Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis
Open accessAbstract
Background & aims Liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) has been shown to predict outcomes of patients with primary biliary cholangitis (PBC) in small-size studies. We aimed to validate the prognostic value of LSM in a large cohort study. Methods We performed an international, multicentre, retrospective follow-up study of 3,985 patients with PBC seen at 23 centres in 12 countries. Eligibility criteria included at least 1 reliable LSM by VCTE and a follow-up ≥ 1 year. Independent derivation (n = 2,740) and validation (n = 568) cohorts were built. The primary endpoint was time to poor clinical outcomes defined as liver-related complications, liver transplantation, or death. Hazard ratios (HRs) with CIs were determined using a time-dependent multivariable Cox regression analysis. Results LSM was independently associated with poor clinical outcomes in the derivation (5,324 LSMs, mean follow-up 5.0 ± 3.1 years) and validation (1,470 LSMs, mean follow-up 5.0 ± 2.8 years) cohorts: adjusted HRs (95% CI) per additional kPa were 1.040 (1.026-1.054) and 1.042 (1.029-1.056), respectively (p <0.0001 for both). Adjusted C-statistics (95% CI) at baseline were 0.83 (0.79-0.87) and 0.92 (0.89-0.95), respectively. Between 5 and 30 kPa, the log-HR increased as a monotonic function of LSM. The predictive value of LSM was stable in time. LSM improved the prognostic ability of biochemical response criteria, fibrosis scores, and prognostic scores. The 8 kPa and 15 kPa cut-offs optimally separated low-, medium-, and high-risk groups. Forty percent of patients were at medium to high risk according to LSM. Conclusions LSM by VCTE is a major, independent, validated predictor of PBC outcome. Its value as a surrogate endpoint for clinical benefit in PBC should be considered. Lay summary Primary biliary cholangitis (PBC) is a chronic autoimmune disease, wherein the body's immune system mistakenly attacks the bile ducts. PBC progresses gradually, so surrogate markers (markers that predict clinically relevant outcomes like the need for a transplant or death long before the event occurs) are often needed to expedite the drug development and approval process. Herein, we show that liver stiffness measurement is a strong predictor of clinical outcomes and could be a useful surrogate endpoint in PBC trials.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A large multicentre retrospective study involving 3985 patients showed that LSM assessed by vibration-controlled transient elastography provided a better prognostic ability than biochemical response.
“A large multicentre retrospective study involving 3985 patients showed that LSM assessed by vibration-controlled transient elastography provided a better prognostic ability than biochemical response.124”
From Primary biliary cholangitis. (2024) · cites this paper as [124]
Cites
Sterling, R. K., Lissen, E., Clumeck, N., Sola, R., Correa, M. C., Montaner, J., S. Sulkowski, M., Torriani, F. J., Dieterich, D. T., Thomas, D. L., et al. (2006) · Hepatology · doi:10.1002/hep.21178 · Cited by 5,021 · see citing works
Baveno VII – Renewing consensus in portal hypertension
de Franchis, R., Bosch, J., Garcia-Tsao, G., Reiberger, T., Ripoll, C., Abraldes, J. G., Albillos, A., Baiges, A., Bajaj, J., Bañares, R., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.12.022 · Cited by 2,930 · see citing works
Self-citationMalinchoc, M., Kamath, P. S., Gordon, F. D., Peine, C. J., Rank, J., & ter Borg, P. C. J. (2000) · Hepatology · doi:10.1053/he.2000.5852 · Cited by 2,893 · see citing works
Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
Sandrin, L., Fourquet, B., Hasquenoph, J.-M., Yon, S., Fournier, C., Mal, F., Christidis, C., Ziol, M., Poulet, B., Kazemi, F., et al. (2003) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2003.07.001 · Cited by 2,734 · see citing works
Berzigotti, A., Tsochatzis, E., Boursier, J., Castera, L., Cazzagon, N., Friedrich-Rust, M., Petta, S., & Thiele, M. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.05.025 · Cited by 1,925 · see citing works
Self-citationPerformance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis
Friedrich‐Rust, M., Ong, M. F., Martens, S., Sarrazin, C., Bojunga, J., Zeuzem, S., & Herrmann, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.034 · Cited by 1,488 · see citing works
Hirschfield, G. M., Beuers, U., Corpechot, C., Invernizzi, P., Jones, D., Marzioni, M., & Schramm, C. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.03.022 · Cited by 1,480 · see citing works
Self-citationSurvival Model Predictive Accuracy and ROC Curves
Heagerty, P. J., & Zheng, Y. (2005) · Biometrics · doi:10.1111/j.0006-341x.2005.030814.x · Cited by 1,471 · see citing works
Pitfalls of Liver Stiffness Measurement: A 5-Year Prospective Study of 13,369 Examinations
