Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma
Open accessAbstract
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Al-Ayadhi and Mostafa and Akintunde et al found evidence of elevated IL-17 levels among children with ASD in serum and PHA-stimulated PBMCs, respectively.
“while Al-Ayadhi and Mostafa (2012) and Akintunde et al (2015) found evidence of elevated IL-17 levels among such children in serum and PHA-stimulated PBMCs, respectively.”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Akintunde et al (2015)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759 · see citing works
Standardizing ADOS Scores for a Measure of Severity in Autism Spectrum Disorders
Gotham, K., Pickles, A., & Lord, C. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0674-3 · Cited by 1,605 · see citing works
TH-17 cells in the circle of immunity and autoimmunity
Bettelli, E., Oukka, M., & Kuchroo, V. K. (2007) · Nature Immunology · doi:10.1038/ni0407-345 · Cited by 1,503 · see citing works
Functional Specialization of Interleukin-17 Family Members
Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.012 · Cited by 1,289 · see citing works
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.003 · Cited by 940 · see citing works
Self-citationTh17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Gagliani, N., Vesely, M. C. A., Iseppon, A., Brockmann, L., Xu, H. Y., Palm, N. W., de Zoete, M. R., Licona-Limón, P., Paiva, R., Ching, T. H., et al. (2015) · Nature · doi:10.1038/nature14452 · Cited by 797 · see citing works
Traffic-Related Air Pollution, Particulate Matter, and Autism
Volk, H. E., Lurmann, F., Penfold, B., Hertz-Picciotto, I., & McConnell, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.266 · Cited by 638 · see citing works
Self-citationThe role of immune dysfunction in the pathophysiology of autism
Onore, C., Careaga, M., & Ashwood, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.08.007 · Cited by 635 · see citing works
Self-citationFunctions of T cells in asthma: more than just TH2 cells
Lloyd, C. M., & Hessel, E. M. (2010) · Nature reviews. Immunology · doi:10.1038/nri2870 · Cited by 578 · see citing works
The role of the mast cell in the pathophysiology of asthma
Bradding, P., Walls, A. F., & Holgate, S. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.02.039 · Cited by 573 · see citing works
Cellular mechanisms of IL-17-induced blood-brain barrier disruption
Huppert, J., Closhen, D., Croxford, A., White, R., Kulig, P., Pietrowski, E., Bechmann, I., Becher, B., Luhmann, H. J., Waisman, A., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-141978 · Cited by 529 · see citing works
The immune response in autism: a new frontier for autism research
Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works
Self-citationChildhood Asthma and Exposure to Traffic and Nitrogen Dioxide
Gauderman, W. J., Avol, E. L., Lurmann, F. W., Künzli, N., Gilliland, F. D., Peters, J. M., & McConnell, R. (2005) · Epidemiology · doi:10.1097/01.ede.0000181308.51440.75 · Cited by 518 · see citing works
Familial Clustering of Autoimmune Disorders and Evaluation of Medical Risk Factors in Autism
Comi, A., Zimmerman, A., Frye, V. H., Law, P., & Peeden, J. (1999) · Journal of Child Neurology · doi:10.1177/088307389901400608 · Cited by 427 · see citing works
Hertz‐Picciotto, I., Croen, L., Hansen, R. L., Jones, C. R., de Water, J. V., & Pessah, I. N. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8483 · Cited by 420 · see citing works
Self-citationGurney, J. G., McPheeters, M. L., & Davis, M. M. (2006) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.160.8.825 · Cited by 411 · see citing works
Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
Barczyk, A., Pierzchała, W., & Sozańska, E. (2003) · Respiratory Medicine · doi:10.1053/rmed.2003.1507 · Cited by 366 · see citing works
Maternal Autoimmune Diseases, Asthma and Allergies, and Childhood Autism Spectrum Disorders
Croen, L., Grether, J. K., Yoshida, C. K., Odouli, R., & de Water, J. V. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.2.151 · Cited by 360 · see citing works
Goines, P. E., Croen, L. A., Braunschweig, D., Yoshida, C. K., Grether, J., Hansen, R., Kharrazi, M., Ashwood, P., & Van de Water, J. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-13 · Cited by 351 · see citing works
Self-citationResidential Proximity to Freeways and Autism in the CHARGE Study
Volk, H. E., Hertz-Picciotto, I., Delwiche, L., Lurmann, F., & McConnell, R. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002835 · Cited by 347 · see citing works
Self-citationThe role of IL-17 in CNS diseases
Waisman, A., Hauptmann, J., & Regen, T. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1402-7 · Cited by 339 · see citing works
Th17 cells: new players in asthma pathogenesis
Cosmi, L., Liotta, F., Maggi, E., Romagnani, S., & Annunziato, F. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02576.x · Cited by 326 · see citing works
Cytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314 · see citing works
Self-citationAltered T cell responses in children with autism
