Pain sensitivity in patients with major depression: differential effect of pain sensitivity measures, somatic cofactors, and disease characteristics
Open accessAbstract
Unlabelled Patients with depression often report pain. Evidence regarding altered pain sensitivity in depressed patients remains, however, inconclusive. In a large cross-sectional study we investigated the association between depression and pain sensitivity with regard to 2 different dimensions of pain sensitivity, as well as the effect of somatic cofactors, symptom severity, and subtype of depression. In 735 patients with a current episode of major depression and 456 never-depressed control participants pain thresholds (pressure pain thresholds, PPTs) were measured at the index finger pad and self-rated suprathreshold pain intensity ratings were obtained using the Pain Sensitivity Questionnaire (PSQ)-minor subscore, an instrument that assesses pain intensity in daily life situations. Additionally, lifestyle factors, medical, and psychiatric conditions were assessed. Unadjusted, patients with depression had lower PPTs and higher PSQ-minor scores indicating increased pain sensitivity. After adjusting for potential mediators, such as poor sleep quality and physical inactivity, patients did not differ from control participants regarding PPTs, but still had significantly higher PSQ-minor ratings. Among patients with depression, severity of anxiety symptoms predicted higher PSQ-minor scores. In conclusion, we found a differential effect of depression on the 2 pain sensitivity dimensions: Decreased experimentally obtained pain thresholds were explained by depression-associated somatic factors whereas increased self-rated suprathreshold pain intensity ratings were associated with increased anxiety symptoms.Perspective Because increased pain intensity perception is hypothesized to be a risk factor for the development of chronic pain, our findings may contribute to understanding the high incidence of chronic pain in depressed patients. They also encourage clinicians to consider the role of anxiety in treatment programs for pain in patients with depression.
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Hyper- and hypo-sensitivity to pain have been reported in depression, schizophrenia, eating disorders, autism, and OCD.
“Beyond sensory responsiveness in developmental disorders, hyper- and hypo-sensitivity to pain have been reported in a number of clinical populations, such as depression (Hermesdorf et al., 2016), schizophrenia (Stubbs et al., 2015), eating disorders (Papezová et al., 2005; Yamamotova et al., 2017), autism (Riquelme et al., 2016), and OCD (Hezel et al., 2012).”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Hermesdorf et al., 2016
Cites
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971 · see citing works
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
International physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Estimation of Relationships for Limited Dependent Variables
Tobin, J. (1958) · Econometrica · doi:10.2307/1907382 · Cited by 6,996 · see citing works
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.009 · Cited by 5,486 · see citing works
Rush, A. J., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N., Markowitz, J. C., Ninan, P. T., Kornstein, S., Manber, R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01866-8 · Cited by 3,829 · see citing works
Depression and Pain Comorbidity: A Literature Review
Bair, M. J., Robinson, R. L., Katon, W., & Kroenke, K. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.20.2433 · Cited by 3,463 · see citing works
A statistical model for the analysis of ordinal level dependent variables
McKelvey, R. D., & Zavoina, W. J. (1975) · Journal of Mathematical Sociology · doi:10.1080/0022250x.1975.9989847 · Cited by 2,636 · see citing works
Treatment gap in mental health care.
Abramowitz, M. Z., Greenberg, D., & Levav, I. (2008) · PubMed · Cited by 1,482 · see citing works
The treatment gap in mental health care.
(2004) · Europe PMC (PubMed Central) · Cited by 1,419 · see citing works
The prevalence of chronic pain in United States adults: Results of an Internet-based survey
Johannes, C. B., Le, T. K., Zhou, X., Johnston, J. A., & Dworkin, R. H. (2010) · The Journal of Pain · doi:10.1016/j.jpain.2010.07.002 · Cited by 1,252 · see citing works
An epidemiologic comparison of pain complaints
Korff, M. V., Dworkin, S. F., LeResche, L., & Kruger, A. (1988) · Pain · doi:10.1016/0304-3959(88)90066-8 · Cited by 966 · see citing works
Lamers, F., van Oppen, P., Comijs, H. C., Smit, J. H., Spinhoven, P., van Balkom, A. J. L. M., Nolen, W. A., Zitman, F. G., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06176blu · Cited by 913 · see citing works
Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network
Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N. P., & Tracey, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09896.2001 · Cited by 822 · see citing works
Racine, M., Tousignant-Laflamme, Y., Kloda, L. A., Dion, D., Dupuis, G., & Choinière, M. (2012) · Pain · doi:10.1016/j.pain.2011.11.025 · Cited by 691 · see citing works
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614 · see citing works
Sleep deprivation and pain perception
LAUTENBACHER, S., KUNDERMANN, B., & KRIEG, J. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.08.001 · Cited by 613 · see citing works
Granot, M., & Ferber, S. G. (2005) · The Clinical Journal of Pain · doi:10.1097/01.ajp.0000135236.12705.2d · Cited by 426 · see citing works
Reliability and Validity of a Pressure Algometer
Kinser, A. M., Sands, W. A., & Stone, M. H. (2009) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31818f051c · Cited by 380 · see citing works
Ruscheweyh, R., Marziniak, M., Stumpenhorst, F., Reinholz, J., & Knecht, S. (2009) · Pain · doi:10.1016/j.pain.2009.06.020 · Cited by 364 · see citing works
Individual Differences in Pain Sensitivity: Measurement, Causation, and Consequences
Nielsen, C. S., Staud, R. M., & Price, D. D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.09.010 · Cited by 342 · see citing works
Comorbid Chronic Pain and Depression: Who Is at Risk?
