Toxicokinetics of Seven Perfluoroalkyl Sulfonic and Carboxylic Acids in Pigs Fed a Contaminated Diet
Abstract
The transfer of a mixture of perfluoroalkyl acids (PFAAs) from contaminated feed into the edible tissues of 24 fattening pigs was investigated. Four perfluoroalkyl sulfonic (PFSAs) and three perfluoroalkyl carboxylic acids (PFCAs) were quantifiable in feed, plasma, edible tissues, and urine. As percentages of unexcreted PFAA, the substances accumulated in plasma (up to 51%), fat, and muscle tissues (collectively, meat 40-49%), liver (under 7%), and kidney (under 2%) for most substances. An exception was perfluorooctanesulfonic acid (PFOS), with lower affinity for plasma (23%) and higher for liver (35%). A toxicokinetic model is developed to quantify the absorption, distribution, and excretion of PFAAs and to calculate elimination half-lives. Perfluorohexanoic acid (PFHxA), a PFCA, had the shortest half-life at 4.1 days. PFSAs are eliminated more slowly (e.g., half-life of 634 days for PFOS). PFAAs in pigs exhibit longer elimination half-lives than in most organisms reported in the literature, but still shorter than in humans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The high HSA binding affinities of PFHxS and PFHpA are consistent with long blood plasma elimination half-lives reported for PFHxS in humans and for PFHpA and PFHxS in pigs.
“These observations are consistent with long blood plasma elimination half-lives reported for PFHxS in humans [54,55] and for PFHpA and PFHxS in pigs [56].”
From In-Vitro and In-Silico Assessment of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Film-Forming Foam (AFFF) Binding to Human Serum Albumin (2021) · cites this paper as [56]
Cites
An Algorithm for Least-Squares Estimation of Nonlinear Parameters
Marquardt, D. W. (1963) · Journal of the Society for Industrial and Applied Mathematics · doi:10.1137/0111030 · Cited by 30,728 · see citing works
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641 · see citing works
Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works
Polyfluorinated Compounds: Past, Present, and Future
Lindstrom, A. B., Strynar, M. J., & Libelo, E. L. (2011) · Environmental Science & Technology · doi:10.1021/es2011622 · Cited by 1,628 · see citing works
Analyses of pig genomes provide insight into porcine demography and evolution
Groenen, M. A. M., Archibald, A. L., Uenishi, H., Tuggle, C. K., Takeuchi, Y., Rothschild, M. F., Rogel-Gaillard, C., Park, C., Denis Milan, A., Megens, H., et al. (2012) · Nature · doi:10.1038/nature11622 · Cited by 1,386 · see citing works
Fluorinated Surfactants and Repellents
(2001) · Textile Research Journal · doi:10.1177/004051750107100823 · Cited by 1,376 · see citing works
Taniyasu, S., Kannan, K., So, M. K., Gulkowska, A., Sinclair, E., Okazawa, T., & Yamashita, N. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.053 · Cited by 602 · see citing works
Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
Zhang, Y., Beesoon, S., Zhu, L., & Martin, J. W. (2013) · Environmental Science & Technology · doi:10.1021/es401905e · Cited by 530 · see citing works
Tracking the Pathways of Human Exposure to Perfluorocarboxylates
Vestergren, R., & Cousins, I. T. (2009) · Environmental Science & Technology · doi:10.1021/es900228k · Cited by 419 · see citing works
Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging
Trier, X., Granby, K., & Christensen, J. H. (2011) · Environmental Science and Pollution Research · doi:10.1007/s11356-010-0439-3 · Cited by 344 · see citing works
Carryover of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) from Soil to Plants
Stahl, T., Heyn, J., Thiele, H.-U., Hüther, J., Failing, K., Georgii, S., & Brunn, H. E. (2008) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-008-9272-9 · Cited by 328 · see citing works
Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats
Heuvel, J. P. V., Kuslikis, B. I., Rafelghem, M. J. V., & Peterson, R. E. (1991) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.2570060202 · Cited by 289 · see citing works
Zhang, L., Ren, X.-M., & Guo, L.-H. (2013) · Environmental Science & Technology · doi:10.1021/es4026722 · Cited by 267 · see citing works
D’eon, J. C., & Mabury, S. A. (2007) · Environmental Science & Technology · doi:10.1021/es070126x · Cited by 259 · see citing works
Bioconcentration of perfluorinated alkyl acids: How important is specific binding?
