Assessing the Human Health Risks of Per- and Polyfluoroalkyl Substances: A Need for Greater Focus on Their Interactions as Mixtures

Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

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Thyroid Hormone Regulation of Metabolism

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A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?

Wang, Z., DeWitt, J. C., Higgins, C. P., & Cousins, I. T. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.6b04806 · Cited by 1,921 · see citing works

Polyfluorinated Compounds: Past, Present, and Future

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Predictive Environmental Risk Assessment of Chemical Mixtures: A Conceptual Framework

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Half-Lives of PFOS, PFHxS and PFOA after End of Exposure to Contaminated Drinking Water

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Tracking complex mixtures of chemicals in our changing environment

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Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant

Barry, V., Winquist, A. G., & Steenland, K. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306615 · Cited by 781 · see citing works

Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)

Steenland, K., Fletcher, T., & Savitz, D. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901827 · Cited by 660 · see citing works

Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life

Zhang, Y., Beesoon, S., Zhu, L., & Martin, J. W. (2013) · Environmental Science & Technology · doi:10.1021/es401905e · Cited by 530 · see citing works

Comparing the toxic potency in vivo of long-chain perfluoroalkyl acids and fluorinated alternatives

Gomis, M. I., Vestergren, R., Borg, D., & Cousins, I. T. (2018) · Environment International · doi:10.1016/j.envint.2018.01.011 · Cited by 438 · see citing works

A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs)

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Perfluorinated Alkyl Acids in Blood Serum from Primiparous Women in Sweden: Serial Sampling during Pregnancy and Nursing, And Temporal Trends 1996–2010

Glynn, A., Berger, U., Bignert, A., Ullah, S., Aune, M., Lignell, S., & Darnerud, P. O. (2012) · Environmental Science & Technology · doi:10.1021/es301168c · Cited by 417 · see citing works

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

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Perfluorooctanoic Acid Exposure and Cancer Outcomes in a Contaminated Community: A Geographic Analysis

Vieira, V. M., Hoffman, K., Shin, H., Weinberg, J., Webster, T. F., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205829 · Cited by 355 · see citing works

Perfluorinated compounds affect the function of sex hormone receptors

Kjeldsen, L. S., & Bonefeld‐Jørgensen, E. C. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1753-3 · Cited by 345 · see citing works

High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples

Liu, Y., D'Agostino, L. A., Qu, G., Jiang, G., & Martin, J. W. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.02.021 · Cited by 344 · see citing works

Pre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)

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Serum Perfluorooctanoate (PFOA) and Perfluorooctane Sulfonate (PFOS) Concentrations and Liver Function Biomarkers in a Population with Elevated PFOA Exposure

Gallo, V., Leonardi, G. S., Genser, B., López-Espinosa, M.-J., Frisbee, S. J., Karlsson, L. G., DUCATMAN, A. M., & Fletcher, T. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104436 · Cited by 298 · see citing works

Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies

Zeng, Z., Song, B., Xiao, R., Zeng, G., Gong, J., Chen, M., Xu, P., Zhang, P., Shen, M., & Yi, H. (2019) · Environment International · doi:10.1016/j.envint.2019.03.002 · Cited by 297 · see citing works

Perfluoroalkylated substances (PFAS) affect oxidative stress biomarkers in vitro

Wielsøe, M., Long, M., Ghisari, M., & Bonefeld‐Jørgensen, E. C. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.10.014 · Cited by 286 · see citing works

Perfluoroalkyl and polyfluoroalkyl substances and human fetal growth: A systematic review

Bach, C., Bech, B., Brix, N., Nøhr, E., Bonde, J. P. E., & Henriksen, T. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.952400 · Cited by 282 · see citing works

Structure-Based Investigation on the Interaction of Perfluorinated Compounds with Human Liver Fatty Acid Binding Protein

Zhang, L., Ren, X.-M., & Guo, L.-H. (2013) · Environmental Science & Technology · doi:10.1021/es4026722 · Cited by 267 · see citing works

Polycyclic aromatic hydrocarbon exposure and pediatric asthma in children: a case–control study

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Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant

López-Espinosa, M.-J., Mondal, D., Armstrong, B., Bloom, M. S., & Fletcher, T. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104370 · Cited by 251 · see citing works

Renal elimination of perfluorocarboxylates (PFCAs)

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Molecular mechanisms of PFOA-induced toxicity in animals and humans: Implications for health risks.