Miller-Matero, L. R., & Caño, A. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.12.007 · Cited by 323 · see citing works
Individual differences in endogenous pain modulation as a risk factor for chronic pain
Edwards, R. R. (2005) · Neurology · doi:10.1212/01.wnl.0000171862.17301.84 · Cited by 283 · see citing works
The epidemiology of pain in depression
Lépine, J., & Briley, M. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.618 · Cited by 275 · see citing works
Dickens, C. M., McGowan, L., & Dale, S. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000041622.69462.06 · Cited by 228 · see citing works
Pain perception in major depression depends on pain modality
Bär, K., Brehm, S., Boettger, M. K., Boettger, S., Wagner, G., & Sauer, H. (2005) · Pain · doi:10.1016/j.pain.2005.05.016 · Cited by 227 · see citing works
Adult attachment, anxiety, and pain self-efficacy as predictors of pain intensity and disability
Meredith, P. J., Strong, J., & Feeney, J. A. (2006) · Pain · doi:10.1016/j.pain.2006.02.025 · Cited by 218 · see citing works
Depression and changed pain perception: Hints for a central disinhibition mechanism
Klauenberg, S., Maier, C., Assion, H., Hoffmann, A., Krumova, E. K., Magerl, W., Scherens, A., Treede, R., & Juckel, G. (2008) · Pain · doi:10.1016/j.pain.2008.09.003 · Cited by 210 · see citing works
Chronic pain and major depressive disorder in the general population
Ohayon, M. M., & Schatzberg, A. F. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.013 · Cited by 193 · see citing works
Quantitative assessment of experimental pain perception: multiple domains of clinical relevance
Edwards, R. R., Sarlani, E., Wesselmann, U., & Fillingim, R. B. (2005) · Pain · doi:10.1016/j.pain.2005.01.007 · Cited by 187 · see citing works
Lautenbacher, S., Hemmeter-Spernal, J., Schreiber, W., & Krieg, J.-C. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199911000-00015 · Cited by 187 · see citing works
The Influence of Resting Blood Pressure and Gender on Pain Responses
Fillingim, R. B., & Maixner, W. D. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199607000-00005 · Cited by 180 · see citing works
Tang, N. K. Y., Salkovskis, P. M., Hodges, A., Wright, K. J., Hanna, M., & Hester, J. (2008) · Pain · doi:10.1016/j.pain.2008.01.018 · Cited by 171 · see citing works
Agüera-Ortíz, L., Failde, I., Micó, J. A., Cervilla, J. A., & López-Ibor, J. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.10.022 · Cited by 168 · see citing works
Validation of the Pain Sensitivity Questionnaire in chronic pain patients
Ruscheweyh, R., Verneuer, B., Dany, K., Marziniak, M., Wolowski, A., Colak-Ekici, R., Schulte, T. L., Bullmann, V., Grewe, S., Gralow, I., et al. (2012) · Pain · doi:10.1016/j.pain.2012.02.025 · Cited by 167 · see citing works
Preoperative Pain Sensitivity and Its Correlation with Postoperative Pain and Analgesic Consumption
Abrishami, A., Chan, J., Chung, F. F., Wong, J., & Warner, D. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3181f85ed2 · Cited by 140 · see citing works
Understanding pain in depression
Stahl, S. M., & Briley, M. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.619 · Cited by 126 · see citing works
von Knorring, L., Perris, C., Eisemann, M. R., Eriksson, U., & Perris, H. (1983) · Pain · doi:10.1016/0304-3959(83)90003-9 · Cited by 125 · see citing works
Pain Inhibition Is Deficient in Chronic Widespread Pain but Normal in Major Depressive Disorder
Normand, E., Potvin, S., Gaumond, I., Cloutier, G., Corbin, J.-F., & Marchand, S. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04969blu · Cited by 110 · see citing works
Pain perception in depression: relationships to symptomatology and naloxone-sensitive mechanisms.
