Neurotrophic factors in Parkinson’s disease are regulated by exercise: Evidence-based practice
Abstract
We carried out a qualitative review of the literature on the influence of forced or voluntary exercise in Parkinson's Disease (PD)-induced animals, to better understand neural mechanisms and the role of neurotrophic factors (NFs) involved in the improvement of motor behavior. A few studies indicated that forced or voluntary exercise may promote neuroprotection, through upregulation of NF expression, against toxicity of drugs that simulate PD. Forced training, such as treadmill exercise and forced-limb use, adopted in most studies, in addition to voluntary exercise on a running wheel are suitable methods for NFs upregulation.
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Training increases BDNF expression in the hippocampus, cerebral cortex, ST, brainstem, and spinal cord.
“Under the influence of the training process, increased BDNF expression in the hippocampus, cerebral cortex, ST, brainstem, and spinal cord was observed [131,174,179,181,182].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [181]
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Neurorestoration by physical exercise: Moving forward
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BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
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Parkinson disease: an evolutionary perspective.
Garcia-Ruiz, P. J., & Espay, A. J. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00157 · Cited by 46 · see citing works
- Authors
- da Silva, P. G. C., Domingues, D. D., de Carvalho, L. A., Allodi, S., & Correa, C. L.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- ORCID
- Allodi, Silvana
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 363
- Pages
- 5-15
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2264299191
- Cited by
- 87
- References
- 115
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 12 · 2016: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (470612/2013, PR2-UFRJ, PR2AVL2012, E26/201.434/2014, E26/110.307/2014)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (470612/2013, PR2-UFRJ, PR2AVL2012, E26/201.434/2014, E26/110.307/2014)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (470612/2013, PR2-UFRJ, PR2AVL2012, E26/201.434/2014, E26/110.307/2014)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, neurotrophic factors, physical activity, voluntary exercise, forced exercise, treadmill exercise, running wheel, neuroprotection, motor behavior, Parkinson's disease model, neurotrophic factor expression
- MeSH terms
- Animals, Humans, Nerve Growth Factors, Parkinson Disease, Exercise, Brain-Derived Neurotrophic Factor, Evidence-Based Medicine, Vascular Endothelial Growth Factor A
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