The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease
Open accessAbstract
Background & aims Intestinal dysbiosis and bacterial translocation are common in patients with advanced liver disease, and there is strong evidence that the translocation of bacteria and their products across the epithelial barrier drives experimental liver disease progression. The aims of our study were to investigate dynamics of bacterial translocation and changes in the enteric microbiome in early stages of liver disease.Methods Cholestatic liver injury was induced by ligation of the common bile duct (BDL) and toxic liver injury by injection of carbon tetrachloride (CCl(4)) in mice.Results Increased intestinal permeability and bacterial translocation occurred one day following liver injury in both disease models. This was accompanied by decreased intestinal expression of the tight junction protein occludin. Although BDL resulted in a rapid onset of intestinal bacterial overgrowth, bacterial overgrowth was observed in mice injected with CCl(4) only in advanced stages of liver fibrosis. To further assess the qualitative changes in the intestinal microbiome, massively parallel pyrosequencing of 16S rRNA genes revealed minor microbial changes following BDL, while CCl(4) administration resulted in a relative abundance of Firmicutes and Actinobacteria compared with oil-injected mice. Four different liver disease models (cholestasis, toxic, alcohol, obesity) show few similarities in their intestinal microbiome.Conclusions Acute liver injury is associated with an early onset of increased intestinal permeability and bacterial translocation that precede changes in the microbiome. The enteric microbiome differs with respect to the etiology of liver disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increases in blood LPS levels reflect gut leakiness and are mirrored by a number of other alterations such as increased intestinal permeability to high molecular weight polyethylene glycol in patients with ALD26 and to FITC-dextran in mouse models of alcoholic and biliary liver disease27,28.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [28]
In the citing paper
“Decreased bile secretion in rodents by either ligation of the common bile duct or induction of cirrhosis contributes to bacterial translocation, which is not only caused by intestinal bacterial overgrowth but also by increased gut permeability20,28,134.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [28]
In the citing paper
“Moreover, there are very limited available studies focused on characterising the microbiome composition during experimental cholestasis and these studies have shown conflicting results25,26.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [26]
In the citing paper
“In addition, microbiome analysis was performed at later timepoints (10 days) after BDL, while our analyses comprised earlier timepoints after surgery; 3 and 7 days after BDL.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [26]
In the citing paper
“While Fouts et al.26 described that BDL did not alter the microbiome in mice, Alaish et al.25 described changes in Bl6/C57 mice at late stages after BDL (14 days) that the authors discussed to be associated with advanced fibrogenesis (cirrhosis).”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [26]
In the citing paper
“Also, the sequencing methodology used in that study was different that the one we have applied. Fouts and colleagues used pyrosequencing26 while we used Illumina sequencing in our work, which provides a higher number of sequences per sample and greater depth of sequences corresponding to the hypervariable zone V3-V4, as opposed to the hypervariable V1–V3 region targeted in the Fouts et al. work26.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 21,481
Simpson, E. (1949) · Nature · doi:10.1038/163688a0 · Cited by 14,753
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Self-citationMetagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Self-citationIntestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Estimating the Population Size for Capture-Recapture Data with Unequal Catchability