Castéra, L., Foucher, J., Bernard, P., Carvalho, F., Allaix, D., Merrouche, W., Couzigou, P., & de Lédinghen, V. (2009) · Hepatology · doi:10.1002/hep.23425 · Cited by 1,157 · see citing works
A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis
Nevens, F., Andreone, P., Mazzella, G., Strasser, S. I., Bowlus, C., Invernizzi, P., Drenth, J. P. H., Pockros, P. J., Regula, J., Beuers, U., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1509840 · Cited by 1,131 · see citing works
Self-citationLindor, K. D., Bowlus, C. L., Boyer, J., Levy, C., & Mayo, M. (2019) · Hepatology · doi:10.1002/hep.30145 · Cited by 913 · see citing works
Determination of reliability criteria for liver stiffness evaluation by transient elastography
Boursier, J., Zarski, J.-P., de Ledinghen, V., Rousselet, M.-C., Sturm, N., Lebail, B., Fouchard-Hubert, I., Gallois, Y., Oberti, F., Bertrais, S., et al. (2013) · Hepatology · doi:10.1002/hep.25993 · Cited by 662 · see citing works
A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis
Corpechot, C., Chazouillères, O., Rousseau, A., Le Gruyer, A., Habersetzer, F., Mathurin, P., Goria, O., Potier, P., Minello, A., Silvain, C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1714519 · Cited by 635 · see citing works
Self-citationCassinotto, C., Boursier, J., de Lédinghen, V., Lebigot, J., Lapuyade, B., Calès, P., Hiriart, J., Michalak, S., Bail, B. L., Cartier, V., et al. (2015) · Hepatology · doi:10.1002/hep.28394 · Cited by 519 · see citing works
Fitting Segmented Regression Models by Grid Search
Lerman, P. M. (1980) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.2307/2346413 · Cited by 505 · see citing works
Lammers, W. J., van Buuren, H. R., Hirschfield, G. M., Janssen, H. L. A., Invernizzi, P., Mason, A. L., Ponsioen, C. Y., Floreani, A., Corpechot, C., Mayo, M. J., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.029 · Cited by 498 · see citing works
Self-citationCorpechot, C., Chazouillères, O., & Poupon, R. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.031 · Cited by 460 · see citing works
Self-citationLammers, W. J., Hirschfield, G. M., Corpechot, C., Nevens, F., Lindor, K. D., Janssen, H. L. A., Floreani, A., Ponsioen, C. Y., Mayo, M. J., Invernizzi, P., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.061 · Cited by 441 · see citing works
Self-citationAssessment of biliary fibrosis by transient elastography in patients with PBC and PSC
Corpechot, C., El Naggar, A., Poujol-Robert, A., Ziol, M., Wendum, D., Chazouillères, O., de Lédinghen, V., Dhumeaux, D., Marcellin, P., Beaugrand, M., et al. (2006) · Hepatology · doi:10.1002/hep.21151 · Cited by 441 · see citing works
Self-citationKang, L., Chen, W., Petrick, N., & Gallas, B. D. (2014) · Statistics in Medicine · doi:10.1002/sim.6370 · Cited by 426 · see citing works
Kumagi, T., Guindi, M., Fischer, S. E., Arenovich, T., Abdalian, R., Coltescu, C., Heathcote, J. E., & Hirschfield, G. M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.216 · Cited by 372 · see citing works
Self-citationCarbone, M., Sharp, S. J., Flack, S., Paximadas, D., Spiess, K., Adgey, C., Griffiths, L., Lim, R., Trembling, P., Williamson, K., et al. (2016) · Hepatology · doi:10.1002/hep.28017 · Cited by 354 · see citing works
Self-citationCorpechot, C., Carrat, F., Poujol-Robert, A., Gaouar, F., Wendum, D., Chazouillères, O., & Poupon, R. (2012) · Hepatology · doi:10.1002/hep.25599 · Cited by 351 · see citing works
Self-citationHirschfield, G. M., Dyson, J. K., Alexander, G. J. M., Chapman, M. H., Collier, J., Hübscher, S., Patanwala, I., Pereira, S. P., Thain, C., Thorburn, D., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315259 · Cited by 347 · see citing works
Self-citationAssessing calibration of prognostic risk scores
Crowson, C. S., Atkinson, E. J., & Therneau, T. M. (2013) · Statistical Methods in Medical Research · doi:10.1177/0962280213497434 · Cited by 295 · see citing works
Harms, M. H., van Buuren, H. R., Corpechot, C., Thorburn, D., Janssen, H. L. A., Lindor, K. D., Hirschfield, G. M., Parés, A., Floreani, A., Mayo, M. J., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.001 · Cited by 289 · see citing works
Self-citationLleo, A., Wang, G.-Q., Gershwin, M. E., & Hirschfield, G. M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31607-x · Cited by 253 · see citing works
Self-citationCritical comparison of elastography methods to assess chronic liver disease
Friedrich‐Rust, M., Poynard, T., & Castéra, L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.86 · Cited by 249 · see citing works
Perez, C., Hirschfield, G. M., Corpechot, C., Floreani, A., Mayo, M. J., van der Meer, A. J., Ponsioen, C. Y., Lammers, W. J., Parés, A. R., Invernizzi, P., et al. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15533 · Cited by 118 · see citing works