Ng, C. A., & Hungerbühler, K. (2013) · Environmental Science & Technology · doi:10.1021/es400981a · Cited by 241 · see citing works
Bischel, H. N., MacManus-Spencer, L. A., Zhang, C., & Luthy, R. G. (2011) · Environmental Toxicology and Chemistry · doi:10.1002/etc.647 · Cited by 182 · see citing works
Disposition of perfluorinated acid isomers in sprague-dawley rats; Part 1: Single dose
Benskin, J. P., Silva, A. O. D., Martin, L. J., Arsenault, G. J., McCrindle, R. I., Riddell, N., Mabury, S. A., & Martin, J. W. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-239.1 · Cited by 178 · see citing works
Grandjean, P., & Budtz–Jørgensen, E. (2013) · Environmental Health · doi:10.1186/1476-069x-12-35 · Cited by 168 · see citing works
JOHNSON, J. (1984) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(84)90235-5 · Cited by 161 · see citing works
Jing, P., Rodgers, P. J., & Amemiya, S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja807961s · Cited by 158 · see citing works
Evaluation of physiologically based pharmacokinetic models for use in risk assessment
Chiu, W. A., Barton, H. A., DeWoskin, R. S., Schlosser, P. M., Thompson, C. M., Sonawane, B. R., Lipscomb, J. C., & Krishnan, K. (2007) · Journal of Applied Toxicology · doi:10.1002/jat.1225 · Cited by 157 · see citing works
Kowalczyk, J., Ehlers, S., Oberhausen, A., Tischer, M., Fürst, P., Schafft, H. A., & Lahrssen‐Wiederholt, M. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304680j · Cited by 153 · see citing works
Self-citationBuhrke, T., Kibellus, A., & Lampen, A. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.025 · Cited by 153 · see citing works
Population pharmacokinetics of total and unbound plasma cisplatin in adult patients
Urien, S., & Lokiec, F. M. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2004.02082.x · Cited by 150 · see citing works
Hundley, S. G., Sarrif, A. M., & Kennedy, G. L. (2006) · Drug and Chemical Toxicology · doi:10.1080/01480540600561361 · Cited by 148 · see citing works
Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages
Loccisano, A. E., Longnecker, M. P., Campbell, J. L., Andersen, M. E., & Clewell, H. J. (2013) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287394.2012.722523 · Cited by 141 · see citing works
Disposition of perfluorinated acid isomers in sprague-dawley rats; Part 2: Subchronic dose
Silva, A. O. D., Benskin, J. P., Martin, L. J., Arsenault, G. J., McCrindle, R. I., Riddell, N., Martin, J. W., & Mabury, S. A. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-254.1 · Cited by 125 · see citing works
Kärrman, A., van Bavel, B., Järnberg, U., Hardell, L., & Lindström, G. (2004) · Analytical Chemistry · doi:10.1021/ac049023c · Cited by 105 · see citing works
Bioaccumulation of perfluoroalkyl acids in dairy cows in a naturally contaminated environment
Vestergren, R., Orata, F., Berger, U., & Cousins, I. T. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1722-x · Cited by 98 · see citing works
Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin
Luo, Z., Shi, X., Hu, Q., Zhao, B., & Huang, M. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300112p · Cited by 87 · see citing works
Kowalczyk, J., Ehlers, S., Fürst, P., Schafft, H. A., & Lahrssen‐Wiederholt, M. (2012) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-012-9759-2 · Cited by 83 · see citing works
Self-citationLoccisano, A. E., Campbell, J. L., Butenhoff, J. L., Andersen, M. E., & M.A., H. J. C. I. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.04.006 · Cited by 83 · see citing works
