The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?
Abstract
Nanoplastics (NPs) and microplastics (MPs) are a heterogeneous class of pollutants with diverse sizes in aquatic environments. To evaluate the hazardous effects of N/MPs with different sizes, the accumulation, oxidative stress, cytochrome P450 (CYP) enzymes, neurotoxicity, and metabolomics changes were investigated in the red tilapia exposed to three sizes of polystyrene (PS) N/MPs (0.3, 5, and 70 - 90 μm). After 14-d exposures, the largest particles (70 - 90 μm) showed the highest accumulation levels in most cases. Exposures to PS-MPs (5 and 70 - 90 μm) caused a more severe oxidative stress in red tilapia than PS-NPs. The activity of CYP3A-related enzyme was obviously inhibited by PS-NPs, whereas the CYP enzymes in the liver may not be sensitive to MP exposures. In the brain, only 5 μm PS-MPs significantly inhibited the acetylcholinesterase activity. After exposures, the treatments with 0.3, 5, and 70 - 90 μm N/MPs resulted in 31, 40, and 23 significantly differentially expressed metabolites, respectively, in which the pathway of tyrosine metabolism was significantly affected by all the three PS-N/MP exposures. Overall, the PS particles within the μm size posed more severe stress to red tilapia. Our results suggest that the toxicity of N/MPs may not show a simply monotonic negative correlation with their sizes.
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Self-citationCurrent opinion: What is a nanoplastic?
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Cited by
Ali, N., Khan, M. H., Ali, M., Sidra, Ahmad, S., Khan, A., Nabi, G., Ali, F., Bououdina, M., & Kyzas, G. Z. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169489 · Cited by 262
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Huang, Y., Ding, J., Zhang, G., Liu, S., Zou, H., Wang, Z., Zhu, W., & Geng, J. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142256 · Cited by 141
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Zitouni, N., Cappello, T., Missawi, O., Boughattas, I., De Marco, G., Belbekhouche, S., Mokni, M., Alphonse, V., Guerbej, H., Bousserrhine, N., et al. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155872 · Cited by 66
Metadata
- Authors
- Ding, J., Huang, Y., Liu, S., Zhang, S., Zou, H., Wang, Z., Zhu, W., & Geng, J.
- Venue
- Journal of Hazardous Materials
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 396
- Pages
- 122693
- ISSN
- 0304-3894 (ISSN-L)
- OpenAlex
- W3017202774
- Cited by
- 269
- References
- 75
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- closed
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