Li, K., Gao, P., Xiang, P., Zhang, X.-X., Cui, X.-Y., & Ma, L. (2017) · Environment International · doi:10.1016/j.envint.2016.11.014 · Cited by 231 · see citing works

Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years

Grandjean, P., Heilmann, C. J., Weihe, P., Nielsen, F., Mogensen, U. B., Timmermann, C. A. G., & Budtz–Jørgensen, E. (2017) · Journal of Immunotoxicology · doi:10.1080/1547691x.2017.1360968 · Cited by 229 · see citing works

Maternal Concentrations of Polyfluoroalkyl Compounds during Pregnancy and Fetal and Postnatal Growth in British Girls

Maisonet, M., Terrell, M. L., Mcgeehin, M., Christensen, K., Holmes, A. K., Calafat, A., & Marcus, M. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1003096 · Cited by 228 · see citing works

Placental transfer of perfluorinated compounds is selective – A Norwegian Mother and Child sub-cohort study

Gützkow, K. B., Haug, L. S., Thomsen, C., Sabaredzovic, A., Becher, G., & Brunborg, G. (2011) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2011.08.011 · Cited by 225 · see citing works

PFOS-induced hepatic steatosis, the mechanistic actions on β-oxidation and lipid transport

Wan, H. T., Zhao, Y. G., Wei, X., Hui, K. Y., Giesy, J. P., & Wong, C. K. C. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.010 · Cited by 217 · see citing works

Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study

Bonefeld‐Jørgensen, E. C., Long, M., Bossi, R., Ayotte, P., Asmund, G., Krüger, T., Ghisari, M., Mulvad, G., Kern, P., Nzulumiki, P., et al. (2011) · Environmental Health · doi:10.1186/1476-069x-10-88 · Cited by 216 · see citing works

Perfluoroalkyl acid (PFAA) levels and profiles in breast milk, maternal and cord serum of French women and their newborns

Cariou, R., Veyrand, B., Yamada, A., Berrebi, A., Zalko, D., Durand, S., Pollono, C., Marchand, P., Leblanc, J., Antignac, J., et al. (2015) · Environment International · doi:10.1016/j.envint.2015.07.014 · Cited by 212 · see citing works

Characterization of cellular uptake of perfluorooctanoate via organic anion-transporting polypeptide 1A2, organic anion transporter 4, and urate transporter 1 for their potential roles in mediating human renal reabsorption of perfluorocarboxylates

Yang, C.-H., Glover, K. P., & Han, X. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq219 · Cited by 197 · see citing works

Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women

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Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells

Eriksen, K. T., Raaschou‐Nielsen, O., Sørensen, M., Roursgaard, M., Loft, S. H., & Möller, P. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.04.024 · Cited by 192 · see citing works

Human exposure to chemical mixtures: Challenges for the integration of toxicology with epidemiology data in risk assessment

Hernández, A. F., & Tsatsakis, A. M. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.03.012 · Cited by 188 · see citing works

Maternal exposure to perfluorinated chemicals and reduced fecundity: the MIREC study

Vélez, M. P., Arbuckle, T. E., & Fraser, W. D. (2015) · Human Reproduction · doi:10.1093/humrep/deu350 · Cited by 187 · see citing works

Cohort Mortality Study of Workers Exposed to Perfluorooctanoic Acid

Steenland, K., & Woskie, S. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws171 · Cited by 181 · see citing works

Roles of Rat Renal Organic Anion Transporters in Transporting Perfluorinated Carboxylates with Different Chain Lengths

Weaver, Y. M., Ehresman, D. J., Butenhoff, J. L., & Hagenbuch, B. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp275 · Cited by 178 · see citing works

Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

Sundström, M., Chang, S., Noker, P. E., Gorman, G. S., Hart, J. A., Ehresman, D. J., Bergman, Å., & Butenhoff, J. L. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.07.004 · Cited by 175 · see citing works

Integrated assessment of biomarker responses in common carp (Cyprinus carpio) exposed to perfluorinated organic compounds

Kim, W., Lee, S.-K., & Jung, J. (2010) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2010.04.044 · Cited by 170 · see citing works

Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys

Chang, S., Noker, P. E., Gorman, G. S., Gibson, S. J., Hart, J. A., Ehresman, D. J., & Butenhoff, J. L. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.07.002 · Cited by 170 · see citing works

Impact of Carbon Chain Length on Binding of Perfluoroalkyl Acids to Bovine Serum Albumin Determined by Spectroscopic Methods

Qin, P., Liu, R., Pan, X., Fang, X., & Mou, Y. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100412q · Cited by 167 · see citing works

Antioxidant defense system responses and DNA damage of earthworms exposed to Perfluorooctane sulfonate (PFOS)

Xu, D., Li, C., Wen, Y., & Liu, W. (2012) · Environmental Pollution · doi:10.1016/j.envpol.2012.10.030 · Cited by 161 · see citing works

Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 compounds

Wolf, C. J., Schmid, J. E., Lau, C. S., & Abbott, B. D. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.09.009 · Cited by 160 · see citing works

Cumulative health risk assessment of 17 perfluoroalkylated and polyfluoroalkylated substances (PFASs) in the Swedish population

Borg, D., Lund, B.-O., Lindquist, N.-G., & Håkansson, H. (2013) · Environment International · doi:10.1016/j.envint.2013.05.009 · Cited by 155 · see citing works

Behavioural effects and bioconcentration of per- and polyfluoroalkyl substances (PFASs) in zebrafish (Danio rerio) embryos

Menger, F., Pohl, J., Ahrens, L., Carlsson, G., & Örn, S. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125573 · Cited by 155 · see citing works

Absorption, Distribution, and Milk Secretion of the Perfluoroalkyl Acids PFBS, PFHxS, PFOS, and PFOA by Dairy Cows Fed Naturally Contaminated Feed

Kowalczyk, J., Ehlers, S., Oberhausen, A., Tischer, M., Fürst, P., Schafft, H. A., & Lahrssen‐Wiederholt, M. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304680j · Cited by 153 · see citing works

In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths

Buhrke, T., Kibellus, A., & Lampen, A. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.025 · Cited by 153 · see citing works

Breastfeeding: A Potential Excretion Route for Mothers and Implications for Infant Exposure to Perfluoroalkyl Acids

Mondal, D., Weldon, R. H., Armstrong, B., Gibson, L. J., López-Espinosa, M.-J., Shin, H., & Fletcher, T. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306613 · Cited by 153 · see citing works

Prenatal Exposure to PFOS or PFOA Alters Motor Function in Mice in a Sex-Related Manner

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Zürich Statement on Future Actions on Per- and Polyfluoroalkyl Substances (PFASs)

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Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish

Cheng, J., Lv, S., Nie, S., Liu, J., Tong, S., Kang, N., Xiao, Y., Dong, Q., Huang, C., & Yang, D. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.04.013 · Cited by 148 · see citing works

Chronic dietary toxicity and carcinogenicity study with potassium perfluorooctanesulfonate in Sprague Dawley rats

Butenhoff, J. L., Chang, S., Olsen, G. W., & Thomford, P. J. (2012) · Toxicology · doi:10.1016/j.tox.2012.01.003 · Cited by 144 · see citing works

Combined effects and toxicological interactions of perfluoroalkyl and polyfluoroalkyl substances mixtures in human liver cells (HepG2)

Ojo, A. F., Peng, C., & Ng, J. C. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114182 · Cited by 139 · see citing works

Toxicological interactions of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) with selected pollutants

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Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study

Hanssen, L., Röllin, H. B., Odland, J. Ø., Moe, M. K., & Sandanger, T. M. (2010) · Journal of Environmental Monitoring · doi:10.1039/b924420d · Cited by 132 · see citing works

Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults

Lin, C., Lin, L., Chiang, C., Wang, W.-J., Su, Y., Hung, K., & Chen, P. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.707 · Cited by 130 · see citing works

Association between perfluoroalkyl acids and kidney function in a cross-sectional study of adolescents

Kataria, A., Trachtman, H., Málaga-Diéguez, L., & Trasande, L. (2015) · Environmental Health · doi:10.1186/s12940-015-0077-9 · Cited by 130 · see citing works

A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

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Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community

Darrow, L. A., Groth, A. C., Winquist, A. G., Shin, H., Bartell, S. M., & Steenland, K. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1510391 · Cited by 126 · see citing works

Effects of perfluorinated compounds on development of zebrafish embryos

Zheng, X., Liu, H., Shi, W. F., Wei, S., Giesy, J. P., & Yu, H. (2012) · Environmental Science and Pollution Research · doi:10.1007/s11356-012-0977-y · Cited by 117 · see citing works

Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health

Itoh, S., Araki, A., Mitsui, T., Miyashita, C., Goudarzi, H., Sasaki, S., Cho, K., Nakazawa, H., Iwasaki, Y., Shinohara, N., et al. (2016) · Environment International · doi:10.1016/j.envint.2016.05.011 · Cited by 115 · see citing works

Combined Effects of PFOS and PFOA on Zebrafish (Danio rerio) Embryos

Ding, G., Zhang, J., Chen, Y., Wang, L., Wang, M., Xiong, D., & Sun, Y. (2013) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-012-9864-2 · Cited by 114 · see citing works

Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children

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Elimination kinetics of perfluorohexanoic acid in humans and comparison with mouse, rat and monkey

