Oral L-Glutamine Pretreatment Attenuates Skeletal Muscle Atrophy Induced by 24-h Fasting in Mice

de Vasconcelos, Diogo Antonio Alves; Giesbertz, Pieter; de Souza, Diego Ribeiro; Vitzel, Kaio Fernando; Abreu, Phablo; Marzuca-Nassr, Gabriel Nasri; Fortes, Marco Aurélio Salomão; Murata, Gilson Masahiro; Hirabara, Sandro Massao; Curi, Rui; Daniel, Hannelore; Pithon-Curi, Tania Cristina

doi:10.1016/j.jnutbio.2019.05.010

Cited by 33Muscle metabolism and nutritionMuscle Physiology and DisordersNutrition and Health in Aging

Oral L-Glutamine Pretreatment Attenuates Skeletal Muscle Atrophy Induced by 24-h Fasting in Mice

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de Vasconcelos, Diogo Antonio Alves, Giesbertz, Pieter, de Souza, Diego Ribeiro, Vitzel, Kaio Fernando, Abreu, Phablo, Marzuca-Nassr, Gabriel Nasri, Fortes, Marco Aurélio Salomão, Murata, Gilson Masahiro +4 more·2019·The Journal of Nutritional Biochemistry

DOI 10.1016/j.jnutbio.2019.05.010

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Abstract

L-Glutamine (L-Gln) supplementation has been pointed out as an anticatabolic intervention, but its effects on protein synthesis and degradation signaling in skeketal muscle are still poorly known. The effects of L-Gln pretreatment (1 g kg-1 day-1 body weight for 10 days) on muscle fiber cross-sectional area (CSA), amino acid composition (measured by LC-MS/MS) and protein synthesis (Akt-mTOR) and degradation (ubiquitin ligases) signaling in soleus and extensor digitorum longus (EDL) muscles in 24-h-fasted mice were investigated. The fiber CSA of EDL muscle was not different between the L-Gln-fasted and L-Gln-fed groups. This finding was associated with reduced contents of L-Leu and L-Iso and activation of protein synthesis signaling (p-RPS6 Ser240/244 and Akt-mTOR). The spectrum of soleus muscle fiber CSA distribution was larger in L-Gln-fasted as compared with placebo-fasted mice. This effect of L-Gln pretreatment was associated with changes in red fibers L-Gln metabolism as indicated by increased intracellular L-glutamine/L-glutamate ratio, L-aspartate and GABA levels. L-Gln supplementation reduced fasting-induced mass loss in tibialis anterior and gastrocnemius muscles. Evidence is presented that pretreatment with L-glutamine attenuates skeletal muscle atrophy induced by 24-h fasting through mechanisms that vary with the muscle fiber type.

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Oral l-glutamine pretreatment attenuates 24-h fasting-induced muscle atrophy in C57BL/6 mice.
“Oral l-glutamine pretreatment attenuates 24-h fasting-induced muscle atrophy in C57BL/6 mice [36].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [36]

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Authors: de Vasconcelos, D. A. A., Giesbertz, P., de Souza, D. R., Vitzel, K. F., Abreu, P., Marzuca-Nassr, G. N., Fortes, M. A. S., Murata, G. M., Hirabara, S. M., Curi, R., Daniel, H., & Pithon-Curi, T. C.
Affiliations: Technical University of Munich (DE)
Universidade de São Paulo (BR)
Universidad de La Frontera (CL)
Universidade Cruzeiro do Sul (BR)
ORCID: Giesbertz, Pieter
Abreu, Phablo
Marzuca-Nassr, Gabriel Nasri
Fortes, Marco Aurélio Salomão
Murata, Gilson Masahiro
Hirabara, Sandro Massao
Curi, Rui
Daniel, Hannelore
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2019-08
Volume: 70
Pages: 202-214
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/j.jnutbio.2019.05.010
OpenAlex: W2945776887
Cited by: 33
References: 72
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 2
FWCI: 2.12
Type: journal article
Language: en
Open access: green
repositorio.ufro.cl
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords: glutamine, skeletal muscle atrophy, fasting, muscle protein synthesis, Akt/mTOR signaling, ubiquitin ligase, muscle fiber cross-sectional area, muscle fiber type, soleus muscle, extensor digitorum longus, amino acid composition, S6 phosphorylation, glutamine metabolism, muscle mass loss
MeSH terms: Adipose Tissue, Administration, Oral, Animals, Fasting, gamma-Aminobutyric Acid, Glutamine, Male, Mice, Inbred C57BL, Muscular Atrophy, Signal Transduction, Muscle, Skeletal, Cell Cycle Proteins, Ribosomal Protein S6, Adaptor Proteins, Signal Transducing, Mice

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Oral L-Glutamine Pretreatment Attenuates Skeletal Muscle Atrophy Induced by 24-h Fasting in Mice

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