Neuroprotective effects of quercetin 3-O-sophoroside from Hibiscus rosa-sinensis Linn. on scopolamine-induced amnesia in mice
Open accessAbstract
Quercetin 3-O-sophoroside (Q3OS) was isolated and identified from Hibiscus rosa-sinensis Linn. (HRS) for the first time. Although Q3OS is common glycosides, its therapeutic potential and mechanism of action against Alzheimer’s disease (AD) have rarely been reported. The results demonstrated that Q3OS treatment effectively ameliorated learning and memory impairment in mice with scopolamine (SCOP)-induced cognitive dysfunction by using the Morris water maze test. Nissl staining results revealed that Q3OS administration blocked neuronal loss in the hippocampal CA1 region. Immunohistochemistry and western blot results also indicated that Q3OS reversed the SCOP-induced decrease in ChAT expression, increase in AChE expression, and decrease in ACh. These findings suggested that Q3OS from HRS could be potentially used to prevent and treat AD, by exerting neuroprotective effects and these effects could be in response to its modification of the cholinergic system function. HRS can be potentially used as a neuroprotective nutrient in the prevention of AD.
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Hibiscus rosa-sinensis decreases ACh.
“decreased ACh”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [168]
Hibiscus rosa-sinensis reverses scopolamine-induced decrease in ChAT expression.
“Reversed the”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [168]
Hibiscus rosa-sinensis increases AChE expression.
“increased”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [168]
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Research works printed but not linked: 3
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Cited by
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Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
- Authors
- Shen, H., Zheng, Y., Chen, R., Huang, X., & Shi, G.
- Affiliations
- Sun Yat-sen University (CN)
- Shantou University (CN)
- Corresponding author
- Shi, Ganggang
- ORCID
- Shi, Ganggang
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 76
- Pages
- 104291
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W3107475200
- Cited by
- 15
- References
- 63
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Guangdong Province
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Hibiscus Plant Research Studies
- Keywords
- Hibiscus rosa-sinensis, scopolamine-induced amnesia, Alzheimer's disease, neuroprotection, learning and memory impairment, cholinergic system, acetylcholinesterase, choline acetyltransferase, flavonoid glycosides, cognitive impairment
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