Self-citationSilveira, M. G., Brunt, E. M., Heathcote, J., Gores, G. J., Lindor, K. D., & Mayo, M. J. (2010) · Hepatology · doi:10.1002/hep.23637 · Cited by 87 · see citing works
Moctezuma-Velazquez, C., Saffioti, F., Tasayco-Huaman, S., Casu, S., Mason, A., Roccarina, D., Vargas, V., Nilsson, J.-E., Tsochatzis, E., Augustin, S., et al. (2019) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0265-7 · Cited by 78 · see citing works
Self-citationCristoferi, L., Calvaruso, V., Overi, D., Viganò, M., Rigamonti, C., Degasperi, E., Cardinale, V., Labanca, S., Zucchini, N., Fichera, A., et al. (2021) · Hepatology · doi:10.1002/hep.31810 · Cited by 69 · see citing works
Self-citationFloreani, A., Cazzagon, N., Martines, D., Cavalletto, L., Baldo, V., & Chemello, L. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.06.011 · Cited by 68 · see citing works
Self-citationOsman, K. T., Maselli, D. B., Idilman, I. S., Rowan, D. J., Viehman, J. K., Harmsen, W. S., Harnois, D. M., Carey, E. J., Gossard, A. A., LaRusso, N. F., et al. (2021) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001433 · Cited by 64 · see citing works
Self-citation(2020) · Springer eBooks · doi:10.1007/978-3-030-40542-7 · Cited by 31 · see citing works
FibroMeter scores for the assessment of liver fibrosis in patients with autoimmune liver diseases
Zachou, K., Lygoura, V., Arvaniti, P., Giannoulis, G., Gatselis, N., Koukoulis, G. Κ., & Dalekos, G. N. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.10.013 · Cited by 24 · see citing works
Self-citationImproving prognosis in primary biliary cholangitis – Therapeutic options and strategy
Harms, M. H., van Buuren, H. R., & van der Meer, A. J. (2018) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2018.06.004 · Cited by 14 · see citing works
Non-invasive diagnosis and follow-up of primary biliary cholangitis
Corpechot, C., Heurgué, A., Tanné, F., Potier, P., Hanslik, B., Decraecker, M., de Lédinghen, V., Ganne‐Carrié, N., Bureau, C., & Bourlière, M. (2021) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2021.101770 · Cited by 12 · see citing works
Self-citationClinical Trials in PBC Going Forward
Corpechot, C. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1687852 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tanaka, A., Ma, X., Takahashi, A., & Vierling, J. M. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01303-5 · Cited by 177 · see citing works
Primary biliary cholangitis: Epidemiology, prognosis, and treatment
Trivella, J., John, B. V., & Levy, C. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000179 · Cited by 159 · see citing works
Ferraioli, G., Barr, R. G., Berzigotti, A., Sporea, I., Wong, V. W., Reiberger, T., Karlas, T., Thiele, M. S., Cardoso, A. C., Ayonrinde, O. T., et al. (2024) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2024.03.013 · Cited by 160 · see citing works
New Treatment Paradigms in Primary Biliary Cholangitis
Levy, C., Manns, M. P., & Hirschfield, G. M. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.02.005 · Cited by 141 · see citing works
Self-citationNoninvasive Assessment of Liver Fibrosis
Castéra, L., Rinella, M. E., & Tsochatzis, E. A. (2025) · New England Journal of Medicine · doi:10.1056/nejmra2403308 · Cited by 115 · see citing works
Corpechot, C., Lemoinne, S., Soret, P.-A., Hansen, B., Hirschfield, G., Gulamhusein, A., Montano-Loza, A. J., Lytvyak, E., Pares, A., Olivas, I., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000529 · Cited by 94 · see citing works
Self-citationDevelopment and Application of an Advanced Biomedical Material‐Silk Sericin
Wang, J., Liu, H., Shi, X., Qin, S., Liu, J., Lv, Q., Liu, J., Li, Q., Wang, Z., & Wang, L. (2024) · Advanced Materials · doi:10.1002/adma.202311593 · Cited by 89 · see citing works
Nevens, F., Trauner, M. A., & Manns, M. P. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.10.007 · Cited by 51 · see citing works
Self-citationDynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis
Lam, L., Soret, P., Lemoinne, S., Hansen, B. E., Hirschfield, G. M., Gulamhusein, A. F., Montaño‐Loza, A. J., Lytvyak, E., Parés, A. R., Olivas, I., et al. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.06.035 · Cited by 44 · see citing works
Self-citationUpdate on the role of elastography in liver disease
Ferraioli, G., & Roccarina, D. (2022) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848221140657 · Cited by 39 · see citing works
Self-citationNon-Invasive Measurement of Hepatic Fibrosis by Transient Elastography: A Narrative Review
Rinaldi, L., Giorgione, C., Mormone, A., Esposito, F., Rinaldi, M., Berretta, M., Marfella, R., & Romano, C. P. (2023) · Viruses · doi:10.3390/v15081730 · Cited by 39 · see citing works
Primary biliary cholangitis drug evaluation and regulatory approval: Where do we go from here?
