The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An Interfacial Sodium Ion is an Essential Structural Feature of Fluc Family Fluoride Channels
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In the citing paper
“In contrast, CrcB export proteins function as passive fluoride-specific ion channels that require Na+ ions for transport activity (4, 5, 23–26).”
From Adaptive evolution of Pseudomonas putida in the presence of fluoride exposes novel functions of a benzoate transporter (2026) · cites this paper as [23]
In the citing paper
“This Na+, together with a universally conserved arginine residue, R22, render the vestibules electropositive, and both R22 and the Na+ are essential for fluoride permeation(75).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [75]
In the citing paper
“This Na+, together with a universally conserved arginine residue, R22, render the vestibules electropositive, and both R22 and the Na+ are essential for fluoride permeation(75).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [75]
In the citing paper
“Of dozens of mutations, none have allowed detectable throughput of any other anion, and increasing the bore of the channel by paring back sidechains has not yet been shown to decrease selectivity(73, 75, 76, 85).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [75]
In the citing paper
“Although there is no known precedent among membrane proteins for such a non-transported structural Na+, the binding site on the symmetry axis, coordinated by backbone carbonyl oxygens, resembles some Na+ binding sites in Na+-coupled transporters(75).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [75]
In the citing paper
“Of dozens of mutations, none have allowed detectable throughput of any other anion, and increasing the bore of the channel by paring back sidechains has not yet been shown to decrease selectivity(73, 75, 76, 85).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [75]
In the citing paper
“This structural Na+ ion is deeply buried, stably bound, and likely inserted upon dimer assembly(75).”
From Membrane exporters of fluoride ion (2021) · cites this paper as [75]
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Citations
Cites
Crystal structures of a double-barrelled fluoride ion channel
Stockbridge, R. B., Kolmakova-Partensky, L., Shane, T., Koide, A., Koide, S., Miller, C., & Newstead, S. (2015) · Nature · doi:10.1038/nature14981 · Cited by 119
Self-citationBacterial fluoride resistance, Fluc channels, and the weak acid accumulation effect
Ji, C., Stockbridge, R. B., & Miller, C. (2014) · Journal of General Physiology · doi:10.1085/jgp.201411243 · Cited by 97
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Research works printed but not linked: 33
- Baker, 2012, Widespread genetic switches and toxicity resistance proteins for fluoride, Science, 335, 233, 10.1126/science.1215063 · DOI · Paper page
- Stockbridge, 2013, A family of fluoride-specific ion channels with dual-topology architecture, Elife, 2
- Stockbridge, 2014, Proof of dual-topology architecture of Fluc F- channels with monobody blockers, Nat. Commun., 5, 5120, 10.1038/ncomms6120 · DOI · Paper page
- Forrest, 2015, Structural symmetry in membrane proteins, Annu. Rev. Biophys., 44, 311, 10.1146/annurev-biophys-051013-023008 · DOI · Paper page
- Nasie, 2010, Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transporters, J. Biol. Chem., 285, 15234, 10.1074/jbc.M110.108746 · DOI
- Keller, 2014, When two turn into one: evolution of membrane transporters from half modules, Biol. Chem., 395, 1379, 10.1515/hsz-2014-0224 · DOI · Paper page
- Last, 2016, Mechanistic signs of double-barreled structure in a fluoride ion channel, Elife, 5, 10.7554/eLife.18767 · DOI · Paper page
- Last, 2017, Molecular determinants of permeation in a fluoride-specific ion channel, Elife, 6, 10.7554/eLife.31259 · DOI · Paper page
- McIlwain, 2018, Cork-in-Bottle occlusion of fluoride ion channels by crystallization chaperones, Structure, 26, 635, 10.1016/j.str.2018.02.004 · DOI · Paper page
- Turman, 2018, Molecular interactions between a fluoride ion channel and synthetic protein blockers, Biochemistry, 57, 1212, 10.1021/acs.biochem.7b01272 · DOI · Paper page
- Last, 2018, A CLC-type F(-)/H(+) antiporter in ion-swapped conformations, Nat. Struct. Mol. Biol., 25, 601, 10.1038/s41594-018-0082-0 · DOI · Paper page