Tonnelier, A., Coecke, S., & Zaldı́var, J. M. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0768-0 · Cited by 80 · see citing works
A toxicokinetic model for the carry-over of dioxins and PCBs from feed and soil to eggs
van Eijkeren, J. C. H., Zeilmaker, M. J., Kan, C. A., Traag, W. A., & Hoogenboom, L. A. P. (2006) · Food Additives & Contaminants · doi:10.1080/02652030500512045 · Cited by 80 · see citing works
Transfer of perfluorooctane sulfonic acid (PFOS) from contaminated feed to dairy milk
Asselt, E. D. V., Kowalczyk, J., van Eijkeren, J. C. H., Zeilmaker, M. J., Ehlers, S., Fürst, P., Lahrssen‐Wiederholt, M., & van der Fels‐Klerx, H. J. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.04.035 · Cited by 80 · see citing works
Self-citationDietary exposure to selected perfluoroalkyl acids (PFAAs) in four European regions
Klenow, S., Heinemeyer, G., Brambilla, G., Dellatte, E., Herzke, D., & de Voogt, P. (2013) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2013.849006 · Cited by 78 · see citing works
Isomer-Specific Biotransformation of Perfluorooctane Sulfonamide in Sprague–Dawley Rats
Ross, M. S., Wong, C. S., & Martin, J. W. (2012) · Environmental Science & Technology · doi:10.1021/es204028v · Cited by 73 · see citing works
Lee, J. J., & Schultz, I. R. (2009) · Environmental Science & Technology · doi:10.1021/es901838y · Cited by 60 · see citing works
Toxicokinetics of perfluorocarboxylate isomers in rainbow trout
Silva, A. O. D., Tseng, P. J., & Mabury, S. A. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-088.1 · Cited by 60 · see citing works
Absorption and Excretion of 14 C-Perfluorooctanoic Acid (PFOA) in Angus Cattle (Bos taurus)
Lupton, S. J., Huwe, J. K., Smith, D. J., Dearfield, K. L., & Johnston, J. J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2042505 · Cited by 60 · see citing works
Progress toward understanding the bioaccumulation of perfluorinated alkyl acids
Martin, J. W., Mabury, S. A., Solomon, K. R., & Muir, D. C. G. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2376 · Cited by 53 · see citing works
Westfälische Wilhelms‐Universität Münster
Werner, H. (2017) · doi:10.1002/9783527693009.ch39 · Cited by 43 · see citing works
Nordén, M., Berger, U., & Engwall, M. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1567-3 · Cited by 35 · see citing works
Watanabe, M. X., Kunisue, T., Tao, L., Kannan, K., Subramanian, A., Tanabe, S., & Iwata, H. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.189 · Cited by 33 · see citing works
A probabilistic model for the carry-over of PCDD/Fs from feed to growing pigs
Adolphs, J., Kleinjung, F., Numata, J., Mielke, H., Abraham, K., Schafft, H. A., Müller‐Graf, C., & Greiner, M. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.06.015 · Cited by 12 · see citing works
Self-citationSielaff, H. (1986) · Food / Nahrung · doi:10.1002/food.19860300742 · Cited by 7 · see citing works
Messung der Nierenperfusion mittels DCE-MRI am narkotisierten Schwein
Elsner, F. L. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8605 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989 · see citing works
Short-chain perfluoroalkyl acids: environmental concerns and a regulatory strategy under REACH
Brendel, S., Fetter, É., Staude, C., Vierke, L., & Biegel-Engler, A. (2018) · Environmental Sciences Europe · doi:10.1186/s12302-018-0134-4 · Cited by 694 · see citing works