Jones, D. E. J., Beuers, U., Bonder, A., Carbone, M., Culver, E., Dyson, J., Gish, R. G., Hansen, B. E., Hirschfield, G., Jones, R., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000864 · Cited by 38 · see citing works
Self-citationPrimary biliary cholangitis: Personalizing second-line therapies
Levy, C., & Bowlus, C. L. (2024) · Hepatology · doi:10.1097/hep.0000000000001166 · Cited by 35 · see citing works
Semmler, G., López, S. A., Pons, M., Lens, S., Dajti, E., Griemsmann, M., Zanetto, A., Burghart, L., Hametner‐Schreil, S., Hartl, L., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.03.015 · Cited by 34 · see citing works
Self-citationGupta, V., Sehrawat, T. S., Pinzani, M., & Strazzabosco, M. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.07.044 · Cited by 35 · see citing works
New Therapies on the Horizon for Primary Biliary Cholangitis
Tanaka, A. (2023) · Drugs · doi:10.1007/s40265-023-01979-1 · Cited by 31 · see citing works
Huang, W., Peng, Y., & Kang, L. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20240010 · Cited by 32 · see citing works
Treatment in primary biliary cholangitis: Beyond ursodeoxycholic acid
van Hooff, M. C., Werner, E., & van der Meer, A. J. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.01.030 · Cited by 27 · see citing works
Guidelines on the Diagnosis and Management of Primary Biliary Cholangitis (2021)
You, H., Duan, W., Li, S., Lv, T., Chen, S., Lu, L., Ma, X., Han, Y., Nan, Y., Xu, X., et al. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00347 · Cited by 29 · see citing works
Current Landscape and Evolving Therapies for Primary Biliary Cholangitis
Fiorucci, S., Urbani, G., Giorgio, C. D., Biagioli, M., & Distrutti, E. (2024) · Cells · doi:10.3390/cells13181580 · Cited by 28 · see citing works
Hernández‐Pérez, M., Riado, D., Pena, E., Méndez, C., Pinedo, F., Ramos, P., Castillo, P., Romero, M., Fernández‐Rodríguez, C., & Olveira, A. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18134 · Cited by 23 · see citing works
Wong, Y. J., Lam, L., Soret, P., Lemoinne, S., Hansen, B. E., Hirschfield, G. M., Gulamhusein, A. F., Lytvyak, E., Parés, A. R., Olivas, I., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.09.024 · Cited by 21 · see citing works
Self-citationHegmar, H., Wester, A., Aleman, S., Backman, J., Degerman, E., Ekvall, H., Lund, K., Lundgren, Å., Nasr, P., Shahnavaz, A., et al. (2024) · Liver International · doi:10.1111/liv.15919 · Cited by 21 · see citing works
Effects of CFTR modulator therapies on liver stiffness and bile flow: A single-centre experience
Calvo, P. L., Giugliano, L., Evangelista, A., Bignamini, E., & Pinon, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.006 · Cited by 19 · see citing works
Ding, D., Guo, G., Cui, L., Jia, G., Wang, X., Zhang, M., Tian, S., Zheng, L., Liu, Y., Hu, Y., et al. (2023) · Hepatology International · doi:10.1007/s12072-023-10587-w · Cited by 18 · see citing works
Primary biliary cholangitis and the narrowing gap towards optimal disease control
Cançado, G. G. L., Lleò, A., Levy, C., Trauner, M., & Hirschfield, G. M. (2025) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(25)00025-1 · Cited by 19 · see citing works
Self-citationLytvyak, E., Hirschfield, G. M., Shreekumar, D., Wong, Y. J., & Montaño‐Loza, A. J. (2025) · Liver International · doi:10.1111/liv.70190 · Cited by 16 · see citing works
Self-citationMontaño‐Loza, A. J., Lytvyak, E., Hirschfield, G. M., Hansen, B. E., Ebadi, M., Berney, T., Toso, C., Magini, G. M., Villamil, A., Nevens, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.05.010 · Cited by 16 · see citing works
Self-citationRigamonti, C., Cittone, M. G., Manfredi, G. F., De Benedittis, C., Paggi, N., Baorda, F., Di Benedetto, D., Minisini, R., & Pirisi, M. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2023.100952 · Cited by 15 · see citing works
Self-citationGóméz, E., Montero, J. L., Molina, E., Garcı́a-Buey, L., Casado, M., Fuentes, J., Simón, M. Á., Díaz‐González, Á., Jorquera, F., Morillas, R. M., et al. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18004 · Cited by 15 · see citing works
Self-citationLiver stiffness measurement predicts clinical outcomes in autoimmune hepatitis
Olivas, I., Arvaniti, P., Gabeta, S., Torres, S. H., Barrio, M. D., Díaz‐González, Á., Esteban, P. P., Riveiro‐Barciela, M., Mauro, E., Rodríguez‐Tajes, S., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101213 · Cited by 15 · see citing works