- Penmatsa, 2013, X-ray structure of dopamine transporter elucidates antidepressant mechanism, Nature, 503, 85, 10.1038/nature12533 · DOI
- Yamashita, 2005, Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters, Nature, 437, 215, 10.1038/nature03978 · DOI
- Wohlert, 2015, Mechanism of Na(+)-dependent citrate transport from the structure of an asymmetrical CitS dimer, Elife, 4, 10.7554/eLife.09375 · DOI
- Hu, 2011, Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT, Nature, 478, 408, 10.1038/nature10450 · DOI
- Sarti, 2019, EncoMPASS: an online database for analyzing structure and symmetry in membrane proteins, Nucleic Acids Res., 47, D315, 10.1093/nar/gky952 · DOI
- Dudev, 2018, Competition between Li(+) and Na(+) in sodium transporters and receptors: which Na(+)-Binding sites are "therapeutic" Li(+) targets?, Chem. Sci., 9, 4093, 10.1039/C7SC05284G · DOI
- Lev, 2013, Relative free energies for hydration of monovalent ions from QM and QM/MM simulations, J. Chem. Theory Comput., 9, 4165, 10.1021/ct400296w · DOI
- Turman, 2017, Mechanism of single- and double-sided inhibition of dual topology fluoride channels by synthetic monobodies, J. Gen. Physiol., 149, 511, 10.1085/jgp.201611747 · DOI · Paper page
- Chadda, 2016, The dimerization equilibrium of a ClC Cl(-)/H(+) antiporter in lipid bilayers, Elife, 5, 10.7554/eLife.17438 · DOI
- Salgado, 2010, Metal templated design of protein interfaces, Proc. Natl. Acad. Sci. U. S. A., 107, 1827, 10.1073/pnas.0906852107 · DOI
- Der, 2012, Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering, Biochemistry, 51, 3933, 10.1021/bi201881p · DOI
- Der, 2012, Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer, J. Am. Chem. Soc., 134, 375, 10.1021/ja208015j · DOI
- Torrance, 2009, A novel main chain motif in proteins bridged by cationic groups: the niche, J. Mol. Biol., 385, 1076, 10.1016/j.jmb.2008.11.007 · DOI
- Dudev, 2016, Factors controlling the selectivity for Na(+) over Mg(2+) in sodium transporters and enzymes, Phys. Chem. Chem. Phys., 18, 16986, 10.1039/C6CP01937D · DOI
- Screpanti, 2007, Discontinuous membrane helices in transport proteins and their correlation with function, J. Struct. Biol., 159, 261, 10.1016/j.jsb.2007.01.011 · DOI
- Macdonald, 2017, A topologically diverse family of fluoride channels, Curr. Opin. Struct. Biol., 45, 142, 10.1016/j.sbi.2017.04.003 · DOI · Paper page
- Li, 2013, Eukaryotic resistance to fluoride toxicity mediated by a widespread family of fluoride export proteins, Proc. Natl. Acad. Sci., 110, 19018, 10.1073/pnas.1310439110 · DOI · Paper page
- Zhang, 2018, Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT, Proc. Natl. Acad. Sci. U. S. A., 115, E8854, 10.1073/pnas.1716870115 · DOI
- Coleman, 2019, Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport, Nature, 569, 141, 10.1038/s41586-019-1135-1 · DOI
- Rudnick, 2019, Serotonin transport in the 21st century, J. Gen. Physiol., 151, 1248, 10.1085/jgp.201812066 · DOI
- Rudnick, 1983, Sodium ion requirements for serotonin transport and imipramine binding, Psychopharmacol. Bull., 19, 545
- Brammer, 2014, F-/Cl- selectivity in CLCF-type F-/H+ antiporters, J. Gen. Physiol., 144, 129, 10.1085/jgp.201411225 · DOI · Paper page
Cited by
Sorted by citations
Membrane exporters of fluoride ion
McIlwain, B. C., Ruprecht, M. T., & Stockbridge, R. B. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-071520-112507 · Cited by 69
Self-citationEts, L., Ilves, H., Juhe, L., Ilmjärv, T., Puiggené, Ò., Nikel, P. I., & Kivisaar, M. (2026) · Journal of Bacteriology · doi:10.1128/jb.00479-25 · Cited by 1
Destruction Of C7, C9 Perfluorocarboxylic Acids By The Strain Ensifer Adhaerens M1
Hkudaigulov, G., Sharipov, D., Starikov, S., & Chetverikov, S. (2024) · Malaysian Journal of Fundamental and Applied Sciences · doi:10.11113/mjfas.v20n6.3655
Metadata
- Authors
- McIlwain, B. C., Martin, K., Hayter, E. A., & Stockbridge, R. B.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 432
- Issue
- 4
- Pages
- 1098-1108
- ISSN
- 0022-2836
- PMC
- PMC7054162
- Cited by
- 24
- References
- 2
- Language
- en
- Licence
- Funders
- National Science Foundation
- Alfred P. Sloan Foundation
- National Institutes of Health
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