Cited by 87Parkinson's Disease Mechanisms and TreatmentsNerve injury and regenerationNuclear Receptors and Signaling

Neurotrophic factors in Parkinson’s disease are regulated by exercise: Evidence-based practice

da Silva, Paula Grazielle Chaves, Domingues, Daniel Desidério, de Carvalho, Litia Alves, Allodi, Silvana, Correa, Clynton Lourenço·2016·Journal of the Neurological Sciences

Abstract

We carried out a qualitative review of the literature on the influence of forced or voluntary exercise in Parkinson's Disease (PD)-induced animals, to better understand neural mechanisms and the role of neurotrophic factors (NFs) involved in the improvement of motor behavior. A few studies indicated that forced or voluntary exercise may promote neuroprotection, through upregulation of NF expression, against toxicity of drugs that simulate PD. Forced training, such as treadmill exercise and forced-limb use, adopted in most studies, in addition to voluntary exercise on a running wheel are suitable methods for NFs upregulation.

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Crossref · 10.1016/j.jns.2016.02.017

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115 of 115 references verified0 citation errors · 0 not checkable

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  • Training increases BDNF expression in the hippocampus, cerebral cortex, ST, brainstem, and spinal cord.

    “Under the influence of the training process, increased BDNF expression in the hippocampus, cerebral cortex, ST, brainstem, and spinal cord was observed [131,174,179,181,182].”

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Authors
da Silva, P. G. C., Domingues, D. D., de Carvalho, L. A., Allodi, S., & Correa, C. L.
Affiliations
Universidade Federal do Rio de Janeiro (BR)
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2016-04
Volume
363
Pages
5-15
ISSN
0022-510X (ISSN-L)
OpenAlex
W2264299191
Cited by
87
References
115
Citations by year
2026: 4 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 12 · 2016: 2
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (470612/2013, PR2-UFRJ, PR2AVL2012, E26/201.434/2014, E26/110.307/2014)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (470612/2013, PR2-UFRJ, PR2AVL2012, E26/201.434/2014, E26/110.307/2014)
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (470612/2013, PR2-UFRJ, PR2AVL2012, E26/201.434/2014, E26/110.307/2014)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, neurotrophic factors, physical activity, voluntary exercise, forced exercise, treadmill exercise, running wheel, neuroprotection, motor behavior, Parkinson's disease model, neurotrophic factor expression
MeSH terms
Animals, Humans, Nerve Growth Factors, Parkinson Disease, Exercise, Brain-Derived Neurotrophic Factor, Evidence-Based Medicine, Vascular Endothelial Growth Factor A

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