Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model
Open accessAbstract
A murine passive transfer model system was employed to ascertain the effects of gestational exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from individual mothers of children with autism (MAU) or mothers with typically developing children (MTD). Growth and behavioral outcomes in offspring were measured from postnatal days 8 to 65 in each group. Comparisons revealed alterations in early growth trajectories, significantly impaired motor and sensory development, and increased anxiety. This report demonstrates for the first time the effects of a single, low dose gestational exposure of IgG derived from individual MAU on their offspring's physical and social development.
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Animal models have yielded many insights into the effects and mechanisms of inflammation and immune activation, as well as the role of toxic agents, in inducing autism-like behaviors in rodent and other species.
“animal models have yielded many intriguing insights into the effects and mechanisms of inflammation and immune activation, as well as the role of toxic agents, in inducing autism-like behaviors in rodent and other species [103, 104, 112–115, 207].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [114]
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Bauman, M. D., Crawley, J. N., & Berman, R. F. (2019) · Wiley eBooks · doi:10.1002/9780470015902.a0022368.pub2 · Cited by 1 · see citing works
Self-citationMaternal autoantibodies in autism spectrum disorder
Jones, K. L., & van de Water, J. A. (2014) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814602167_0017
Abou-Donia, M. B. (2020) · Journal of Cellular Immunology · doi:10.33696/immunology.1.019
Overview of Mechanisms Underlying Neuroimmune Diseases
Sonar, S. A., & Lal, G. (2024) · Springer eBooks · doi:10.1007/978-3-031-24297-7_1-1
Overview of Mechanisms Underlying Neuroimmune Diseases
Sonar, S. A., & Lal, G. (2024) · Springer eBooks · doi:10.1007/978-3-031-60006-7_1
Maternal autoantibodies and fetal neurodevelopment
de Water, J. V., & Wassman, E. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-21987-0.00005-5
Antibody Mediating Autoimmune Reaction in Autism Spectrum Disorder
Noris-García, E., Rodríguez-Ravelo, M. A., Villalón, Y. A., Sierra, G., & Robinson-Agramonte, M. D. L. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-16321-5_10
- Authors
- Braunschweig, D., Golub, M. S., Koenig, C. M., Qi, L., Pessah, I. N., Van de Water, J., & Berman, R. F.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Braunschweig, Daniel
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 252
- Issue
- 1-2
- Pages
- 56-65
- ISSN
- 0165-5728 (ISSN-L)
- PMC
- PMC4096980
- OpenAlex
- W2061466372
- Cited by
- 71
- References
- 35
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 2 · 2016: 7 · 2015: 9 · 2014: 6 · 2013: 6 · 2012: 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIEHS (1P01ES11269-0)
- U.S. EPA (R829388)
- Autism Speaks
- JB Johnson Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- autism spectrum disorder, maternal IgG, passive transfer, offspring development, motor development, sensory development, anxiety, social development (developmental psychology), postnatal growth
- MeSH terms
- Animals, Anxiety, Autistic Disorder, Autoantibodies, Autoantigens, Behavior, Animal, Brain, Disease Models, Animal, Female, Humans, Immunoglobulin G, Mice, Inbred C57BL, Mothers, Pregnancy, Prenatal Exposure Delayed Effects, Growth and Development, Mice
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