Lautenbacher, S., Roscher, S., Strian, D., Fassbender, K., Krumrey, K., & Krieg, J. C. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199407000-00010 · Cited by 104 · see citing works
Influence of gender and hemispheric lateralization on heat pain perception in major depression
Bär, K., Greiner, W., Letsch, A., Köbele, R., & Sauer, H. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00051-7 · Cited by 101 · see citing works
Physical Activity Is Related to Pain Sensitivity in Healthy Women
Ellingson, L. D., Colbert, L. H., & Cook, D. B. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318248f648 · Cited by 89 · see citing works
Self‐reported pain sensitivity: Lack of correlation with pain threshold and tolerance
Edwards, R. R., & Fillingim, R. B. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2006.09.008 · Cited by 85 · see citing works
The effect of chronic pain upon the response to noxious stimuli by psychiatric patients
Merskey, H. (1965) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(65)90083-8 · Cited by 82 · see citing works
Teismann, H., Wersching, H., Nagel, M., Arolt, V., Heindel, W. L., Baune, B. T., Wellmann, J., Hense, H., & Berger, K. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-174 · Cited by 74 · see citing works
Suija, K., Timonen, M., Suviola, M., Jokelainen, J. J., Järvelin, M., & Tammelin, T. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-535 · Cited by 67 · see citing works
Pathophysiology of Pain Perception
Lautenbacher, S., & Fillingim, R. B. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9068-6 · Cited by 61 · see citing works
Wagner, G., Koschke, M., Leuf, T., Schlösser, R. G. M., & Bär, K. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.10.021 · Cited by 59 · see citing works
Andrzejewski, W., Kassolik, K., Brzozowski, M., & Cymer, K. (2009) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2009.07.004 · Cited by 52 · see citing works
Pain thresholds during and after treatment of severe depression with electroconvulsive therapy
Gormsen, L. K., Ribe, A. R., Raun, P., Rosenberg, R., Videbech, P., Vestergaard, P., Bach, F. W., & Jensen, T. S. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2003.11.015 · Cited by 51 · see citing works
The treatment of depression with different formulations of venlafaxine: a comparative analysis
Olver, J. S., Burrows, G. D., & Norman, T. R. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.551 · Cited by 39 · see citing works
Hemmeter-Spernal, J., Krieg, J.-C., & Lautenbacher, S. (2003) · Neuropsychobiology · doi:10.1159/000073632 · Cited by 36 · see citing works
Bär, K., Terhaar, J., Boettger, M. K., Boettger, S., Berger, S., & Weiß, T. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182046797 · Cited by 33 · see citing works
Pain sensitivity, depression, and sleep deprivation: Links with serotoninergic dysfunction
Ohayon, M. M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.007 · Cited by 31 · see citing works
Arendt‐Nielsen, L., & Lautenbacher, S. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9068-6_2 · Cited by 23 · see citing works
Hennings, A., Schwarz, M., Riemer, S., Stapf, T. M., Selberdinger, V. B., & Rief, W. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318243e2d1 · Cited by 23 · see citing works
Reliability of four experimental mechanical pain tests in children
Soee, A.-B. L., Thomsen, Skov, L., & Tornøe, B. (2013) · Journal of Pain Research · doi:10.2147/jpr.s38514 · Cited by 15 · see citing works
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1 of the 61 references couldn’t be matched to a known paper.