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.09.002 · Cited by 281 · see citing works
Self-citationAssociations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.10.025 · Cited by 279 · see citing works
Self-citationAshwood, P., Enstrom, A., Krakowiak, P., Hertz-Picciotto, I., Hansen, R. L., Croen, L. A., Ozonoff, S., Pessah, I. N., & de Water, J. V. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.07.006 · Cited by 271 · see citing works
Self-citationDiesel exhaust particle induction of IL-17A contributes to severe asthma
Brandt, E. B., Kovacic, M. B., Lee, G. B., Gibson, A. M., Acciani, T. H., Cras, T. D. L., Ryan, P., Budelsky, A., & Hershey, G. K. K. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.06.048 · Cited by 265 · see citing works
Enstrom, A. M., Lit, L., Onore, C. E., Gregg, J. P., Hansen, R. L., Pessah, I. N., Hertz-Picciotto, I., Van de Water, J. A., Sharp, F. R., & Ashwood, P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.08.001 · Cited by 257 · see citing works
Self-citationPlasma Cytokine Profiles in Subjects with High-Functioning Autism Spectrum Disorders
Suzuki, K., Matsuzaki, H., Iwata, K., Kameno, Y., Shimmura, C., Kawai, S., Yoshihara, Y., Wakuda, T., Takebayashi, K., Takagai, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020470 · Cited by 252 · see citing works
Brightling, C. E., Symon, F. A., Birring, S. S., Bradding, P. H., Pavord, I. D., & Wardlaw, A. J. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.129698 · Cited by 218 · see citing works
Jyonouchi, H., Geng, L., Ruby, A., & Zimmerman-Bier, B. (2005) · Neuropsychobiology · doi:10.1159/000084164 · Cited by 201 · see citing works
Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms
Heuer, L., Ashwood, P., Schauer, J., Goines, P., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., Croen, L. A., Pessah, I. N., & Van de Water, J. (2008) · Autism Research · doi:10.1002/aur.42 · Cited by 190 · see citing works
Self-citationImmune dysfunction in autism: A pathway to treatment
Careaga, M., Water, J., & Ashwood, P. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.003 · Cited by 166 · see citing works
Self-citationThe lived experience of US parents of children with autism spectrum disorders
Corcoran, J., Berry, A., & Hill, S. (2015) · Journal of Intellectual Disabilities · doi:10.1177/1744629515577876 · Cited by 142 · see citing works
Autoantibodies to cerebellum in children with autism associate with behavior
Goines, P., Haapanen, L., Boyce, R., Duncanson, P., Braunschweig, D., Delwiche, L., Hansen, R., Hertz-Picciotto, I., Ashwood, P., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.11.017 · Cited by 134 · see citing works
Self-citationStamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.12.001 · Cited by 128 · see citing works
Asthma: The importance of dysregulated barrier immunity
Lambrecht, B. N., & Hammad, H. (2013) · European Journal of Immunology · doi:10.1002/eji.201343730 · Cited by 127 · see citing works
In Utero Exposure to Toxic Air Pollutants and Risk of Childhood Autism
Ehrenstein, O. S. V., Aralis, H. J., Cockburn, M., & Ritz, B. R. (2014) · Epidemiology · doi:10.1097/ede.0000000000000150 · Cited by 116 · see citing works
Hashimoto, T., Akiyama, K., Kobayashi, N., et al. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000085432 · Cited by 110 · see citing works
Autism and autoimmune disease: A family study
Money, J., Bobrow, N. A., & Clarke, F. C. (1971) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01537954 · Cited by 106 · see citing works
Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study
Lyall, K., de Water, J. V., Ashwood, P., & Hertz‐Picciotto, I. (2015) · Autism Research · doi:10.1002/aur.1471 · Cited by 98 · see citing works
Self-citationInnate lymphoid cells and allergic inflammation
Kim, B., Wojno, E. D. T., & Artis, D. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.07.013 · Cited by 97 · see citing works
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay
Lyall, K., Ashwood, P., de Water, J. V., & Hertz‐Picciotto, I. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-2017-2 · Cited by 91 · see citing works
Self-citationFournié, G. J., Cautain, B., Xystrakis, E., et al. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1840114.x · Cited by 85 · see citing works
Food allergy and food‐based therapies in neurodevelopmental disorders
de Theije, C. G. M., Bavelaar, B. M., da Silva, S. L., Korte, S. M., Olivier, B., Garssen, J., & Kraneveld, A. D. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12149 · Cited by 71 · see citing works
Immune allergic response in Asperger syndrome
Magalhães, E. S. D. S., Mariz, F. P., Bastos-Pinto, S., Pontes, A. T., Prado, E. A., & deAzevedo, L. C. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.09.015 · Cited by 69 · see citing works
AL-Ayadhi, L. Y., & Mostafa, G. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-54 · Cited by 68 · see citing works
Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders
Onore, C. E., Enstrom, A. M., Krakowiak, P., Hertz‐Picciotto, I., Hansen, R., de Water, J. V., & Ashwood, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.09.005 · Cited by 67 · see citing works
Self-citationCluster Analysis of Autistic Patients Based on Principal Pathogenetic Components
Sacco, R., Lenti, C., Saccani, M., Curatolo, P., Manzi, B., Bravaccio, C., & Persico, A. M. (2012) · Autism Research · doi:10.1002/aur.1226 · Cited by 65 · see citing works
Atopic features in early childhood autism
Bakkaloglu, B., Anlar, B., Anlar, F. Y., et al. (2008) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2007.12.008 · Cited by 56 · see citing works
Ashwood, P., Schauer, J. D., Pessah, I. N., & de Water, J. V. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.012 · Cited by 54 · see citing works
Self-citationJyonouchi, H., Geng, L., Streck, D. L., & Törüner, G. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-4 · Cited by 53 · see citing works
Altered T Helper 17 Responses in Children with Food Allergy
Dhuban, K. B., d'Hennezel, E. B., Ben‐Shoshan, M., et al. (2013) · International Archives of Allergy and Immunology · doi:10.1159/000354028 · Cited by 51 · see citing works
Detection of IL-17 and IL-23 in Plasma Samples of Children with Autism
Enstrom, A., Onore, C., Hertz-Picc, I., Hansen, R., Croen, L., Water, J. V. D., & Ashwood, P. (2008) · American Journal of Biochemistry and Biotechnology · doi:10.3844/ajbbsp.2008.114.120 · Cited by 51 · see citing works
Self-citationSystemic auto-antibodies in children with autism
Mostafa, G. A., El-Sherif, D. F., & AL-Ayadhi, L. Y. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.04.011 · Cited by 34 · see citing works
Type17 T-cells in Central Nervous System Autoimmunity and Tumors
Okada, H., & Khoury, S. J. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9686-z · Cited by 28 · see citing works
Brief report: Allergological evaluation of children with autism
Menchetti, G., Zappella, M., Renzoni, E. A., et al. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02179294 · Cited by 25 · see citing works
Fombonne, E. J. (1999) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1022123822135 · Cited by 25 · see citing works
The “environment” for autism research: signs of improvement?
Lawler, C. P. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.12107 · Cited by 17 · see citing works
Singh, A., Holvöet, S., Weiss, M., Beaumont, M., Zuercher, A. W., & Mercenier, A. (2011) · Results in Immunology · doi:10.1016/j.rinim.2011.07.002 · Cited by 8 · see citing works
An IgE mechanism in autistic hypersensitivity?
Menage, P., Thibault, G., Martineau, J., Hérault, J., Müh, J. P., Barthélémy, C., Lelord, G., & BARDOS, P. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90208-h · Cited by 7 · see citing works
CD8+ T cell function in children with autism
Ashwood, P., de Water, J. V., & Enstrom, A. M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.07.143 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Ashwood P Krakowiak P Hertz-Picciotto I Hansen R Pessah IN Van de Water J Altered T cell responses in children with autism Brain Behav. Immun 2011a 25 840 849 20833247 PMC3039713
Cited by
Sorted by citations
Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder
Vuong, H. E., & Hsiao, E. Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.024 · Cited by 595 · see citing works
The Role of the Immune System in Autism Spectrum Disorder
Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533 · see citing works
Jiang, H.-Y., Xu, L.-L., Shao, L., Xia, R.-M., Yu, Z.-H., Ling, Z.-X., Yang, F., Deng, M., & Ruan, B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.005 · Cited by 391 · see citing works
Ahmad, S. F., Zoheir, K. M. A., Ansari, M. A., Nadeem, A., Bakheet, S. A., AL-Ayadhi, L. Y., Alzahrani, M. Z., Al-Shabanah, O. A., Al-Harbi, M. M., & Attia, S. M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9977-0 · Cited by 155 · see citing works
- Authors
- Akintunde, M. E., Rose, M., Krakowiak, P., Heuer, L., Ashwood, P., Hansen, R., Hertz-Picciotto, I., & Van de Water, J.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Akintunde, Marjannie Eloi
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 286
- Pages
- 33-41
- ISSN
- 0165-5728 (ISSN-L)
- PMC
- PMC4548834
- OpenAlex
- W1774639140
- Cited by
- 96
- References
- 63
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 10 · 2020: 5 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 8
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Environmental Health Sciences (NIEHS) (T32-ES007058-33)
- NIEHS Center for Children's Environmental Health and Environmental Protection Agency (EPA) (2P01ES011269-11, 83543201)
- NIEHS (R01ES015359)
- NICHD (U54HD079125)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- autism spectrum disorder, asthma, IL-17, IL-13, IL-4, cytokine production, T cell stimulation, inflammation, comorbidities, children
- MeSH terms
- Asthma, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Male, Mitogens, Phytohemagglutinins, Interleukin-7, Case-Control Studies, Cytokines, Th2 Cells, Statistics, Nonparametric, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
