CoChat
Sign Up
Cited by 128Liver Diseases and ImmunityHealth and Well-being StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Health-related quality of life, depression, and anxiety in patients with autoimmune hepatitis

Schramm, Christoph, Wahl, Inka, Weiler-Normann, Christina, Voigt, Katharina, Wiegard, Christiane, Glaubke, Claudia, Brähler, Elmar, Löwe, Bernd +2 more·2014·Journal of Hepatology
DOI 10.1016/j.jhep.2013.10.035
Open this paper in CoChat — free account

Abstract

Background & aims Improving health related quality of life (HrQoL) in patients with chronic diseases such as autoimmune hepatitis (AIH) should be a major treatment goal. However, little is known on the HrQoL in patients with AIH, and the topic is not given attention in current practice guidelines. We therefore conducted a single center study evaluating HrQoL in 103 consecutive outpatients with AIH.Methods Patient-reported HrQoL data were analysed in relation to clinical disease parameters and compared to representative data of the German population as well as control patients.Results Based on patient-reported data, a major depressive syndrome (10.8%) was found to be five times more frequent in AIH patients compared to the general population (p<0.001). The rate of severe symptoms of anxiety was also found to be significantly increased compared to the general population (p=0.006). In seven of the eleven patients who scored for a major depressive syndrome a psychiatric comorbidity had not been diagnosed before. Major factors associated with depression and anxiety were concerns with regard to the progression of the liver disease.Conclusions This study identified--for the first time--a high rate of previously unrecognized severe symptoms of depression and anxiety in patients with AIH. Of importance for daily clinical practice, the factors associated with these symptoms may in part be amenable to targeted counselling and adequate treatment of the disease, thereby offering the chance to improve the care and HrQoL of AIH-patients.

Integrity signals

Registry

Crossref · 10.1016/j.jhep.2013.10.035

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Schramm and colleagues reported the frequency of moderate anxiety among 103 German patients with autoimmune hepatitis to be twice that observed in the German general population (8.3% vs 4.4%).

    “Schramm and colleagues reported that the frequency of self-reported DEP and moderate ANX among 103 German patients with AIH to be twice that observed in the German general population (ie, 5.9% vs. 2.6% DEP and 8.3% vs. 4.4% ANX).”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [27]

  • Schramm and colleagues reported the frequency of self-reported depression among 103 German patients with autoimmune hepatitis to be twice that observed in the German general population (5.9% vs 2.6%).

    “Schramm and colleagues reported that the frequency of self-reported DEP and moderate ANX among 103 German patients with AIH to be twice that observed in the German general population (ie, 5.9% vs. 2.6% DEP and 8.3% vs. 4.4% ANX).”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [27]

  • 10.8% of patients with autoimmune hepatitis met criteria for major depressive disorder and 4.2% presented with severe anxiety, which were respectively 5 and 4 times greater than rates in the general population (1.9% MDD and 1.1% anxiety).

    “Further, 10.8% of patients with AIH met criteria for MDD and 4.2% presented with severe ANX, which were respectively, 5 and 4 times greater than rates in the general population (ie, 1.9% MDD and 1.1% ANX).[27]”

    From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [27]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Schramm, C., Wahl, I., Weiler-Normann, C., Voigt, K., Wiegard, C., Glaubke, C., Brähler, E., Löwe, B., Lohse, A. W., & Rose, M.
Affiliations
  • University Medical Center Hamburg-Eppendorf (DE)
  • Schön Klinik Hamburg Eilbek (DE)
  • Leipzig University (DE)
Corresponding author
Schramm, Christoph
ORCID
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2014-03
Volume
60
Issue
3
Pages
618-624
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2013.10.035
OpenAlex
W1972531935
Cited by
128
References
36
Citations by year
2026: 12 · 2025: 16 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 3
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Alberta Innovates - Health Solutions
Topics
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
autoimmune hepatitis, health-related quality of life, depression, anxiety, psychiatric comorbidity, patient-reported outcomes, chronic liver disease
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Hepatitis, Autoimmune

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review