(CONTAM), E. P. O. C. I. T. F. C., Knutsen, H. K., Alexander, J., Barregård, L., Bignami, M., Brüschweiler, B. J., Ceccatelli, S., Cottrill, B., Dinovi, M., Edler, L., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5194 · Cited by 519 · see citing works
Per- and polyfluoroalkyl substances (PFAS) in livestock and game species: A review
Death, C. E., Bell, C., Champness, D., Milne, C. M., Reichman, S. M., & Hagen, T. G. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144795 · Cited by 244 · see citing works
Ojo, A. F., Peng, C., & Ng, J. C. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124863 · Cited by 221 · see citing works
Fragki, S., Dirven, H. A. A. M., Fletcher, T., Grasl‐Kraupp, B., Gützkow, K. B., Hoogenboom, L. A. P., Kersten, S., Lindeman, B., Louisse, J., Peijnenburg, A., et al. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1888073 · Cited by 189 · see citing works
Ng, C. A., & Hungerbühler, K. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03000 · Cited by 122 · see citing works
Kim, S., Heo, S.-H., Lee, D., Hwang, I., Lee, Y., & Cho, H. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.09.017 · Cited by 106 · see citing works
Short-chain and long-chain fluorosurfactants in firefighting foam: a review
Peshoria, S., Nandini, D., Tanwar, R. K., & Narang, R. (2020) · Environmental Chemistry Letters · doi:10.1007/s10311-020-01015-8 · Cited by 100 · see citing works
Franklin, J. (2015) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.1642 · Cited by 93 · see citing works
Perfluorinated Compounds: An Overview
Lau, C. S. (2015) · Molecular and integrative toxicology · doi:10.1007/978-3-319-15518-0_1 · Cited by 86 · see citing works
Göckener, B., Eichhorn, M., Lämmer, R., Kotthoff, M., Kowalczyk, J., Numata, J., Schafft, H. A., Lahrssen‐Wiederholt, M., & Bücking, M. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04456 · Cited by 83 · see citing works
Self-citationXing, Y., Zhou, Y., Zhang, X., Lin, X., Li, J.-Y., Liu, P., Lee, H. K., & Huang, Z. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167313 · Cited by 75 · see citing works
Kolpin, D. W., Hubbard, L. E., Cwiertny, D. M., Meppelink, S. M., Thompson, D. A., & Gray, J. L. (2021) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.1c00750 · Cited by 67 · see citing works
Luz, A. L., Anderson, J. K., Goodrum, P., & Durda, J. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.01.019 · Cited by 63 · see citing works
Zhang, H., Vestergren, R., Wang, T., Yu, J., Jiang, G., & Herzke, D. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00246 · Cited by 60 · see citing works
Kowalczyk, J., Göckener, B., Eichhorn, M., Kotthoff, M., Bücking, M., Schafft, H. A., Lahrssen‐Wiederholt, M., & Numata, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04485 · Cited by 55 · see citing works
Self-citationPFAS in Paper and Board for Food Contact
Trier, D. X., Taxvig, C., Rosenmai, A. K., & Pedersen, G. A. (2018) · TemaNord · doi:10.6027/tn2017-573 · Cited by 55 · see citing works
Rupp, J., Guckert, M., Berger, U., Drost, W., Mader, A., Nödler, K., Nürenberg, G., Schulze, J., Söhlmann, R., & Reemtsma, T. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162028 · Cited by 54 · see citing works
Brambilla, G., D’Hollander, W., Oliaei, F., Stahl, T., & Weber, R. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.09.050 · Cited by 54 · see citing works
Li, W., Hu, Y., & Bischel, H. N. (2021) · Toxics · doi:10.3390/toxics9030063 · Cited by 53 · see citing works
“These observations are consistent with long blood plasma elimination half-lives reported for PFHxS in humans [54,55] and for PFHpA and PFHxS in pigs [56].”