Self-citationCarbone, M., Gerussi, A., Cardinale, V., Cazzagon, N., Cossiga, V., Lleò, A., Marrone, G., Marzioni, M., Moschetta, A., Muratori, L., et al. (2024) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.05.002 · Cited by 16 · see citing works
Self-citationDing, D., Jia, G., Cui, L., Liu, Y., Wang, X., Sun, R., Deng, J., Guo, G., Shang, Y., & Han, Y. (2025) · Digestive and Liver Disease · doi:10.1016/j.dld.2024.12.024 · Cited by 13 · see citing works
Wiegand, J., Franke, A., Müller, T., Stein, K., Bantel, H., Günther, R., Denk, G., Reuken, P. A., Schattenberg, J. M., Naumann, U., et al. (2024) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2382-7720 · Cited by 12 · see citing works
Self-citationRisk Stratification in Primary Biliary Cholangitis
Martini, F., Balducci, D., Mancinelli, M., Buzzanca, V., Fracchia, E., Tarantino, G., Benedetti, A., Marzioni, M., & Maroni, L. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175713 · Cited by 9 · see citing works
Prognostic models and autoimmune liver diseases
D’Amato, D., & Carbone, M. (2023) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2023.101878 · Cited by 10 · see citing works
Self-citationThe Treatment of Primary Biliary Cholangitis: Time for Personalized Medicine
Men, X., Liu, Y., Zhao, H., Xie, B., Guo, C., Leung, P. S. C., Timilsina, S., Gershwin, M. E., Shang, Y., & Han, Y. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09074-x · Cited by 8 · see citing works
Corpechot, C., Hornus, P., Cals, M., Rinder, P., Marcille, T., Malek, A., Belkacem, K. B., Gaouar, F., Chabane, Y., Corret, P., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101546 · Cited by 8 · see citing works
Self-citationDíaz‐González, Á., Schregel, I., Carballo‐Folgoso, L., Álvarez‐Navascués, C., Frisancho-Morales, E., Miquel, M., Garcı́a-Retortillo, M., Gómez, J., Horta, D., Mateos, B., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101562 · Cited by 8 · see citing works
Self-citationAbbas, N., Smith, R. A., Lytvyak, E., Scraravaglio, M., Halliday, N., Almahroos, A., Eden, N., Lloyd‐Madden, D., Sharma, S., Ferguson, J., et al. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70378 · Cited by 8 · see citing works
Self-citationTransient Elastography and Fibroscan: Stethoscope of a Hepatologist in Today’s World
Jalil, S., Pagadala, M. R., Dunn, N., Blaney, H. L., Elfeki, M. A., Thakral, N., & Singal, A. K. (2025) · Current Hepatology Reports · doi:10.1007/s11901-025-00713-7 · Cited by 8 · see citing works
Roccarina, D., Saffioti, F., Rosselli, M., Marshall, A., Pinzani, M., & Thorburn, D. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100873 · Cited by 8 · see citing works
Self-citationAdvances in clinical detection methods and nanomaterials for autoimmune liver diseases
Chen, J., Zhu, Y., Wang, Q., Ding, J., & Chen, X. (2023) · Nano TransMed · doi:10.1016/j.ntm.2023.100003 · Cited by 8 · see citing works
Terracciani, F., Vincentis, A. D., D’Amato, D., Cristoferi, L., Gerussi, A., Invernizzi, P., Scaravaglio, M., Vanni, E., Campion, D., Morgando, A., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101448 · Cited by 7 · see citing works
Self-citationTana, M. M.-S., & Hirschfield, G. M. (2025) · JAMA · doi:10.1001/jama.2025.20067 · Cited by 7 · see citing works
Self-citationEvaluating the safety and efficacy of seladelpar for adults with primary biliary cholangitis
Caines, A., Trudeau, S., & Gordon, S. C. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2390120 · Cited by 7 · see citing works
Autorinnen/Autoren, & Collaborators (2025) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2558-5204 · Cited by 6 · see citing works
Primary biliary cholangitis (PBC): evolving approaches and expert perspectives
Invernizzi, P., Aghemo, A., Calvaruso, V., Lleò, A., Marzioni, M., Piscaglia, F., Rigamonti, C., Gentilucci, U. V., Brillanti, S., Carbone, M., et al. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2601220 · Cited by 6 · see citing works
Self-citationDing, D., Hu, Y., Jia, G., Wang, B., Zheng, L., Deng, J., Sun, R., Wang, X., Guo, G., Cui, L., et al. (2024) · Hepatology International · doi:10.1007/s12072-024-10743-w · Cited by 6 · see citing works
Noninvasive Evaluation of Fibrosis and Portal Hypertension in Primary Biliary Cholangitis
Corpechot, C. (2022) · Clinics in Liver Disease · doi:10.1016/j.cld.2022.06.010 · Cited by 6 · see citing works
Self-citationTanaka, A., Treeprasertsuk, S., Chang, M., Tan, S.-S., Efe, C., Jeong, S., Ma, X., Weltman, M., Isayama, H., & Jia, J. (2025) · Hepatology International · doi:10.1007/s12072-025-10965-6 · Cited by 5 · see citing works