Cited by
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Howard, D. M., Adams, M. J., Shirali, M., Clarke, T.-K., Marioni, R. E., Davies, G., Coleman, J. R. I., Alloza, C., Shen, X., Barbu, M. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03819-3 · Cited by 612 · see citing works
Depression, anxiety and acute pain: links and management challenges
Michaelides, A., & Zis, P. (2019) · Postgraduate Medicine · doi:10.1080/00325481.2019.1663705 · Cited by 430 · see citing works
Atypical interoception as a common risk factor for psychopathology: A review
Brewer, R., Murphy, J., & Bird, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.036 · Cited by 180 · see citing works
Deep brain stimulation targets for treating depression
Drobisz, D., & Damborská, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.004 · Cited by 159 · see citing works
Palmitoylethanolamide: A Natural Compound for Health Management
Clayton, P., Hill, M., Bogoda, N. O., Subah, S., & Venkatesh, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105305 · Cited by 145 · see citing works
Lipoedema: a paradigm shift and consensus
Bertsch, T., Erbacher, G., Elwell, R., & Partsch, H. (2020) · Journal of Wound Care · doi:10.12968/jowc.2020.29.sup11b.1 · Cited by 109 · see citing works
Adams, G. R., Gandhi, W., Harrison, R. N., van Reekum, C. M., Wood-Anderson, D., Gilron, I., & Salomons, T. V. (2022) · Pain · doi:10.1097/j.pain.0000000000002830 · Cited by 102 · see citing works
Lipoedema – myths and facts, Part 5
Bertsch, T., Erbacher, G., Corda, D., Damstra, R. J., van Duinen, K., Elwell, R., Smeenge, J., Faerber, G., Fetzer, S., Fink, J. M., et al. (2020) · Phlebologie · doi:10.1055/a-1012-7670 · Cited by 56 · see citing works
Karabatsiakis, A., & Schönfeldt‐Lecuona, C. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00901-7 · Cited by 52 · see citing works
Rosner, R., Rimane, E., Vogel, A., Rau, J., & Hagl, M. (2018) · Trials · doi:10.1186/s13063-018-2618-3 · Cited by 36 · see citing works
A Mind–Body Approach to Pediatric Pain Management
Brown, M. L., Rojas, E., & Gouda, S. R. (2017) · Children · doi:10.3390/children4060050 · Cited by 39 · see citing works
Springborg, A. H., Visby, L., Kehlet, H., & Foss, N. B. (2023) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.14301 · Cited by 41 · see citing works
The Wistar Kyoto Rat: A Model of Depression Traits
Redei, E. E., Udell, M. E., Woods, L. C. S., & Chen, H. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221129120902 · Cited by 35 · see citing works
Kuo, Y., Raji, M. A., Liaw, V., Baillargeon, J., & Goodwin, J. S. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15332 · Cited by 35 · see citing works
Lalouni, M., Fust, J., Bjureberg, J., Kastrati, G., Fondberg, R., Fransson, P., Jayaram‐Lindström, N., Kosek, E., Hellner, C., & Jensen, K. B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01639-y · Cited by 33 · see citing works
Grundström, H., Larsson, B. K., Arendt‐Nielsen, L., Gerdle, B. U. C., & Kjølhede, P. (2019) · European Journal of Pain · doi:10.1002/ejp.1439 · Cited by 31 · see citing works
Lee, R. Y., Oxford, M. L., Sonney, J., Enquobahrie, D. A., & Cato, K. (2022) · Journal of Adolescence · doi:10.1002/jad.12012 · Cited by 31 · see citing works
Ruscheweyh, R., Wersching, H., Kugel, H., Sundermann, B., & Teuber, A. (2018) · Pain · doi:10.1097/j.pain.0000000000001219 · Cited by 27 · see citing works
Validity of the cold pressor test and pain sensitivity questionnaire via online self-administration
McIntyre, M. H., Kless, A., Hein, P., Field, M. J., & Tung, J. Y. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231697 · Cited by 25 · see citing works
Paredes, A. C., Pinto, J. M., Almeida, A., & Pinto, P. R. (2021) · Pain · doi:10.1097/j.pain.0000000000002385 · Cited by 25 · see citing works
The Diabetic Foot–Pain–Depression Cycle
Brooks, B. M., Shih, C.-D., Brooks, B. M., Tower, D. E., Tran, T., Simon, J. E., & Armstrong, D. G. (2023) · Journal of the American Podiatric Medical Association · doi:10.7547/22-126 · Cited by 24 · see citing works
Wilson, S. J., Padin, A. C., Birmingham, D. J., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2018) · The Gerontologist · doi:10.1093/geront/gny150 · Cited by 23 · see citing works
Desai, R. A., CAMACHO, F. T., Tan, X., LeBaron, V. T., Blackhall, L. J., & Balkrishnan, R. (2019) · Journal of Oncology Practice · doi:10.1200/jop.18.00781 · Cited by 22 · see citing works