BackgroundAbraham, K., Mertens, H., Richter, L., Mielke, H., Schwerdtle, T., & Monien, B. H. (2024) · Environment International · doi:10.1016/j.envint.2024.109047 · Cited by 52 · see citing works
Zafeiraki, E., Vassiliadou, I., Costopoulou, D., Leondiadis, L., Schafft, H. A., Hoogenboom, L. A. P., & van Leeuwen, S. P. J. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.05.003 · Cited by 51 · see citing works
Self-citationBost, P. C., Strynar, M. J., Reiner, J. L., Zweigenbaum, J. A., Secoura, P. L., Lindstrom, A. B., & Dye, J. A. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.027 · Cited by 50 · see citing works
Hubbard, L. E., Kolpin, D. W., Givens, C. E., Blackwell, B. R., Bradley, P. M., Gray, J. L., Lane, R. F., Masoner, J. R., McCleskey, R. B., Romanok, K. M., et al. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c06821 · Cited by 46 · see citing works
Half-lives of several polyfluoroalkyl substances (PFAS) in cattle serum and tissues
Drew, R., Hagen, T. G., Champness, D., & Sellier, A. (2022) · Food Additives & Contaminants: Part A · doi:10.1080/19440049.2021.1991004 · Cited by 42 · see citing works
Kowalczyk, J., Numata, J., Zimmermann, B., Klinger, R. J., Habedank, F., Just, P., Schafft, H. A., & Lahrssen‐Wiederholt, M. (2018) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-018-0552-8 · Cited by 40 · see citing works
Self-citationGuruge, K. S., Noguchi, M., Yoshioka, K., Yamazaki, E., Taniyasu, S., Yoshioka, M., Yamanaka, N., Ikezawa, M., TANIMURA, N., Sato, M., et al. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3145 · Cited by 38 · see citing works
Lupton, S. J., Dearfield, K. L., Johnston, J. J., Wagner, S., & Huwe, J. K. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b04565 · Cited by 37 · see citing works
Wang, G., Lu, J., Xing, Z., Li, S., Liu, Z., & Tong, Y. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14090970 · Cited by 36 · see citing works
Pan, X., Qin, P., Liu, R., Yu, W., & Dong, X. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02197 · Cited by 34 · see citing works
Mikkonen, A., Martin, J., Upton, R. N., Barker, A. O., Brumley, C. M., Taylor, M. P., Mackenzie, L., & Roberts, M. S. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115518 · Cited by 32 · see citing works
Mertens, H., Noll, B., Schwerdtle, T., Abraham, K., & Monien, B. H. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04867-5 · Cited by 31 · see citing works
Starnes, H. M., Jackson, T. W., Rock, K. D., & Belcher, S. M. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae028 · Cited by 29 · see citing works
Current per- and polyfluoroalkyl substance (PFAS) research points to a growing threat in animals
Brake, H. D., Langfeldt, A., Kaneene, J. B., & Wilkins, M. J. (2023) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.22.12.0582 · Cited by 28 · see citing works
Jouanneau, W., Bårdsen, B., Herzke, D., Johnsen, T. V., Eulaers, I., & Bustnes, J. O. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b06818 · Cited by 28 · see citing works
Qin, W., Escher, B. I., Huchthausen, J., Fu, Q., & Henneberger, L. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c10824 · Cited by 25 · see citing works
Fluorine mass balance analysis in wild boar organs from the Bohemian Forest National Park
Schröder, T., Müller, V., Preihs, M., Borovička, J., de Vega, R. G., Kindness, A., & Feldmann, J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.171187 · Cited by 25 · see citing works
Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction
González-Alvarez, M. E., Antwi-Boasiako, C., & Keating, A. F. (2024) · Toxics · doi:10.3390/toxics12070455 · Cited by 23 · see citing works
Length-specific occurrence and profile of perfluoroalkyl acids (PFAAs) in animal protein feeds
Li, X., Gao, K., Dong, S., Liu, X., Fu, K., Wang, P., Zhang, A., Su, X., & Fu, J. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.03.074 · Cited by 23 · see citing works
Mikkonen, A., Martin, J., Upton, R. N., Moenning, J.-L., Numata, J., Taylor, M. P., Roberts, M. S., & Mackenzie, L. (2023) · Environment International · doi:10.1016/j.envint.2023.108218 · Cited by 22 · see citing works
Self-citationMikołajczyk, S., Warenik-Bany, M., Pajurek, M., & Marchand, P. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174071 · Cited by 22 · see citing works
Ferretti, F., Barbarossa, A., & Bardhi, A. (2026) · Environmental Science and Pollution Research · doi:10.1007/s11356-026-37412-9 · Cited by 21 · see citing works
Hanvoravongchai, J., Laochindawat, M., Kimura, Y., Mise, N., & Ichihara, S. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.143745 · Cited by 20 · see citing works
Chen, D., Zhao, Y., Xu, W., Pan, Y., Wei, Q., & Xie, S. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115611 · Cited by 20 · see citing works
Feng, Q.-J., Luo, X., Ye, M., Hu, K., Zeng, Y., & Mai, B. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167008 · Cited by 19 · see citing works
Xie, S., Cui, Y., Yang, Y., Meng, K., Pan, Y., Liu, Z., & Chen, D. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126016 · Cited by 19 · see citing works
Kowalczyk, J., Flor, M., Karl, H., & Lahrssen‐Wiederholt, M. (2019) · Food Additives and Contaminants Part B · doi:10.1080/19393210.2019.1690052 · Cited by 18 · see citing works
Self-citationAccumulation of per- and polyfluoroalkyl substances (PFAS) in tissues of wild boar (Sus scrofa)
Mertens, H., Schwerdtle, T., Weikert, C., Abraham, K., & Monien, B. H. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179668 · Cited by 13 · see citing works
Lerch, S., Siegenthaler, R., Numata, J., Moenning, J.-L., Dohme‐Meier, F., & Zennegg, M. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02626 · Cited by 12 · see citing works
Self-citationShurson, G. C. (2025) · Sustainability · doi:10.3390/su17156957 · Cited by 12 · see citing works
Sakuma, A., Ochi, H. W., Yoshioka, M., Yamanaka, N., Ikezawa, M., & Guruge, K. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210110 · Cited by 12 · see citing works
Savvateeva, D., Numata, J., Pieper, R., Schafft, H. A., Lahrssen‐Wiederholt, M., & Bulik, S. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02617-0 · Cited by 12 · see citing works
Self-citationMi, K., & Lin, Z. (2025) · Environment International · doi:10.1016/j.envint.2025.109372 · Cited by 11 · see citing works
Brake, H. D., Wilkins, M. J., & Kaneene, J. B. (2023) · American Journal of Veterinary Research · doi:10.2460/ajvr.22.12.0221 · Cited by 10 · see citing works
Garmo, L. C., Herroon, M. K., Mecca, S., Wilson, A., Allen, D. R., Agarwal, M., Kim, S., Petriello, M. C., & Podgorski, I. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117047 · Cited by 8 · see citing works
Lupton, S. J., Smith, D. J., Howey, E. B., Predgen, A. S., Schmidt, C. E., Scholljegerdes, E. J., Ivey, S. L., Esteban, E., & Johnston, J. J. (2025) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2024.2444560 · Cited by 8 · see citing works