van Hooff, M. C., de Veer, R. C., Werner, E., Beuers, U. H., Drenth, J. P. H., Cuperus, F. J. C., van Hoek, B., Veldt, B. J., Klemt‐Kropp, M., van Meer, S., et al. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003879 · Cited by 5 · see citing works
Self-citationLevy, C., Lleo, A., Martins, A., Scaravaglio, M., Bowlus, C. L., Carbone, M., Corpechot, C., Couto, C. A., Hansen, B. E., Hirschfield, G. M., et al. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2026.03.038 · Cited by 7 · see citing works
Self-citationChe, L., Jiang, R., Wang, C., He, J., Zhang, Z. J., & Qian, B. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002680 · Cited by 5 · see citing works
Biris, A. I., Karamatzanis, I., Biri, D., Biris, I. A., & Maravegias, N. (2024) · Cureus · doi:10.7759/cureus.72087 · Cited by 5 · see citing works
Rigopoulou, E. I., Lygoura, V., Gabeta, S., Gatselis, N., Giannoulis, G., & Dalekos, G. Ν. (2025) · Liver International · doi:10.1111/liv.70074 · Cited by 5 · see citing works
Self-citationAdvancing care in primary biliary cholangitis: emerging insights and novel therapies
Vögelin, M., & Kremer, A. E. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2516622 · Cited by 5 · see citing works
Self-citationShen, Y. G., Chen, H., Wu, S., & Jiang, W. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.08.013 · Cited by 5 · see citing works
Werner, E., van Hooff, M. C., Weijsters, G. H. X., Abbas, N., Gerussi, A., Willemse, J., Mitchell-Thain, R., Leburgue, A., Hirschfield, G. M., Corpechot, C., et al. (2025) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2025.01.037 · Cited by 4 · see citing works
Self-citationPrimary cilium‐mediated signaling cascade suppresses age‐related biliary fibrosis
Hong, R., Tian, X., Ma, H., Ni, H., Yang, J. N., Bu, W., Li, T., Yang, S., Li, D., Liu, M., et al. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31113 · Cited by 4 · see citing works
Pharmacologic Treatment of Portal Hypertension
Wong, Y. J., & Abraldeṣ, J. G. (2024) · Clinics in Liver Disease · doi:10.1016/j.cld.2024.03.002 · Cited by 4 · see citing works
Optimizing treatment of primary biliary cholangitis: Is good, good enough?
Bowlus, C. L., & Levy, C. (2023) · Hepatology · doi:10.1097/hep.0000000000000556 · Cited by 4 · see citing works
Díaz‐González, Á., Molera, C., Domínguez, E. G., Muñoz‐Bartolo, G., Ampuero, J., Fernández‐Rodríguez, C., Quintero, J., Molina, E., Salcedo, M., Olveira, A., et al. (2025) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2026.502629 · Cited by 3 · see citing works
Liu, Z., Jiang, H., Li, F., Xie, R., & Wang, H. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70189 · Cited by 3 · see citing works
Werner, E., van Hooff, M. C., Weijsters, G. H. X., van de Vrie, M. A., de Veer, R. C., Beuers, U. H., Drenth, J. P. H., Cuperus, F. J. C., van Dijk, R., Veldt, B. J., et al. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70669 · Cited by 3 · see citing works
Self-citationThe unhealthy lifestyle in primary biliary cholangitis: An enemy to fight
Cossiga, V., Cazzagon, N., Montalti, R., Ciminnisi, S., Attanasio, M. R., Pezzato, F., Giacchetto, M., Guarino, M., Calvaruso, V., Floreani, A., et al. (2022) · Digestive and Liver Disease · doi:10.1016/j.dld.2022.12.009 · Cited by 3 · see citing works
Self-citationCurrent and future opportunities for the management of primary biliary cholangitis
Naffouj, S., & Wang, J. R. (2023) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2023.1241901 · Cited by 3 · see citing works
Gerussi, A., Nofit, E., Bernasconi, D. P., Kroll, C., Groß, F., Schregel, I., Marini, A., Cristoferi, L., Malinverno, F., Papp, M., et al. (2025) · United European Gastroenterology Journal · doi:10.1002/ueg2.70134 · Cited by 3 · see citing works
Self-citationNoninvasive evaluation of fibrosis in adult biliary diseases
Helgadóttir, H., & Vesterhus, M. N. (2023) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000909 · Cited by 3 · see citing works
Wang, H., Li, Y., Pu, X., Liang, X. S., Tang, R., & Ma, X. (2023) · Journal of Gastroenterology · doi:10.1007/s00535-023-02045-z · Cited by 3 · see citing works
Cançado, G. G. L., Gomes, N. M. D. F., Couto, C. A., Cançado, E. L. R., Terrabuio, D. R. B., Villela‐Nogueira, C. A., Braga, M. H., Nardelli, M. J., Faria, L. C., Oliveira, E. M. G., et al. (2024) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002744 · Cited by 3 · see citing works
Primary biliary cholangitis: personalized medicine for optimal therapeutic opportunities
Shang, Y., Leung, P. S. C., Gershwin, M. E., & Han, Y. (2022) · 中国科学通报：英文版 · doi:10.1016/j.scib.2022.11.029 · Cited by 3 · see citing works