Chao, A. (1987) · Biometrics · doi:10.2307/2531532 · Cited by 2,459
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 311
The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection
Yang, R., Yao, X., Dai, Z., Lin, X., & Wang, H. (2018) · Journal of Immunology Research · doi:10.1155/2018/2361963 · Cited by 56
Animal models of cholestasis: An update on inflammatory cholangiopathies
Mariotti, V., Cadamuro, M., Spirlı̀, C., Fiorotto, R., Strazzabosco, M., & Fabris, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.025 · Cited by 58
Alaish, S. M., Smith, A. D., Timmons, J., Greenspon, J., Eyvazzadeh, D., Murphy, E., Shea-Donahue, T., Cirimotich, S., Mongodin, E., Zhao, A., et al. (2013) · Gut Microbes · doi:10.4161/gmic.24706 · Cited by 54
Ommati, M. M., Amjadinia, A., Mousavi, K., Azarpira, N., Jamshidzadeh, A., & Heidari, R. (2020) · Stress · doi:10.1080/10253890.2020.1777970 · Cited by 55
Recent advances in understanding and managing cholestasis
Wagner, M., & Trauner, M. (2016) · F1000Research · doi:10.12688/f1000research.8012.1 · Cited by 53
Gut Microbiota of Nonalcoholic Fatty Liver Disease
Abdou, R., Zhu, L., Baker, R. D., & Baker, S. S. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4045-1 · Cited by 52
Systemic Immunoregulatory Consequences of Gut Commensal Translocation
McPherson, A. C., Pandey, S., Bender, M. J., & Meisel, M. (2021) · Trends in Immunology · doi:10.1016/j.it.2020.12.005 · Cited by 51
Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafish
Forn‐Cuní, G., Varela, M., Fernández‐Rodríguez, C., Figueras, A. J., & Novoa, B. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0398 · Cited by 50
A role for intestinal alkaline phosphatase in preventing liver fibrosis
Liu, Y., Cavallaro, P. M., Kim, B., Liu, T., Wang, H., Kühn, F., Adiliaghdam, F., Liu, E., Vasan, R. V., Samarbafzadeh, E., et al. (2020) · Theranostics · doi:10.7150/thno.48468 · Cited by 50
Microbiome in Death and Beyond: Current Vistas and Future Trends
Roy, D., Tomo, S., Purohit, P., & Setia, P. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.630397 · Cited by 55
Gut microbiota-related complications in cirrhosis
Gómez‐Hurtado, I. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i42.15624 · Cited by 49
Panyod, S., Wu, W., Lu, K., Liu, C.-T., Chu, Y., Ho, C., Hsiao, W. L. W., Lai, Y.-S., Chen, W.-C., Lin, Y., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07555 · Cited by 46
Wu, S., Wen, F., Zhong, X., Du, W., Chen, M., & Wang, J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2216942 · Cited by 45
Probiotics for Alleviating Alcoholic Liver Injury
Gu, Z., Liu, Y., Hu, S., You, Y., Li, W., & Wang, Y. (2019) · Gastroenterology Research and Practice · doi:10.1155/2019/9097276 · Cited by 45
Probiotics for the treatment of hyperlipidemia: Focus on gut-liver axis and lipid metabolism
You, M. S., Zhou, L., Wu, F., Zhang, L., Zhu, S.-X., & Zhang, H. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107694 · Cited by 53
Wang, L., Hartmann, P., Haimerl, M., Bathena, S. P., Sjöwall, C., Almer, S. H., Alnouti, Y., Hofmann, A. F., & Schnabl, B. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.012 · Cited by 44
Self-citationRaju (2005) · doi:10.3389/fvets.2021.640968 · Cited by 42
Cláudia-Ferreira, A., Barbosa, D. J., Saegeman, V., Fernández-Rodríguez, A., Dinis‐Oliveira, R. J., Freitas, A. R., & on behalf of the ESCMID Study Group of Forensic and Post-Mortem Microbiology (ESGFOR) (2023) · Microorganisms · doi:10.3390/microorganisms11102509 · Cited by 47
Moratalla, A., Gómez‐Hurtado, I., Santacruz, A., Moya-Pérez, Á., Peiró, G., Zapater, P., González-Navajas, J. M., Giménez, P., Such, J. M., Sanz, Y., et al. (2013) · Liver International · doi:10.1111/liv.12380 · Cited by 42
Antimicrobial proteins: intestinal guards to protect against liver disease
Hendrikx, T., & Schnabl, B. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1521-8 · Cited by 42
Self-citationPathogenesis of Alcoholic Fatty Liver a Narrative Review
Seitz, H. K., Moreira, B., & Neuman, M. G. (2023) · Life · doi:10.3390/life13081662 · Cited by 41
Gut microbiome and intestinal barrier failure – The “Achilles heel” in hepatology?