Good, S. L., Antwi-Boasiako, C., González-Alvarez, M. E., Buol, B. M., Baumgard, L. H., Keating, A. F., & Charbonnet, J. A. (2025) · Toxicological Sciences · doi:10.1093/toxsci/kfaf013 · Cited by 7 · see citing works
Ingelido, A. M., Abballe, A., Dellatte, E., Ferri, F., Iacovella, N., Marra, V., Valentini, S., & Felip, E. D. (2025) · Chemosphere · doi:10.1016/j.chemosphere.2025.144297 · Cited by 7 · see citing works
Draghi, S., Curone, G., Pavlović, R., Cesare, F. D., Cagnardi, P., Silva, C. F., Pellegrini, A., Riva, F., Arioli, F., & Fidani, M. (2024) · Animals · doi:10.3390/ani14040529 · Cited by 7 · see citing works
Chemical Contamination of Red Meat
Smith, D. J., & Kim, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100674-0.00018-7 · Cited by 7 · see citing works
Microbial Resources from Wild and Captive Animals
Singh, B., Mal, G., Gautam, S. K., & Mukesh, M. (2019) · Springer eBooks · doi:10.1007/978-3-030-21309-1_4 · Cited by 5 · see citing works
Rispens, B., & Hendriks, A. J. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142253 · Cited by 5 · see citing works
Persistente organische Kontaminanten in Lebensmitteln
Pabel, U., Buhrke, T., Abraham, K., Nölke, T., Gehling, M., Lampen, A., Lahrssen‐Wiederholt, M., & Wittkowski, R. (2017) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-017-2563-4 · Cited by 5 · see citing works
Self-citationCina, M., Mandelli, A., Ponce, M. D. V., Guiñez, M., & Cerutti, S. E. (2026) · Foods · doi:10.3390/foods15030517 · Cited by 4 · see citing works
Perfluorooctane sulfonate and perfluorooctanoic acid
Kuzukıran, Ö., Şimşek, İ., Filazı, A., & Yurdakök-Di̇kmen, B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89773-0.00041-2 · Cited by 4 · see citing works
Scrambled eggs—Negative impacts of heat stress and chemical exposures on ovarian function in swine
González-Alvarez, M. E., Roach, C. M., & Keating, A. F. (2023) · Molecular Reproduction and Development · doi:10.1002/mrd.23669 · Cited by 4 · see citing works
Felder, C., Mateus-Vargas, R. H., Fischer, I., Skutlarek, D., Färber, H. A., Kowalczyk, J., Pieper, R., Rupp, J., Durkalec, M., Mader, A., et al. (2025) · Environmental Research · doi:10.1016/j.envres.2025.123583 · Cited by 3 · see citing works
Self-citationMateus-Vargas, R. H., Numata, J., Mader, A., Knapp, H., Georgii, S., Falk, S. R. N., Habedank, F., Pieper, R., Steinhoff‐Wagner, J., & Kowalczyk, J. (2025) · Journal of Consumer Protection and Food Safety · doi:10.1007/s00003-025-01550-y · Cited by 3 · see citing works
Self-citationHe, C., Tang, Y., Chen, S., Huang, S., Xiong, Y., Bai, Y., Xu, J., Zhong, Y., Cheng, H., Wang, L., et al. (2025) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2025.108013 · Cited by 3 · see citing works
Transfer of selected PFAS to muscle, liver and plasma of adolescent sheep
Aßhoff, N., Krause, T., Bernsmann, T., Esselen, M., Knappstein, K., Albert, C., Jira, W., Maul, R., Stahl, T., & Lamp, J. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.127845 · Cited by 2 · see citing works
A Daily Accumulation Model for Predicting PFOS Residues in Beef Cattle Muscle After Oral Exposure
Edhlund, I., Post, L. O., & Sklenka, S. (2025) · Toxics · doi:10.3390/toxics13080649 · Cited by 2 · see citing works
Can perfluoroalkyl acids biodegrade in the rumen simulation technique (RUSITEC)?