Robin, C., Beck, C., Armstrong, B., Waite, T. D., Rubin, G. J., English National Study of Flooding and Health Study Group, Waite, T. D., Beck, C. R., Amlôt, R., Kovats, S., et al. (2020) · European Journal of Public Health · doi:10.1093/eurpub/ckaa049 · Cited by 21 · see citing works
Melotti, R., Ruscheweyh, R., Pramstaller, P. P., Hicks, A. A., & Pattaro, C. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.06.007 · Cited by 21 · see citing works
Vuontisjärvi, S., Rossi, H., Herrala, S., Morin-Papunen, L. C., Tapanainen, J. S., Karjula, S., Karppinen, J. I., AUVINEN, J. P., & Piltonen, T. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.02.005 · Cited by 17 · see citing works
Padin, A. C., Wilson, S. J., Bailey, B. E., Malarkey, W. B., Lustberg, M. B., Farrar, W. B., Povoski, S. P., Agnese, D. M., Reinbolt, R. E., Wesolowski, R., et al. (2019) · International Journal of Behavioral Medicine · doi:10.1007/s12529-019-09778-3 · Cited by 17 · see citing works
Stefano, V. D., Steardo, L., D’Angelo, M., Monaco, F., & Steardo, L. (2025) · Biomedicines · doi:10.3390/biomedicines13061271 · Cited by 16 · see citing works
Characteristics of somatic symptoms among Chinese patients diagnosed with major depressive episode
Jian, Y., Jia, S., Shi, Z., Zhao, Y., Li, P., Chen, L., & Yang, L. (2020) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2020.11.001 · Cited by 16 · see citing works
Association between self-perceived pain sensitivity and pain intensity after cardiac surgery
Bjørnnes, A. K., Lie, I., Parry, M. J. E., Falk, R. S., Leegaard, M., Rustøen, T., & Valeberg, B. T. (2018) · Journal of Pain Research · doi:10.2147/jpr.s167524 · Cited by 16 · see citing works
Neuropathic pain in burn patients – A common problem with little literature: A systematic review
Stanton, E. W., Won, P., Manasyan, A., Gurram, S., Gilllenwater, T. J., & Yenikomshian, H. A. (2024) · Burns · doi:10.1016/j.burns.2024.02.013 · Cited by 15 · see citing works
Unveiling the interoception impairment in various major depressive disorder stages
Zhou, H., Liu, J., Wu, Y., Huang, Z., Wang, W., Ma, Y., Zhu, H., Zhou, Z., Wang, J., & Jiang, C. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14923 · Cited by 13 · see citing works
The Influence of Expectancies on Pain and Function Over Time After Total Knee Arthroplasty
Carrière, J. S., Martel, M. O., Loggia, M. L., Campbell, C. M., Smith, M. T., Haythornthwaite, J. A., & Edwards, R. R. (2022) · Pain Medicine · doi:10.1093/pm/pnac067 · Cited by 14 · see citing works
Raemen, L., Claes, L., Buelens, T., Vankerckhoven, L., van Oudenhove, L., & Luyckx, K. (2023) · Journal of Youth and Adolescence · doi:10.1007/s10964-023-01811-9 · Cited by 12 · see citing works
Dualé, C., Bauer, U., Storme, B., Eljezi, V., Ruscheweyh, R., Eschalier, S., Dubray, C., & Guiguet‐Auclair, C. (2019) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-019-01377-w · Cited by 12 · see citing works
Turan, Ş., Sağlam, N. G. U., Bakay, H., & Gökler, M. E. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.08.018 · Cited by 12 · see citing works
Knežević, A., Kovačević, M., Jeremić-Knežević, M., Nikolašević, Ž., Tomašević-Todorović, S., Živanović, Ž., Spasojević, T., Garipi, E., Vojnović, L., Popović, D., et al. (2023) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2022.102841 · Cited by 11 · see citing works
Yun, Y., Zhang, Q., Zhao, W., Ma, T., Fan, H., Bai, L., Ma, B., Qi, S., Wang, Z., An, H., et al. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.111069 · Cited by 11 · see citing works
Shepherd, W. S., Wiese, A. D., Cho, H. E., Rork, W. C., Baig, M., Kostick, K. M., Nguyen, D. D., Carter, E. M., Members of the, B. B. D. C., Sutton, V. R., et al. (2024) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-023-09991-z · Cited by 12 · see citing works
Atanassova, D. V., Madariaga, V. I., Oosterman, J. M., & Brazil, I. A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105786 · Cited by 12 · see citing works
Salas-González, J., Heredia‐Rizo, A. M., Fricke-Comellas, H., Chimenti, R. L., & Casuso-Holgado, M. J. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105530 · Cited by 14 · see citing works
de Andrade, D. C., & Valiengo, L. D. C. L. (2025) · European Journal of Pain · doi:10.1002/ejp.70077 · Cited by 10 · see citing works