Benten, D., & Wiest, R. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.03.003 · Cited by 41
Clarembeau, F., Bale, G., & Lanthier, N. (2020) · Clinical Science · doi:10.1042/cs20200022 · Cited by 40
Li, N., Li, J., Zhang, Q., Gao, S., Quan, X., Liu, P., & Xu, C. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116387 · Cited by 41
Human Gut Microbiome and Liver Diseases: From Correlation to Causation
Li, R., Mao, Z., Ye, X., & Zuo, T. (2021) · Microorganisms · doi:10.3390/microorganisms9051017 · Cited by 40
Liu, F., Sun, Z., Hu, P., Tian, Q., Xu, Z., Li, Z., Tian, X., Chen, M., & Huang, C. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.06.028 · Cited by 39
Targeting the Gut–Liver Axis in Cirrhosis: Antibiotics and Non-Selective β-Blockers
Madsen, B. S., Havelund, T., & Krag, A. (2013) · Advances in Therapy · doi:10.1007/s12325-013-0044-1 · Cited by 38
Intestinal Failure-Associated Liver Disease and the Use of Fish Oil-Based Lipid Emulsions
Goulet, O. (2014) · World review of nutrition and dietetics · doi:10.1159/000365604 · Cited by 37
Gut–Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology
Maroni, L., Ninfole, E., Pinto, C., Benedetti, A., & Marzioni, M. (2020) · Cells · doi:10.3390/cells9030736 · Cited by 37
TREM-1 Promotes Survival during Klebsiella pneumoniae Liver Abscess in Mice
Lin, Y.-T., Tseng, K.-Y., Yeh, Y., Yang, F.-C., Fung, C.-P., & Chen, N. (2014) · Infection and Immunity · doi:10.1128/iai.01347-13 · Cited by 36
Outside the liver box: The gut microbiota as pivotal modulator of liver diseases
Wahlstrom, A. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.004 · Cited by 35
Protective Effect of Ursolic Acid on the Intestinal Mucosal Barrier in a Rat Model of Liver Fibrosis
Zhang, W., Gan, D., Jian, J., Huang, C., Luo, F., Wan, S., Jiang, M., Wan, Y., Wang, A., Li, B., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00956 · Cited by 36
Chen, L., Huang, Y., Duan, Z., Huang, P.-Q., Yao, H., Zhou, Y., Ji, Q., & Liu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716209 · Cited by 38
The gut microbiota of nonalcoholic fatty liver disease: current methods and their interpretation
van Best, N., Jansen, P. L. M., & Rensen, S. S. (2015) · Hepatology International · doi:10.1007/s12072-015-9640-2 · Cited by 37
Xu, M.-Y., Guo, C.-C., Li, M., Lou, Y.-H., Chen, Z., Liu, B., & Lan, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1040749 · Cited by 35
Ceccarelli, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16443 · Cited by 34
Cavallari, J. F., Pokrajac, N. T., Zlitni, S., Foley, K. P., Henriksbo, B. D., & Schertzer, J. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00181.2020 · Cited by 36
Zhang, L., Lv, H., Li, Y., Dong, N., Bi, C., Shan, A., Wu, Z., & Shi, B. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107058 · Cited by 35
Contribution of gut microbiota to drug-induced liver injury
Chu, H., Ai, Y., Cheng, Z., Yang, L., & Hou, X. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.06.008 · Cited by 35
Lee, P., Hsieh, Y.-C., Huo, T., Yang, U., Lin, C., Li, C., Huang, Y., Hou, M., Lin, H., & Lee, K. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000937 · Cited by 34
Ma, H., Xu, J., Liu, X., Zhu, Y., Gao, B., Karin, M., Tsukamoto, H., Jeste, D. V., Grant, I., Roberts, A. J., et al. (2016) · Current Pathobiology Reports · doi:10.1007/s40139-016-0097-3 · Cited by 33
Self-citationWang, M., Zhang, X., Yan, C., He, C., Li, P., Chen, M., Su, H., & Wan, J. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.03.012 · Cited by 32
Gut Microbiome Contributes to Liver Fibrosis Impact on T Cell Receptor Immune Repertoire
Liang, Q. D., Zhang, M., Hu, Y., Zhang, W., Zhu, P., Chen, Y., Xue, P., Li, Q., & Wang, K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.571847 · Cited by 33
Zhang, Y., Jiang, W., Xu, J., Wu, N., Wang, Y., Lin, T., Liu, Y., & Liu, Y. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.535940 · Cited by 32
Shi, Y., Leng, Y., Liu, D., Liu, X., Ren, Y., Zhang, J., & Chen, F. (2021) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x21500191 · Cited by 31
Host Factors in Dysregulation of the Gut Barrier Function during Alcohol-Associated Liver Disease
Maccioni, L., Leclercq, I. A., Schnabl, B., & Stärkel, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312687 · Cited by 31
Self-citationDong, X., Feng, X., Liu, J., Xu, Y., Pan, Q., Ling, Z., Yu, J., Yang, J., Li, L., & Cao, H. (2019) · Stem Cells International · doi:10.1155/2019/2403793 · Cited by 29
Kassa, Y., Million, Y., Gedefie, A., & Moges, F. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s305901 · Cited by 29
Meng, Z., Huang, S., Sun, W., Yan, S., Chen, X., Diao, J., Zhou, Z., & Zhu, W. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05508 · Cited by 29
The role of gut microbiota in intestinal and liver diseases
Hrncir, T., Hrncirova, L., Kverka, M., & Tlaskalová‐Hogenová, H. (2018) · Laboratory Animals · doi:10.1177/0023677218818605 · Cited by 29
Targeting Microbiota: What Do We Know about It at Present?
