The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Human Skin Is the Largest Epithelial Surface for Interaction with Microbes
Open accessAbstract
Human skin contains an abundant and diverse population of microbial organisms. Many of these microbes inhabit follicular structures of the skin. Furthermore, numerous studies have shown that the interaction of some members of the skin microbiome with host cells will result in changes in cell function. However, estimates of the potential for the microbiome to influence human health through skin have ignored the inner follicular surface, and therefore vastly underestimated the potential of the skin microbiome to have a systemic effect on the human body. By calculating the surface area of follicular and the interfollicular epithelial surface it is shown that skin provides a vast interface for interactions with the microbiome.
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Citations
Cites
Simplified calculation of body surface area
(1987) · New England Journal of Medicine · doi:10.1056/nejm198710223171717 · Cited by 3,238
Signals from the gut microbiota to distant organs in physiology and disease
Schroeder, B. O., & Bäckhed, F. (2016) · Nature Medicine · doi:10.1038/nm.4185 · Cited by 1,409
Compartmentalized Control of Skin Immunity by Resident Commensals
Naik, S., Bouladoux, N., Wilhelm, C., Molloy, M. J., Salcedo, R., Kastenmuller, W., Deming, C., Quinones, M., Koo, L., Conlan, S., et al. (2012) · Science · doi:10.1126/science.1225152 · Cited by 1,092
Skin microbiota: a source of disease or defence?
Cogen, A. L., Nizet, V., & Gallo, R. L. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08437.x · Cited by 952
Self-citationSurface area of the digestive tract – revisited
Helander, H. F., & Fändriks, L. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.898326 · Cited by 860
Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781
Self-citationFunctions of the skin microbiota in health and disease
Sanford, J. A., & Gallo, R. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.005 · Cited by 479
Self-citationThe microbiome extends to subepidermal compartments of normal skin
Nakatsuji, T., Chiang, H.-I., Jiang, S. B., Nagarajan, H., Zengler, K., & Gallo, R. L. (2013) · Nature Communications · doi:10.1038/ncomms2441 · Cited by 450 · cited 1×
“A careful study of the skin using laser-capture microdissection and in situ hybridization has revealed that microbes reside not only on the external interfollicular epithelial surface but also on the entire skin appendage surface and even below the basement membrane (Nakatsuji et al., 2013, 2016).”
BackgroundSelf-citationNakatsuji, T., Chen, T. H., Two, A. M., Chun, K. A., Narala, S., Geha, R. S., Hata, T. R., & Gallo, R. L. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.05.127 · Cited by 362
Self-citationDistribution of Bacteria in the Epidermal Layers and Hair Follicles of the Human Skin
Lange‐Asschenfeldt, B., Marenbach, D., Lang, C., Patzelt, A., Ulrich, M., Maltusch, A., Terhorst‐Molawi, D., Stockfleth, E., Sterry, W., & Lademann, J. M. (2011) · Skin Pharmacology and Physiology · doi:10.1159/000328728 · Cited by 160
Cited by
The microbiome in patients with atopic dermatitis
Paller, A. S., Kong, H. H., Seed, P., Naik, S., Scharschmidt, T. C., Gallo, R. L., Luger, T., & Irvine, A. D. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.015 · Cited by 525
Self-citationMahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 466
Staphylococcus epidermidis and its dual lifestyle in skin health and infection
Severn, M. M., & Horswill, A. R. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00780-3 · Cited by 355
Challenges in exploring and manipulating the human skin microbiome
Boxberger, M., Cenizo, V., Cassir, N., & La Scola, B. (2021) · Microbiome · doi:10.1186/s40168-021-01062-5 · Cited by 247
The Human Skin Microbiome in Selected Cutaneous Diseases
Carmona-Cruz, S., Orozco-Covarrubias, L., & Sáez-de-Ocariz, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.834135 · Cited by 170
Metadata
- Authors
- Gallo, R. L.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 137
- Issue
- 6
- Pages
- 1213-1214
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2605292630
- Cited by
- 341
- References
- 12
- FWCI
- 14.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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