R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112241 · Cited by 258
Self-citationGut microbiome response to sucralose and its potential role in inducing liver inflammation in mice
Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00487 · Cited by 258
Di, T., Chen, G., Sun, Y., Ou, S., Zeng, X., & Ye, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.10.040 · Cited by 181
Metadata
- Authors
- Fernández, J., Redondo-Blanco, S., Gutiérrez-del-Río, I., Miguélez, E. M., Villar, C. J., & Lombó, F.
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 25
- Pages
- 511-522
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2462553956
- Cited by
- 367
- References
- 103
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Fernández, J., Redondo-Blanco, S., Gutiérrez-del-Río, I., Miguélez, E. M., Villar, C. J., & Lombó, F. (2016). Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review. Journal of Functional Foods. https://doi.org/10.1016/j.jff.2016.06.032
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