Kowalczyk, J., Riede, S., Schafft, H. A., Breves, G., & Lahrssen‐Wiederholt, M. (2015) · Environmental Sciences Europe · doi:10.1186/s12302-015-0063-4 · Cited by 2 · see citing works
Self-citationZhu, C., Luo, X., Guan, K., Guo, J., Chen, P., Chen, X., Zeng, Y., & Mai, B. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.126842 · Cited by 2 · see citing works
Jahnke, A., Simon, K., Goedecke-Röber, C., Kowalczyk, J., Weiss, M., & Lüth, A. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09362
Self-citationInauen, D., Lautz, L. S., Hendriks, A. J., & Gehring, R. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04421-z · Cited by 1 · see citing works
Reemtsma, T., Rupp, J., Guckert, M., Berger, U., Nödler, K., & Nürenberg, G. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4158193 · Cited by 1 · see citing works
Trier, X., Taxvig, C., Rosenmai, A. K., & Pedersen, G. A. (2018) · TemaNord · doi:10.6027/f5e88671-en
Trier, X., Taxvig, C., Rosenmai, A. K., & Pedersen, G. A. (2018) · TemaNord · doi:10.6027/fedb3330-en
Luo, X., Feng, Q.-J., Ye, M., Hu, K., Zeng, Y., & Mai, B. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4500465
Brominated flame retardants and per- and polyfluoroalkyl substances
Kodavanti, P. R. S., Yamashita, N., Hines, E. P., Dixon, A., Meyrueix, L. P., Freeborn, D. L., & Stoker, T. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29007-7.00001-7
Veenaas, C., Hoogenveen, R. T., Zeilmaker, M. J., & Berntssen, M. H. G. (2025) · Chemosphere · doi:10.1016/j.chemosphere.2025.144489
An assessment of PFAS contamination in wild boar meat and liver
Brossmann, M., Valentin, I., & Brunn, H. E. (2026) · Environmental Sciences Europe · doi:10.1186/s12302-026-01372-1
Felder, C., Okyir, H. K., Azanu, D., Agyekum, T. P., Skutlarek, D., Färber, H., Nkansah, M. A., & Mutters, N. T. (2026) · Exposure and Health · doi:10.1007/s12403-026-00784-x
Bioaccumulation, distribution and depuration of PFAS in chickens from a contaminated region
Aarab, C. E. A., Murphy, A., Fosseprez, G., Azghay, H., Voorspoels, S., Masquelier, J., Hoeck, E. V., Eppe, G., & Joly, L. (2026) · Chemosphere · doi:10.1016/j.chemosphere.2026.144951
Hua, L., Gu, E., Cunlu, L., Xue, X., Wang, X., Zhang, T., & Xu, F. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128361
A PBK model for PFAS transfer from feed to fillet in farmed Atlantic salmon
Ly, T.-K., Veenaas, C., Bodin, C., Lie, K. K., Beaudouin, R., & Berntssen, M. H. G. (2026) · npj Emerging Contaminants · doi:10.1038/s44454-026-00043-3
PFAS: challenges and scientific perspectives in human health risk assessment
Kowalczyk, J., Abraham, K., August, C., Boeddinghaus, R. S., CHAN, J. C. Y., Eckhardt, A., Fletcher, T., Freeling, F., Göckener, B., Halldorsson, T. I., et al. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04523-8
Self-citationKaurinović, J., Varga, I., Bilandžić, N., Čalopek, B., Đokić, M., Varenina, I., Kolanović, B. S., Sedak, M., Bošković, I., & Fattore, E. (2026) · Toxics · doi:10.3390/toxics14100867
- Authors
- Numata, J., Kowalczyk, J., Adolphs, J., Ehlers, S., Schafft, H., Fuerst, P., Müller-Graf, C., Lahrssen-Wiederholt, M., & Greiner, M.
- Affiliations
- German Federal Institute for Risk Assessment (BfR) (DE)
- Johannes Kepler University of Linz (AT)
- Chemisches und Veterinäruntersuchungsamt Münsterland-Emscher-Lippe (DE)
- BfR − Federal Institute for Risk Assessment, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany
- University of Veterinary Medicine Hannover, Foundation (DE)
- Corresponding author
- Numata, Jorge
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-06-30
- Volume
- 62
- Issue
- 28
- Pages
- 6861-6870
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2334536065
- Cited by
- 92
- References
- 47
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 1
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- OpenAgrar (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- perfluoroalkyl acids, perfluoroalkyl sulfonic acids, perfluorinated carboxylic acids, PFOS, perfluorohexanoic acid, toxicokinetics, pigs, feed contamination, tissue distribution, elimination half-life, toxicokinetic modeling, edible tissues, plasma
- MeSH terms
- Animals, Animal Feed, Carboxylic Acids, Female, Fluorocarbons, Food Contamination, Half-Life, Male, Meat, Sulfonic Acids, Sus scrofa, Food Safety, Toxicokinetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