Derovs, A., Laivacuma, S., & Krūmiņa, A. (2019) · Medicina · doi:10.3390/medicina55080459 · Cited by 31
Gut microbiome and liver diseases
Tilg, H., & Moschen, A. R. (2015) · Wiley eBooks · doi:10.1002/9781118663387.ch30 · Cited by 29
l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice
Wu, G., Niu, M., Tang, W., Hu, J., Wei, G., He, Z., Chen, Y., Jiang, Y., & Chen, P. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1718-x · Cited by 27
Xiang, D., Yang, J., Xu, Y., Lan, L., Li, G., Zhang, C., & Liu, D. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119367 · Cited by 27
mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity
Llorente, C., Tonetti, F. R., Bruellman, R., Brea, R., Pell, N., Hartmann, P., Maccioni, L., Han, H., Cabré, N., Liu, J., et al. (2025) · Nature · doi:10.1038/s41586-025-09395-z · Cited by 26
Self-citationNiu, M., Luo, Z., Gong, S., Win, S., Kaplowitz, N., Jiang, Y., & Chen, P. (2020) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.09.009 · Cited by 26
Goodus, M. T., Carson, K. E., Sauerbeck, A. D., Dey, P., Alfredo, A. N., Popovich, P. G., Bruno, R. S., & McTigue, D. M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113725 · Cited by 28
Eritoran Attenuates Hepatic Inflammation and Fibrosis in Mice with Chronic Liver Injury
Hsieh, Y., Lee, K., Wu, P.-S., Huo, T., Huang, Y., Hou, M., & Lin, H. (2021) · Cells · doi:10.3390/cells10061562 · Cited by 28
Microbial Products and Metabolites Contributing to Alcohol‐Related Liver Disease
Gao, B., Emami, A., Nath, S., & Schnabl, B. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000023 · Cited by 25
Self-citationChaurasia, R., Salovey, A., Guo, X., Désir, G. V., & Vinetz, J. M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.926994 · Cited by 25
Zhang, R., Huang, X., Jiang, Y., Li, N., Wang, J., & Chen, S. (2020) · PubMed Central · Cited by 24
Zhang, Y., Li, Y., Mu, T., Tong, N., & Cheng, P. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16209 · Cited by 24
Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
Gerkins, C., Hajjar, R., Oliero, M., & Santos, M. M. (2022) · Journal of Visualized Experiments · doi:10.3791/64710 · Cited by 24
Microbiome-liver crosstalk: A multihit therapeutic target for liver disease
Kirundi, J., Moghadamrad, S., & Urbaniak, C. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i11.1651 · Cited by 24
Murine Model of Chemotherapy-Induced Extraintestinal Pathogenic Escherichia coli Translocation
Green, S. I., Ajami, N. J., Ma, L. M., Poole, N. M., Price, R. E., Petrosino, J. F., & Maresso, A. W. (2015) · Infection and Immunity · doi:10.1128/iai.00684-15 · Cited by 25
Vega‐Magaña, N., Delgado‐Rizo, V., García‐Benavides, L., del Toro‐Arreola, S., Segura‐Ortega, J. E., Zepeda‐Morales, A. S. M., Zepeda-Nuño, J. S., Escarra‐Senmarti, M., Gutiérrez‐Franco, J., Haramati, J., et al. (2018) · Annals of Hepatology · doi:10.5604/01.3001.0010.8663 · Cited by 23
Fu, L., Qian, Y., Shang, Z., Sun, X., Kong, X., & Gao, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.972518 · Cited by 25
Microbiome in Human Health and Disease
Madupu, R., Szpakowski, S., & Nelson, K. E. (2013) · Science Progress · doi:10.3184/003685013x13683759820813 · Cited by 23
Self-citationAdvances in hepatic stem/progenitor cell biology
Verhulst, S., Best, J., van Grunsven, L. A., & Dollé, L. (2015) · PubMed Central · doi:10.17179/excli2014-576 · Cited by 23
