Association of perfluoroalkyl substances exposure with impaired lung function in children

Interpretative strategies for lung function tests

Pellegrino, R., Viegi, G., Brusasco, V., Crapo, R. O., Burgos, F., Casaburi, R., Coates, A., van der Grinten, C. P. M., Gustafsson, P., Hankinson, J., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00035205 · Cited by 5,945 · see citing works

Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins

Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641 · see citing works

Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma

Program, P., & theDiagnosis, T. E. P. O. (1997) · Cited by 4,082 · see citing works

Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma–Summary Report 2007

(2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.029 · Cited by 2,181 · see citing works

Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production Workers

Olsen, G. W., Burris, J. M., Ehresman, D. J., Froehlich, J. W., Seacat, A. M., Butenhoff, J. L., & Zobel, L. R. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10009 · Cited by 2,049 · see citing works

Outdoor air pollution and asthma.

Guarnieri, M., & Balmes, J. R. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60617-6 · Cited by 1,889 · see citing works

The development of allergic inflammation

Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839 · see citing works

Polyfluorinated Compounds: Past, Present, and Future

Lindstrom, A. B., Strynar, M. J., & Libelo, E. L. (2011) · Environmental Science & Technology · doi:10.1021/es2011622 · Cited by 1,628 · see citing works

A longitudinal, population-based, cohort study of childhood asthma followed to adulthood

Sears, M. R., Greene, J. M., Willan, A. R., Wiecek, E. M., Taylor, D. R., Flannery, E. M., Cowan, J. O., Herbison, G. P., Silva, P. A., & Poulton, R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022363 · Cited by 1,460 · see citing works

The effect of air pollution on lung development from 10 to 18 years of age

Gauderman, W. J., Avol, E., Gilliland, F., Vora, H., Thomas, D., Berhane, K., McConnell, R., Kuenzli, N., Lurmann, F., Rappaport, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040610 · Cited by 1,440 · see citing works

Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC)

Lai, C.-Y., Beasley, R. W., Crane, J., Foliaki, S., Shah, J., Weiland, S. K., & the ISAAC Phase Three Study Group (2009) · Thorax · doi:10.1136/thx.2008.106609 · Cited by 1,063 · see citing works

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

Kuperman, D. A., Huang, X., Koth, L. L., Chang, G. H., Dolganov, G., Zhu, Z., Elias, J. A., Sheppard, D., & Erle, D. J. (2002) · Nature Medicine · doi:10.1038/nm734 · Cited by 938 · see citing works

A summary of the new GINA strategy: a roadmap to asthma control

Reddel, H. K., Bateman, E. D., Becker, A. B., Boulet, L., Cruz, Á. A., Drazen, J. M., Haahtela, T., Hurd, S. S., Inoue, H., de Jongste, J. C., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.00853-2015 · Cited by 790 · see citing works

Accumulation of perfluoroalkyl substances in human tissues

Pérez, F., Nadal, M., Navarro-Ortega, A., Fàbrega, F., Domingo, J. L., Barceló, D., & Farré, M. (2013) · Environment International · doi:10.1016/j.envint.2013.06.004 · Cited by 730 · see citing works

Patterns of growth and decline in lung function in persistent childhood asthma

McGeachie, M. J., Yates, K. P., Zhou, X., Guo, F., Sternberg, A. L., Van Natta, M. L., Wise, R. A., Szefler, S. J., Sharma, S., Kho, A. T., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513737 · Cited by 608 · see citing works

The many paths to asthma: phenotype shaped by innate and adaptive immunity

Kim, H. Y., DeKruyff, R. H., & Umetsu, D. T. (2010) · Nature Immunology · doi:10.1038/ni.1892 · Cited by 588 · see citing works

Risk factors for asthma: is prevention possible?