Bruton, A. M., Senders, A., Tost, G., Ast, H. K., Robinette, L. M., Leung, B. M. Y., Hatsu, I. E., Arnold, L. E., & Johnstone, J. M. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2043946 · Cited by 10 · see citing works
Niederstrasser, N. G., & Cook, S. (2020) · Journal of Pain · doi:10.1016/j.jpain.2020.07.005 · Cited by 10 · see citing works
Headache, eating disorders, PTSD, and comorbidity: implications for assessment and treatment
Brewerton, T. D., Perlman, M. M., Gavidia, I., Suro, G., & Jahraus, J. (2022) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-022-01414-6 · Cited by 9 · see citing works
Liu, Q., Huang, Y., Wang, B., Li, Y., Zhou, W., Yu, J., Chen, H., & Wang, C. (2024) · Geriatric Nursing · doi:10.1016/j.gerinurse.2024.06.039 · Cited by 9 · see citing works
Hirpara, A., Bine, C., Williams, K., Fry, S. A., Whitney, K. E., & Dragoo, J. L. (2025) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2025.01.067 · Cited by 9 · see citing works
Granot, M., Srulovici, E., Granovsky, Y., Yarnitsky, D., & Kuperman, P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262076 · Cited by 9 · see citing works
Lucas, R., Talih, M., Soares, S., & Fraga, S. J. D. S. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.10.022 · Cited by 10 · see citing works
Fear acquisition and extinction in elderly patients with depression
Rainer, C., Nasrouei, S., Tschofen, S., Bliem, H. R., Wilhelm, F. H., & Marksteiner, J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.044 · Cited by 9 · see citing works
Mulrooney, E., Neogi, T., Dagfinrud, H. S., Hammer, H. B., Pettersen, P. S., Gløersen, M., Kvien, T. K., Magnusson, K., & Haugen, I. K. (2023) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2023.100367 · Cited by 9 · see citing works
Opioids for acute and chronic pain when receiving psychiatric medications
Janakiram, C., Okunev, I., Tranby, E. P., Fontelo, P. A., Iafolla, T., & Dye, B. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286179 · Cited by 8 · see citing works
Favaretto, E., Gögele, M., Bedani, F., Hicks, A. A., Erfurth, A., Perugi, G., Pramstaller, P. P., & Melotti, R. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.015 · Cited by 8 · see citing works
Hadeiy, S. K., Habtemariam, S., Shankayi, Z., Shahyad, S., Sahraei, H., Rezaei, M. A., & Bahrami, F. (2023) · Sleep Medicine X · doi:10.1016/j.sleepx.2023.100069 · Cited by 8 · see citing works
Neelapala, Y. V. R., Neogi, T., Hanna, S., Frey‐Law, L., Macedo, L. G., Kobsar, D., Lewis, C. E., Nevitt, M. C., & Carlesso, L. C. (2025) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2025.01.007 · Cited by 7 · see citing works
Bajcar, E. A., Bieniek, H., Brączyk, J., & Bąbel, P. (2022) · European Journal of Pain · doi:10.1002/ejp.2063 · Cited by 7 · see citing works
Imamura, M., Rebello‐Sanchez, I., Parente, J., Marduy, A., Vásquez-Ávila, K., Pacheco‐Barrios, K., Castelo-Branco, L., Simis, M., Battistella, L. R., & Fregni, F. (2023) · PM&R · doi:10.1002/pmrj.13038 · Cited by 7 · see citing works
Shiraishi, M., Sowa, Y., Tsuge, I., Shiraishi, A., Inafuku, N., Nakayama, I., & Morimoto, N. (2022) · Breast Cancer · doi:10.1007/s12282-022-01392-8 · Cited by 7 · see citing works
Shen, Q., Zhang, Q., Liu, Y., Cui, Y., Shang, J., Yuan, X., Geng, F., Sun, L., Liu, Z., Yang, R., et al. (2024) · Psychology Research and Behavior Management · doi:10.2147/prbm.s473074 · Cited by 6 · see citing works
Pontén, M., Lee, M., Khoo, S., Nilsson, G., Nevin, E., Walldén, Y., Ougrin, D., Cummins, T. M., Flygare, O., & Bjureberg, J. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116638 · Cited by 6 · see citing works
Hernandez, S. G., Mannix, R., Kerr, Z. Y., Lempke, L. B., Chandran, A. S., Walton, S. R., DeFreese, J., Echemendía, R. J., Guskiewicz, K. M., McCrea, M., et al. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104577 · Cited by 6 · see citing works
Stigmatized experience is associated with exacerbated pain perception in depressed patients
Zhang, M., Zhang, Y., Zhu, Y., Lin, X., Zhi, Y., Zhu, Y., Shi, C., & Kong, Y. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104252 · Cited by 6 · see citing works
Martins, A. C., Oliveira, D. S., Nicolau, R., Martins-Rocha, T., Bernardo, A., Costa, L. M. S. F., Pimenta, S., & Bernardes, M. (2023) · Clinical Rheumatology · doi:10.1007/s10067-023-06806-2 · Cited by 5 · see citing works
Zhao, H., Ran, S., Gan, K., Du, Y., & Li, W. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03689-2 · Cited by 5 · see citing works