Wiegand, J., Franke, A., Stein, K., Trautwein, C., & Berg, T. (2023) · Hepatology · doi:10.1097/hep.0000000000000744 · Cited by 3 · see citing works
Corpechot, C., Lemoinne, S., Soret, P., Chazouillères, O., & de Lédinghen, V. (2023) · Hepatology · doi:10.1097/hep.0000000000000746 · Cited by 3 · see citing works
Self-citationChen, J., Hou, Y., Liu, Y., Jiang, Y., & Wang, X. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i41.111256 · Cited by 2 · see citing works
Maxwell, M., Deng, Y., Chen, B., Silveira, M. G., Boyer, J. L., & Assis, D. N. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70574 · Cited by 2 · see citing works
AI in the Prediction of Hepatic Fibrosis Progression Using Non-Coding RNAs
Roy, D., Hussain, M. S., Khan, Y., Patel, D. N., Smerat, A., Bainsal, N., Ashique, S., Kumar, D. A., Khan, I. A., Ochilova, D., et al. (2026) · Clinica Chimica Acta · doi:10.1016/j.cca.2026.120973 · Cited by 2 · see citing works
Sebode, M., Bantel, H., Baumann, U., Bufler, P., Demir, M., Dold, L., Keitel, V., Klein, R., Kremer, A. E., Jansen, P. L., et al. (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2769-2475 · Cited by 2 · see citing works
Self-citationPrognostic modeling in biliary diseases
Ciobanu, C., & Russo, M. W. (2023) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000911 · Cited by 2 · see citing works
Mechanical mechanics-reclaiming a new battlefield for chronic liver disease
Zhang, Y., Ma, T., Lu, X., Hua, H., Wu, L., & Chen, Z. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.028 · Cited by 2 · see citing works
Rigamonti, C., Benedittis, C. D., Labanca, S., Vanni, E., Morgando, A., Manfredi, G. F., Azzolina, D., Cittone, M. G., Giannini, E. G., Saracco, G. M., et al. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002582 · Cited by 2 · see citing works
Self-citationUltrasound imaging findings in primary biliary cholangitis
Zhang, Y., Hu, X., Chang, J. K., Li, W., Huang, C., Zhang, H., Shen, J., Shang, N., & Meng, F. (2023) · BMC Gastroenterology · doi:10.1186/s12876-023-03083-w · Cited by 2 · see citing works
Ritter, T. E., Hanson, C., Fernandes, C. T., MacEwan, J. P., Zhao, X., Parzynski, C. S., Mercer, D., Ness, E., Wheeler, D., Kowdley, K. V., et al. (2025) · Journal of Comparative Effectiveness Research · doi:10.57264/cer-2024-0198 · Cited by 1 · see citing works
Optimizing Care in Primary Biliary Cholangitis: Current Treatments and the Second-Line Decision
Choi, G., Jesudian, A. B., & Saab, S. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09537-3 · Cited by 1 · see citing works
Romeo, M., Nardo, F. D., Basile, C., Napolitano, C., Vaia, P., Martinelli, G., Gregorio, A. D., Puorto, L. D., Indipendente, M., Dallio, M., et al. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15120597 · Cited by 2 · see citing works
Stein, K., Hofmann, W. P., Franke, A., Petroff, D., Müller, T., Bantel, H., Günther, R., Denk, G., Reuken, P. A., Schattenberg, J. M., et al. (2025) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2721-1160 · Cited by 1 · see citing works
Self-citationWilliams, E. E., Lammert, C. S., & Vuppalanchi, R. (2026) · Digestive Diseases and Sciences · doi:10.1007/s10620-026-09672-5 · Cited by 1 · see citing works
Barrio, M. D., Sala, M., Gómez, J., Horta, D., Hernández‐Guerra, M., Salcedo, M., Goñi, S., León, R. R., Herreros, Á. M., Santiago, J. M. G., et al. (2026) · Liver International · doi:10.1111/liv.70713 · Cited by 1 · see citing works
Bowlus, C. L., Nevens, F., Kowdley, K. V., Bonder, A., Capozza, T. A., Li, J., Nair, R., Trauner, M. A., & Jones, D. E. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70832 · Cited by 1 · see citing works
Self-citationChazouillères, O., Bellet, J., Schramm, C., Trivedi, P., Thorburn, D., Färkkilä, M., Floreani, A., Pares, A., Levy, C., Beuers, U., et al. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.07.019 · Cited by 1 · see citing works
Self-citationCamilleri, M., & Ford, A. C. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18527 · Cited by 1 · see citing works
Ding, D., Jia, G., Guo, G., Cui, L., & Han, Y. (2025) · Hepatology International · doi:10.1007/s12072-025-10820-8 · Cited by 1 · see citing works
Kugiyama, Y., Abe, M., Namisaki, T., Yoshiji, H., Abe, K., Ohira, H., Shirahashi, R., Yokoyama, K., Fukunaga, A., Kawata, K., et al. (2025) · Hepatology Research · doi:10.1111/hepr.70035 · Cited by 1 · see citing works
Va, I., & Goncharov, A. A. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i8.115416 · Cited by 1 · see citing works
Diagnostik- und Therapieleitfaden 2023 für PBC in Österreich
