Cited by 121Phytochemicals and Medicinal PlantsNatural Antidiabetic Agents StudiesMedicinal Plants and Neuroprotection

Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: Prevention by extracts of Withania somnifera and Aloe vera

Parihar, M.S, Chaudhary, Madhulika, Shetty, Rajani, Hemnani, Taruna·2004·Journal of Clinical Neuroscience

Abstract

Diabetes mellitus is reported to impair the memory function in experimental animals. Since the mammalian hippocampus and cerebral cortex play a pivotal role in a diverse set of cognitive functions, such as novelty detection and memory, we examined the vulnerability of cortex and hippocampus regions of the brain to oxidative damage in streptozotocin (STZ) diabetic mice. We next examined the attenuating effect of extracts of Withania somnifera and Aloe vera on prevention of hippocampal and cortical cell degenerations. Doses of both plant extracts given to experimental animals were based on the evaluation of their total antioxidant activity and also their potency to reduce Fe(3+). We assayed lipid peroxidation (LPO) and protein carbonyl (PC) in both regions of the brain and observed the changes in memory and motor behavioral functions in diabetic and control mice. The results showed a significant (P < 0.05) increase in LPO and PC in hippocampus and cortical regions of STZ diabetic mice. We also found a significant impairment in both motor and memory behavioral functions in diabetic mice. However, when diabetic mice were supplemented with the extracts of Withania somnifera and Aloe vera, the oxidative damage in both brain regions was reduced as marked by a significant (p < 0.05) declines in both LPO and PC. The combination of extracts of Withania somnifera and Aloe vera was more effective in reducing oxidative damage in brain regions than the supplementation of single plant extract. The combination also lowered the blood glucose level in comparison to STZ diabetic mice. Memory impairment and motor dysfunction were also improved by the plant extracts supplementation. We conclude that impairments in the hippocampus and cortex in STZ diabetic mice are associated with an increased free radical mediated oxidative damage and that the supplementation of plant extracts showed preventive effects in attenuating oxidative damage in both brain regions possibly via antioxidative mechanisms.

Integrity signals

Registry

Crossref · 10.1016/j.jocn.2003.09.008

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Parihar, M. S., Chaudhary, M., Shetty, R., & Hemnani, T.
Affiliations
Vikram University (IN)
Corresponding author
Parihar, M.S
Venue
Journal of Clinical Neuroscience
Publisher
Elsevier BV
Published
2004-05
Volume
11
Issue
4
Pages
397-402
ISSN
0967-5868 (ISSN-L)
OpenAlex
W2066909002
Cited by
121
References
54
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 7
FWCI
12.47
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
University Grants Commission
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
streptozotocin-induced diabetes, hippocampus, cerebral cortex, oxidative stress, Withania somnifera, Aloe vera, plant extracts, lipid peroxidation, protein carbonylation, memory impairment, motor impairment, antioxidant activity, blood glucose, neuroprotection
MeSH terms
Aloe, Analysis of Variance, Animals, Behavior, Animal, Blood Glucose, Cerebral Cortex, Drug Interactions, Female, Hippocampus, Memory, Motor Activity, Oxidation-Reduction, Plant Extracts, Streptozocin, Time Factors, Lipid Peroxidation, Maze Learning, Withania, Protein Carbonylation, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review