Innate Immune Response Gene Expression Profiles of N9 Microglia Are Pathogen-Type Specific

McKimmie, Clive S.; Roy, Douglas; Forster, Thorsten; Fazakerley, John K.

doi:10.1016/j.jneuroim.2006.03.012

Cited by 51Neuroinflammation and Neurodegeneration MechanismsImmune Response and InflammationInflammasome and immune disorders

Innate Immune Response Gene Expression Profiles of N9 Microglia Are Pathogen-Type Specific

McKimmie, Clive S., Roy, Douglas, Forster, Thorsten, Fazakerley, John K.·2006·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2006.03.012

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Abstract

Glial cells, particularly microglia, are thought to play a pivotal role in initiating and guiding innate immune responses to CNS infections and in perpetuating inflammation and pathology in CNS diseases such as multiple sclerosis and Alzheimer's disease. We describe here the development and use of a new microarray designed to specifically profile transcript expression of innate immunity genes. Microarray analysis validated by quantitative PCR demonstrated an extensive range of pattern recognition receptor gene expression in resting N9 microglia, including Toll-like receptors, scavenger receptors and lectins. Stimulation with LPS or infection with virus modulated pattern recognition receptor, cytokine, chemokine and other innate immune transcripts in a distinct and stimulus-specific manner. This study demonstrates that a single glial cell phenotype has an innate capability to detect infection, determine its form and generate specific responses.

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The anterior chamber, vitreous cavity, and subretinal space of the retina are largely exempt from systemic immune surveillance with the resident microglial cell expressing low levels of pathogen recognition receptors in resting state.
“The anterior chamber, vitreous cavity, and subretinal space of the retina are largely exempt from systemic immune surveillance with the resident immune cell, the microglial cell, expressing low levels of pathogen recognition receptor (PRRs) in resting state [60].”
From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [60]

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[Toll-like receptors: recognition receptors of the innate immune system and target structures for therapeutical intervention].
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Authors: McKimmie, C. S., Roy, D., Forster, T., & Fazakerley, J. K.
Affiliations: University of Edinburgh (GB)
ORCID: McKimmie, Clive S.
Forster, Thorsten
Fazakerley, John K.
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2006-06
Volume: 175
Issue: 1-2
Pages: 128-141
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2006.03.012
OpenAlex: W2039008625
Cited by: 51
References: 79
Citations by year: 2023: 7 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 6
FWCI: 2.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: microglia, innate immunity, gene expression profiling, pattern recognition receptors, Toll-like receptors, scavenger receptors, lectins, lipopolysaccharide, viral infection, cytokines, chemokines, central nervous system infection, microarray
MeSH terms: Animals, Epitopes, Cells, Cultured, Immunity, Innate, Semliki forest virus, Microglia, Alphavirus Infections, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Receptors, Pattern Recognition, Mice

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Innate Immune Response Gene Expression Profiles of N9 Microglia Are Pathogen-Type Specific

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