The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Toll-Like Receptors in Antiviral Innate Immunity
Open accessAbstract
Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune system, which detect conserved molecular signatures of a wide range of microbial pathogens and initiate innate immune responses via distinct signaling pathways. Various TLRs are implicated in the early interplay of host cells with invading viruses, which regulates viral replication and/or host responses, ultimately impacting on viral pathogenesis. To survive the host innate defense mechanisms, many viruses have developed strategies to evade or counteract signaling through the TLR pathways, creating an advantageous environment for their propagation. Here we review the current knowledge of the roles TLRs play in antiviral innate immune responses, discuss examples of TLR-mediated viral recognition, and describe strategies used by viruses to antagonize the host antiviral innate immune responses.
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Cites
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A Toll-like receptor recognizes bacterial DNA
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“TLR9 recognizes unmethylated CpG motifs that are commonly found in bacterial and viral DNA [133,134].”
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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
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Toll-like receptors in innate immunity
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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
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Decoding the Patterns of Self and Nonself by the Innate Immune System
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Cited by
Zhang, Q.-S., Heng, Y., Yuan, Y.-H., & Chen, N.-H. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2016.11.002 · Cited by 156
Abdul-Cader, M. S., Amarasinghe, A., & Abdul-Careem, M. F. (2016) · Archives of Virology · doi:10.1007/s00705-016-2904-x · Cited by 99
Tripathi, U., Nchioua, R., Prata, L. G. P. L., Zhu, Y., Gerdes, E. O. W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espindola-Netto, J. M., et al. (2021) · Aging · doi:10.18632/aging.203560 · Cited by 88
Precision-cut human liver slice cultures as an immunological platform
Wu, X., Roberto, J. B., Knupp, A., Kenerson, H. L., Truong, C. D., Yuen, S. Y., Brempelis, K. J., Tuefferd, M., Chen, A., Horton, H., et al. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.01.012 · Cited by 81
Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?
Wang, Y., Jia, J., Wang, Y., Li, F., Song, X., Qin, S., Wang, Z., Kitazato, K., & Wang, Y. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1660615 · Cited by 40
Metadata
- Authors
- Lester, S. N., & Li, K.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 426
- Issue
- 6
- Pages
- 1246-1264
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2052046406
- Cited by
- 735
- References
- 18
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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