Beasley, R. W., Semprini, A. C., & Mitchell, E. A. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00156-7 · Cited by 512 · see citing works

Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α

Heuvel, J. P. V., Thompson, J. T., Frame, S. R., & Gillies, P. J. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl014 · Cited by 479 · see citing works

Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (α, β/δ, γ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate

Takacs, M. L., & Abbott, B. D. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfl135 · Cited by 396 · see citing works

Immunotoxicity of Perfluorooctanoic Acid and Perfluorooctane Sulfonate and the Role of Peroxisome Proliferator-Activated Receptor Alpha

DeWitt, J., Shnyra, A., Badr, M., Loveless, S., Hoban, D., Frame, S., Cunard, R., Anderson, S., Meade, B., Peden-Adams, M., et al. (2009) · Critical Reviews in Toxicology · doi:10.1080/10408440802209804 · Cited by 272 · see citing works

Air Pollution, Airway Inflammation, and Lung Function in a Cohort Study of Mexico City Schoolchildren

Barraza‐Villarreal, A., Sunyer, J., Cadena, L. H., Escamilla-Núñez, C., Sienra-Monge, J. J. L., Ramírez-Aguilar, M., Cortez‐Lugo, M., Holguín, F., Díaz-Sánchez, D., Olin, A. C., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10926 · Cited by 243 · see citing works

Highly Elevated Serum Concentrations of Perfluoroalkyl Substances in Fishery Employees from Tangxun Lake, China

Zhou, Z., Shi, Y., Vestergren, R., Wang, T., Liang, Y., & Cai, Y. (2014) · Environmental Science & Technology · doi:10.1021/es4057467 · Cited by 205 · see citing works

Serum Polyfluoroalkyl Concentrations, Asthma Outcomes, and Immunological Markers in a Case–Control Study of Taiwanese Children

Dong, G., Tung, K., Tsai, C., Liu, M.-M., Wang, D., Liu, W., Jin, Y., Hsieh, W., Lee, Y. L., & Chen, P. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205351 · Cited by 193 · see citing works

Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12–19 y: National Health and Nutrition Examination Survey

Stein, C. R., McGovern, K. J., Pajak, A., Maglione, P. J., & Wolff, M. S. (2015) · Pediatric Research · doi:10.1038/pr.2015.213 · Cited by 186 · see citing works

Traffic-related Air Pollution and Lung Function in Children at 8 Years of Age: A Birth Cohort Study

Schultz, E. S., Gruzieva, O., Bellander, T., Bottai, M., Hallberg, J., Kull, I., Svartengren, M., Melén, E., & Pershagen, G. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-1045oc · Cited by 165 · see citing works

Occurrence of perfluorinated substances in an adult German population in southern Bavaria

Fromme, H., Midasch, O., Twardella, D., Angerer, J., Boehmer, S., & Liebl, B. (2006) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-006-0136-1 · Cited by 158 · see citing works

Monitoring asthma in children

Pijnenburg, M. W. H., Baraldi, E., Brand, P. L. P., Carlsen, K., Eber, E., Frischer, T., Hedlin, G., Kulkarni, N., Lex, C., Mäkelä, M. J., et al. (2015) · European Respiratory Journal · doi:10.1183/09031936.00088814 · Cited by 149 · see citing works

Impact of Environmental Chemicals on Lung Development

Miller, M. D., & Marty, M. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901856 · Cited by 139 · see citing works

Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children

Smit, L. A. M., Lenters, V. C., Høyer, B. B., Lindh, C. H., Pedersen, H. S., Liermontova, Y. O., Jönsson, B., Piersma, A. H., Bonde, J. P., Toft, G. V., et al. (2015) · Allergy · doi:10.1111/all.12605 · Cited by 132 · see citing works

Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice

Dong, G., Liu, M.-M., Da, W., Li, Z., Liang, Z., & Jin, Y. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0661-x · Cited by 122 · see citing works

Perfluoroalkyl Chemicals and Asthma among Children 12–19 Years of Age: NHANES (1999–2008)

Humblet, O., Diaz‐Ramirez, L. G., Balmes, J. R., Pinney, S. M., & Hiatt, R. A. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1306606 · Cited by 102 · see citing works

Exposure to the Immunosuppresant, Perfluorooctanoic Acid, Enhances the Murine IgE and Airway Hyperreactivity Response to Ovalbumin

Fairley, K. J., Purdy, R., Kearns, S., Anderson, S. E., & Meade, B. J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm053 · Cited by 98 · see citing works

Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring

Chen, T. X., Zhang, L., Yue, J., Lv, Z., Xia, W., Wan, Y., Li, Y.-Y., & Xu, S. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.03.003 · Cited by 93 · see citing works

Perfluorooctanoic acid induces mast cell-mediated allergic inflammation by the release of histamine and inflammatory mediators

Singh, T. S. K., Lee, S., Kim, H.-H., Choi, J. K., & Kim, S. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.01.014 · Cited by 89 · see citing works

Tissue Distribution of 35S-Labelled Perfluorooctane Sulfonate (PFOS) in C57Bl/6 Mice Following Late Gestational Exposure

Borg, D., Bogdanska, J., Sundström, M., Nobel, S., Håkansson, H., Bergman, Å., DePierre, J. W., Halldin, K., & Bergström, U. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.07.004 · Cited by 76 · see citing works

Chronic exposure to perfluorinated compounds: Impact on airway hyperresponsiveness and inflammation

Ryu, M. H., Jha, A., Ojo, O. O., Mahood, T. H., Basu, S., Detillieux, K. A., Nikoobakht, N., Wong, C. S., Loewen, M., Becker, A. B., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00100.2014 · Cited by 72 · see citing works

Clinically Useful Spirometry in Preschool-Aged Children: Evaluation of the 2007 American Thoracic Society Guidelines

Gaffin, J. M., Shotola, N. L., Martin, T. R., et al. (2010) · Journal of Asthma · doi:10.3109/02770903.2010.485664 · Cited by 72 · see citing works

Polyfluoroalkyl Compounds in Texas Children from Birth through 12 Years of Age

Schecter, A. J., Malik-Bass, N., Calafat, A. M., Kato, K., Colacino, J. A., Gent, T. L., Hynan, L. S., Harris, T. R., Malla, S., & Birnbaum, L. S. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1104325 · Cited by 71 · see citing works

Perfluorooctane sulfonate induces apoptosis in lung cancer A549 cells through reactive oxygen species‐mediated mitochondrion‐dependent pathway

Mao, Z., Xia, W., Wang, J., Chen, T., Zeng, Q., Xu, B., Li, W., Chen, X., & Xu, S. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2785 · Cited by 69 · see citing works

Type 1 and Type 2 cytokines imbalance in adult male C57BL/6 mice following a 7-day oral exposure to perfluorooctanesulfonate (PFOS)

Zheng, L., Dong, G., Zhang, Y.-H., et al. (2011) · Journal of Immunotoxicology · doi:10.3109/1547691x.2010.537287 · Cited by 62 · see citing works

Self-Reported Health Effects among Community Residents Exposed to Perfluorooctanoate

Anderson-Mahoney, P. J., Kotlerman, J. B., Takhar, H. S., Gray, D. B., & Dahlgren, J. G. (2008) · NEW SOLUTIONS A Journal of Environmental and Occupational Health Policy · doi:10.2190/ns.18.2.d · Cited by 53 · see citing works

Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area: The Seven Northeastern Cities (SNEC) study

Zeng, X., Vivian, E., Mohammed, K. A., Jakhar, S., Vaughn, M. G., Huang, J., Zelicoff, A. P., Xaverius, P. K., Bai, Z., Lin, S., et al. (2016) · Atmospheric Environment · doi:10.1016/j.atmosenv.2016.05.003 · Cited by 50 · see citing works

Perfluorononanoic acid-induced apoptosis in rat spleen involves oxidative stress and the activation of caspase-independent death pathway

Fang, X., Feng, Y., Wang, J., & Dai, J. (2009) · Toxicology · doi:10.1016/j.tox.2009.10.020 · Cited by 46 · see citing works

Predictive Equations Using Regression Analysis of Pulmonary Function for Healthy Children in Northeast China

Ma, Y., Wang, J., Dong, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063875 · Cited by 38 · see citing works

Spirometry values for detecting a restrictive pattern in occupational health settings.