Peck‐Radosavljevic, M., Aigner, E. S., Ferlitsch, A., Graziadei, I. W., Gschwantler, M., Halilbasic, E., Hametner‐Schreil, S., Putz‐Bankuti, C., & Reiberger, T. (2023) · Journal für Gastroenterologische und Hepatologische Erkrankungen · doi:10.1007/s41971-023-00151-6
Yao, D.-W., Jiang, H.-X., & Qin, S. (2024) · Hepatitis Monthly · doi:10.5812/hepatmon-138304
Roberts, E. (2024) · EMJ Hepatology · doi:10.33590/emjhepatol/pgqp6795
Khakoo, N. S., & Levy, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00039-4
Li, Z., Zhang, F., Lu, W., Lü, C., Yuan, Z., & Wang, Z. (2025) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/0115734056379090250611073434
Neue Standards in der Behandlung der primären biliären Cholangitis
Vögelin, M., & Kremer, A. E. (2025) · Schweizer Gastroenterologie · doi:10.1007/s43472-025-00173-w
Self-citation
- Authors
- Corpechot, C., Carrat, F., Gaouar, F., Chau, F., Hirschfield, G., Gulamhusein, A., Montano-Loza, A. J., Lytvyak, E., Schramm, C., Pares, A., Olivas, I., Eaton, J. E., Osman, K. T., Dalekos, G., Gatselis, N., Nevens, F., Cazzagon, N., Zago, A., Russo, F. P., Abbas, N., Trivedi, P., Thorburn, D., Saffioti, F., Barkai, L., Roccarina, D., Calvaruso, V., Fichera, A., Delamarre, A., Medina-Morales, E., Bonder, A., Patwardhan, V., Rigamonti, C., Carbone, M., Invernizzi, P., Cristoferi, L., van der Meer, A., de Veer, R., Zigmond, E., Yehezkel, E., Kremer, A. E., Deibel, A., Dumortier, J., Bruns, T., Große, K., Pageaux, G.-P., Wetten, A., Dyson, J., Jones, D., Chazouillères, O., Hansen, B., & de Lédinghen, V.
- Affiliations
- Inserm (FR)
- Sorbonne Université (FR)
- University Health Network (CA)
- University of Alberta (CA)
- Universität Hamburg (DE)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Mayo Clinic (US)
- University Hospital of Larissa (GR)
- Universitair Ziekenhuis Leuven (BE)
- University of Padua (IT)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- The Royal Free Hospital (GB)
- University of Palermo (IT)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Beth Israel Deaconess Medical Center (US)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Milano-Bicocca (IT)
- Tel Aviv Sourasky Medical Center (IL)
- University Hospital Zurich (CH)
- Hospices Civils de Lyon (FR)
- Universitätsklinikum Aachen (DE)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Newcastle upon Tyne Hospital (GB)
- Corresponding author
- Corpechot, Christophe
- ORCID
- Corpechot, Christophe
- Carrat, Fabrice
- Hirschfield, Gideon
- Gulamhusein, Aliya
- Lytvyak, Ellina
- Schramm, Christoph
- Pares, Albert
- Olivas, Ignasi
- Eaton, John E.
- Osman, Karim T.
- Dalekos, George
- Gatselis, Nikolaos
- Nevens, Frederik
- Cazzagon, Nora
- Zago, Alessandra
- Russo, Francesco Paolo
- Abbas, Nadir
- Trivedi, Palak
- Thorburn, Douglas
- Saffioti, Francesca
- Roccarina, Davide
- Delamarre, Adèle
- Medina-Morales, Esli
- Bonder, Alan
- Patwardhan, Vilas
- Rigamonti, Cristina
- Carbone, Marco
- Invernizzi, Pietro
- Cristoferi, Laura
- van der Meer, Adriaan
- Zigmond, Ehud
- Yehezkel, Eyal
- Kremer, Andreas E.
- Deibel, Ansgar
- Dumortier, Jérôme
- Bruns, Tony
- Große, Karsten
- Pageaux, Georges-Philippe
- Wetten, Aaron
- Dyson, Jessica
- Chazouillères, Olivier
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 77
- Issue
- 6
- Pages
- 1545-1553
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W4283645165
- Cited by
- 128
- References
- 40
- Citations by year
- 2026: 30 · 2025: 40 · 2024: 27 · 2023: 25 · 2022: 6
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Hepatology (acceptedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by-nc-nd)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion, other-oa)
- BOA (University of Milano-Bicocca) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Falk Foundation
- GlaxoSmithKline
- Inventiva Pharma
- National Institute for Health and Care Research (NIHR200243, NF-SI-0513-10091)
- Swedish Orphan Biovitrum
- Grifols
- Medical Research Council (MR/L001489/1)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- primary biliary cirrhosis, liver stiffness measurement, vibration-controlled transient elastography, prognosis, liver complications, liver transplantation, mortality, liver fibrosis, surrogate endpoints, risk stratification, cut-off values, prognostic validation, fibrosis score, autoimmune liver disease, time-dependent Cox regression, concordance index
- MeSH terms
- Follow-Up Studies, Humans, Liver, Liver Cirrhosis, Liver Cirrhosis, Biliary, Prognosis, Retrospective Studies, Vibration, Cohort Studies, Elasticity Imaging Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