Caparrós, E., Juanola, O., Gómez‐Hurtado, I., Puig‐Kröger, A., Piñero, P., Zapater, P., Linares, R., Tarín, F., Martínez‐López, S., Gracia‐Sancho, J., et al. (2020) · Cells · doi:10.3390/cells9051227 · Cited by 23
Gil‐Gómez, A., Brescia, P., Rescigno, M., & Romero‐Gómez, M. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1723752 · Cited by 24
O'Brien, A. J., China, L., Massey, K. A., Nicolaou, A., Winstanley, A. M., Newson, J., Hobbs, A. J., Audzevich, T., & Gilroy, D. W. (2015) · Liver International · doi:10.1111/liv.12876 · Cited by 23
Soriano, G., Sánchez, E., Guarner, C., & Schiffrin, E. J. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.019 · Cited by 22
Bi, C., Xiao, G., Liu, C., Yan, J., Chen, J., Si, W., Zhang, J., & Liu, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.702414 · Cited by 25
Santiago, A., Sánchez, E., Clark, A. P., Pozuelo, M., Calvo, M., Yáñez, F., Sarrabayrouse, G., Perea, L., Vidal, S., Gallardo, A., et al. (2019) · mSystems · doi:10.1128/msystems.00278-18 · Cited by 23
Role of pregnane X-receptor in regulating bacterial translocation in chronic liver diseases
Mohandas, S., & Vairappan, B. (2017) · World Journal of Hepatology · doi:10.4254/wjh.v9.i32.1210 · Cited by 21
Cao, Y. C., Bi, L., Chen, Q., Liu, Y., Zhao, H., Jin, L., & Peng, R. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.124103 · Cited by 23
Sánchez, E., Nieto, J. C., Vidal, S., Santiago, A., Martínez, X., Sancho, F. J., Sancho‐Bru, P., Mirelis, B., Corominola, H., Juárez, C., et al. (2017) · Scientific Reports · doi:10.1038/srep45712 · Cited by 21
Microbiota, Liver Diseases, and Alcohol
Cassard, A., Gérard, P., & Perlemuter, G. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0007-2016 · Cited by 21
Wang, P., Yao, D., Hu, Y., & Li, Y. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.052 · Cited by 21
Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
Bragazzi, M. C., Venere, R., Vignone, A., Alvaro, D., & Cardinale, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076660 · Cited by 21
Cuenca, S., Sánchez, E., Santiago, A., khader, I. E., Panda, S., Vidal, S., Nieto, J. C., Juárez, C., Sancho, F. J., Guarner, F., et al. (2013) · Journal of Innate Immunity · doi:10.1159/000356454 · Cited by 20
Ursolic acid improves the bacterial community mapping of the intestinal tract in liver fibrosis mice
Wan, S., Huang, C., Wang, A., & Zhu, X. (2020) · PeerJ · doi:10.7717/peerj.9050 · Cited by 18
Lou, D., Han, J., Zhou, L., Ma, H., Xv, J., Shou, J., Xu, Z., Jiang, L., & Qian, Y. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6586 · Cited by 19
Pritchard, M. T., & McCracken, J. M. (2015) · Current Drug Targets · doi:10.2174/1389450116666150825111439 · Cited by 19
Model of Liver Fibrosis Induction by Thioacetamide in Rats for Regenerative Therapy Studies
Enciso, N., Amiel-Pérez, J., Domínguez, F. F., Pando, J., Rojas, N., Cisneros-Huamaní, C., Nava, E., & Enciso, J. (2022) · Analytical Cellular Pathology · doi:10.1155/2022/2841894 · Cited by 19
Microbioma y traslocación bacteriana en la cirrosis
Gómez‐Hurtado, I., Such, J. M., & Francés, R. (2016) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2015.10.013 · Cited by 18
Moghadamrad, S., Hassan, M., McCoy, K. D., Kirundi, J., Kellmann, P., & Gottardi, A. D. (2019) · The FASEB Journal · doi:10.1096/fj.201901113r · Cited by 18
The role of the gut microbiome in graft fibrosis after pediatric liver transplantation