Mehrparvar, A. H., Sakhvidi, M. J. Z., Mostaghaci, M., et al. (2014) · PubMed · Cited by 32 · see citing works

Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure

Ye, L., Zhao, B., Yuan, K., Chu, Y., Li, C., Zhao, C., Lian, Q., & Ge, R. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2011.12.013 · Cited by 29 · see citing works

The PPAR resource page

VANDENHEUVEL, J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.03.007 · Cited by 22 · see citing works

The Impact Of A Perfluorinated Compound (PFC) On Airway Function In An Allergic Murine Model

Loewen, M., Basu, S., Halayko, A. J., et al. (2011) · doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3249 · Cited by 4 · see citing works

Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research

Fenton, S. E., Ducatman, A., Boobis, A., DeWitt, J. C., Lau, C., Ng, C., Smith, J. S., & Roberts, S. M. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4890 · Cited by 2,445 · see citing works

Risk to human health related to the presence of perfluoroalkyl substances in food

Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989 · see citing works

Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature

Rappazzo, K., Coffman, E., & Hines, E. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14070691 · Cited by 405 · see citing works

Assessing the Human Health Risks of Per- and Polyfluoroalkyl Substances: A Need for Greater Focus on Their Interactions as Mixtures

Ojo, A. F., Peng, C., & Ng, J. C. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124863 · Cited by 221 · see citing works

Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: Review of epidemiologic studies

von Holst, H., Nayak, P., Dembek, Z., Buehler, S., Echeverria, D., Fallacara, D., & John, L. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08160 · Cited by 167 · see citing works

Waste type, incineration, and aeration are associated with per- and polyfluoroalkyl levels in landfill leachates

Solo-Gabriele, H. M., Jones, A. S., Lindstrom, A. B., & Lang, J. R. (2020) · Waste Management · doi:10.1016/j.wasman.2020.03.034 · Cited by 147 · see citing works

Perfluoroalkyl acids on suspended particles: Significant transport pathways in surface runoff, surface waters, and subsurface soils

Borthakur, A., Wang, M., He, M., Ascencio, K., Blotevogel, J., Adamson, D. T., Mahendra, S., & Mohanty, S. K. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126159 · Cited by 87 · see citing works

Asthma and decreased lung function in children exposed to perfluoroalkyl and polyfluoroalkyl substances (PFAS): An updated meta-analysis unveiling research gaps

Rafiee, A., Faridi, S., Sly, P. D., Stone, L., Kennedy, L. P., & Mahabee-Gittens, E. M. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119827 · Cited by 20 · see citing works

Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS

Hasan, M., Habib, A., Alam, M., Islam, S., & Halim, E. (2025) · Pollutants · doi:10.3390/pollutants5040043 · Cited by 21 · see citing works

Evaluation of per- and polyfluoroalkyl substances (PFAS) in landfill liquids from Pennsylvania, Colorado, and Wisconsin

Chen, Y., Zhang, H., Liu, Y., Bowden, J. A., Townsend, T. G., & Solo-Gabriele, H. M. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.141719 · Cited by 12 · see citing works

Sonochemical Decomposition of Perfluorooctane Sulfonate and Perfluorooctanoic Acid

Moriwaki, H., Takagi, Y., Tanaka, M., Tsuruho, K., Okitsu, K., & Maeda, Y. (2005) · Environmental Science & Technology · doi:10.1021/es040342v · Cited by 464 · see citing works

Correspondence on “Defluorination of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) by Acidimicrobium sp. Strain A6”

Liu, J., Edwards, E. A., Hamme, J. D. V., Manefield, M. J., Higgins, C. P., Blotevogel, J., Liu, J., & Lee, L. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c06681 · Cited by 24 · see citing works

Determination of Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Lake Victoria Gulf Water

Orata, F., Quinete, N., Werres, F., & Wilken, R. (2008) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-008-9543-1 · Cited by 66 · see citing works

POPsのリスク評価にむけてのヒト曝露長期モニタリングのための試料バンクの創設に関する研究 試料バンクの有用性の検証 新たな難分解性化学物質-Perfluorooctane sulfonate(PFOS)およびPerfluorooctanoic acid(PFOA)の分析法および処理法の開発 PFOS・PFOAの処理方法の検討

藤井滋穂 (2006)

Contamination characteristics of perfluorooctane sulfonate(PFOS) and perfluorooctanoic acid(PFOA) in aquatic products from Guangzhou

Li-jua, Z. (2013) · China Environmental Science · Cited by 1 · see citing works