Russell, M. H., Nilsson, H., & Buck, R. C. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.08.060 · Cited by 110 · see citing works

Tissue Distribution of 35S-Labelled Perfluorooctane Sulfonate in Adult Mice after Oral Exposure to a Low Environmentally Relevant Dose or a High Experimental Dose

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Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach

Berg, V., Nøst, T. H., Hansen, S., Elverland, A., Veyhe, A. S., Jorde, R., Odland, J. Ø., & Sandanger, T. M. (2015) · Environment International · doi:10.1016/j.envint.2015.01.007 · Cited by 109 · see citing works

Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice

Long, Y., Wang, Y., Ji, G., Yan, L., Hu, F., & Gu, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054176 · Cited by 106 · see citing works

Gender differences in pharmacokinetics and tissue distribution of 3 perfluoroalkyl and polyfluoroalkyl substances in rats

Kim, S., Heo, S.-H., Lee, D., Hwang, I., Lee, Y., & Cho, H. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.09.017 · Cited by 106 · see citing works

Chronic Exposure to Perfluorooctane Sulfonate Induces Behavior Defects and Neurotoxicity through Oxidative Damages, In Vivo and In Vitro

Chen, N., Li, J., Li, D., Yang, Y., & He, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113453 · Cited by 105 · see citing works

Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma)

Huang, Q., Fang, C., Wu, X., Fan, J., & Dong, S. (2011) · Aquatic Toxicology · doi:10.1016/j.aquatox.2011.05.012 · Cited by 101 · see citing works

Perfluorooctanoic acid disrupts the blood–testis barrier and activates the TNFα/p38 MAPK signaling pathway in vivo and in vitro

Lu, Y., Luo, B., Li, J., & Dai, J. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1492-y · Cited by 100 · see citing works

Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance

Klaunig, J. E., Hocevar, B. A., & Kamendulis, L. M. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.10.014 · Cited by 99 · see citing works

PFOS Induces Behavioral Alterations, Including Spontaneous Hyperactivity that Is Corrected by Dexamfetamine in Zebrafish Larvae

Spulber, S., Kilian, P., Wan Ibrahim, W. N., Onishchenko, N., Ulhaq, M., Norrgren, L., Negri, S., Di Tuccio, M., & Ceccatelli, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094227 · Cited by 98 · see citing works

Effects of developmental perfluorooctane sulfonate exposure on spatial learning and memory ability of rats and mechanism associated with synaptic plasticity

Wang, Y., Liu, W., Zhang, Q., Zhao, H., & Quan, X. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.12.008 · Cited by 98 · see citing works

Perfluorooctane sulphonate induces oxidative hepatic damage via mitochondria-dependent and NF-κB/TNF-α-mediated pathway

Han, R., Hu, M., Zhong, Q., Wan, C., Liu, L., Li, F., Zhang, F., & Ding, W. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.08.070 · Cited by 97 · see citing works

Comparative assessment of the environmental hazards of and exposure to perfluoroalkyl phosphonic and phosphinic acids (PFPAs and PFPiAs): Current knowledge, gaps, challenges and research needs

Wang, Z., Cousins, I. T., Berger, U., Hungerbühler, K., & Scheringer, M. (2016) · Environment International · doi:10.1016/j.envint.2016.01.023 · Cited by 96 · see citing works

Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: By sex status

Zhou, Y., Hu, L., Qian, Z. M., Chang, J., King, C. S., Paul, G. E., Lin, S., Chen, P., Lee, Y. L., & Dong, G. (2016) · Environment International · doi:10.1016/j.envint.2016.05.018 · Cited by 95 · see citing works

Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues

Abbott, B. D., Wood, C. R., Watkins, A. M., Tatum-Gibbs, K. R., Das, K. P., & Lau, C. S. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.11.005 · Cited by 94 · see citing works

Chronic perfluorooctanesulphonic acid (PFOS) exposure produces estrogenic effects in zebrafish

Chen, J., Wang, X., Ge, X., Wang, D., Wang, T., Zhang, L., Tanguay, R. L., Simonich, M. T., Huang, C., & Dong, Q. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.07.064 · Cited by 94 · see citing works

Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration

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Hazard quotient profiles used as a risk assessment tool for PFOS and PFOA serum levels in three distinctive European populations

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POPsのリスク評価にむけてのヒト曝露長期モニタリングのための試料バンクの創設に関する研究 試料バンクの有用性の検証 新たな難分解性化学物質-Perfluorooctane sulfonate(PFOS)およびPerfluorooctanoic acid(PFOA)の分析法および処理法の開発 PFOS・PFOAの処理方法の検討

藤井滋穂 (2006)

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