Berry, C., Boyce, A. M., Kaban, L. B., Peacock, Z. S., Mannstadt, M., Upadhyay, J., van der Heijden, H. C., Golden, E., Westbrook, A., Shah, N., et al. (2024) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2024.12.001 · Cited by 5 · see citing works
Steffen, D. A., Najafi, A., & Binkert, C. A. (2022) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-022-03290-0 · Cited by 5 · see citing works
Théberge, E. T., Burden, E., Leung, K., Parvand, M., Prodan‐Bhalla, N., Humphries, K. H., & Sedlak, T. (2024) · CJC Open · doi:10.1016/j.cjco.2024.08.013 · Cited by 5 · see citing works
Association between psychotropic drug use and prescription opioid use among older adults
Khan, S. R., Heller, D. A., Latty, L. L., Cadieux, R. J., LaSure, M., & Brown, T. V. (2020) · Geriatric Nursing · doi:10.1016/j.gerinurse.2020.04.017 · Cited by 5 · see citing works
Risks of complicated acute appendicitis in patients with psychiatric disorders
Kim, J., Yang, C., Joo, H. J., Park, R. W., Kim, G. E., Kim, D., Choi, J., Lee, J. H., Kim, E., Park, S., et al. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04428-7 · Cited by 5 · see citing works
Xu, J., Cao, S., Hu, D., Lu, J. G., Li, Y., Zhang, H., & Tian, Z. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07184-6 · Cited by 4 · see citing works
Ramadan, B., & Waes, V. V. (2025) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2025.103055 · Cited by 4 · see citing works
Balasa, A., Bala, A., Olejnik, A., Marchel, A., & Kunert, P. (2023) · Medicine · doi:10.1097/md.0000000000033738 · Cited by 4 · see citing works
Wu, Q., Luo, Y., Han, M., Li, J., & Kang, F. (2023) · Journal of Pain Research · doi:10.2147/jpr.s419719 · Cited by 4 · see citing works
Piezo Ion Channels and Their Association With Haptic Technology Use: A Narrative Review
Gudin, J. A., Sakr, M., Fason, J., & Hurwitz, P. L. (2025) · Cureus · doi:10.7759/cureus.77433 · Cited by 4 · see citing works
Xerostomia correlates with pain sensitivity in burning mouth syndrome patients
Zhao, H., Ran, S., Huo, W., Gan, K., & Li, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-97048-6 · Cited by 4 · see citing works
Lara-Cinisomo, S., & Akinbode, T. D. (2020) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1016/j.jogn.2020.05.005 · Cited by 5 · see citing works
Pain perception and physiological correlates in body-focused repetitive behavior disorders
Löchner, C., Roos, J., Kidd, M., Hendricks, G., Peris, T. S., Ricketts, E. J., Dougherty, D. D., Woods, D. W., Keuthen, N. J., Stein, D. J., et al. (2022) · CNS Spectrums · doi:10.1017/s1092852922000062 · Cited by 4 · see citing works
Accuracy of Pain Tolerance Self-assessment Versus Objective Pressure Sensitivity
Haupt, E. T., Porter, G. M., Charlton, T., & Thordarson, D. B. (2023) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/jaaos-d-22-00500 · Cited by 4 · see citing works
Chen, S.-P., Yang, S., Hu, K.-C., Satyanarayanan, S. K., & Su, K. (2024) · Healthcare · doi:10.3390/healthcare12040490 · Cited by 3 · see citing works
Chen, Y., Wang, S., Fang, Q., Wu, Y., Huang, H., Zhang, Y., & Duan, G. (2025) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2025.105223 · Cited by 3 · see citing works
McKegg, P. C., Hodson, N. M., Zamzam, M. E., Driessche, A. M., North, T. W., & Charters, M. A. (2025) · The Journal of Arthroplasty · doi:10.1016/j.arth.2025.10.004 · Cited by 3 · see citing works
Greif, D. N., Shaikh, H. J. F., Neumanitis, J., Ramirez, G., Maloney, M. D., Bronstein, R. D., Giordano, B. D., Nicandri, G. T., Voloshin, I., & Mannava, S. (2023) · JSES International · doi:10.1016/j.jseint.2023.11.012 · Cited by 3 · see citing works
Vranceanu, A.-M. (2018) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999.0000000000000172 · Cited by 5 · see citing works
Butler, S., Draleau, K. S., Heinrich, R., Nguyen, L., Shbeeb, D., Sigalovsky, D., Koh, W. Y., Hull, S., & Cao, L. (2020) · Pain Medicine · doi:10.1093/pm/pnaa191 · Cited by 3 · see citing works
Krunić, J., Mladenović, I., Radović, I., & Stojanović, N. (2020) · Journal of Oral Rehabilitation · doi:10.1111/joor.13116 · Cited by 3 · see citing works
The thermal grill elicits central sensitization
Cormie, M. A., Seminowicz, D. A., & Moayedi, M. (2025) · Pain · doi:10.1097/j.pain.0000000000003776 · Cited by 3 · see citing works
Preexisting Psychiatric Risk Factors and Any and Long-Term Opioid Use in Head and Neck Cancer.
