Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease: a systematic review and meta-analysis
Open accessAbstract
BACKGROUND: Animal models of exercise and Parkinson's disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic factor (BDNF). No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human PD. RESEARCH DESIGN AND METHODS: We searched MEDLINE, EMBASE, Cochrane Library, PsycINFO and PubMed from inception to June 2017. RESULTS: Data aggregated from two randomized controlled trials and four pre-experimental studies with a total of 100 ambulatory patients with idiopathic PD (Hoehn/Yahr ≤3) found improvements in BDNF blood concentration levels in all 6 studies (two RCTs and 4 pre-experimental studies). Pooled BDNF level change scores from the 2 RCTs resulted in a significant homogeneous summary effect size (Standardized Mean Difference 2.06, 95% CI 1.36 to 2.76), and a significant heterogeneous SES for the motor part of the UPDRS-III examination (MD -5.53, 95% CI -10.42 to -0.64). Clinical improvements were noted in all studies using a variety of outcome measures. LIMITATIONS: The evidence-base consists primarily of small studies with low to moderate methodological quality. CONCLUSIONS: This review provides preliminary evidence for the effectiveness of physical exercise treatments for persons with PD on BDNF blood levels. Further research is needed.
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A meta-analysis of 100 ambulatory patients with idiopathic Parkinson's disease (Hoehn/Yahr ≤3) found improvements in BDNF blood concentration levels after physical activity in all six analyzed studies.
“Interestingly, a meta-analysis performed by Hirsch et al. [167], in which results regarding 100 ambulatory patients with idiopathic PD (Hoehn/Yahr ≤3) were reviewed, found improvements in BDNF blood concentration levels after physical activity in all six analyzed studies.”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [167]
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Research works printed but not linked: 2
- [11]Hirsch MA Farley BG Exercise, neuroplasticity and Parkinson’s disease Eur J Phys Rehabil Med 2009 45 2 215 29 19532109
- [83]Polacchini A Metelli G Francavilla R Baj G Florean M Mascaretti LG Tongiorgi E A method for reproducible measurements of serum BDNF: comparison of the performance of six commercial assays Scientific Reports 2015 5 17989 10.1038/srep17989 26656852 PMC4675070 · DOI · Paper page
Cited by
Sorted by citations
BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Ahern, L., Timmons, S., Lamb, S. E., & McCullagh, R. (2024) · HRB Open Research · doi:10.12688/hrbopenres.13843.1 · Cited by 2 · see citing works
- Authors
- Hirsch, M. A., van Wegen, E. E. H., Newman, M. A., & Heyn, P. C.
- Affiliations
- Carolinas Healthcare System (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Hirsch, Mark A.
- Venue
- Translational Neurodegeneration
- Published
- 2018-03-20
- Volume
- 7
- Issue
- 1
- Pages
- 7-7
- ISSN
- 2047-9158 (ISSN-L)
- PMC
- PMC5859548
- OpenAlex
- W2802570735
- Cited by
- 134
- References
- 93
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 21 · 2023: 14 · 2022: 15 · 2021: 18 · 2020: 17 · 2019: 15 · 2018: 9
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Translational Neurodegeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- BIBSYS Brage (BIBSYS (Norway)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, brain-derived neurotrophic factor, physical activity, exercise therapy, motor function, UPDRS-III, neurodegeneration, methodological quality of trials
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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