Qin, T., Fu, J., & Verkade, H. J. (2020) · Human Genetics · doi:10.1007/s00439-020-02221-8 · Cited by 18
Diet-Regulating Microbiota and Host Immune System in Liver Disease
Eom, J. A., Kwon, G.-H., Kim, N. Y., Park, E. J., Won, S. M., Jeong, J., Ganesan, R., Gupta, H., Gebru, Y. A., Sharma, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126326 · Cited by 18
Ouyang, J., Zaongo, S. D., Zhang, X., Qi, M., Hu, A., Wu, H., & Chen, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.755890 · Cited by 18
Liu, Y., Niu, G., Li, C., Guo, J., Song, J. M., Li, H., & Zhang, X. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.695019 · Cited by 19
Yang, T., Guan, Q., Shi, J., Xu, Z., & Geng, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166664 · Cited by 17
Hu, Y., Ding, X., Liu, H., Ma, W., Feng, X.-Y., & Ma, L. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i11.1556 · Cited by 17
Selective bowel decontamination improves the survival of 90% hepatectomy in rats
Ren, W., Wang, X., Zhang, A., Li, C., Chen, G., Ge, X., Pan, K., & Dong, J. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.01.024 · Cited by 17
Li, Y., Guo, S., Ren, Q., Wei, D., Zhao, M., Su, S., Tang, Z., & Duan, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072047 · Cited by 17
Hepatic Branch Vagotomy Modulates the Gut-Liver-Brain Axis in Murine Cirrhosis
Zhang, Y., Kang, J. D., Zhao, D., Ghosh, S., Wang, Y., Tai, Y., González‐Maeso, J., Sikaroodi, M., Gillevet, P. M., Lippman, H. R., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.702646 · Cited by 17
Park, N.-H., Lee, S.-J., Mechesso, A. F., Boby, N., Yixian, Q., Yoon, W.-K., Lee, S.-P., Lee, J.-S., & Park, S.-C. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-2866-0 · Cited by 16
Lei, W., Zhao, C., Sun, J., Jin, Y., & Duan, Z. (2022) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2022.02.001 · Cited by 16
Zhu, X., Zhou, Z., & Pan, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1342356 · Cited by 17
Metadata
- Authors
- Fouts, D. E., Torralba, M., Nelson, K. E., Brenner, D. A., & Schnabl, B.
- Affiliations
- J. Craig Venter Institute (US)
- University of California San Diego (US)
- Corresponding author
- Schnabl, Bernd
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 56
- Issue
- 6
- Pages
- 1283-1292
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC3357486
- OpenAlex
- W2153223490
- Cited by
- 311
- References
- 52
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 13 · 2023: 24 · 2022: 21 · 2021: 26 · 2020: 31 · 2019: 27 · 2018: 34 · 2017: 20 · 2016: 21 · 2015: 21 · 2014: 21 · 2013: 18 · 2012: 11
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of California, San Diego
- National Institute on Alcohol Abuse and Alcoholism (R01AA020703)
- National Institute of General Medical Sciences (R01GM041804)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK080506, DK 080506, R01DK072237, K08DK081830)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- bacterial translocation, gut microbiota, gut dysbiosis, intestinal permeability, occludin, tight junctions, cholestatic liver injury, common bile duct ligation, carbon tetrachloride, liver fibrosis, Firmicutes, actinobacteria, alcoholic liver disease
- MeSH terms
- Animals, Carbon Tetrachloride, Cholestasis, Disease Models, Animal, Intestines, Liver Diseases, Male, Mice, Inbred BALB C, Permeability, Bacterial Translocation, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