Osazuwa-Peters, N., Gao, M. Z., Kahmke, R., Ramkumar, S. P., Bates, N. E., & Scherrer, J. F. (2025) · JAMA Otolaryngology - Head and Neck Surgery · doi:10.1001/jamaoto.2025.2649 · Cited by 2 · see citing works
Neupane, S. P., Onyeka, I. N., Bull, V. H., & Daray, F. M. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107285 · Cited by 3 · see citing works
Nadjidai, S. E., Kusljic, S., Dowling, N. L., Magennis, J., Stokes, L., Ng, C. H., & Daniel, C. (2020) · International Journal of Mental Health Nursing · doi:10.1111/inm.12764 · Cited by 2 · see citing works
A Retrospective Study of Psychotropic Drug Use and Prescription Opioid Initiation Among Older Adults
Khan, S. R., Heller, D. A., Latty, L. L., LaSure, M., & Brown, T. V. (2021) · Population Health Management · doi:10.1089/pop.2021.0129 · Cited by 2 · see citing works
Linking interpretation bias to individual differences in pain sensitivity
Guo, Z., Zhang, W., Lyu, X., Ye, Q., & Peng, W. (2022) · Current Psychology · doi:10.1007/s12144-022-03793-6 · Cited by 2 · see citing works
Seok, S. Y., Cho, J. H., Lee, H. R., Lee, D., Park, S., Lee, C. S., & Hwang, E. S. (2023) · Journal of Orthopaedic Science · doi:10.1016/j.jos.2023.04.008 · Cited by 2 · see citing works
The influence of depression on clinical outcomes of total shoulder arthroplasty: a systematic Review
Bindi, V. E., Hones, K. M., Schoch, B. S., Hampton, H., Wright, T. W., King, J. J., & Hao, K. A. (2024) · European Journal of Orthopaedic Surgery & Traumatology · doi:10.1007/s00590-024-03911-z · Cited by 2 · see citing works
García, M., Amayra, I., Pérez, M., Rodríguez, A. A., Salgueiro, M., & Infante, J. (2024) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2024.01010 · Cited by 2 · see citing works
Are there any differences in pain thresholds during the menstrual cycle?
Savic, A., Savanov, B., Subic, L., Popović, D., Aleksandrić, T., & Knežević, A. (2024) · Medicinski pregled · doi:10.2298/mpns2408228s · Cited by 2 · see citing works
The modulatory effects of depression on pain perception: A review of animal model studies
Wang, N., Wei, X., Wang, J., & Luo, F. (2018) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972017-01255 · Cited by 2 · see citing works
Reducing the Pain Behind Opioid Prescribing in Primary Care
González, J. L., Prabhakar, R., Marks, J. R., Vigen, C. L. P., Shukla, J., & Bannister, B. (2019) · Pain Medicine · doi:10.1093/pm/pnz365 · Cited by 2 · see citing works
Schmerzphänomene bei Depression
Weiß, T., & Bär, K. (2021) · Der Schmerzpatient · doi:10.1055/a-1551-6739 · Cited by 2 · see citing works
Editorial: Pain and Depression
Zhao, Q., Kong, Y., & Wan, L. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.865071 · Cited by 2 · see citing works
Comments on: Incidence of persistent opioid use following traumatic injury
Lee, J. M., Butt, A. L., & Pak, A. (2023) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2023-104879 · Cited by 2 · see citing works
- Authors
- Hermesdorf, M., Berger, K., Baune, B. T., Wellmann, J., Ruscheweyh, R., & Wersching, H.
- Affiliations
- University of Münster (DE)
- The University of Adelaide (AU)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Wersching, Heike
- ORCID
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 17
- Issue
- 5
- Pages
- 606-616
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W2261932613
- Cited by
- 140
- References
- 61
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 16 · 2023: 20 · 2022: 19 · 2021: 6 · 2020: 16 · 2019: 6 · 2018: 12 · 2017: 2
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Health and Medical Research Council
- Bundesministerium für Bildung und Forschung (01ER0816, 01ER1205)
- Pfizer
- Else Kröner-Fresenius-Stiftung
- Friedrich-Baur-Stiftung
- Allergan
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- major depressive disorder, pain sensitivity, pressure pain threshold, Pain Sensitivity Questionnaire, anxiety symptoms, sleep quality, physical inactivity, chronic pain risk, depression subtypes, symptom severity
- MeSH terms
- Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Pain Measurement, Pressure, Psychiatric Status Rating Scales, Surveys and Questionnaires, Sleep Wake Disorders, Cohort Studies, Exercise, Pain Threshold, Self Report, Pain Perception
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